Sarah Lamere

Title(s)Assistant Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Cornell University, Ithaca, NYD.V.M.05/2007Veterinary Medicine
    The Scripps Research Institute, La Jolla, CAPh.D.05/2015Immunology

    Collapse Overview 
    Collapse Overview
    I am a veterinarian focused on comparative medicine, and an Assistant Professor of Medicine at UCSD with training in retrovirology, immunology, and epigenetics. I have a strong interest in the “One Health” philosophy, which espouses that cross-talk between the human and animal medical professions will help to advance both fields. My original research focus was on understanding the pathogenicity of retroviruses in wildlife species, particularly in cetaceans. However, I turned my attention to the fields of epigenetics and immunology with the perspective that I could apply what I learned about these processes to our understanding of how they impact retroviral latency and reactivation in multiple species, allowing us to decipher their pathogenic potential. In humans, it is well established that people with HIV on antiretroviral therapy (ART) will maintain persistent reservoirs of the HIV provirus, and elucidating the epigenetic processes guiding persistence and reactivation will allow us to develop more effective strategies for eliminating this reservoir. I am currently using cutting-edge epigenomics assays, including single cell strategies, to evaluate the chromatin conformation and epigenetic modifications of both the human genome in the context of HIV infection and the HIV provirus itself to study HIV persistence in tissues.

    Collapse Research 
    Collapse Research Activities and Funding
    The impact of proviral epigenetics on HIV-1 rebound
    NIH R21AI162225Mar 19, 2021 - Feb 28, 2023
    Role: Principal Investigator
    Comparative Retroviral Epigenomics
    NIH K01OD026565Mar 15, 2018 - Jun 30, 2023
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Challenges in Quantifying Cytosine Methylation in the HIV Provirus. mBio. 2019 01 22; 10(1). LaMere SA, Chaillon A, Huynh C, Smith DM, Gianella S. PMID: 30670613; PMCID: PMC6343035.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    2. Microdroplet PCR for Highly Multiplexed Targeted Bisulfite Sequencing. Methods Mol Biol. 2018; 1708:333-348. Komori HK, LaMere SA, Hart T, Head SR, Torkamani A, Salomon DR. PMID: 29224152.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3. J Immunol. 2017 11 01; 199(9):3158-3175. LaMere SA, Thompson RC, Meng X, Komori HK, Mark A, Salomon DR. PMID: 28947543; PMCID: PMC5679303.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    4. Promoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells. Genes Immun. 2016 07; 17(5):283-97. LaMere SA, Thompson RC, Komori HK, Mark A, Salomon DR. PMID: 27170561; PMCID: PMC4956548.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    5. Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation. J Immunol. 2015 Feb 15; 194(4):1565-79. Komori HK, Hart T, LaMere SA, Chew PV, Salomon DR. PMID: 25576597; PMCID: PMC4364524.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    6. Library construction for next-generation sequencing: overviews and challenges. Biotechniques. 2014; 56(2):61-4, 66, 68, passim. Head SR, Komori HK, LaMere SA, Whisenant T, Van Nieuwerburgh F, Salomon DR, Ordoukhanian P. PMID: 24502796; PMCID: PMC4351865.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    7. Finding the active genes in deep RNA-seq gene expression studies. BMC Genomics. 2013 Nov 11; 14:778. Hart T, Komori HK, LaMere S, Podshivalova K, Salomon DR. PMID: 24215113; PMCID: PMC3870982.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    8. New opportunities for organ transplantation research: epigenetics is likely to be an important determinant of the host immune response. Epigenomics. 2013 Jun; 5(3):243-6. LaMere SA, Komori HK, Salomon DR. PMID: 23750639.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Application of microdroplet PCR for large-scale targeted bisulfite sequencing. Genome Res. 2011 Oct; 21(10):1738-45. Komori HK, LaMere SA, Torkamani A, Hart GT, Kotsopoulos S, Warner J, Samuels ML, Olson J, Head SR, Ordoukhanian P, Lee PL, Link DR, Salomon DR. PMID: 21757609; PMCID: PMC3202290.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    10. Phylogenetic analysis of marine mammal herpesviruses. Vet Microbiol. 2011 Apr 21; 149(1-2):23-9. Maness HT, Nollens HH, Jensen ED, Goldstein T, LaMere S, Childress A, Sykes J, St Leger J, Lacave G, Latson FE, Wellehan JF. PMID: 21055885.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    11. Molecular characterization of a novel gammaretrovirus in killer whales (Orcinus orca). J Virol. 2009 Dec; 83(24):12956-67. Lamere SA, St Leger JA, Schrenzel MD, Anthony SJ, Rideout BA, Salomon DR. PMID: 19812152; PMCID: PMC2786842.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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