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Sanjaya Saxena

Title(s)Clinical Professor, Psychiatry
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    UCLA Crump Institute for Biological ImagingResearch Fellowship in Neuroimaging1996UCLA School of Medicine
    UCLA Neuropsychiatric InstitutePsychiatry Residency1994
    University of Minnesota Medical SchoolM.D.1990

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    Collapse Overview

    Biography

    Dr. Saxena received his Bachelor's degree from Swarthmore College and his medical degree (Alpha Omega Alpha) from University of Minnesota Medical School. He did his psychiatry residency at UCLA Neuropsychiatric Institute, then completed a research fellowship in neuroimaging in neuropsychiatric disorders, receiving a Charles A. Dana Foundation Scholarship. He was on the faculty of the UCLA Department of Psychiatry & Biobehavioral Sciences for nine years before coming to UCSD and the VA San Diego Healthcare System in November, 2005. In 2006, he became the Director of the UCSD Obsessive-Compulsive Disorders (OCD) Program. He also created San Diego VA Anxiety Disorders Clinic and directed it for four years. Since 2010, he has served as Director of UCSD Outpatient Psychiatric Services and also continues to direct the UCSD OCD Clinic. Dr. Saxena has been elected into Best Doctors in America every year since 2005, and into Castle Connelly’s and US News & World Report’s America’s Top Doctors every year since 2008. Dr. Saxena is also heavily involved in teaching psychiatric residents and medical students at UCSD.

    Research Interests

    His research focuses on the neurobiology and treatment of OCD, Hoarding Disorder (HD), and related disorders. He has received awards and grants from the American Psychiatric Association, American Neuropsychiatric Association, International OCD Foundation, and the National Institute of Mental Health. Dr. Saxena serves on the Scientific Advisory Board for the International OCD Foundation and was an advisor to the DSM-5 Workgroup on Obsessive-Compulsive Spectrum Disorders. He and his colleagues developed the diagnostic criteria for Hoarding Disorder, which is now listed as a separate diagnosis in DSM-5. His research has garnered attention from local, national, and international media.

    Collapse Research 
    Collapse Research Activities and Funding
    Neurobiology of Obsessive-Compulsive Hoarding
    NIH/NIMH R01MH069433Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    NEUROANATOMY AND PHARMACOTHERAPY OF OCD AND MAJOR DEPRES
    NIH/NIMH K23MH001694Jun 10, 1999 - May 31, 2004
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ayers CR, Dozier ME, Twamley EW, Saxena S, Granholm E, Mayes TL, Wetherell JL. Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) for Hoarding Disorder in Older Adults: A Randomized Clinical Trial. J Clin Psychiatry. 2018 Mar/Apr; 79(2). PMID: 28541646.
      View in: PubMed
    2. Sumner JM, Noack CG, Filoteo JV, Maddox WT, Saxena S. Neurocognitive performance in unmedicated patients with hoarding disorder. Neuropsychology. 2016 Feb; 30(2):157-68. PMID: 26301774.
      View in: PubMed
    3. Saxena S, Ayers CR, Dozier ME, Maidment KM. The UCLA Hoarding Severity Scale: development and validation. J Affect Disord. 2015 Apr 01; 175:488-93. PMID: 25681559.
      View in: PubMed
    4. Saxena S, Sumner J. Venlafaxine extended-release treatment of hoarding disorder. Int Clin Psychopharmacol. 2014 Sep; 29(5):266-73. PMID: 24722633.
      View in: PubMed
    5. Ayers CR, Saxena S, Espejo E, Twamley EW, Granholm E, Wetherell JL. Novel treatment for geriatric hoarding disorder: an open trial of cognitive rehabilitation paired with behavior therapy. Am J Geriatr Psychiatry. 2014 Mar; 22(3):248-52. PMID: 23831173.
      View in: PubMed
    6. Ayers CR, Wetherell JL, Schiehser D, Almklov E, Golshan S, Saxena S. Executive functioning in older adults with hoarding disorder. Int J Geriatr Psychiatry. 2013 Nov; 28(11):1175-81. PMID: 23440720.
      View in: PubMed
    7. O'Neill J, Gorbis E, Feusner JD, Yip JC, Chang S, Maidment KM, Levitt JG, Salamon N, Ringman JM, Saxena S. Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder. J Psychiatr Res. 2013 Apr; 47(4):494-504. PMID: 23290560.
      View in: PubMed
    8. Ayers CR, Bratiotis C, Saxena S, Wetherell JL. Therapist and patient perspectives on cognitive-behavioral therapy for older adults with hoarding disorder: a collective case study. Aging Ment Health. 2012; 16(7):915-21. PMID: 22548463.
      View in: PubMed
    9. Ayers CR, Wetherell JL, Golshan S, Saxena S. Cognitive-behavioral therapy for geriatric compulsive hoarding. Behav Res Ther. 2011 Oct; 49(10):689-94. PMID: 21784412.
      View in: PubMed
    10. Saxena S. Pharmacotherapy of compulsive hoarding. J Clin Psychol. 2011 May; 67(5):477-84. PMID: 21404273.
      View in: PubMed
    11. Saxena S, Ayers CR, Maidment KM, Vapnik T, Wetherell JL, Bystritsky A. Quality of life and functional impairment in compulsive hoarding. J Psychiatr Res. 2011 Apr; 45(4):475-80. PMID: 20822778.
      View in: PubMed
    12. Mataix-Cols D, Frost RO, Pertusa A, Clark LA, Saxena S, Leckman JF, Stein DJ, Matsunaga H, Wilhelm S. Hoarding disorder: a new diagnosis for DSM-V? Depress Anxiety. 2010 Jun; 27(6):556-72. PMID: 20336805.
      View in: PubMed
    13. Leckman JF, Denys D, Simpson HB, Mataix-Cols D, Hollander E, Saxena S, Miguel EC, Rauch SL, Goodman WK, Phillips KA, Stein DJ. Obsessive-compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V. Depress Anxiety. 2010 Jun; 27(6):507-27. PMID: 20217853.
      View in: PubMed
    14. Phillips KA, Stein DJ, Rauch SL, Hollander E, Fallon BA, Barsky A, Fineberg N, Mataix-Cols D, Ferrão YA, Saxena S, Wilhelm S, Kelly MM, Clark LA, Pinto A, Bienvenu OJ, Farrow J, Leckman J. Should an obsessive-compulsive spectrum grouping of disorders be included in DSM-V? Depress Anxiety. 2010 Jun; 27(6):528-55. PMID: 20533367.
      View in: PubMed
    15. Pertusa A, Frost RO, Fullana MA, Samuels J, Steketee G, Tolin D, Saxena S, Leckman JF, Mataix-Cols D. Refining the diagnostic boundaries of compulsive hoarding: a critical review. Clin Psychol Rev. 2010 Jun; 30(4):371-86. PMID: 20189280.
      View in: PubMed
    16. Ayers CR, Saxena S, Golshan S, Wetherell JL. Age at onset and clinical features of late life compulsive hoarding. Int J Geriatr Psychiatry. 2010 Feb; 25(2):142-9. PMID: 19548272.
      View in: PubMed
    17. Brody AL, Olmstead RE, Abrams AL, Costello MR, Khan A, Kozman D, Saxena S, Farahi J, London ED, Mandelkern MA. Effect of a history of major depressive disorder on smoking-induced dopamine release. Biol Psychiatry. 2009 Nov 01; 66(9):898-901. PMID: 19640507.
      View in: PubMed
    18. Feusner JD, Kerwin L, Saxena S, Bystritsky A. Differential efficacy of memantine for obsessive-compulsive disorder vs. generalized anxiety disorder: an open-label trial. Psychopharmacol Bull. 2009; 42(1):81-93. PMID: 19204653.
      View in: PubMed
    19. Saxena S. Neurobiology and treatment of compulsive hoarding. CNS Spectr. 2008 Sep; 13(9 Suppl 14):29-36. PMID: 18849909.
      View in: PubMed
    20. Saxena S. Recent advances in compulsive hoarding. Curr Psychiatry Rep. 2008 Aug; 10(4):297-303. PMID: 18627667.
      View in: PubMed
    21. Brody AL, Mandelkern MA, Olmstead RE, Allen-Martinez Z, Scheibal D, Abrams AL, Costello MR, Farahi J, Saxena S, Monterosso J, London ED. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacology. 2009 Jan; 34(2):282-9. PMID: 18563061.
      View in: PubMed
    22. Feusner JD, Yaryura-Tobias J, Saxena S. The pathophysiology of body dysmorphic disorder. Body Image. 2008 Mar; 5(1):3-12. PMID: 18314401.
      View in: PubMed
    23. Saxena S, Gorbis E, O'Neill J, Baker SK, Mandelkern MA, Maidment KM, Chang S, Salamon N, Brody AL, Schwartz JM, London ED. Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder. Mol Psychiatry. 2009 Feb; 14(2):197-205. PMID: 18180761.
      View in: PubMed
    24. Fineberg NA, Saxena S, Zohar J, Craig KJ. Obsessive-compulsive disorder: boundary issues. CNS Spectr. 2007 May; 12(5):359-64, 367-375. PMID: 17514081.
      View in: PubMed
    25. Matsui T, Saxena S, Kawabe J, Matsunaga H, Kohagura K, Higashiyama S, Kiriike N. Secondary obsessive-compulsive disorder related to diaschisis after pontine infarction, successfully treated with paroxetine. Psychiatry Clin Neurosci. 2007 Apr; 61(2):186-9. PMID: 17362437.
      View in: PubMed
    26. Saxena S. Is compulsive hoarding a genetically and neurobiologically discrete syndrome? Implications for diagnostic classification. Am J Psychiatry. 2007 Mar; 164(3):380-4. PMID: 17329459.
      View in: PubMed
    27. Brody AL, Mandelkern MA, Olmstead RE, Scheibal D, Hahn E, Shiraga S, Zamora-Paja E, Farahi J, Saxena S, London ED, McCracken JT. Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry. 2006 Jul; 63(7):808-16. PMID: 16818870.
      View in: PubMed
    28. Saxena S, Brody AL, Maidment KM, Baxter LR. Paroxetine treatment of compulsive hoarding. J Psychiatr Res. 2007 Sep; 41(6):481-7. PMID: 16790250.
      View in: PubMed
    29. Kohn R, Saxena S, Levav I, Saraceno B. The treatment gap in mental health care. Bull World Health Organ. 2004 Nov; 82(11):858-66. PMID: 15640922.
      View in: PubMed
    30. Saxena S, Maidment KM. Treatment of compulsive hoarding. J Clin Psychol. 2004 Nov; 60(11):1143-54. PMID: 15389621.
      View in: PubMed
    31. Saxena S, Brody AL, Maidment KM, Smith EC, Zohrabi N, Katz E, Baker SK, Baxter LR. Cerebral glucose metabolism in obsessive-compulsive hoarding. Am J Psychiatry. 2004 Jun; 161(6):1038-48. PMID: 15169692.
      View in: PubMed
    32. Brody AL, Mandelkern MA, Lee G, Smith E, Sadeghi M, Saxena S, Jarvik ME, London ED. Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Res. 2004 Apr 30; 130(3):269-81. PMID: 15135160.
      View in: PubMed
    33. Bystritsky A, Ackerman DL, Rosen RM, Vapnik T, Gorbis E, Maidment KM, Saxena S. Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trial. J Clin Psychiatry. 2004 Apr; 65(4):565-8. PMID: 15119922.
      View in: PubMed
    34. Saxena S, Brody AL, Ho ML, Zohrabi N, Maidment KM, Baxter LR. Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am J Psychiatry. 2003 Mar; 160(3):522-32. PMID: 12611834.
      View in: PubMed
    35. Brody AL, Mandelkern MA, London ED, Childress AR, Lee GS, Bota RG, Ho ML, Saxena S, Baxter LR, Madsen D, Jarvik ME. Brain metabolic changes during cigarette craving. Arch Gen Psychiatry. 2002 Dec; 59(12):1162-72. PMID: 12470133.
      View in: PubMed
    36. Saxena S, Brody AL, Ho ML, Alborzian S, Maidment KM, Zohrabi N, Ho MK, Huang SC, Wu HM, Baxter LR. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry. 2002 Mar; 59(3):250-61. PMID: 11879163.
      View in: PubMed
    37. Saxena S, Maidment KM, Vapnik T, Golden G, Rishwain T, Rosen RM, Tarlow G, Bystritsky A. Obsessive-compulsive hoarding: symptom severity and response to multimodal treatment. J Clin Psychiatry. 2002 Jan; 63(1):21-7. PMID: 11838621.
      View in: PubMed
    38. Hollander E, Bienstock CA, Koran LM, Pallanti S, Marazziti D, Rasmussen SA, Ravizza L, Benkelfat C, Saxena S, Greenberg BD, Sasson Y, Zohar J. Refractory obsessive-compulsive disorder: state-of-the-art treatment. J Clin Psychiatry. 2002; 63 Suppl 6:20-9. PMID: 12027116.
      View in: PubMed
    39. Hurley RA, Saxena S, Rauch SL, Hoehn-Saric R, Taber KH. Predicting treatment response in obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 2002; 14(3):249-53. PMID: 12154147.
      View in: PubMed
    40. Small GW, Chen ST, Komo S, Ercoli L, Miller K, Siddarth P, Kaplan A, Dorsey D, Lavretsky H, Saxena S, Bookheimer SY. Memory self-appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease. Int J Geriatr Psychiatry. 2001 Nov; 16(11):1071-7. PMID: 11746653.
      View in: PubMed
    41. Saxena S, Brody AL, Ho ML, Alborzian S, Ho MK, Maidment KM, Huang SC, Wu HM, Au SC, Baxter LR. Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently. Biol Psychiatry. 2001 Aug 01; 50(3):159-70. PMID: 11513814.
      View in: PubMed
    42. Brody AL, Saxena S, Mandelkern MA, Fairbanks LA, Ho ML, Baxter LR. Brain metabolic changes associated with symptom factor improvement in major depressive disorder. Biol Psychiatry. 2001 Aug 01; 50(3):171-8. PMID: 11513815.
      View in: PubMed
    43. Brody AL, Saxena S, Stoessel P, Gillies LA, Fairbanks LA, Alborzian S, Phelps ME, Huang SC, Wu HM, Ho ML, Ho MK, Au SC, Maidment K, Baxter LR. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Arch Gen Psychiatry. 2001 Jul; 58(7):631-40. PMID: 11448368.
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    44. Saxena S, Bota RG, Brody AL. Brain-behavior relationships in obsessive-compulsive disorder. Semin Clin Neuropsychiatry. 2001 Apr; 6(2):82-101. PMID: 11296309.
      View in: PubMed
    45. Brody AL, Barsom MW, Bota RG, Saxena S. Prefrontal-subcortical and limbic circuit mediation of major depressive disorder. Semin Clin Neuropsychiatry. 2001 Apr; 6(2):102-12. PMID: 11296310.
      View in: PubMed
    46. Saxena S, Winograd A, Dunkin JJ, Maidment K, Rosen R, Vapnik T, Tarlow G, Bystritsky A. A retrospective review of clinical characteristics and treatment response in body dysmorphic disorder versus obsessive-compulsive disorder. J Clin Psychiatry. 2001 Jan; 62(1):67-72; quiz 73. PMID: 11235937.
      View in: PubMed
    47. Bystritsky A, Liberman RP, Hwang S, Wallace CJ, Vapnik T, Maindment K, Saxena S. Social functioning and quality of life comparisons between obsessive-compulsive and schizophrenic disorders. Depress Anxiety. 2001; 14(4):214-8. PMID: 11754128.
      View in: PubMed
    48. Saxena S, Rauch SL. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am. 2000 Sep; 23(3):563-86. PMID: 10986728.
      View in: PubMed
    49. Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, Saunders AM, Pericak-Vance MA, Roses AD, Barrio JR, Phelps ME. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6037-42. PMID: 10811879.
      View in: PubMed
    50. Brody AL, Saxena S, Fairbanks LA, Alborzian S, Demaree HA, Maidment KM, Baxter LR. Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetine. J Clin Psychiatry. 2000 May; 61(5):349-55. PMID: 10847309.
      View in: PubMed
    51. Saxena S, Brody AL, Maidment KM, Dunkin JJ, Colgan M, Alborzian S, Phelps ME, Baxter LR. Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology. 1999 Dec; 21(6):683-93. PMID: 10633474.
      View in: PubMed
    52. Brody AL, Saxena S, Silverman DH, Alborzian S, Fairbanks LA, Phelps ME, Huang SC, Wu HM, Maidment K, Baxter LR. Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine. Psychiatry Res. 1999 Oct 11; 91(3):127-39. PMID: 10641577.
      View in: PubMed
    53. Small GW, Chen ST, Komo S, Ercoli L, Bookheimer S, Miller K, Lavretsky H, Saxena S, Kaplan A, Dorsey D, Scott WK, Saunders AM, Haines JL, Roses AD, Pericak-Vance MA. Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele. Am J Psychiatry. 1999 Jul; 156(7):1035-8. PMID: 10401448.
      View in: PubMed
    54. Bystritsky A, Saxena S, Maidment K, Vapnik T, Tarlow G, Rosen R. Quality-of-life changes among patients with obsessive-compulsive disorder in a partial hospitalization program. Psychiatr Serv. 1999 Mar; 50(3):412-4. PMID: 10096650.
      View in: PubMed
    55. Brody AL, Saxena S, Schwartz JM, Stoessel PW, Maidment K, Phelps ME, Baxter LR. FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res. 1998 Nov 09; 84(1):1-6. PMID: 9870412.
      View in: PubMed
    56. Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl. 1998; (35):26-37. PMID: 9829024.
      View in: PubMed
    57. Small GW, Komo S, La Rue A, Saxena S, Phelps ME, Mazziotta JC, Saunders AM, Haines JL, Pericak-Vance MA, Roses AD. Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging. Ann N Y Acad Sci. 1996 Dec 16; 802:70-8. PMID: 8993486.
      View in: PubMed
    58. Saxena S, Wang D, Bystritsky A, Baxter LR. Risperidone augmentation of SRI treatment for refractory obsessive-compulsive disorder. J Clin Psychiatry. 1996 Jul; 57(7):303-6. PMID: 8666572.
      View in: PubMed
    59. Baxter LR, Saxena S, Brody AL, Ackermann RF, Colgan M, Schwartz JM, Allen-Martinez Z, Fuster JM, Phelps ME. Brain Mediation of Obsessive-Compulsive Disorder Symptoms: Evidence From Functional Brain Imaging Studies in the Human and Nonhuman Primate. Semin Clin Neuropsychiatry. 1996 Jan; 1(1):32-47. PMID: 10229782.
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    60. Frey WH, Emory CR, Wiebenga ME, Saxena S, Cardelli D, Ala TA, Tollefson GD. Inhibitor of antagonist binding to the muscarinic receptor is elevated in Alzheimer's brain. Brain Res. 1994 Aug 29; 655(1-2):153-60. PMID: 7812767.
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    61. Saxena K, Saxena S. Scopolamine withdrawal syndrome. Postgrad Med. 1990 Jan; 87(1):63-6. PMID: 2296571.
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    62. Tollefson GD, Saxena S, Luxenberg M, Garvey MJ. A retrospective evaluation of plasma trazodone concentrations and clinical response in a primary care clinic. Hillside J Clin Psychiatry. 1988; 10(2):183-7. PMID: 3224945.
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    63. Tollefson GD, Zander J, Luxenberg M, Saxena S, Godes M, Garvey MJ. Prediction of postdexamethasone cortisol levels by serum sodium levels in patients with major depression. Am J Psychiatry. 1986 Jan; 143(1):81-4. PMID: 3942292.
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