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Russell Doolittle

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentChemistry
Address9500 Gilman Drive #0314
La Jolla CA 92093
Phone858-534-4417
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    Collapse Research 
    Collapse Research Activities and Funding
    Characterization of the flexible portions of fibrinogen
    NIH/NHLBI R01HL081553Jul 5, 2005 - Jun 30, 2009
    Role: Principal Investigator
    GENOME ANALYSIS
    NIH/NHGRI T32HG000005Sep 30, 1990 - Aug 31, 1996
    Role: Co-Principal Investigator
    PEPTIDE SYNTHESIZER-ANALYZER COMBINATION
    NIH/NCRR S10RR005674May 18, 1990 - May 17, 1991
    Role: Principal Investigator
    XTH CONGRESS ISTH
    NIH/NHLBI R13HL034037Apr 1, 1985 - Mar 31, 1986
    Role: Principal Investigator
    PROTEIN STRUCTURE AND EVOLUTION--A COMPUTER-BASED STUDY
    NIH/NIGMS R01GM034434Dec 1, 1984 - Nov 30, 1990
    Role: Principal Investigator
    Structural Studies on Fibrinogen and Fibrin
    NIH/NHLBI R01HL026873May 1, 1981 - Apr 30, 2005
    Role: Principal Investigator
    STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRIN
    NIH/NHLBI R37HL026873May 1, 1981 - Apr 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Doolittle R. S. Jonathan Singer: A man who loved ideas and detested walls. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):3550-3551. PMID: 28325869.
      View in: PubMed
    2. Doolittle R. The conversion of fibrinogen to fibrin: A brief history of some key events. Matrix Biol. 2017 07; 60-61:5-7. PMID: 27519977.
      View in: PubMed
    3. Doolittle R. Some Important Milestones in the Field of Blood Clotting. J Innate Immun. 2016; 8(1):23-9. PMID: 26667674.
      View in: PubMed
    4. Doolittle R. Bioinformatic Characterization of Genes and Proteins Involved in Blood Clotting in Lampreys. J Mol Evol. 2015 Oct; 81(3-4):121-30. PMID: 26437661.
      View in: PubMed
    5. Doolittle R. Clotting of mammalian fibrinogens by papain: a re-examination. Biochemistry. 2014 Oct 28; 53(42):6687-94. PMID: 25283163.
      View in: PubMed
    6. Duttke SH, Doolittle R, Wang YL, Kadonaga JT. TRF2 and the evolution of the bilateria. Genes Dev. 2014 Oct 01; 28(19):2071-6. PMID: 25274724; PMCID: PMC4180970.
    7. Doolittle R, McNamara K, Lin K. Correlating structure and function during the evolution of fibrinogen-related domains. Protein Sci. 2012 Dec; 21(12):1808-23. PMID: 23076991; PMCID: PMC3575912.
    8. Watson JW, Doolittle R. Peptide-derivatized albumins that inhibit fibrin polymerization. Biochemistry. 2011 Nov 15; 50(45):9923-7. PMID: 22010909.
      View in: PubMed
    9. Doolittle R. Clots vs bugs: who's ahead? Blood. 2011 Sep 01; 118(9):2382-4. PMID: 21885608.
      View in: PubMed
    10. Doolittle R. The protochordate Ciona intestinalis has a protein like full-length vertebrate fibrinogen. J Innate Immun. 2012; 4(2):219-22. PMID: 21860218.
      View in: PubMed
    11. Doolittle R. Coagulation in vertebrates with a focus on evolution and inflammation. J Innate Immun. 2011; 3(1):9-16. PMID: 20980726.
      View in: PubMed
    12. Doolittle R. The roots of bioinformatics in protein evolution. PLoS Comput Biol. 2010 Jul 29; 6(7):e1000875. PMID: 20686682; PMCID: PMC2912333.
    13. Doolittle R. Step-by-step evolution of vertebrate blood coagulation. Cold Spring Harb Symp Quant Biol. 2009; 74:35-40. PMID: 19667012.
      View in: PubMed
    14. Pandi L, Kollman JM, Lopez-Lira F, Burrows JM, Riley M, Doolittle R. Two families of synthetic peptides that enhance fibrin turbidity and delay fibrinolysis by different mechanisms. Biochemistry. 2009 Aug 04; 48(30):7201-8. PMID: 19588915.
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    15. Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle R. Crystal structure of human fibrinogen. Biochemistry. 2009 May 12; 48(18):3877-86. PMID: 19296670.
      View in: PubMed
    16. Doolittle R. Searching for differences between fibrinogen and fibrin that affect the initiation of fibrinolysis. Cardiovasc Hematol Agents Med Chem. 2008 Jul; 6(3):181-9. PMID: 18673232.
      View in: PubMed
    17. Doolittle R, Jiang Y, Nand J. Genomic evidence for a simpler clotting scheme in jawless vertebrates. J Mol Evol. 2008 Feb; 66(2):185-96. PMID: 18283387.
      View in: PubMed
    18. Doolittle R, Pandi L. Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini. Biochemistry. 2007 Sep 04; 46(35):10033-8. PMID: 17688324.
      View in: PubMed
    19. Rojas A, Doolittle R. The occurrence of type S1A serine proteases in sponge and jellyfish. J Mol Evol. 2006 Dec; 55(6):790-4. PMID: 17476731.
      View in: PubMed
    20. Doolittle R, Chen A, Pandi L. Differences in binding specificity for the homologous gamma- and beta-chain "holes" on fibrinogen: exclusive binding of Ala-His-Arg-Pro-amide by the beta-chain hole. Biochemistry. 2006 Nov 28; 45(47):13962-9. PMID: 17115691.
      View in: PubMed
    21. Doolittle R, Kollman JM. Natively unfolded regions of the vertebrate fibrinogen molecule. Proteins. 2006 May 01; 63(2):391-7. PMID: 16288455.
      View in: PubMed
    22. Doolittle R, Pandi L. Binding of synthetic B knobs to fibrinogen changes the character of fibrin and inhibits its ability to activate tissue plasminogen activator and its destruction by plasmin. Biochemistry. 2006 Feb 28; 45(8):2657-67. PMID: 16489759.
      View in: PubMed
    23. Doolittle R. Evolutionary aspects of whole-genome biology. Curr Opin Struct Biol. 2005 Jun; 15(3):248-53. PMID: 15963888.
      View in: PubMed
    24. Kollman JM, Doolittle R. Unusual non-crystallographic symmetry in crystals of a 420 kDa crustacean clottable protein. Acta Crystallogr D Biol Crystallogr. 2005 Apr; 61(Pt 4):485-9. PMID: 15805605.
      View in: PubMed
    25. Sirinupong N, Suwanmanee P, Doolittle R, Suvachitanont W. Molecular cloning of a new cDNA and expression of 3-hydroxy-3-methylglutaryl-CoA synthase gene from Hevea brasiliensis. Planta. 2005 Jun; 221(4):502-12. PMID: 15744497.
      View in: PubMed
    26. Yang S, Doolittle R, Bourne PE. Phylogeny determined by protein domain content. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):373-8. PMID: 15630082; PMCID: PMC540256.
    27. Doolittle R. Some comments on John Ferry's most enduring paper. Biophys Chem. 2004 Dec 20; 112(2-3):177-80. PMID: 15572245.
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    28. Doolittle R. Martin David Kamen (27 August 1913 - 31 August 2002). Proc Am Philos Soc. 2004 Dec; 148(4):499-503. PMID: 15818877.
      View in: PubMed
    29. Doolittle R. Determining the crystal structure of fibrinogen. J Thromb Haemost. 2004 May; 2(5):683-9. PMID: 15099268.
      View in: PubMed
    30. Jacobson MF, Sharpe VA, Angell M, Ashford NA, Blum A, Chary LK, Cho M, Coull BC, Davis D, Doolittle R, Egilman D, Epstein SS, Greenberg M, Hooper K, Huff J, Joshi TK, Krimsky S, LaDou J, Levenstein C, Miles S, Needleman H, Pellegrino ED, Ravanesi B, Sass J, Schecter A, Schneiderman JS, Schubert D, Soffritti M, Suzuki D, Takaro TK, Temple NJ, Terracini B, Thompson A, Wallinga D, Wing S. Editorial policies on financial disclosure. Nat Neurosci. 2003 Oct; 6(10):1001. PMID: 14513030.
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    31. Doolittle R. X-ray crystallographic studies on fibrinogen and fibrin. J Thromb Haemost. 2003 Jul; 1(7):1559-65. PMID: 12871291.
      View in: PubMed
    32. Jiang Y, Doolittle R. The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7527-32. PMID: 12808152; PMCID: PMC164620.
    33. Doolittle R. Structural basis of the fibrinogen-fibrin transformation: contributions from X-ray crystallography. Blood Rev. 2003 Mar; 17(1):33-41. PMID: 12490209.
      View in: PubMed
    34. Doolittle R. Some notes on crystallizing fibrinogen and fibrin fragments. Biophys Chem. 2003; 100(1-3):307-13. PMID: 12646373.
      View in: PubMed
    35. Yang Z, Pandi L, Doolittle R. The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 2002 Dec 31; 41(52):15610-7. PMID: 12501189.
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    36. Doolittle R. The grand assault. Nature. 2002 Oct 03; 419(6906):493-4. PMID: 12368861.
      View in: PubMed
    37. Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle R. Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide. Biochemistry. 2002 Aug 13; 41(32):10218-24. PMID: 12162736.
      View in: PubMed
    38. Doolittle R. Biodiversity: microbial genomes multiply. Nature. 2002 Apr 18; 416(6882):697-700. PMID: 11961543.
      View in: PubMed
    39. Doolittle R, York AL. Bacterial actins? An evolutionary perspective. Bioessays. 2002 Apr; 24(4):293-6. PMID: 11948613.
      View in: PubMed
    40. Doolittle R, Yang Z, Mochalkin I. Crystal structure studies on fibrinogen and fibrin. Ann N Y Acad Sci. 2001; 936:31-43. PMID: 11460486.
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    41. Doolittle R. Searching for the common ancestor. Res Microbiol. 2000 Mar; 151(2):85-9. PMID: 10865952.
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    42. Doolittle R. On the trail of protein sequences. Bioinformatics. 2000 Jan; 16(1):24-33. PMID: 10812474.
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    43. Doolittle R, Spraggon G, Everse SJ. Crystal structures of fragments D and double-D from fibrinogen and fibrin. Thromb Haemost. 1999 Aug; 82(2):271-6. PMID: 10605713.
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    44. Doolittle R, Spraggon G, Everse SJ. Three-dimensional structural studies on fragments of fibrinogen and fibrin. Curr Opin Struct Biol. 1998 Dec; 8(6):792-8. PMID: 9914253.
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    45. Doolittle R, Handy J. Evolutionary anomalies among the aminoacyl-tRNA synthetases. Curr Opin Genet Dev. 1998 Dec; 8(6):630-6. PMID: 9914200.
      View in: PubMed
    46. Blomback B, Doolittle R. The sequence of amino acids at the N-terminal end of bovine fibrinopeptide B. Acta Chem Scand. 1963; 17(6):1816-9. PMID: 22132444.
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    47. Blomback B, Doolittle R. Amino acid sequence studies on fibrinopeptides from several species. Acta Chem Scand. 1963; 17(6):1819-22. PMID: 22132445.
      View in: PubMed
    48. Doolittle R, Surgenor DM. Blood coagulation in fish. Am J Physiol. 1962 Nov; 203:964-70. PMID: 22103034.
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    49. Doolittle R, Oncley JL, Surgenor DM. Species differences in the interaction of thrombin and fibrinogen. J Biol Chem. 1962 Oct; 237:3123-7. PMID: 22103031.
      View in: PubMed
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