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Rodrigo Dos Santos Chaves

Title(s)Postdoctoral Scholar, Orthopedic Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #NULL
La Jolla CA 92093
Phone000-000-NULL
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    Universidade Metodista de São Paulo, São Paulo/Brazil Bachelor's01/2011Biological Sciences
    Universidade de São Paulo, São Paulo/Brazil Doctor of Philosophy10/2015Experimental Physiopathology
    University od California San Diego , San Diego/United States of AmericaVisiting Scholar01/2015Stem Cells and Alzheimer's disease
    University California San Diego , San Diego/ United States of AmericaPostdoctoral FellowCurrentTraumatic brain injury / Alzheimer's disease

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    My long-term research interests involve the development of a comprehensive understanding of cellular and molecular dysfunctions occurring early in Sporadic Alzheimer’s disease (SAD). During my training, I particularly investigated how GWAS identified risk factors for Alzheimer’s disease (AD), such as aging and traumatic brain injury, influence disease progression and severity. Using a diversified array of SAD models such as; human inducible pluripotent stem cell (hIPSC) derived neurons, primary cell cultures and in vivo experiments using mice and rats. I investigate how canonical disease-associated pathways were affected by the presence of AD associated-risk factors, which allowed us to develop a better understanding of how risk factors are mechanistically coupled with AD etiology.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols. Neurotox Res. 2019 Feb; 35(2):410-420. Melo KP, Silva CM, Almeida MF, Chaves RS, Marcourakis T, Cardoso SM, Demasi M, Netto LES, Ferrari MFR. PMID: 30276717.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-ß clearance in human astrocytes. J Biol Chem. 2018 07 20; 293(29):11341-11357. Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. PMID: 29858247.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Effects of mild running on substantia nigra during early neurodegeneration. J Sports Sci. 2018 Jun; 36(12):1363-1370. Almeida MF, Silva CM, Chaves RS, Lima NCR, Almeida RS, Melo KP, Demasi M, Fernandes T, Oliveira EM, Netto LES, Cardoso SM, Ferrari MFR. PMID: 28895489.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration. IBRO Rep. 2016 Dec; 1:32-45. Chaves RS, Kazi AI, Silva CM, Almeida MF, Lima RS, Carrettiero DC, Demasi M, Ferrari MFR. PMID: 30135926.
      View in: PubMed   Mentions:
    5. BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity. IBRO Rep. 2016 Dec; 1:19-31. Almeida MF, Chaves RS, Silva CM, Chaves JCS, Melo KP, Ferrari MFR. PMID: 30135925.
      View in: PubMed   Mentions:
    6. Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone. Acta Neurobiol Exp (Wars). 2013; 73(4):541-56. Chaves RS, Melo TQ, D'Unhao AM, Farizatto KL, Ferrari MF. PMID: 24457644.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases. Cell Mol Neurobiol. 2013 Apr; 33(3):327-35. Melo TQ, D'unhao AM, Martins SA, Farizatto KL, Chaves RS, Ferrari MF. PMID: 23263842.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Protein aggregation containing ß-amyloid, a-synuclein and hyperphosphorylated t in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. BMC Neurosci. 2010 Nov 10; 11:144. Chaves RS, Melo TQ, Martins SA, Ferrari MF. PMID: 21067569.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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