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Samuel Klein

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0956
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics. J Clin Invest. 2020 Jun 01; 130(6):3305-3314. Smith GI, Polidori DC, Yoshino M, Kearney ML, Patterson BW, Mittendorfer B, Klein S. PMID: 32191646.
      View in: PubMed   Mentions:    Fields:    
    2. Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. J Clin Invest. 2020 Mar 02; 130(3):1453-1460. Smith GI, Shankaran M, Yoshino M, Schweitzer GG, Chondronikola M, Beals JW, Okunade AL, Patterson BW, Nyangau E, Field T, Sirlin CB, Talukdar S, Hellerstein MK, Klein S. PMID: 31805015.
      View in: PubMed   Mentions: 2     Fields:    
    3. Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction. Sci Rep. 2020 Feb 25; 10(1):3417. Ding X, Iyer R, Novotny C, Metzger D, Zhou HH, Smith GI, Yoshino M, Yoshino J, Klein S, Swaminath G, Talukdar S, Zhou Y. PMID: 32099031.
      View in: PubMed   Mentions:    Fields:    
    4. Striatal Dopamine Responses to Feeding are Altered in People with Obesity. Obesity (Silver Spring). 2020 Apr; 28(4):765-771. Eisenstein SA, Black KJ, Samara A, Koller JM, Dunn JP, Hershey T, Klein S, Smith GI. PMID: 32086877.
      View in: PubMed   Mentions:    Fields:    
    5. Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity. Nat Metab. 2019 Dec; 1(12):1243-1257. An YA, Crewe C, Asterholm IW, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, Scherer PE. PMID: 31984308.
      View in: PubMed   Mentions:
    6. Obesity dysregulates fasting-induced changes in glucagon secretion. J Endocrinol. 2019 11; 243(2):149-160. Stern JH, Smith GI, Chen S, Unger RH, Klein S, Scherer PE. PMID: 31454790.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Metabolically healthy obesity: facts and fantasies. J Clin Invest. 2019 10 01; 129(10):3978-3989. Smith GI, Mittendorfer B, Klein S. PMID: 31524630.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    8. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019 Jan; 1(1):86-97. Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM. PMID: 31528845.
      View in: PubMed   Mentions:
    9. The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol. 2018 10; 596(19):4681-4692. van Vliet S, Smith GI, Porter L, Ramaswamy R, Reeds DN, Okunade AL, Yoshino J, Klein S, Mittendorfer B. PMID: 30054913.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring). 2018 May; 26(5):854-861. Smith GI, Commean PK, Reeds DN, Klein S, Mittendorfer B. PMID: 29687650.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial. Diabetes Obes Metab. 2018 05; 20(5):1302-1305. Pettus J, Reeds D, Cavaiola TS, Boeder S, Levin M, Tobin G, Cava E, Thai D, Shi J, Yan H, Bautista E, McMillan J, Unger R, Henry RR, Klein S. PMID: 29283470.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Effect of Weight Gain and Weight Loss on In Vivo Colonocyte Proliferation Rate in People with Obesity. Obesity (Silver Spring). 2017 11; 25 Suppl 2:S81-S86. Magkos F, Sullivan S, Fitch M, Smith G, Fabbrini E, Mittendorfer B, Hellerstein M, Klein S. PMID: 29086514.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion. J Clin Endocrinol Metab. 2017 10 01; 102(10):3858-3864. Harris LLS, Smith GI, Mittendorfer B, Eagon JC, Okunade AL, Patterson BW, Klein S. PMID: 28938478.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    14. Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion-Induced Insulin Resistance. Diabetes. 2017 07; 66(7):1871-1878. Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade AL, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B. PMID: 28473464.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. HIV infection does not prevent the metabolic benefits of diet-induced weight loss in women with obesity. Obesity (Silver Spring). 2017 04; 25(4):682-688. Reeds DN, Pietka TA, Yarasheski KE, Cade WT, Patterson BW, Okunade A, Abumrad NA, Klein S. PMID: 28245099.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    16. High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women. Cell Rep. 2016 10 11; 17(3):849-861. Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B. PMID: 27732859.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    17. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial. Am J Clin Nutr. 2016 Sep; 104(3):576-86. Weiss EP, Albert SG, Reeds DN, Kress KS, McDaniel JL, Klein S, Villareal DT. PMID: 27465384.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Effect of Duodenal-Jejunal Bypass Surgery on Glycemic Control in Type 2 Diabetes: A Randomized Controlled Trial. Obesity (Silver Spring). 2015 Oct; 23(10):1973-9. Petry TZ, Fabbrini E, Otoch JP, Carmona MA, Caravatto PP, Salles JE, Sarian T, Correa JL, Schiavon CA, Patterson BW, Cohen R, Klein S. PMID: 26414562.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015 Jul; 102(1):115-22. Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. PMID: 25994567.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    20. Calorie Restriction and Matched Weight Loss From Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men. Diabetes Care. 2015 Jul; 38(7):1253-62. Weiss EP, Albert SG, Reeds DN, Kress KS, Ezekiel UR, McDaniel JL, Patterson BW, Klein S, Villareal DT. PMID: 25877812.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    21. Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes. 2015 May; 64(5):1555-63. Smith GI, Yoshino J, Stromsdorfer KL, Klein SJ, Magkos F, Reeds DN, Klein S, Mittendorfer B. PMID: 25475435.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    22. Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial. Aesthet Surg J. 2013 Mar; 33(3):400-8. Reeds DN, Mohammed BS, Klein S, Boswell CB, Young VL. PMID: 23439063.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Very Low Density Lipoprotein Metabolism in Patients with Chronic Kidney Disease. Cardiorenal Med. 2012 Feb; 2(1):57-65. Wang X, Belani S, Coyne DW, Fabbrini E, Reeds DN, Patterson BW, Mittendorfer B, Klein S. PMID: 22493604.
      View in: PubMed   Mentions: 2     Fields:    
    24. Ginseng and ginsenoside Re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care. 2011 May; 34(5):1071-6. Reeds DN, Patterson BW, Okunade A, Holloszy JO, Polonsky KS, Klein S. PMID: 21411505.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    25. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009 May; 136(5):1552-60. Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Mayurranjan MS, Patterson BW, Klein S. PMID: 19208352.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    26. Long-term effects of large-volume liposuction on metabolic risk factors for coronary heart disease. Obesity (Silver Spring). 2008 Dec; 16(12):2648-51. Mohammed BS, Cohen S, Reeds D, Young VL, Klein S. PMID: 18820648.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    27. Adipose tissue, hepatic, and skeletal muscle insulin sensitivity in extremely obese subjects with acanthosis nigricans. Metabolism. 2006 Dec; 55(12):1658-63. Reeds DN, Stuart CA, Perez O, Klein S. PMID: 17142140.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E812-9. Cade WT, Reeds DN, Mittendorfer B, Patterson BW, Powderly WG, Klein S, Yarasheski KE. PMID: 17106066.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    29. Whole-body proteolysis rate is elevated in HIV-associated insulin resistance. Diabetes. 2006 Oct; 55(10):2849-55. Reeds DN, Cade WT, Patterson BW, Powderly WG, Klein S, Yarasheski KE. PMID: 17003352.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    30. Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy. Metabolism. 2005 May; 54(5):561-7. Chaparro J, Reeds DN, Wen W, Xueping E, Klein S, Semenkovich CF, Bae KT, Quirk EK, Powderly WG, Yarasheski KE, Li E. PMID: 15877283.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity. Am J Physiol Endocrinol Metab. 2003 Apr; 284(4):E708-15. Mittendorfer B, Patterson BW, Klein S, Sidossis LS. PMID: 12475756.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    32. Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial. Diabetes Care. 2002 Jun; 25(6):1033-41. Kelley DE, Bray GA, Pi-Sunyer FX, Klein S, Hill J, Miles J, Hollander P. PMID: 12032111.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
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