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Robert Oshima

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone858-646-3147
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    Collapse Research 
    Collapse Research Activities and Funding
    Tumor repressive role of Ets2 in the intestine
    NIH/NIDDK R01DK092084Sep 30, 2010 - Aug 31, 2013
    Role: Principal Investigator
    An Ets2 dependent stromal restriction of breast cancer
    NIH/NCI R01CA098778Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator
    Ets Transcription Factors in Development and Cancer
    NIH/NCI R01CA074547Jun 2, 1997 - Mar 31, 2005
    Role: Principal Investigator
    DEVELOPMENTAL CONTROL OF CYTOKERATIN EXPRESSION
    NIH/NCI R01CA042302May 1, 1986 - Dec 31, 2003
    Role: Principal Investigator
    DEVELOPMENTAL GENE REGULATION
    NIH/NCI T32CA009497Sep 1, 1984 - Aug 31, 1990
    Role: Principal Investigator
    TERATOCARCINOMA CYTOSKELETAL PROTEINS
    NIH/NCI R01CA033946Jun 1, 1982 - Aug 31, 1989
    Role: Principal Investigator
    CHROMATIN PROTEINS OF EMBRYONAL CARCINOMA CELLS
    NIH/NCI R01CA033011Feb 1, 1982 - Jan 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima R, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity. Oncotarget. 2018 May 18; 9(38):25057-25074. PMID: 29861853.
      View in: PubMed
    2. Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima R, Maurer J. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget. 2016 Dec 13; 7(50):83278-83293. PMID: 27829216.
      View in: PubMed
    3. Wu B, Wang S, De SK, Barile E, Quinn BA, Zharkikh I, Purves A, Stebbins JL, Oshima R, Fisher PB, Pellecchia M. Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells. Chem Biol. 2015 Jul 23; 22(7):876-887. PMID: 26165155; PMCID: PMC4515144.
    4. John S, Russell L, Chin SS, Luo W, Oshima R, Garrett-Sinha LA. Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation. Mol Cell Biol. 2014 Feb; 34(3):522-32. PMID: 24277931; PMCID: PMC3911503.
    5. Castro DJ, Maurer J, Hebbard L, Oshima R. ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell. Stem Cells. 2013 Jan; 31(1):12-22. PMID: 22961723; PMCID: PMC3967738.
    6. Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima R, Willerson JT, Potaman VN, Schwartz RJ. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13016-21. PMID: 22826236; PMCID: PMC3420197.
    7. Xia Z, Correa RG, Das JK, Farhana L, Castro DJ, Yu J, Oshima R, Fontana JA, Reed JC, Dawson MI. Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines. J Med Chem. 2012 Jan 12; 55(1):233-49. PMID: 22136251.
      View in: PubMed
    8. Xia Z, Farhana L, Correa RG, Das JK, Castro DJ, Yu J, Oshima R, Reed JC, Fontana JA, Dawson MI. Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. J Med Chem. 2011 Jun 09; 54(11):3793-816. PMID: 21548569.
      View in: PubMed
    9. Múnera J, Ceceña G, Jedlicka P, Wankell M, Oshima R. Ets2 regulates colonic stem cells and sensitivity to tumorigenesis. Stem Cells. 2011 Mar; 29(3):430-9. PMID: 21425406; PMCID: PMC3339631.
    10. Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima R, Terskikh AV. Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo. Cancer Res. 2010 Nov 01; 70(21):8863-73. PMID: 20861186; PMCID: PMC3990264.
    11. Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima R, Amagai T, Su DM. Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem. 2010 Feb 19; 285(8):5836-47. PMID: 19955175; PMCID: PMC2820809.
    12. Morioka Y, Isotani A, Oshima R, Okabe M, Ikawa M. Placenta-specific gene activation and inactivation using integrase-defective lentiviral vectors with the Cre/LoxP system. Genesis. 2009 Dec; 47(12):793-8. PMID: 19830817.
      View in: PubMed
    13. Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima R, Leone G, Ostrowski MC. Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood. 2009 Jul 30; 114(5):1123-30. PMID: 19411629; PMCID: PMC2721789.
    14. Maurer J, Nelson B, Ceceña G, Bajpai R, Mercola M, Terskikh A, Oshima R. Contrasting expression of keratins in mouse and human embryonic stem cells. PLoS One. 2008; 3(10):e3451. PMID: 18941637; PMCID: PMC2565505.
    15. Jaksch M, Múnera J, Bajpai R, Terskikh A, Oshima R. Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines. Cancer Res. 2008 Oct 01; 68(19):7882-6. PMID: 18829544; PMCID: PMC2561223.
    16. Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima R, Baribault H, Omary MB. Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury. Am J Pathol. 2008 Apr; 172(4):882-92. PMID: 18349119; PMCID: PMC2276414.
    17. Hebbard LW, Garlatti M, Young LJ, Cardiff RD, Oshima R, Ranscht B. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res. 2008 Mar 01; 68(5):1407-16. PMID: 18316604; PMCID: PMC2676344.
    18. Kairouz-Wahbe R, Biliran H, Luo X, Khor I, Wankell M, Besch-Williford C, Pascual J, Oshima R, Ruoslahti E. Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1528-32. PMID: 18218778; PMCID: PMC2234178.
    19. Vervoort VS, Lu M, Valencia F, Lesperance J, Breier G, Oshima R, Pasquale EB. A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature. Transgenic Res. 2008 Jun; 17(3):403-15. PMID: 18027100.
      View in: PubMed
    20. Wen F, Tynan JA, Cecena G, Williams R, Múnera J, Mavrothalassitis G, Oshima R. Ets2 is required for trophoblast stem cell self-renewal. Dev Biol. 2007 Dec 01; 312(1):284-99. PMID: 17977525; PMCID: PMC2211385.
    21. Allen SD, Garrett JT, Rawale SV, Jones AL, Phillips G, Forni G, Morris JC, Oshima R, Kaumaya PT. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. J Immunol. 2007 Jul 01; 179(1):472-82. PMID: 17579068.
      View in: PubMed
    22. Papadaki C, Alexiou M, Cecena G, Verykokakis M, Bilitou A, Cross JC, Oshima R, Mavrothalassitis G. Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol. 2007 Jul; 27(14):5201-13. PMID: 17502352; PMCID: PMC1951951.
    23. Oshima R. Intermediate filaments: a historical perspective. Exp Cell Res. 2007 Jun 10; 313(10):1981-94. PMID: 17493611; PMCID: PMC1950476.
    24. Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoguchi A, Oh-Hora M, Mori Y, Ogata M, Oshima R, Okabe M, Ikawa M. Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer. Nat Biotechnol. 2007 Feb; 25(2):233-7. PMID: 17220877.
      View in: PubMed
    25. Vervoort VS, Roselli S, Oshima R, Pasquale EB. Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. Gene. 2007 Apr 15; 391(1-2):161-70. PMID: 17270363; PMCID: PMC1876674.
    26. Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima R, Muller WJ, Feng GS. Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem. 2006 Nov 10; 281(45):34374-80. PMID: 16959766; PMCID: PMC1761121.
    27. Cecena G, Wen F, Cardiff RD, Oshima R. Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene. Am J Pathol. 2006 Jan; 168(1):310-20. PMID: 16400032; PMCID: PMC1592648.
    28. Nakamichi I, Toivola DM, Strnad P, Michie SA, Oshima R, Baribault H, Omary MB. Keratin 8 overexpression promotes mouse Mallory body formation. J Cell Biol. 2005 Dec 19; 171(6):931-7. PMID: 16365160; PMCID: PMC2171301.
    29. Tynan JA, Wen F, Muller WJ, Oshima R. Ets2-dependent microenvironmental support of mouse mammary tumors. Oncogene. 2005 Oct 20; 24(46):6870-6. PMID: 16007139.
      View in: PubMed
    30. Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima R, Abraham RT. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. Cancer Res. 2005 Jun 15; 65(12):5325-36. PMID: 15958580.
      View in: PubMed
    31. Wei G, Guo J, Doseff AI, Kusewitt DF, Man AK, Oshima R, Ostrowski MC. Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model. J Immunol. 2004 Jul 15; 173(2):1374-9. PMID: 15240733.
      View in: PubMed
    32. Oshima R, Lesperance J, Munoz V, Hebbard L, Ranscht B, Sharan N, Muller WJ, Hauser CA, Cardiff RD. Angiogenic acceleration of Neu induced mammary tumor progression and metastasis. Cancer Res. 2004 Jan 01; 64(1):169-79. PMID: 14729621.
      View in: PubMed
    33. Galang CK, Muller WJ, Foos G, Oshima R, Hauser CA. Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors. J Biol Chem. 2004 Mar 19; 279(12):11281-92. PMID: 14662758.
      View in: PubMed
    34. Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima R. Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol. 2003 Dec; 23(23):8614-25. PMID: 14612405; PMCID: PMC262691.
    35. Hevér A, Oshima R, Hauser CA. Ets2 is not required for Ras or Neu/ErbB-2 mediated cellular transformation in vitro. Exp Cell Res. 2003 Oct 15; 290(1):132-43. PMID: 14516794.
      View in: PubMed
    36. Jaquemar D, Kupriyanov S, Wankell M, Avis J, Benirschke K, Baribault H, Oshima R. Keratin 8 protection of placental barrier function. J Cell Biol. 2003 May 26; 161(4):749-56. PMID: 12771125; PMCID: PMC2199358.
    37. Wen F, Cecena G, Munoz-Ritchie V, Fuchs E, Chambon P, Oshima R. Expression of conditional cre recombinase in epithelial tissues of transgenic mice. Genesis. 2003 Feb; 35(2):100-6. PMID: 12533792; PMCID: PMC2405925.
    38. Lee JC, Schickling O, Stegh AH, Oshima R, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J Cell Biol. 2002 Sep 16; 158(6):1051-66. PMID: 12235123; PMCID: PMC2173221.
    39. Cardiff RD, Bern HA, Faulkin LJ, Daniel CW, Smith GH, Young LJ, Medina D, Gardner MB, Wellings SR, Shyamala G, Guzman RC, Rajkumar L, Yang J, Thordarson G, Nandi S, MacLeod CL, Oshima R, Man AK, Sawai ET, Gregg JP, Cheung AT, Lau DH. Contributions of mouse biology to breast cancer research. Comp Med. 2002 Feb; 52(1):12-31. PMID: 11900409.
      View in: PubMed