Loading...

Richard Schwab

TitleAssociate Clinical Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0820
La Jolla CA 92093
Phone858-657-5090
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Research Interests
    Dr. Schwab's research focuses on biomarkers to diagnosis and refine the treatment of cancer. His current projects include precision oncology using DNA sequencing, target discovery using RNA sequencing, and validation of novel cancer initiating cell markers.

    In support of these, and future, biomarker studies Dr. Schwab co-directs a biorepository to prospectively collect de-identified blood, urine and tumor specimens. This resource has a series of key features to maximize its future utility; (1) specimens are associated with detailed clinical data that is regularly updated, (2) three methods to ensure follow up data are available are used, including social security number queries to the national databases, (3) samples are stored as small volume aliquots at –80 degrees Celsius to prevent freeze/thaw damage, (4) subjects are consented for germ line DNA sequencing (5) buffy coat is stored in nucleic acid stabilizing solution and (6) through a collaboration with The Jackson Laboratory patient derived xenografts are generated.

    Education and Training
    BA - Molecular and Cell Biology, University of California, Berkeley - 1995
    MD - Albert Einstein College of Medicine - 2000
    Residency - Internal Medicine, University of California, San Diego - 2003
    Fellowship - Hematology/Oncology, University of California, San Diego - 2006


    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Schwaederle M, Krishnamurthy N, Daniels GA, Piccioni DE, Kesari S, Fanta PT, Schwab R, Patel SP, Parker BA, Kurzrock R. Telomerase reverse transcriptase promoter alterations across cancer types as detected by next-generation sequencing: A clinical and molecular analysis of 423 patients. Cancer. 2018 Mar 15; 124(6):1288-1296. PMID: 29211306.
      View in: PubMed
    2. Martínez ME, Gomez SL, Tao L, Cress R, Rodriguez D, Unkart J, Schwab R, Nodora JN, Cook L, Komenaka I, Li C. Erratum to: Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women. Breast Cancer Res Treat. 2017 11; 166(1):195. PMID: 28871561.
      View in: PubMed
    3. D Antonio M, Weghorn D, D Antonio-Chronowska A, Coulet F, Olson KM, DeBoever C, Drees F, Arias A, Alakus H, Richardson AL, Schwab R, Farley EK, Sunyaev SR, Frazer KA. Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. Nat Commun. 2017 09 05; 8(1):436. PMID: 28874753.
      View in: PubMed
    4. Martínez ME, Gomez SL, Tao L, Cress R, Rodriguez D, Unkart J, Schwab R, Nodora JN, Cook L, Komenaka I, Li C. Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women. Breast Cancer Res Treat. 2017 Nov; 166(1):185-193. PMID: 28698973.
      View in: PubMed
    5. Martínez ME, Unkart JT, Tao L, Kroenke CH, Schwab R, Komenaka I, Gomez SL. Prognostic significance of marital status in breast cancer survival: A population-based study. PLoS One. 2017; 12(5):e0175515. PMID: 28475579.
      View in: PubMed
    6. Nodora JN, Komenaka IK, Bouton ME, Ohno-Machado L, Schwab R, Kim HE, Farcas C, Perez G, Elena Martinez M. Biospecimen Sharing Among Hispanic Women in a Safety-Net Clinic: Implications for the Precision Medicine Initiative. J Natl Cancer Inst. 2017 02; 109(2). PMID: 27688295.
      View in: PubMed
    7. Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ, Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 07; 375(1):23-34. PMID: 27406347.
      View in: PubMed
    8. Park JW, Liu MC, Yee D, Yau C, van 't Veer LJ, Symmans WF, Paoloni M, Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt DW, Pusztai L, Moulder SL, Lang JE, Viscusi RK, Euhus DM, Haley BB, Khan QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst GL, Sanil A, Esserman LJ, Berry DA. Adaptive Randomization of Neratinib in Early Breast Cancer. N Engl J Med. 2016 Jul 07; 375(1):11-22. PMID: 27406346.
      View in: PubMed
    9. Schwaederle M, Husain H, Fanta PT, Piccioni DE, Kesari S, Schwab R, Patel SP, Harismendy O, Ikeda M, Parker BA, Kurzrock R. Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients. Clin Cancer Res. 2016 Nov 15; 22(22):5497-5505. PMID: 27185373.
      View in: PubMed
    10. Schwaederle M, Husain H, Fanta PT, Piccioni DE, Kesari S, Schwab R, Banks KC, Lanman RB, Talasaz A, Parker BA, Kurzrock R. Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay. Oncotarget. 2016 Mar 01; 7(9):9707-17. PMID: 26848768; PMCID: PMC4891078.
      View in: PubMed, PubMed Central
    11. Schwaederle M, Parker BA, Schwab R, Daniels GA, Piccioni DE, Kesari S, Helsten TL, Bazhenova LA, Romero J, Fanta PT, Lippman SM, Kurzrock R. Precision Oncology: The UC San Diego Moores Cancer Center PREDICT Experience. Mol Cancer Ther. 2016 04; 15(4):743-52. PMID: 26873727.
      View in: PubMed
    12. Komenaka IK, Nodora JN, Madlensky L, Winton LM, Heberer MA, Schwab R, Weitzel JN, Martinez ME. Participation of low-income women in genetic cancer risk assessment and BRCA 1/2 testing: the experience of a safety-net institution. J Community Genet. 2016 Jul; 7(3):177-83. PMID: 26690931; PMCID: PMC4960024.
      View in: PubMed, PubMed Central
    13. Bao L, Messer K, Schwab R, Harismendy O, Pu M, Crain B, Yost S, Frazer KA, Rana B, Hasteh F, Wallace A, Parker BA. Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors. PLoS One. 2015; 10(11):e0142487. PMID: 26554380; PMCID: PMC4640562.
      View in: PubMed, PubMed Central
    14. Patel SP, Schwaederle M, Daniels GA, Fanta PT, Schwab R, Shimabukuro KA, Kesari S, Piccioni DE, Bazhenova LA, Helsten TL, Lippman SM, Parker BA, Kurzrock R. Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology. Oncotarget. 2015 Oct 20; 6(32):32602-9. PMID: 26418953; PMCID: PMC4741715.
      View in: PubMed, PubMed Central
    15. Schwab R, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson DA, Parker BA. A window-of-opportunity biomarker study of etodolac in resectable breast cancer. Cancer Med. 2015 Oct; 4(10):1583-8. PMID: 26275572; PMCID: PMC4618628.
      View in: PubMed, PubMed Central
    16. Parker BA, Schwaederlé M, Scur MD, Boles SG, Helsten T, Subramanian R, Schwab R, Kurzrock R. Breast Cancer Experience of the Molecular Tumor Board at the University of California, San Diego Moores Cancer Center. J Oncol Pract. 2015 Nov; 11(6):442-9. PMID: 26243651.
      View in: PubMed
    17. Mausbach BT, Schwab R, Irwin SA. Depression as a predictor of adherence to adjuvant endocrine therapy (AET) in women with breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2015 Jul; 152(2):239-46. PMID: 26077640; PMCID: PMC4861253.
      View in: PubMed, PubMed Central
    18. Schwaederle M, Daniels GA, Piccioni DE, Fanta PT, Schwab R, Shimabukuro KA, Parker BA, Kurzrock R. On the Road to Precision Cancer Medicine: Analysis of Genomic Biomarker Actionability in 439 Patients. Mol Cancer Ther. 2015 Jun; 14(6):1488-94. PMID: 25852059.
      View in: PubMed
    19. Schwaederlé M, Daniels GA, Piccioni DE, Fanta PT, Schwab R, Shimabukuro KA, Parker BA, Kurzrock R. Cyclin alterations in diverse cancers: Outcome and co-amplification network. Oncotarget. 2015 Feb 20; 6(5):3033-42. PMID: 25596748; PMCID: PMC4413635.
      View in: PubMed, PubMed Central
    20. Schwaederle M, Daniels GA, Piccioni DE, Kesari S, Fanta PT, Schwab R, Shimabukuro KA, Parker BA, Kurzrock R. Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer. Cell Cycle. 2015; 14(11):1730-7. PMID: 25928476; PMCID: PMC4614790.
      View in: PubMed, PubMed Central
    21. Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17266-71. PMID: 25411317; PMCID: PMC4260559.
      View in: PubMed, PubMed Central
    22. Baker JL, Schwab R, Wallace AM, Madlensky L. Breast cancer in a RAD51D mutation carrier: case report and review of the literature. Clin Breast Cancer. 2015 Feb; 15(1):e71-5. PMID: 25445424.
      View in: PubMed
    23. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab R, Peterson MR, Lowy AM, Frazer KA, Harismendy O. Correction: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(7):53. PMID: 25228923; PMCID: PMC4165363.
      View in: PubMed, PubMed Central
    24. Ettinger DS, Handorf CR, Agulnik M, Bowles DW, Cates JM, Cristea M, Dotan E, Eaton KD, Fidias PM, Gierada D, Gilcrease GW, Godby K, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Schwab R, Shulman LN, Smerage JB, Stevenson MM, Varadhachary GR, Zager JS, Zhen WK, Bergman MA, Freedman-Cass DA. Occult primary, version 3.2014. J Natl Compr Canc Netw. 2014 Jul; 12(7):969-74. PMID: 24994917.
      View in: PubMed
    25. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab R, Peterson MR, Lowy AM, Frazer KA, Harismendy O. Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(5):43. PMID: 24944587; PMCID: PMC4062050.
      View in: PubMed, PubMed Central
    26. Schwaederle M, Parker BA, Schwab R, Fanta PT, Boles SG, Daniels GA, Bazhenova LA, Subramanian R, Coutinho AC, Ojeda-Fournier H, Datnow B, Webster NJ, Lippman SM, Kurzrock R. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014 Jun; 19(6):631-6. PMID: 24797821; PMCID: PMC4041669.
      View in: PubMed, PubMed Central
    27. Yan M, Parker BA, Schwab R, Kurzrock R. HER2 aberrations in cancer: implications for therapy. Cancer Treat Rev. 2014 Jul; 40(6):770-80. PMID: 24656976.
      View in: PubMed
    28. Sicklick JK, Leonard SY, Babicky ML, Tang CM, Mose ES, French RP, Jaquish DV, Hoh CK, Peterson M, Schwab R, Lowy AM. Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. J Transl Med. 2014 Feb 10; 12:41. PMID: 24507750; PMCID: PMC3930355.
      View in: PubMed, PubMed Central
    29. Anderson KN, Schwab R, Martinez ME. Reproductive risk factors and breast cancer subtypes: a review of the literature. Breast Cancer Res Treat. 2014 Feb; 144(1):1-10. PMID: 24477977; PMCID: PMC4026199.
      View in: PubMed, PubMed Central
    30. Harismendy O, Schwab R, Alakus H, Yost SE, Matsui H, Hasteh F, Wallace AM, Park HL, Madlensky L, Parker B, Carpenter PM, Jepsen K, Anton-Culver H, Frazer KA. Evaluation of ultra-deep targeted sequencing for personalized breast cancer care. Breast Cancer Res. 2013 Dec 10; 15(6):R115. PMID: 24326041; PMCID: PMC3978701.
      View in: PubMed, PubMed Central
    31. Patel A, Schwab R, Liu YT, Bafna V. Amplification and thrifty single-molecule sequencing of recurrent somatic structural variations. Genome Res. 2014 Feb; 24(2):318-28. PMID: 24307551; PMCID: PMC3912422.
      View in: PubMed, PubMed Central
    32. Grando A, Schwab R. Building and evaluating an ontology-based tool for reasoning about consent permission. AMIA Annu Symp Proc. 2013; 2013:514-23. PMID: 24551354; PMCID: PMC3900195.
      View in: PubMed, PubMed Central
    33. Martinez ME, Wertheim BC, Natarajan L, Schwab R, Bondy M, Daneri-Navarro A, Meza-Montenegro MM, Gutierrez-Millan LE, Brewster A, Komenaka IK, Thompson PA. Reproductive factors, heterogeneity, and breast tumor subtypes in women of mexican descent. Cancer Epidemiol Biomarkers Prev. 2013 Oct; 22(10):1853-61. PMID: 23950213; PMCID: PMC3799795.
      View in: PubMed, PubMed Central
    34. Fang DD, Zhang CC, Gu Y, Jani JP, Cao J, Tsaparikos K, Yuan J, Thiel M, Jackson-Fisher A, Zong Q, Lappin PB, Hayashi T, Schwab R, Wong A, John-Baptiste A, Bagrodia S, Los G, Bender S, Christensen J, Vanarsdale T. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PLoS One. 2013; 8(6):e67258. PMID: 23826249; PMCID: PMC3695076.
      View in: PubMed, PubMed Central
    35. Yost SE, Alakus H, Matsui H, Schwab R, Jepsen K, Frazer KA, Harismendy O. Mutascope: sensitive detection of somatic mutations from deep amplicon sequencing. Bioinformatics. 2013 Aug 01; 29(15):1908-9. PMID: 23712659; PMCID: PMC3712217.
      View in: PubMed, PubMed Central
    36. Barrett CL, Schwab R, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. PMID: 23527012; PMCID: PMC3604164.
      View in: PubMed, PubMed Central
    37. Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A. Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem. 2012 Jun 29; 287(27):22593-608. PMID: 22549775; PMCID: PMC3391140.
      View in: PubMed, PubMed Central
    38. Yost SE, Smith EN, Schwab R, Bao L, Jung H, Wang X, Voest E, Pierce JP, Messer K, Parker BA, Harismendy O, Frazer KA. Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens. Nucleic Acids Res. 2012 Aug; 40(14):e107. PMID: 22492626; PMCID: PMC3413110.
      View in: PubMed, PubMed Central
    39. Paul AK, Schwab R. Efficacy and pharmacogenomic biomarkers in breast cancer. Biomark Med. 2012 Apr; 6(2):211-21. PMID: 22448796.
      View in: PubMed
    40. Harismendy O, Schwab R, Bao L, Olson J, Rozenzhak S, Kotsopoulos SK, Pond S, Crain B, Chee MS, Messer K, Link DR, Frazer KA. Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing. Genome Biol. 2011 Dec 20; 12(12):R124. PMID: 22185227; PMCID: PMC3334619.
      View in: PubMed, PubMed Central
    41. Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, Chen X, Varki A, Schwab R. Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 2011 May 01; 71(9):3352-63. PMID: 21505105.
      View in: PubMed
    42. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab R, Carson DA. Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. PMID: 20368435; PMCID: PMC2867719.
      View in: PubMed, PubMed Central
    Richard's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (244) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (64) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    ↑