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    Richard Dutton

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0063
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sell S, Guest I, Kai McKinstry K, Strutt TM, Kohlmeier JE, Brincks E, Tighe M, Blackman MA, Woodland DL, Dutton R, Swain SL. Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza. Viral Immunol. 2014 Dec; 27(10):484-96. PMID: 25479178.
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      2. Strutt TM, McKinstry KK, Marshall NB, Vong AM, Dutton R, Swain SL. Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus. Immunol Rev. 2013 Sep; 255(1):149-64. PMID: 23947353.
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      3. McKinstry KK, Dutton R, Swain SL, Strutt TM. Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful. Arch Immunol Ther Exp (Warsz). 2013 Oct; 61(5):341-53. PMID: 23708562.
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      4. Hamada H, Bassity E, Flies A, Strutt TM, Garcia-Hernandez Mde L, McKinstry KK, Zou T, Swain SL, Dutton R. Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J Immunol. 2013 Jan 1; 190(1):296-306. PMID: 23197262.
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      5. McKinstry KK, Strutt TM, Kuang Y, Brown DM, Sell S, Dutton R, Swain SL. Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest. 2012 Aug 1; 122(8):2847-56. PMID: 22820287.
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      6. Yeh N, Glosson NL, Wang N, Guindon L, McKinley C, Hamada H, Li Q, Dutton R, Shrikant P, Zhou B, Brutkiewicz RR, Blum JS, Kaplan MH. Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol. 2010 Aug 15; 185(4):2089-98. PMID: 20624947.
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      7. Strutt TM, McKinstry KK, Dibble JP, Winchell C, Kuang Y, Curtis JD, Huston G, Dutton R, Swain SL. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med. 2010 May; 16(5):558-64, 1p following 564. PMID: 20436484.
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      8. Garcia-Hernandez Mde L, Hamada H, Reome JB, Misra SK, Tighe MP, Dutton R. Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol. 2010 Apr 15; 184(8):4215-27. PMID: 20237297.
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      9. McKinstry KK, Strutt TM, Buck A, Curtis JD, Dibble JP, Huston G, Tighe M, Hamada H, Sell S, Dutton R, Swain SL. IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol. 2009 Jun 15; 182(12):7353-63. PMID: 19494257.
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      10. Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton R. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009 Mar 15; 182(6):3469-81. PMID: 19265125.
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      11. Powell TJ, Strutt T, Reome J, Hollenbaugh JA, Roberts AD, Woodland DL, Swain SL, Dutton R. Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. J Immunol. 2007 Jan 15; 178(2):1030-8. PMID: 17202366.
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      12. Dutton R, Swain SL, Woodland DL. Vaccines against pandemic influenza. Viral Immunol. 2007; 20(2):326-7. PMID: 17603849.
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      13. Hollenbaugh JA, Dutton R. IFN-gamma regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor. J Immunol. 2006 Sep 1; 177(5):3004-11. PMID: 16920936.
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      14. Powell TJ, Dwyer DW, Morgan T, Hollenbaugh JA, Dutton R. The immune system provides a strong response to even a low exposure to virus. Clin Immunol. 2006 Apr; 119(1):87-94. PMID: 16386960.
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      15. Crowe SR, Miller SC, Brown DM, Adams PS, Dutton R, Harmsen AG, Lund FE, Randall TD, Swain SL, Woodland DL. Uneven distribution of MHC class II epitopes within the influenza virus. Vaccine. 2006 Jan 23; 24(4):457-67. PMID: 16140434.
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      16. Powell TJ, Brown DM, Hollenbaugh JA, Charbonneau T, Kemp RA, Swain SL, Dutton R. CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency. Clin Immunol. 2004 Oct; 113(1):89-100. PMID: 15380534.
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      17. Kemp RA, Powell TJ, Dwyer DW, Dutton R. Cutting edge: regulation of CD8+ T cell effector population size. J Immunol. 2004 Sep 1; 173(5):2923-7. PMID: 15322149.
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      18. Swain SL, Dutton R. Mouse T-lymphocyte subpopulations: relationships between function and Lyt antigen phenotype. Immunol Today. 1980 Sep; 1(3):61-5. PMID: 25289764.
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      19. Hollenbaugh JA, Reome J, Dobrzanski M, Dutton R. The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis. J Immunol. 2004 Aug 1; 173(3):1738-43. PMID: 15265903.
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      20. Reome JB, Hylind JC, Dutton R, Dobrzanski MJ. Type 1 and type 2 tumor infiltrating effector cell subpopulations in progressive breast cancer. Clin Immunol. 2004 Apr; 111(1):69-81. PMID: 15093554.
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      21. Dobrzanski MJ, Reome JB, Hollenbaugh JA, Dutton R. Tc1 and Tc2 effector cell therapy elicit long-term tumor immunity by contrasting mechanisms that result in complementary endogenous type 1 antitumor responses. J Immunol. 2004 Feb 1; 172(3):1380-90. PMID: 14734713.
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      22. Swain SL, Dutton R, Woodland DL. T cell responses to influenza virus infection: effector and memory cells. Viral Immunol. 2004; 17(2):197-209. PMID: 15279699.
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      23. Dobrzanski MJ, Reome JB, Hollenbaugh JA, Hylind JC, Dutton R. Effector cell-derived lymphotoxin alpha and Fas ligand, but not perforin, promote Tc1 and Tc2 effector cell-mediated tumor therapy in established pulmonary metastases. Cancer Res. 2004 Jan 1; 64(1):406-14. PMID: 14729652.
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      24. Dutton R, Hogan MM. In memoriam. Charles A. Janeway, Jr. February 5, 1943-April 12, 2003. J Immunol. 2003 Dec 15; 171(12):6314-5. PMID: 14662824.
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      25. Woodland DL, Dutton R. Heterogeneity of CD4(+) and CD8(+) T cells. Curr Opin Immunol. 2003 Jun; 15(3):336-42. PMID: 12787761.
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      26. Sepulveda H, Cerwenka A, Morgan T, Dutton R. CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation. J Immunol. 1999 Aug 1; 163(3):1133-42. PMID: 10415007.
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      27. Zhang X, Brunner T, Carter L, Dutton R, Rogers P, Bradley L, Sato T, Reed JC, Green D, Swain SL. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med. 1997 May 19; 185(10):1837-49. PMID: 9151709.
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      28. Carter LL, Dutton R. Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J Immunol. 1995 Aug 1; 155(3):1028-31. PMID: 7543509.
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      29. Croft M, Carter L, Swain SL, Dutton R. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med. 1994 Nov 1; 180(5):1715-28. PMID: 7525836.
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      30. Dutton R. How does the immune system remember? Curr Biol. 1993 Dec 1; 3(12):901-3. PMID: 15335831.
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      31. Thor G, Sepulveda H, Chada S, Dutton R. Monoclonal antibody that distinguishes between a phosphorylated, beta 2-microglobulin-associated, and a free, nonphosphorylated, chain of MHC class I. J Immunol. 1993 Jul 1; 151(1):211-24. PMID: 7686933.
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      32. Muralidhar G, Sepulveda H, Feeney AJ, Riblet R, Dutton R. Restricted IgH V gene usage in the response to the ese epitope on "Hi" sheep red blood cells. J Immunol. 1992 Dec 1; 149(11):3574-9. PMID: 1431127.
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      33. Voland JR, Wyzykowski RJ, Huang M, Dutton R. Cloning and sequencing of a trophoblast-endothelial-activated lymphocyte surface protein: cDNA sequence and genomic structure. Proc Natl Acad Sci U S A. 1992 Nov 1; 89(21):10425-9. PMID: 1438229.
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      34. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton R, Huston G. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev. 1991 Oct; 123:115-44. PMID: 1684776.
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      35. Swain SL, Dutton R. Is autoimmunity good for you? The Molecular Basis of Recognition in the Immune System sponsored by the European Federation of Immunological Societies, Edinburgh, UK, September 10-12, 1990. New Biol. 1991 Feb; 3(2):117-20. PMID: 2065006.
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      36. Southern SO, Dutton R. A role for class I MHC antigens in responses of activated B lymphocytes. J Immunol. 1989 May 15; 142(10):3384-91. PMID: 2497173.
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      37. Southern SO, Swain SL, Dutton R. Induction of the H-2 D antigen during B cell activation. J Immunol. 1989 Jan 1; 142(1):336-42. PMID: 2642506.
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      38. Swain SL, Dutton R, McKenzie D, Helstrom H, English M. Role of antigen in the B cell response. Specific antigen and the lymphokine IL-5 synergize to drive B cell lymphoma proliferation and differentiation to Ig secretion. J Immunol. 1988 Jun 15; 140(12):4224-30. PMID: 2453572.
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      39. Swain SL, McKenzie DT, Dutton R, Tonkonogy SL, English M. The role of IL4 and IL5: characterization of a distinct helper T cell subset that makes IL4 and IL5 (Th2) and requires priming before induction of lymphokine secretion. Immunol Rev. 1988 Feb; 102:77-105. PMID: 2966763.
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      40. Voland JR, Frisman DM, Fan QH, Dutton R. Expression of an endothelial surface antigen on activated human lymphocytes: lymphocyte subset distribution and kinetics of antigen activation. Cell Immunol. 1987 Dec; 110(2):197-208. PMID: 3121187.
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      41. Pfeifer JD, McKenzie DT, Swain SL, Dutton R. B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J Exp Med. 1987 Nov 1; 166(5):1464-70. PMID: 3500262.
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      42. McKenzie DT, Filutowicz HI, Swain SL, Dutton R. Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). J Immunol. 1987 Oct 15; 139(8):2661-8. PMID: 3498767.
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      43. Swain SL, Dutton R. Consequences of the direct interaction of helper T cells with B cells presenting antigen. Immunol Rev. 1987 Oct; 99:263-80. PMID: 2960607.
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