Richard Dutton

Title(s)Emeritus Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    CD8 memory T cells: mechanisms of protection
    NIH/NIAID R56AI078298Jul 14, 2009 - Oct 31, 2009
    Role: Principal Investigator
    NIH/NIAID R13AI043520Aug 1, 1998 - Jul 31, 1999
    Role: Principal Investigator
    Analysis of CD8 T cell responses to tumors
    NIH/NCI R01CA071833May 15, 1997 - Jul 31, 2010
    Role: Principal Investigator
    NIH/NIAID R01AI036263Oct 2, 1996 - Sep 30, 1997
    Role: Principal Investigator
    NIH/NIAID P01AI023287May 1, 1986 - May 31, 1994
    Role: Principal Investigator
    NIH/NCI T32CA009174Jul 1, 1980 - Sep 29, 1996
    Role: Principal Investigator
    NIH/NIAID R37AI008795Dec 1, 1978 - Nov 30, 1993
    Role: Principal Investigator
    NIH/NIAID R01AI008795Dec 1, 1978 - Nov 30, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza. Viral Immunol. 2014 Dec; 27(10):484-96. Sell S, Guest I, McKinstry KK, Strutt TM, Kohlmeier JE, Brincks E, Tighe M, Blackman MA, Woodland DL, Dutton RW, Swain SL. PMID: 25479178.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    2. Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus. Immunol Rev. 2013 Sep; 255(1):149-64. Strutt TM, McKinstry KK, Marshall NB, Vong AM, Dutton RW, Swain SL. PMID: 23947353.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    3. Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful. Arch Immunol Ther Exp (Warsz). 2013 Oct; 61(5):341-53. McKinstry KK, Dutton RW, Swain SL, Strutt TM. PMID: 23708562.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    4. Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J Immunol. 2013 Jan 01; 190(1):296-306. Hamada H, Bassity E, Flies A, Strutt TM, Garcia-Hernandez Mde L, McKinstry KK, Zou T, Swain SL, Dutton RW. PMID: 23197262.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    5. Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest. 2012 Aug; 122(8):2847-56. McKinstry KK, Strutt TM, Kuang Y, Brown DM, Sell S, Dutton RW, Swain SL. PMID: 22820287.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    6. Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol. 2010 Aug 15; 185(4):2089-98. Yeh N, Glosson NL, Wang N, Guindon L, McKinley C, Hamada H, Li Q, Dutton RW, Shrikant P, Zhou B, Brutkiewicz RR, Blum JS, Kaplan MH. PMID: 20624947.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    7. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med. 2010 May; 16(5):558-64, 1p following 564. Strutt TM, McKinstry KK, Dibble JP, Winchell C, Kuang Y, Curtis JD, Huston G, Dutton RW, Swain SL. PMID: 20436484.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    8. Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol. 2010 Apr 15; 184(8):4215-27. Garcia-Hernandez Mde L, Hamada H, Reome JB, Misra SK, Tighe MP, Dutton RW. PMID: 20237297.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    9. IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol. 2009 Jun 15; 182(12):7353-63. McKinstry KK, Strutt TM, Buck A, Curtis JD, Dibble JP, Huston G, Tighe M, Hamada H, Sell S, Dutton RW, Swain SL. PMID: 19494257.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    10. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009 Mar 15; 182(6):3469-81. Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW. PMID: 19265125.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    11. Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. J Immunol. 2007 Jan 15; 178(2):1030-8. Powell TJ, Strutt T, Reome J, Hollenbaugh JA, Roberts AD, Woodland DL, Swain SL, Dutton RW. PMID: 17202366.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    12. Vaccines against pandemic influenza. Viral Immunol. 2007; 20(2):326-7. Dutton RW, Swain SL, Woodland DL. PMID: 17603849.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    13. IFN-gamma regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor. J Immunol. 2006 Sep 01; 177(5):3004-11. Hollenbaugh JA, Dutton RW. PMID: 16920936.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. The immune system provides a strong response to even a low exposure to virus. Clin Immunol. 2006 Apr; 119(1):87-94. Powell TJ, Dwyer DW, Morgan T, Hollenbaugh JA, Dutton RW. PMID: 16386960.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Uneven distribution of MHC class II epitopes within the influenza virus. Vaccine. 2006 Jan 23; 24(4):457-67. Crowe SR, Miller SC, Brown DM, Adams PS, Dutton RW, Harmsen AG, Lund FE, Randall TD, Swain SL, Woodland DL. PMID: 16140434.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    16. CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency. Clin Immunol. 2004 Oct; 113(1):89-100. Powell TJ, Brown DM, Hollenbaugh JA, Charbonneau T, Kemp RA, Swain SL, Dutton RW. PMID: 15380534.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. Cutting edge: regulation of CD8+ T cell effector population size. J Immunol. 2004 Sep 01; 173(5):2923-7. Kemp RA, Powell TJ, Dwyer DW, Dutton RW. PMID: 15322149.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    18. Mouse T-lymphocyte subpopulations: relationships between function and Lyt antigen phenotype. Immunol Today. 1980 Sep; 1(3):61-5. Swain SL, Dutton RW. PMID: 25289764.
      View in: PubMed   Mentions: 2     Fields:    
    19. The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis. J Immunol. 2004 Aug 01; 173(3):1738-43. Hollenbaugh JA, Reome J, Dobrzanski M, Dutton RW. PMID: 15265903.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Type 1 and type 2 tumor infiltrating effector cell subpopulations in progressive breast cancer. Clin Immunol. 2004 Apr; 111(1):69-81. Reome JB, Hylind JC, Dutton RW, Dobrzanski MJ. PMID: 15093554.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Tc1 and Tc2 effector cell therapy elicit long-term tumor immunity by contrasting mechanisms that result in complementary endogenous type 1 antitumor responses. J Immunol. 2004 Feb 01; 172(3):1380-90. Dobrzanski MJ, Reome JB, Hollenbaugh JA, Dutton RW. PMID: 14734713.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    22. Effector cell-derived lymphotoxin alpha and Fas ligand, but not perforin, promote Tc1 and Tc2 effector cell-mediated tumor therapy in established pulmonary metastases. Cancer Res. 2004 Jan 01; 64(1):406-14. Dobrzanski MJ, Reome JB, Hollenbaugh JA, Hylind JC, Dutton RW. PMID: 14729652.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    23. T cell responses to influenza virus infection: effector and memory cells. Viral Immunol. 2004; 17(2):197-209. Swain SL, Dutton RW, Woodland DL. PMID: 15279699.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    24. In memoriam. Charles A. Janeway, Jr. February 5, 1943-April 12, 2003. J Immunol. 2003 Dec 15; 171(12):6314-5. Dutton RW, Hogan MM. PMID: 14662824.
      View in: PubMed   Mentions:    Fields:    
    25. Heterogeneity of CD4(+) and CD8(+) T cells. Curr Opin Immunol. 2003 Jun; 15(3):336-42. Woodland DL, Dutton RW. PMID: 12787761.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    26. CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation. J Immunol. 1999 Aug 01; 163(3):1133-42. Sepulveda H, Cerwenka A, Morgan T, Dutton RW. PMID: 10415007.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    27. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med. 1997 May 19; 185(10):1837-49. Zhang X, Brunner T, Carter L, Dutton RW, Rogers P, Bradley L, Sato T, Reed JC, Green D, Swain SL. PMID: 9151709.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    28. Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J Immunol. 1995 Aug 01; 155(3):1028-31. Carter LL, Dutton RW. PMID: 7543509.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    29. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med. 1994 Nov 01; 180(5):1715-28. Croft M, Carter L, Swain SL, Dutton RW. PMID: 7525836.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    30. How does the immune system remember? Curr Biol. 1993 Dec 01; 3(12):901-3. Dutton RW. PMID: 15335831.
      View in: PubMed   Mentions:    Fields:    
    31. Monoclonal antibody that distinguishes between a phosphorylated, beta 2-microglobulin-associated, and a free, nonphosphorylated, chain of MHC class I. J Immunol. 1993 Jul 01; 151(1):211-24. Thor G, Sepulveda H, Chada S, Dutton RW. PMID: 7686933.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. Restricted IgH V gene usage in the response to the ese epitope on "Hi" sheep red blood cells. J Immunol. 1992 Dec 01; 149(11):3574-9. Muralidhar G, Sepulveda H, Feeney AJ, Riblet R, Dutton RW. PMID: 1431127.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Cloning and sequencing of a trophoblast-endothelial-activated lymphocyte surface protein: cDNA sequence and genomic structure. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10425-9. Voland JR, Wyzykowski RJ, Huang M, Dutton RW. PMID: 1438229.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev. 1991 Oct; 123:115-44. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RW, Huston G. PMID: 1684776.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    35. Is autoimmunity good for you? The Molecular Basis of Recognition in the Immune System sponsored by the European Federation of Immunological Societies, Edinburgh, UK, September 10-12, 1990. New Biol. 1991 Feb; 3(2):117-20. Swain SL, Dutton RW. PMID: 2065006.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. A role for class I MHC antigens in responses of activated B lymphocytes. J Immunol. 1989 May 15; 142(10):3384-91. Southern SO, Dutton RW. PMID: 2497173.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    37. Induction of the H-2 D antigen during B cell activation. J Immunol. 1989 Jan 01; 142(1):336-42. Southern SO, Swain SL, Dutton RW. PMID: 2642506.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Role of antigen in the B cell response. Specific antigen and the lymphokine IL-5 synergize to drive B cell lymphoma proliferation and differentiation to Ig secretion. J Immunol. 1988 Jun 15; 140(12):4224-30. Swain SL, Dutton RW, McKenzie D, Helstrom H, English M. PMID: 2453572.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. The role of IL4 and IL5: characterization of a distinct helper T cell subset that makes IL4 and IL5 (Th2) and requires priming before induction of lymphokine secretion. Immunol Rev. 1988 Feb; 102:77-105. Swain SL, McKenzie DT, Dutton RW, Tonkonogy SL, English M. PMID: 2966763.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    40. Expression of an endothelial surface antigen on activated human lymphocytes: lymphocyte subset distribution and kinetics of antigen activation. Cell Immunol. 1987 Dec; 110(2):197-208. Voland JR, Frisman DM, Fan QH, Dutton RW. PMID: 3121187.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J Exp Med. 1987 Nov 01; 166(5):1464-70. Pfeifer JD, McKenzie DT, Swain SL, Dutton RW. PMID: 3500262.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). J Immunol. 1987 Oct 15; 139(8):2661-8. McKenzie DT, Filutowicz HI, Swain SL, Dutton RW. PMID: 3498767.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Consequences of the direct interaction of helper T cells with B cells presenting antigen. Immunol Rev. 1987 Oct; 99:263-80. Swain SL, Dutton RW. PMID: 2960607.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
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