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    Russell Doolittle

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0314
    CA La Jolla 92093
    Phone858-534-4417
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Characterization of the flexible portions of fibrinogen
      NIH/NHLBI R01HL081553Jul 5, 2005 - Jun 30, 2009
      Role: Principal Investigator
      GENOME ANALYSIS
      NIH/NHGRI T32HG000005Sep 30, 1990 - Aug 31, 1996
      Role: Co-Principal Investigator
      PEPTIDE SYNTHESIZER-ANALYZER COMBINATION
      NIH/NCRR S10RR005674May 18, 1990 - May 17, 1991
      Role: Principal Investigator
      XTH CONGRESS ISTH
      NIH/NHLBI R13HL034037Apr 1, 1985 - Mar 31, 1986
      Role: Principal Investigator
      PROTEIN STRUCTURE AND EVOLUTION--A COMPUTER-BASED STUDY
      NIH/NIGMS R01GM034434Dec 1, 1984 - Nov 30, 1990
      Role: Principal Investigator
      Structural Studies on Fibrinogen and Fibrin
      NIH/NHLBI R01HL026873May 1, 1981 - Apr 30, 2005
      Role: Principal Investigator
      STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRIN
      NIH/NHLBI R37HL026873May 1, 1981 - Apr 30, 1996
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Doolittle R. S. Jonathan Singer: A man who loved ideas and detested walls. Proc Natl Acad Sci U S A. 2017 Apr 04; 114(14):3550-3551. PMID: 28325869.
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      2. Doolittle R. The conversion of fibrinogen to fibrin: A brief history of some key events. Matrix Biol. 2016 Aug 09. PMID: 27519977.
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      3. Doolittle R. Some Important Milestones in the Field of Blood Clotting. J Innate Immun. 2016; 8(1):23-9. PMID: 26667674.
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      4. Doolittle R. Bioinformatic Characterization of Genes and Proteins Involved in Blood Clotting in Lampreys. J Mol Evol. 2015 Oct; 81(3-4):121-30. PMID: 26437661.
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      5. Doolittle R. Clotting of Mammalian Fibrinogens by Papain: A Re-examination. Biochemistry. 2014 Oct 28; 53(42):6687-94. PMID: 25283163.
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      6. Duttke SH, Doolittle R, Wang YL, Kadonaga JT. TRF2 and the evolution of the bilateria. Genes Dev. 2014 Oct 1; 28(19):2071-6. PMID: 25274724.
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      7. Doolittle R, McNamara K, Lin K. Correlating structure and function during the evolution of fibrinogen-related domains. Protein Sci. 2012 Dec; 21(12):1808-23. PMID: 23076991.
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      8. Watson JW, Doolittle R. Peptide-derivatized albumins that inhibit fibrin polymerization. Biochemistry. 2011 Nov 15; 50(45):9923-7. PMID: 22010909.
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      9. Doolittle R. Clots vs bugs: who's ahead? Blood. 2011 Sep 1; 118(9):2382-4. PMID: 21885608.
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      10. Doolittle R. The protochordate Ciona intestinalis has a protein like full-length vertebrate fibrinogen. J Innate Immun. 2012; 4(2):219-22. PMID: 21860218.
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      11. Doolittle R. Coagulation in vertebrates with a focus on evolution and inflammation. J Innate Immun. 2011; 3(1):9-16. PMID: 20980726.
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      12. Doolittle R. The roots of bioinformatics in protein evolution. PLoS Comput Biol. 2010; 6(7):e1000875. PMID: 20686682.
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      13. Doolittle R. Step-by-step evolution of vertebrate blood coagulation. Cold Spring Harb Symp Quant Biol. 2009; 74:35-40. PMID: 19667012.
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      14. Pandi L, Kollman JM, Lopez-Lira F, Burrows JM, Riley M, Doolittle R. Two families of synthetic peptides that enhance fibrin turbidity and delay fibrinolysis by different mechanisms. Biochemistry. 2009 Aug 4; 48(30):7201-8. PMID: 19588915.
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      15. Doolittle R, Hong S, Wilcox D. Evolution of the fibrinogen gamma' chain: implications for the binding of factor XIII, thrombin and platelets. J Thromb Haemost. 2009 Aug; 7(8):1431-3. PMID: 19552683.
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      16. Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle R. Crystal structure of human fibrinogen. Biochemistry. 2009 May 12; 48(18):3877-86. PMID: 19296670.
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      17. Ponczek MB, Gailani D, Doolittle R. Evolution of the contact phase of vertebrate blood coagulation. J Thromb Haemost. 2008 Nov; 6(11):1876-83. PMID: 18761718.
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      18. Doolittle R. Searching for differences between fibrinogen and fibrin that affect the initiation of fibrinolysis. Cardiovasc Hematol Agents Med Chem. 2008 Jul; 6(3):181-9. PMID: 18673232.
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      19. Doolittle R, Jiang Y, Nand J. Genomic evidence for a simpler clotting scheme in jawless vertebrates. J Mol Evol. 2008 Feb; 66(2):185-96. PMID: 18283387.
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      20. Doolittle R, Pandi L. Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini. Biochemistry. 2007 Sep 4; 46(35):10033-8. PMID: 17688324.
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      21. Rojas A, Doolittle R. The occurrence of type S1A serine proteases in sponge and jellyfish. J Mol Evol. 2006 Dec; 55(6):790-4. PMID: 17476731.
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      22. Doolittle R, Chen A, Pandi L. Differences in binding specificity for the homologous gamma- and beta-chain "holes" on fibrinogen: exclusive binding of Ala-His-Arg-Pro-amide by the beta-chain hole. Biochemistry. 2006 Nov 28; 45(47):13962-9. PMID: 17115691.
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      23. Doolittle R, Kollman JM. Natively unfolded regions of the vertebrate fibrinogen molecule. Proteins. 2006 May 1; 63(2):391-7. PMID: 16288455.
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      24. Doolittle R, Pandi L. Binding of synthetic B knobs to fibrinogen changes the character of fibrin and inhibits its ability to activate tissue plasminogen activator and its destruction by plasmin. Biochemistry. 2006 Feb 28; 45(8):2657-67. PMID: 16489759.
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      25. Doolittle R. Evolutionary aspects of whole-genome biology. Curr Opin Struct Biol. 2005 Jun; 15(3):248-53. PMID: 15963888.
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      26. Kollman JM, Doolittle R. Unusual non-crystallographic symmetry in crystals of a 420 kDa crustacean clottable protein. Acta Crystallogr D Biol Crystallogr. 2005 Apr; 61(Pt 4):485-9. PMID: 15805605.
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      27. Sirinupong N, Suwanmanee P, Doolittle R, Suvachitanont W. Molecular cloning of a new cDNA and expression of 3-hydroxy-3-methylglutaryl-CoA synthase gene from Hevea brasiliensis. Planta. 2005 Jun; 221(4):502-12. PMID: 15744497.
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      28. Yang S, Doolittle R, Bourne PE. Phylogeny determined by protein domain content. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):373-8. PMID: 15630082.
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      29. Doolittle R. Some comments on John Ferry's most enduring paper. Biophys Chem. 2004 Dec 20; 112(2-3):177-80. PMID: 15572245.
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      30. Doolittle R. Martin David Kamen (27 August 1913 - 31 August 2002). Proc Am Philos Soc. 2004 Dec; 148(4):499-503. PMID: 15818877.
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      31. Doolittle R. Determining the crystal structure of fibrinogen. J Thromb Haemost. 2004 May; 2(5):683-9. PMID: 15099268.
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      32. Jacobson MF, Sharpe VA, Angell M, Ashford NA, Blum A, Chary LK, Cho M, Coull BC, Davis D, Doolittle R, Egilman D, Epstein SS, Greenberg M, Hooper K, Huff J, Joshi TK, Krimsky S, LaDou J, Levenstein C, Miles S, Needleman H, Pellegrino ED, Ravanesi B, Sass J, Schecter A, Schneiderman JS, Schubert D, Soffritti M, Suzuki D, Takaro TK, Temple NJ, Terracini B, Thompson A, Wallinga D, Wing S. Editorial policies on financial disclosure. Nat Neurosci. 2003 Oct; 6(10):1001. PMID: 14513030.
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      33. Doolittle R. X-ray crystallographic studies on fibrinogen and fibrin. J Thromb Haemost. 2003 Jul; 1(7):1559-65. PMID: 12871291.
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      34. Jiang Y, Doolittle R. The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7527-32. PMID: 12808152.
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      35. Doolittle R. Structural basis of the fibrinogen-fibrin transformation: contributions from X-ray crystallography. Blood Rev. 2003 Mar; 17(1):33-41. PMID: 12490209.
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      36. Doolittle R. Some notes on crystallizing fibrinogen and fibrin fragments. Biophys Chem. 2003; 100(1-3):307-13. PMID: 12646373.
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      37. Yang Z, Pandi L, Doolittle R. The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 2002 Dec 31; 41(52):15610-7. PMID: 12501189.
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      38. Doolittle R. The grand assault. Nature. 2002 Oct 3; 419(6906):493-4. PMID: 12368861.
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      39. Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle R. Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide. Biochemistry. 2002 Aug 13; 41(32):10218-24. PMID: 12162736.
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      40. Doolittle R. Biodiversity: microbial genomes multiply. Nature. 2002 Apr 18; 416(6882):697-700. PMID: 11961543.
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      41. Doolittle R, York AL. Bacterial actins? An evolutionary perspective. Bioessays. 2002 Apr; 24(4):293-6. PMID: 11948613.
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      42. Yang Z, Kollman JM, Pandi L, Doolittle R. Crystal structure of native chicken fibrinogen at 2.7 A resolution. Biochemistry. 2001 Oct 23; 40(42):12515-23. PMID: 11601975.
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      43. Doolittle R, Yang Z, Mochalkin I. Crystal structure studies on fibrinogen and fibrin. Ann N Y Acad Sci. 2001; 936:31-43. PMID: 11460486.
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      44. Yang Z, Mochalkin I, Doolittle R. A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14156-61. PMID: 11121023.
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      45. Kollman JM, Doolittle R. Determining the relative rates of change for prokaryotic and eukaryotic proteins with anciently duplicated paralogs. J Mol Evol. 2000 Aug; 51(2):173-81. PMID: 10948274.
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      46. Yang Z, Mochalkin I, Veerapandian L, Riley M, Doolittle R. Crystal structure of native chicken fibrinogen at 5.5-A resolution. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3907-12. PMID: 10737772.
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      47. Lin YC, Doolittle R. A latent inhibitor of fibrin polymerization with ancillary anticoagulant activity. Thromb Res. 2000 Mar 1; 97(5):375-8. PMID: 10709915.
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      48. Doolittle R. Searching for the common ancestor. Res Microbiol. 2000 Mar; 151(2):85-9. PMID: 10865952.
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      49. Doolittle R. On the trail of protein sequences. Bioinformatics. 2000 Jan; 16(1):24-33. PMID: 10812474.
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      50. Handy J, Doolittle R. An attempt to pinpoint the phylogenetic introduction of glutaminyl-tRNA synthetase among bacteria. J Mol Evol. 1999 Dec; 49(6):709-15. PMID: 10594171.
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      51. Doolittle R. Do you dig my groove? Nat Genet. 1999 Sep; 23(1):6-8. PMID: 10471485.
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      52. Doolittle R, Spraggon G, Everse SJ. Crystal structures of fragments D and double-D from fibrinogen and fibrin. Thromb Haemost. 1999 Aug; 82(2):271-6. PMID: 10605713.
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      53. Doolittle R, Feng DF, Cho G. Determining divergence times with protein clocks. Biol Bull. 1999 Jun; 196(3):356-7; discussion 357-8. PMID: 11536911.
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      54. Everse SJ, Spraggon G, Veerapandian L, Doolittle R. Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. Biochemistry. 1999 Mar 9; 38(10):2941-6. PMID: 10074346.
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      55. Doolittle R, Handy J. Evolutionary anomalies among the aminoacyl-tRNA synthetases. Curr Opin Genet Dev. 1998 Dec; 8(6):630-6. PMID: 9914200.
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      56. Doolittle R, Spraggon G, Everse SJ. Three-dimensional structural studies on fragments of fibrinogen and fibrin. Curr Opin Struct Biol. 1998 Dec; 8(6):792-8. PMID: 9914253.
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      57. Spraggon G, Applegate D, Everse SJ, Zhang JZ, Veerapandian L, Redman C, Doolittle R, Grieninger G. Crystal structure of a recombinant alphaEC domain from human fibrinogen-420. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9099-104. PMID: 9689040.
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      58. Everse SJ, Spraggon G, Doolittle R. A three-dimensional consideration of variant human fibrinogens. Thromb Haemost. 1998 Jul; 80(1):1-9. PMID: 9684777.
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      59. Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle R. Crystal structure of fragment double-D from human fibrin with two different bound ligands. Biochemistry. 1998 Jun 16; 37(24):8637-42. PMID: 9628725.
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      60. Tsyguelnaia I, Doolittle R. Presence of a fibronectin type III domain in a plant protein. J Mol Evol. 1998 May; 46(5):612-4. PMID: 9545471.
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      61. Doolittle R. Microbial genomes opened up. Nature. 1998 Mar 26; 392(6674):339-42. PMID: 9537318.
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      62. Feng DF, Cho G, Doolittle R. Determining divergence times with a protein clock: update and reevaluation. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13028-33. PMID: 9371794.
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      63. Spraggon G, Everse SJ, Doolittle R. Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. Nature. 1997 Oct 2; 389(6650):455-62. PMID: 9333233.
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      64. Doolittle R. A bug with excess gastric avidity. Nature. 1997 Aug 7; 388(6642):515-6. PMID: 9252182.
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      65. Cho G, Doolittle R. Intron distribution in ancient paralogs supports random insertion and not random loss. J Mol Evol. 1997 Jun; 44(6):573-84. PMID: 9169549.
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      66. Feng DF, Doolittle R. Converting amino acid alignment scores into measures of evolutionary time: a simulation study of various relationships. J Mol Evol. 1997 Apr; 44(4):361-70. PMID: 9089075.
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      67. Doolittle R. Some reflections on the early days of sequence searching. J Mol Med (Berl). 1997 Apr; 75(4):239-41. PMID: 9151208.
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      68. Doolittle R, Spraggon G, Everse SJ. Evolution of vertebrate fibrin formation and the process of its dissolution. Ciba Found Symp. 1997; 212:4-17; discussion 17-23. PMID: 9524761.
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      69. Doolittle R, Feng DF, Tsang S, Cho G, Little E. Response: dating the cenancester of organisms. Science. 1996 Dec 6; 274(5293):1751-3. PMID: 17842248.
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      70. Doolittle R, Everse SJ, Spraggon G. Human fibrinogen: anticipating a 3-dimensional structure. FASEB J. 1996 Nov; 10(13):1464-70. PMID: 8940292.
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      71. Roger AJ, Smith MW, Doolittle R, Doolittle WF. Evidence for the Heterolobosea from phylogenetic analysis of genes encoding glyceraldehyde-3-phosphate dehydrogenase. J Eukaryot Microbiol. 1996 Nov-Dec; 43(6):475-85. PMID: 8976605.
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      72. Doolittle R. Overview of the symposium on molecular anthropology. Wayne State University, March 13-14, 1995. Mol Phylogenet Evol. 1996 Feb; 5(1):266-8. PMID: 8673295.
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      73. Doolittle R, Feng DF, Tsang S, Cho G, Little E. Determining divergence times of the major kingdoms of living organisms with a protein clock. Science. 1996 Jan 26; 271(5248):470-7. PMID: 8560259.
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      74. Feng DF, Doolittle R. Progressive alignment of amino acid sequences and construction of phylogenetic trees from them. Methods Enzymol. 1996; 266:368-82. PMID: 8743694.
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      75. Doolittle R. The origins and evolution of eukaryotic proteins. Philos Trans R Soc Lond B Biol Sci. 1995 Sep 29; 349(1329):235-40. PMID: 8577833.
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      76. Nagel GM, Doolittle R. Phylogenetic analysis of the aminoacyl-tRNA synthetases. J Mol Evol. 1995 May; 40(5):487-98. PMID: 7783224.
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      77. Everse SJ, Pelletier H, Doolittle R. Crystallization of fragment D from human fibrinogen. Protein Sci. 1995 May; 4(5):1013-6. PMID: 7663337.
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      78. Doolittle R. Of archae and eo: what's in a name? Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2421-3. PMID: 7708656.
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      79. Shipwash E, Pan Y, Doolittle R. The minor form alpha' chain from lamprey fibrinogen is rapidly crosslinked during clotting. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):968-72. PMID: 7862675.
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      80. Doolittle R. The multiplicity of domains in proteins. Annu Rev Biochem. 1995; 64:287-314. PMID: 7574483.
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      81. Little E, Bork P, Doolittle R. Tracing the spread of fibronectin type III domains in bacterial glycohydrolases. J Mol Evol. 1994 Dec; 39(6):631-43. PMID: 7528812.
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      82. Bork P, Doolittle R. Drosophila kelch motif is derived from a common enzyme fold. J Mol Biol. 1994 Mar 11; 236(5):1277-82. PMID: 8126718.
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      83. Doolittle R. Protein sequence comparisons: searching databases and aligning sequences. Curr Opin Biotechnol. 1994 Feb; 5(1):24-8. PMID: 7764639.
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      84. Doolittle R. Convergent evolution: the need to be explicit. Trends Biochem Sci. 1994 Jan; 19(1):15-8. PMID: 8140615.
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      85. Doolittle R, Bork P. Evolutionarily mobile modules in proteins. Sci Am. 1993 Oct; 269(4):50-6. PMID: 8235550.
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      86. Doolittle R. The evolution of vertebrate blood coagulation: a case of Yin and Yang. Thromb Haemost. 1993 Jul 1; 70(1):24-8. PMID: 8236110.
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      87. Bork P, Doolittle R. Fibronectin type III modules in the receptor phosphatase CD45 and tapeworm antigens. Protein Sci. 1993 Jul; 2(7):1185-7. PMID: 8358302.
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      88. Doolittle R. The comings and goings of homing endonucleases and mobile introns. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5379-81. PMID: 8390659.
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      89. Narumi H, Hishida T, Sasaki T, Feng DF, Doolittle R. Molecular cloning of silkworm (Bombyx mori) antichymotrypsin. A new member of the serpin superfamily of proteins from insects. Eur J Biochem. 1993 May 15; 214(1):181-7. PMID: 8508791.
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      90. Doolittle R, Riley M, Pan Y. Direct measurement of a second fibrinogen alpha chain in lamprey blood plasma. Thromb Res. 1992 Dec 15; 68(6):489-93. PMID: 1341060.
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      91. Doolittle R. A detailed consideration of a principal domain of vertebrate fibrinogen and its relatives. Protein Sci. 1992 Dec; 1(12):1563-77. PMID: 1304888.
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      92. Smith MW, Feng DF, Doolittle R. Evolution by acquisition: the case for horizontal gene transfers. Trends Biochem Sci. 1992 Dec; 17(12):489-93. PMID: 1471257.
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      93. Yamazumi K, Doolittle R. The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion. Protein Sci. 1992 Dec; 1(12):1719-20. PMID: 1304901.
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      94. Bork P, Doolittle R. Proposed acquisition of an animal protein domain by bacteria. Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):8990-4. PMID: 1409594.
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      95. Smith MW, Doolittle R. Anomalous phylogeny involving the enzyme glucose-6-phosphate isomerase. J Mol Evol. 1992 Jun; 34(6):544-5. PMID: 1593646.
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      96. Yamazumi K, Doolittle R. Photoaffinity labeling of the primary fibrin polymerization site: localization of the label to gamma-chain Tyr-363. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2893-6. PMID: 1557396.
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      97. Shimizu A, Nagel GM, Doolittle R. Photoaffinity labeling of the primary fibrin polymerization site: isolation and characterization of a labeled cyanogen bromide fragment corresponding to gamma-chain residues 337-379. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2888-92. PMID: 1557395.
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      98. Pan Y, Doolittle R. cDNA sequence of a second fibrinogen alpha chain in lamprey: an archetypal version alignable with full-length beta and gamma chains. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2066-70. PMID: 1549566.
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      99. Gray JE, Doolittle R. Characterization, primary structure, and evolution of lamprey plasma albumin. Protein Sci. 1992 Feb; 1(2):289-302. PMID: 1304910.
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      100. Smith MW, Doolittle R. A comparison of evolutionary rates of the two major kinds of superoxide dismutase. J Mol Evol. 1992 Feb; 34(2):175-84. PMID: 1556751.
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      101. Doolittle R. Stein and Moore Award address. Reconstructing history with amino acid sequences. Protein Sci. 1992 Feb; 1(2):191-200. PMID: 1339026.
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      102. Doolittle R, Feng DF. Tracing the origin of retroviruses. Curr Top Microbiol Immunol. 1992; 176:195-211. PMID: 1376225.
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      103. Nagel GM, Doolittle R. Evolution and relatedness in two aminoacyl-tRNA synthetase families. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8121-5. PMID: 1896459.
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      104. Doolittle R. Counting and discounting the universe of exons. Science. 1991 Aug 9; 253(5020):677-80. PMID: 1871603.
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      105. Doolittle R, Feng DF, Anderson KL, Alberro MR. A naturally occurring horizontal gene transfer from a eukaryote to a prokaryote. J Mol Evol. 1990 Nov; 31(5):383-8. PMID: 2124629.
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      106. Seely O, Feng DF, Smith DW, Sulzbach D, Doolittle R. Construction of a facsimile data set for large genome sequence analysis. Genomics. 1990 Sep; 8(1):71-82. PMID: 2081603.
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      107. Xu X, Doolittle R. Presence of a vertebrate fibrinogen-like sequence in an echinoderm. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2097-101. PMID: 2315305.
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      108. Doolittle R, Riley M. The amino-terminal sequence of lobster fibrinogen reveals common ancestry with vitellogenins. Biochem Biophys Res Commun. 1990 Feb 28; 167(1):16-9. PMID: 2310387.
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      109. Doolittle R. Searching through sequence databases. Methods Enzymol. 1990; 183:99-110. PMID: 2314299.
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      110. Doolittle R, Feng DF, McClure MA, Johnson MS. Retrovirus phylogeny and evolution. Curr Top Microbiol Immunol. 1990; 157:1-18. PMID: 2203607.
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      111. Feng DF, Doolittle R. Progressive alignment and phylogenetic tree construction of protein sequences. Methods Enzymol. 1990; 183:375-87. PMID: 2314283.
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      112. Doolittle R, Feng DF. Nearest neighbor procedure for relating progressively aligned amino acid sequences. Methods Enzymol. 1990; 183:659-69. PMID: 2314298.
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      113. Doolittle R. The structure and evolution of vertebrate fibrinogen: a comparison of the lamprey and mammalian proteins. Adv Exp Med Biol. 1990; 281:25-37. PMID: 2102616.
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      114. Wang YZ, Patterson J, Gray JE, Yu C, Cottrell BA, Shimizu A, Graham D, Riley M, Doolittle R. Complete sequence of the lamprey fibrinogen alpha chain. Biochemistry. 1989 Dec 12; 28(25):9801-6. PMID: 2611265.
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      115. Doolittle R. Similar amino acid sequences revisited. Trends Biochem Sci. 1989 Jul; 14(7):244-5. PMID: 2773041.
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      116. Doolittle R. Immunodeficiency viruses: the simian-human connection. Nature. 1989 Jun 1; 339(6223):338-9. PMID: 2725658.
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      117. Doolittle R, Feng DF, Johnson MS, McClure MA. Origins and evolutionary relationships of retroviruses. Q Rev Biol. 1989 Mar; 64(1):1-30. PMID: 2469098.
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      118. Doolittle R. Lens proteins. More molecular opportunism. Nature. 1988 Nov 3; 336(6194):18. PMID: 3185715.
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      119. McClure MA, Johnson MS, Feng DF, Doolittle R. Sequence comparisons of retroviral proteins: relative rates of change and general phylogeny. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2469-73. PMID: 2451824.
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      120. Reeck GR, de Haën C, Teller DC, Doolittle R, Fitch WM, Dickerson RE, Chambon P, McLachlan AD, Margoliash E, Jukes TH. "Homology" in proteins and nucleic acids: a terminology muddle and a way out of it. Cell. 1987 Aug 28; 50(5):667. PMID: 3621342.
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      121. Vogt PK, Bos TJ, Doolittle R. Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun. Proc Natl Acad Sci U S A. 1987 May; 84(10):3316-9. PMID: 3554236.
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      122. McClure MA, Johnson MS, Doolittle R. Relocation of a protease-like gene segment between two retroviruses. Proc Natl Acad Sci U S A. 1987 May; 84(9):2693-7. PMID: 3106974.
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      123. Pontes M, Xu X, Graham D, Riley M, Doolittle R. cDNA sequences of two apolipoproteins from lamprey. Biochemistry. 1987 Mar 24; 26(6):1611-7. PMID: 3593681.
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      124. Doolittle R, Feng DF. Reconstructing the evolution of vertebrate blood coagulation from a consideration of the amino acid sequences of clotting proteins. Cold Spring Harb Symp Quant Biol. 1987; 52:869-74. PMID: 3483343.
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      125. Feng DF, Doolittle R. Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J Mol Evol. 1987; 25(4):351-60. PMID: 3118049.
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      126. Chomyn A, Cleeter MW, Ragan CI, Riley M, Doolittle R, Attardi G. URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit. Science. 1986 Oct 31; 234(4776):614-8. PMID: 3764430.
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      127. Bohonus VL, Doolittle R, Pontes M, Strong DD. Complementary DNA sequence of lamprey fibrinogen beta chain. Biochemistry. 1986 Oct 21; 25(21):6512-6. PMID: 3790537.
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      128. Johnson MS, McClure MA, Feng DF, Gray J, Doolittle R. Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7648-52. PMID: 2429313.
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      129. Doolittle R, Johnson MS, Husain I, Van Houten B, Thomas DC, Sancar A. Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins. Nature. 1986 Oct 2-8; 323(6087):451-3. PMID: 3762695.
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      130. Kuyas C, Doolittle R. Gly-Pro-Arg-Pro derivatives that bind to human plasma albumin and prevent fibrin formation. Thromb Res. 1986 Aug 15; 43(4):485-90. PMID: 3764804.
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      131. Fong HK, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, Doolittle R, Simon MI. Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A. 1986 Apr; 83(7):2162-6. PMID: 3083416.
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      132. Mariottini P, Chomyn A, Riley M, Cottrell B, Doolittle R, Attardi G. Identification of the polypeptides encoded in the unassigned reading frames 2, 4, 4L, and 5 of human mitochondrial DNA. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1563-7. PMID: 3456601.
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      133. Doolittle R, Feng DF, Johnson MS, McClure MA. Relationships of human protein sequences to those of other organisms. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:447-55. PMID: 3472734.
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      134. Attardi G, Chomyn A, Doolittle R, Mariottini P, Ragan CI. Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:103-14. PMID: 3472707.
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      135. Johnson MS, Doolittle R. A method for the simultaneous alignment of three or more amino acid sequences. J Mol Evol. 1986; 23(3):267-78. PMID: 3100815.
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      136. Doolittle R. Proteins. Sci Am. 1985 Oct; 253(4):88-99. PMID: 4071032.
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      137. Chomyn A, Mariottini P, Cleeter MW, Ragan CI, Matsuno-Yagi A, Hatefi Y, Doolittle R, Attardi G. Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. Nature. 1985 Apr 18-24; 314(6012):592-7. PMID: 3921850.
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      138. Strong DD, Moore M, Cottrell BA, Bohonus VL, Pontes M, Evans B, Riley M, Doolittle R. Lamprey fibrinogen gamma chain: cloning, cDNA sequencing, and general characterization. Biochemistry. 1985 Jan 1; 24(1):92-101. PMID: 2581603.
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      139. Jue RA, Doolittle R. Determination of the relative positions of amino acids by partial specific cleavages of end-labeled proteins. Biochemistry. 1985 Jan 1; 24(1):162-70. PMID: 3922399.
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      140. Horwich AL, Fenton WA, Williams KR, Kalousek F, Kraus JP, Doolittle R, Konigsberg W, Rosenberg LE. Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Science. 1984 Jun 8; 224(4653):1068-74. PMID: 6372096.
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      141. Peterson TA, Yochem J, Byers B, Nunn MF, Duesberg PH, Doolittle R, Reed SI. A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26. Nature. 1984 Jun 7-13; 309(5968):556-8. PMID: 6374468.
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      142. Doolittle R, Feng DF, Johnson MS. Computer-based characterization of epidermal growth factor precursor. Nature. 1984 Feb 9-15; 307(5951):558-60. PMID: 6607417.
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      143. Feng DF, Johnson MS, Doolittle R. Aligning amino acid sequences: comparison of commonly used methods. J Mol Evol. 1984-1985; 21(2):112-25. PMID: 6100188.
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      144. Doolittle R. Fibrinogen and fibrin. Annu Rev Biochem. 1984; 53:195-229. PMID: 6383194.
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      145. Doolittle R. Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family. Science. 1983 Oct 28; 222(4622):417-9. PMID: 6604942.
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      146. Chomyn A, Mariottini P, Gonzalez-Cadavid N, Attardi G, Strong DD, Trovato D, Riley M, Doolittle R. Identification of the polypeptides encoded in the ATPase 6 gene and in the unassigned reading frames 1 and 3 of human mtDNA. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5535-9. PMID: 6225122.
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      147. Doolittle R. The structure and evolution of vertebrate fibrinogen. Ann N Y Acad Sci. 1983 Jun 27; 408:13-27. PMID: 6575681.
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      148. Hawiger J, Kloczewiak M, Timmons S, Strong D, Doolittle R. Interaction of fibrinogen with staphylococcal clumping factor and with platelets. Ann N Y Acad Sci. 1983 Jun 27; 408:521-35. PMID: 6223560.
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      149. Laudano AP, Cottrell BA, Doolittle R. Synthetic peptides modeled on fibrin polymerization sites. Ann N Y Acad Sci. 1983 Jun 27; 408:315-29. PMID: 6575692.
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      150. Hoeprich PD, Doolittle R. Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation. Biochemistry. 1983 Apr 26; 22(9):2049-55. PMID: 6860649.
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      151. Mariottini P, Chomyn A, Attardi G, Trovato D, Strong DD, Doolittle R. Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria. Cell. 1983 Apr; 32(4):1269-77. PMID: 6301689.
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      152. Sauer RT, Yocum RR, Doolittle R, Lewis M, Pabo CO. Homology among DNA-binding proteins suggests use of a conserved super-secondary structure. Nature. 1982 Jul 29; 298(5873):447-51. PMID: 6896364.
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      153. Doolittle R, Woodbury NW, Jue RA. Ribosomal protein S1 is the product of a series of contiguous duplications. Biosci Rep. 1982 Jun; 2(6):405-12. PMID: 7049263.
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      154. Kyte J, Doolittle R. A simple method for displaying the hydropathic character of a protein. J Mol Biol. 1982 May 5; 157(1):105-32. PMID: 7108955.
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      155. Hawiger J, Timmons S, Strong DD, Cottrell BA, Riley M, Doolittle R. Identification of a region of human fibrinogen interacting with staphylococcal clumping factor. Biochemistry. 1982 Mar 16; 21(6):1407-13. PMID: 7074095.
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      156. Strong DD, Laudano AP, Hawiger J, Doolittle R. Isolation, characterization, and synthesis of peptides from human fibrinogen that block the staphylococcal clumping reaction and construction of a synthetic clumping particle. Biochemistry. 1982 Mar 16; 21(6):1414-20. PMID: 7074096.
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      157. Brown JP, Hewick RM, Hellström I, Hellström KE, Doolittle R, Dreyer WJ. Human melanoma-associated antigen p97 is structurally and functionally related to transferrin. Nature. 1982 Mar 11; 296(5853):171-3. PMID: 7063021.
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      158. Hawiger J, Timmons S, Kloczewiak M, Strong DD, Doolittle R. gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):2068-71. PMID: 6281794.
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      159. Doolittle R. Fibrinogen and fibrin. Sci Am. 1981 Dec; 245(6):126-35. PMID: 7323804.
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      160. Olexa SA, Budzynski AZ, Doolittle R, Cottrell BA, Greene TC. Structure of fragment E species from human cross-linked fibrin. Biochemistry. 1981 Oct 13; 20(21):6139-45. PMID: 6458323.
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      161. Doolittle R. Similar amino acid sequences: chance or common ancestry? Science. 1981 Oct 9; 214(4517):149-59. PMID: 7280687.
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      162. Laudano AP, Doolittle R. Influence of calcium ion on the binding of fibrin amino terminal peptides to fibrinogen. Science. 1981 Apr 24; 212(4493):457-9. PMID: 7209542.
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      163. Van Beveren C, Galleshaw JA, Jonas V, Berns AJ, Doolittle R, Donoghue DJ, Verma IM. Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus. Nature. 1981 Jan 22; 289(5795):258-62. PMID: 6256659.
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      164. Price TM, Strong DD, Rudee ML, Doolittle R. Shadow-cast electron microscopy of fibrinogen with antibody fragments bound to specific regions. Proc Natl Acad Sci U S A. 1981 Jan; 78(1):200-4. PMID: 6941244.
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      165. Simon M, Zieg J, Silverman M, Mandel G, Doolittle R. Phase variation: evolution of a controlling element. Science. 1980 Sep 19; 209(4463):1370-4. PMID: 6251543.
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      166. Walter G, Scheidtmann KH, Carbone A, Laudano AP, Doolittle R. Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5197-200. PMID: 6254066.
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      167. Jue RA, Woodbury NW, Doolittle R. Sequence homologies among E. coli ribosomal proteins: evidence for evolutionarily related groupings and internal duplications. J Mol Evol. 1980 May; 15(2):129-48. PMID: 6995620.
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      168. Laudano AP, Doolittle R. Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. Biochemistry. 1980 Mar 4; 19(5):1013-9. PMID: 7356959.
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      169. Cottrell BA, Strong DD, Watt KW, Doolittle R. Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites. Biochemistry. 1979 Nov 27; 18(24):5405-10. PMID: 518845.
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      170. Watt KW, Cottrell BA, Strong DD, Doolittle R. Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence. Biochemistry. 1979 Nov 27; 18(24):5410-6. PMID: 518846.
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      171. Strong DD, Watt KW, Cottrell BA, Doolittle R. Amino acid sequence studies on the alpha chain of human fibrinogen. Complete sequence of the largest cyanogen bromide fragment. Biochemistry. 1979 Nov 27; 18(24):5399-404. PMID: 518844.
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      172. Doolittle R, Watt KW, Cottrell BA, Strong DD, Riley M. The amino acid sequence of the alpha-chain of human fibrinogen. Nature. 1979 Aug 9; 280(5722):464-8. PMID: 460425.
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      173. Watt KW, Takagi T, Doolittle R. Amino acid sequence of the beta chain of human fibrinogen. Biochemistry. 1979 Jan 9; 18(1):68-76. PMID: 420779.
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      174. Doolittle R, Cottrell BA, Strong D, Watt KW. Preliminary report on the amino acid sequence of the alpha-chain of human fibrinogen. Thromb Res. 1979; 14(4-5):787-92. PMID: 158235.
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      175. Doolittle R, Cottrell BA, Strong D, Watt KW. Sequence of amino acids comprising the single intra-chain disulfide loop in the alpha-chain of human fibrinogen. Biochem Biophys Res Commun. 1978 Sep 29; 84(2):495-500. PMID: 152630.
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      176. Bouma H, Takagi T, Doolittle R. The arrangement of disulfide bonds in fragment D from human fibrinogen. Thromb Res. 1978 Sep; 13(3):557-62. PMID: 741445.
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      177. Friedmann T, Doolittle R, Walter G. Amino acid sequence homology between polyoma and SV40 tumour antigens deduced from nucleotide sequences. Nature. 1978 Jul 20; 274(5668):291-3. PMID: 210390.
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      178. Laudano AP, Doolittle R. Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3085-9. PMID: 277910.
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      179. Cottrell BA, Doolittle R. The amino acid sequence of the carboxy-terminal 142 amino acids of the alpha-chain of human fibrinogen. Thromb Res. 1978 Jun; 12(6):1135-46. PMID: 694821.
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      180. Doolittle R, Goldbaum DM, Doolittle LR. Designation of sequences involved in the "coiled-coil" interdomainal connections in fibrinogen: constructions of an atomic scale model. J Mol Biol. 1978 Apr 5; 120(2):311-25. PMID: 642011.
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      181. Watt KW, Takagi T, Doolittle R. Amino acid sequence of the beta chain of human fibrinogen: homology with the gamma chain. Proc Natl Acad Sci U S A. 1978 Apr; 75(4):1731-5. PMID: 273904.
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      182. Sakarellos-Daitsiotis M, Verlander M, Doolittle R, Goodman M. Synthesis and thrombolytic properties of some flufenamate derivatives. Thromb Res. 1978 Apr; 12(4):707-11. PMID: 663904.
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      183. Doolittle R, Cassman KG, Cottrell BA, Friezner SJ. Amino acid sequence studies on the alpha chain of human fibrinogen. Isolation and characterization of two linked alpha-chained cyanogen bromide fragments from fully cross-linked fibrin. Biochemistry. 1977 Apr 19; 16(8):1715-9. PMID: 851527.
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      184. Doolittle R, Cassman KG, Cottrell BA, Friezner SJ, Hucko JT, Takagi T. Amino acid sequence studies on the alpha chain of human fibrinogen. Characterization of 11 cyanogen bromide fragments. Biochemistry. 1977 Apr 19; 16(8):1703-9. PMID: 856257.
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      185. Doolittle R, Cassman KG, Cottrell BA, Friezner SJ, Takagi T. Amino acid sequence studies on the alpha chain of human fibrinogen. Covalent structure of the alpha-chain portion of fragment D. Biochemistry. 1977 Apr 19; 16(8):1710-5. PMID: 139916.
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      186. Doolittle R. Sequencing peptides and proteins lacking free alpha-amino groups. Mol Biol Biochem Biophys. 1977; 25:38-54. PMID: 411023.
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      187. Doolittle R. Structure and function of fibrinogen. Horiz Biochem Biophys. 1977; 3:164-91. PMID: 328365.
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      188. Doolittle R, Cottrell BA, Riley M. Amino acid compositions of the subunit chains of lamprey fibrinogen. Evolutionary significance of some structural anomalies. Biochim Biophys Acta. 1976 Dec 22; 453(2):439-52. PMID: 826275.
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      189. Cottrell BA, Doolittle R. Amino acid sequences of lamprey fibrinopeptides A and B and characterizations of the junctions split by lamprey and mammalian thrombins. Biochim Biophys Acta. 1976 Dec 22; 453(2):426-38. PMID: 999898.
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      190. Cottrell BA, Doolittle R. The amino acid sequence of a 27-residue peptide released from the alpha-chain carboxy-terminus during the plasmic digestion of human fibrinogen. Biochem Biophys Res Commun. 1976 Aug 9; 71(3):754-61. PMID: 134710.
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      191. Doolittle R. The evolution of vertebrate fibrinogen. Fed Proc. 1976 Aug; 35(10):2145-9. PMID: 947794.
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      192. Takagi T, Doolittle R. Amino acid sequence studies on the alpha chain of human fibrinogen. Location of four plasmin attack points and a covalent cross-linking site. Biochemistry. 1975 Nov 18; 14(23):5149-56. PMID: 127612.
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      193. Takagi T, Doolittle R. The amino acid sequences of those portions of human fibrinogen fragment E which are not included in the amino-terminal disulfide knot. Thromb Res. 1975 Nov; 7(5):813-8. PMID: 54947.
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      194. Gaulton GN, Doolittle R. Amino-terminal analysis of human fibrinogen treated with estrogenic steroids: failure to support a thrombin-mimetic proteolytic effect. Thromb Res. 1975 Nov; 7(5):789-95. PMID: 1209562.
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      195. Takagi T, Doolittle R. Amino acid sequence of the carboxy-terminal cyanogen bromide peptide of the human fibrinogen beta-chain: homology with the corresponding gamma-chain peptide and presence in fragment D. Biochim Biophys Acta. 1975 Apr 29; 386(2):617-22. PMID: 124585.
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      196. Takagi T, Doolittle R. Amino acid sequence studies on plasmin-derived fragments of human fibrinogen: amino-terminal sequences of intermediate and terminal fragments. Biochemistry. 1975 Mar 11; 14(5):940-6. PMID: 123758.
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      197. Doolittle R, Wooding GL. The subunit structure of lamprey fibrinogen and fibrin. Biochim Biophys Acta. 1974 Dec 18; 371(2):277-82. PMID: 4474019.
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      198. Doolittle R, Cottrell BA. Lamprey fibrinopeptide B is a glycopeptide. Biochem Biophys Res Commun. 1974 Oct 8; 60(3):1090-6. PMID: 4429563.
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      199. Doolittle R, Takagi T, Cottrell BA. Platelet and plasma fibrinogens are identical gene products. Science. 1974 Jul 26; 185(4148):368-70. PMID: 4834369.
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      200. Takagi T, Doolittle R. Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin. Biochemistry. 1974 Feb 12; 13(4):750-6. PMID: 4811064.
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      201. Doolittle R. Some symmetry considerations for the fibrinogen-fibrin assembly system. J Supramol Struct. 1974; 2(2-4):138-49. PMID: 4474572.
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      202. Doolittle R. Structural aspects of the fibrinogen to fibrin conversion. Adv Protein Chem. 1973; 27:1-109. PMID: 4589664.
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      203. Doolittle R, Cassman KG, Chen R, Sharp JJ, Wooding GL. Correlation of the mode of fibrin polymerization with the pattern of cross-linking. Ann N Y Acad Sci. 1972 Dec 8; 202:114-26. PMID: 4508919.
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      204. Weinstein MJ, Doolittle R. The effect of some synthetic arginyl and lysyl compounds on clotting and fibrinolysis. Thromb Diath Haemorrh. 1972 Oct 31; 28(2):289-97. PMID: 4639661.
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      205. Sharp JJ, Cassman KG, Doolittle R. Amino acid sequence of the carboxy-terminal cyanogen bromide fragment from bovine and human fibrinogen gamma-chains. FEBS Lett. 1972 Sep 15; 25(2):334-336. PMID: 11946783.
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      206. Doolittle R, Fuller GM. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis studies on lobster fibrinogen and fibrin. Biochim Biophys Acta. 1972 May 18; 263(3):805-9. PMID: 5034221.
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      207. Weinstein MJ, Doolittle R. Differential specificities of the thrombin, plasmin and trypsin with regard to synthetic and natural substrates and inhibitors. Biochim Biophys Acta. 1972 Feb 28; 258(2):577-90. PMID: 4258697.
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      208. Doolittle R. [18] Terminal pyrrolidonecarboxylic acid: Cleavage with enzymes. Methods Enzymol. 1972; 25:231-44. PMID: 23014405.
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      209. Chen R, Doolittle R. - cross-linking sites in human and bovine fibrin. Biochemistry. 1971 Nov 23; 10(24):4487-91. PMID: 5168975.
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      210. Doolittle R, Chen R, Lau F. Hybrid fibrin: proof of the intermolecular nature of - crosslinking units. Biochem Biophys Res Commun. 1971 Jul 2; 44(1):94-100. PMID: 5165618.
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      211. Fuller GM, Doolittle R. Studies of invertebrate fibrinogen. I. Purification and characterization of fibrinogen from the spiny lobster. Biochemistry. 1971 Apr 13; 10(8):1305-11. PMID: 5580651.
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      212. Fuller GM, Doolittle R. Studies of invertebrate fibrinogen. II. Transformation of lobster fibrinogen into fibrin. Biochemistry. 1971 Apr 13; 10(8):1311-5. PMID: 5580652.
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      213. Doolittle R, Wooding GL, Lin Y, Riley M. Hominoid evolution as judged by fibrinopeptide structures. J Mol Evol. 1971; 1(1):74-83. PMID: 5006251.
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      214. Mross GA, Doolittle R, Roberts BF. Gibbon fibrinopeptides: identification of a glycine-serine allelism at position B-3. Science. 1970 Oct 23; 170(3956):468-70. PMID: 5466708.
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      215. Doolittle R, Chen R, Glasgow C, Mross G, Weinstein M. The molecular constancy of fibrinopeptides A and B from 125 individual humans. Humangenetik. 1970 Aug 17; 10(1):15-29. PMID: 4988845.
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      216. Chen R, Doolittle R. Isolation, characterization, and location of a donor-acceptor unit from cross-linked fibrin. Proc Natl Acad Sci U S A. 1970 Jun; 66(2):472-9. PMID: 5271175.
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      217. Doolittle R, Mross GA. Identity of chimpanzee with human fibrinopeptides. Nature. 1970 Feb 14; 225(5233):643-4. PMID: 5461008.
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      218. Chen R, Doolittle R. Identification of the polypeptide chains involved in the cross-linking of fibrin. Proc Natl Acad Sci U S A. 1969 Jun; 63(2):420-7. PMID: 5257132.
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      219. Doolittle R, Armentrout RW. Pyrrolidonyl peptidase. An enzyme for selective removal of pyrrolidonecarboxylic acid residues from polypeptides. Biochemistry. 1968 Feb; 7(2):516-21. PMID: 5644127.
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      220. Doolittle R, Astrin KH. Light chains of rabbit immunoglobulin: assignment to the kappa class. Science. 1967 Jun 30; 156(3783):1755-7. PMID: 4180574.
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      221. Doolittle R, Fuller GM. Quantitative determination of amino-terminal amino acids in crosslinked and non-crosslinked fibrin. Biochem Biophys Res Commun. 1967 Feb 8; 26(3):327-33. PMID: 6034356.
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      222. Doolittle R, Schubert D, Schwartz SA. Amino acid sequence studies on artiodactyl fibrinopeptides. I. Dromedary camel, mule deer, and cape buffalo. Arch Biochem Biophys. 1967 Feb; 118(2):456-67. PMID: 6033721.
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      223. Doolittle R, Singer SJ, Metzger H. Evolution of immunoglobulin polypeptide chains: carboxy-terminal of an IgM heavy chain. Science. 1966 Dec 23; 154(3756):1561-2. PMID: 4162777.
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      224. Doolittle R. The amino-terminal amino acid sequences of rabbit immunoglobulin light chains. Proc Natl Acad Sci U S A. 1966 May; 55(5):1195-201. PMID: 4163205.
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      225. DOOLITTLE RF. DIFFERENCES IN THE CLOTTING OF LAMPREY FIBRINOGEN BY LAMPREY AND BOVINE THROMBINS. Biochem J. 1965 Mar; 94:735-41. PMID: 14340065.
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      226. DOOLITTLE RF. CHARACTERIZATION OF LAMPREY FIBRINOPEPTIDES. Biochem J. 1965 Mar; 94:742-50. PMID: 14340066.
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      227. DOOLITTLE RF, BLOMBAECK B. AMINO-ACID SEQUENCE INVESTIGATIONS OF FIBRINOPEPTIDES FROM VARIOUS MAMMALS: EVOLUTIONARY IMPLICATIONS. Nature. 1964 Apr 11; 202:147-52. PMID: 14156289.
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      228. BLOMBAECK B, BLOMBAECK M, DOOLITTLE RF, HESSEL B, EDMAN P. ON THE PROPERTIES OF A NEW HUMAN FIBRINOPEPTIDE. Biochim Biophys Acta. 1963 Nov 15; 78:563-6. PMID: 14088795.
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      229. DOOLITTLE RF. FURTHER STUDIES ON CLOTTING AND FIBRINOLYSIS IN PLASMA FROM THE SMOOTH DOGFISH (MUSTELIS CANIS). Br J Haematol. 1963 Oct; 9:464-70. PMID: 14076128.
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      230. LORAND L, DOOLITTLE RF, KONISHI K, RIGGS SK. A NEW CLASS OF BLOOD COAGULATION INHIBITORS. Arch Biochem Biophys. 1963 Aug; 102:171-9. PMID: 14064978.
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      231. Blomback B, Doolittle R. Amino acid sequence studies on fibrinopeptides from several species. Acta Chem Scand. 1963; 17(6):1819-22. PMID: 22132445.
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      232. Doolittle R, Lorand L, Jacobsen A. Some comparative aspects of the fibrinogen-fibrin conversion. Biochim Biophys Acta. 1963 Jan 1; 69:161-3. PMID: 22132443.
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      233. Blomback B, Doolittle R. The sequence of amino acids at the N-terminal end of bovine fibrinopeptide B. Acta Chem Scand. 1963; 17(6):1816-9. PMID: 22132444.
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      234. Doolittle R, Surgenor DM. Blood coagulation in fish. Am J Physiol. 1962 Nov; 203:964-70. PMID: 22103034.
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      235. Doolittle R, Oncley JL, Surgenor DM. Species differences in the interaction of thrombin and fibrinogen. J Biol Chem. 1962 Oct; 237:3123-7. PMID: 22103031.
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      236. EYLAR EH, DOOLITTLE RF, MADOFF MA. Sialic acid from blood cells of the lamprey eel. Nature. 1962 Mar 24; 193:1183-4. PMID: 13891105.
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