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    Randolph Hastings

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentAnesthesiology
    Address9500 Gilman Drive #9125
    CA La Jolla 92093
    Phone858-552-8585
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      Collapse Research 
      Collapse Research Activities and Funding
      Mastery of Videolaryngoscopy through Deliberate Practice
      VA I21HX001317Jan 1, 2014 - Dec 31, 2014
      Role: Principal Investigator
      Sex-Dependent PTHrP Processing and Lung Cancer Survival
      VA I01BX001501Jul 1, 2012 - Jun 30, 2016
      Role: Principal Investigator
      ALVEOLAR TYPE II CELL GROWTH IN INJURY
      NIH/NIEHS R01ES009227Sep 15, 1999 - Aug 31, 2005
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hastings R, Montgrain PR, Quintana RA, Chobrutskiy B, Davani A, Miyanohara A, Mahooti S. Lung carcinoma progression and survival versus amino- and carboxyl-parathyroid hormone-related protein expression. J Cancer Res Clin Oncol. 2017 Aug; 143(8):1395-1407. PMID: 28342003.
        View in: PubMed
      2. Delson N, Paez Y, Ruiz J, Vatanpur A, Kouchaki S, Majit MR, Hastings R. Videolaryngoscopy Simulator: New Technology Leads to New Training Challenges. Stud Health Technol Inform. 2016; 220:84-90. PMID: 27046558.
        View in: PubMed
      3. Montgrain PR, Phun J, Vander Werff R, Quintana RA, Davani AJ, Hastings R. Parathyroid-hormone-related protein signaling mechanisms in lung carcinoma growth inhibition. Springerplus. 2015; 4:268. PMID: 26090315; PMCID: PMC4469590.
      4. Hastings R, Rickard TC. Deliberate practice for achieving and maintaining expertise in anesthesiology. Anesth Analg. 2015 Feb; 120(2):449-59. PMID: 25602455.
        View in: PubMed
      5. Hastings R. Airway evaluation: thin sliced and packaged. Anesth Analg. 2014 Feb; 118(2):247-8. PMID: 24445623.
        View in: PubMed
      6. Hastings R, Dueck R. Bohr dead space calculation. Anesth Analg. 2012 Dec; 115(6):1472; author reply 1472. PMID: 23175577.
        View in: PubMed
      7. Delson N, Sloan C, McGee T, Kedarisetty S, Yim WW, Hastings R. Parametrically adjustable intubation mannequin with real-time visual feedback. Simul Healthc. 2012 Jun; 7(3):183-91. PMID: 22333883.
        View in: PubMed
      8. Glaser D, Hastings R. An introduction to multilevel modeling for anesthesiologists. Anesth Analg. 2011 Oct; 113(4):877-87. PMID: 21680861.
        View in: PubMed
      9. Montgrain PR, Deftos LJ, Arenberg D, Tipps A, Quintana R, Carskadon S, Hastings R. Prognostic implications of parathyroid hormone-related protein in males and females with non--small-cell lung cancer. Clin Lung Cancer. 2011 May; 12(3):197-205. PMID: 21663864.
        View in: PubMed
      10. Downs TM, Burton DW, Araiza FL, Hastings R, Deftos LJ. PTHrP stimulates prostate cancer cell growth and upregulates aldo-keto reductase 1C3. Cancer Lett. 2011 Jul 01; 306(1):52-9. PMID: 21444150.
        View in: PubMed
      11. Hastings R, Burton DW, Nefzi A, Montgrain PR, Quintana R, Deftos LJ. Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression. Cancer Biol Ther. 2010 Nov 15; 10(10):1067-75. PMID: 20890111.
        View in: PubMed
      12. Wong W, Kedarisetty S, Delson N, Glaser D, Moitoza J, Davis DP, Hastings R. The effect of cross-training with adjustable airway model anatomies on laryngoscopy skill transfer. Anesth Analg. 2011 Oct; 113(4):862-8. PMID: 20966442.
        View in: PubMed
      13. Hastings R, Delson N. Balancing the force of direct laryngoscopy with manual in-line stabilization. Anesthesiology. 2009 Nov; 111(5):1158-9; author reply 1159-60. PMID: 19858878.
        View in: PubMed
      14. Hastings R, Montgrain PR, Quintana R, Rascon Y, Deftos LJ, Healy E. Cell cycle actions of parathyroid hormone-related protein in non-small cell lung carcinoma. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L578-85. PMID: 19633068; PMCID: PMC2770787.
      15. Aiken SD, Delson N, Davidson TM, Hastings R. A two-dimensional model of anatomic relationships during laryngoscopy. Anesth Analg. 2007 Oct; 105(4):1118-26, table of contents. PMID: 17898397.
        View in: PubMed
      16. Montgrain PR, Quintana R, Rascon Y, Burton DW, Deftos LJ, Casillas A, Hastings R. Parathyroid hormone-related protein varies with sex and androgen status in nonsmall cell lung cancer. Cancer. 2007 Sep 15; 110(6):1313-20. PMID: 17676588.
        View in: PubMed
      17. Yang M, Burton DW, Geller J, Hillegonds DJ, Hastings R, Deftos LJ, Hoffman RM. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15; 12(8):2602-6. PMID: 16638872.
        View in: PubMed
      18. Hastings R, Laux AM, Casillas A, Xu R, Lukas Z, Ernstrom K, Deftos LJ. Sex-specific survival advantage with parathyroid hormone-related protein in non-small cell lung carcinoma patients. Clin Cancer Res. 2006 Jan 15; 12(2):499-506. PMID: 16428492.
        View in: PubMed
      19. Pache JC, Burton DW, Deftos LJ, Hastings R. A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export. Endocrinology. 2006 Feb; 147(2):990-8. PMID: 16293661.
        View in: PubMed
      20. Burton DW, Geller J, Yang M, Jiang P, Barken I, Hastings R, Hoffman RM, Deftos LJ. Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP. Prostate. 2005 Feb 15; 62(3):275-81. PMID: 15389781.
        View in: PubMed
      21. Tsigelny I, Burton DW, Sharikov Y, Hastings R, Deftos LJ. Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma. J Biomed Biotechnol. 2005; 2005(4):353-63. PMID: 16489268; PMCID: PMC1361488.
      22. Hastings R. Parathyroid hormone-related protein and lung biology. Respir Physiol Neurobiol. 2004 Sep 15; 142(2-3):95-113. PMID: 15450473.
        View in: PubMed
      23. Hastings R, Araiza F, Burton DW, Bedley M, Deftos LJ. Parathyroid hormone-related protein regulates apoptosis in lung cancer cells through protein kinase A. Am J Physiol Cell Physiol. 2004 Dec; 287(6):C1616-22. PMID: 15282196.
        View in: PubMed
      24. Hastings R, Araiza F, Burton DW, Deftos LJ. Role of parathyroid hormone-related protein in lung cancer cell survival. Chest. 2004 May; 125(5 Suppl):150S. PMID: 15136475.
        View in: PubMed
      25. Hastings R, Folkesson HG, Matthay MA. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L679-89. PMID: 15003932.
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      26. Lee J, Choi JH, Lee YK, Kim ES, Kwon OK, Hastings R. The Callander laryngoscope blade modification is associated with a decreased risk of dental contact. Can J Anaesth. 2004 Feb; 51(2):181-4. PMID: 14766698.
        View in: PubMed
      27. Hastings R, Quintana RA, Sandoval R, Burton DW, Deftos LJ. Amino-terminal and midmolecule parathyroid hormone-related protein, phosphatidylcholine, and type II cell proliferation in silica-injured lung. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1312-22. PMID: 12922983.
        View in: PubMed
      28. Hastings R, Araiza F, Burton DW, Zhang L, Bedley M, Deftos LJ. Parathyroid hormone-related protein ameliorates death receptor-mediated apoptosis in lung cancer cells. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1429-36. PMID: 12917104.
        View in: PubMed
      29. Hastings R, Quintana RA, Sandoval R, Duey D, Rascon Y, Burton DW, Deftos LJ. Proapoptotic effects of parathyroid hormone-related protein in type II pneumocytes. Am J Respir Cell Mol Biol. 2003 Dec; 29(6):733-42. PMID: 12791677.
        View in: PubMed
      30. Delson NJ, Koussa N, Hastings R, Weinger MB. Quantifying expert vs. novice skill in vivo for development of a laryngoscopy simulator. Stud Health Technol Inform. 2003; 94:45-51. PMID: 15455862.
        View in: PubMed
      31. Hastings R, Deftos LJ. Parathyroid hormone-related protein and lung injury. Chest. 2002 Oct; 122(4):1494; author reply 1494-5. PMID: 12377889.
        View in: PubMed
      32. Hastings R, Asirvatham A, Quintana R, Sandoval R, Dutta R, Burton DW, Deftos LJ. Parathyroid hormone-related protein-(38-64) regulates lung cell proliferation after silica injury. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L12-21. PMID: 12060556.
        View in: PubMed
      33. Hastings R, Ryan RM, D'Angio CT, Holm BA, Patel A, Quintana R, Biederman E, Burton DW, Deftos LJ. Parathyroid hormone-related protein response to hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Jun; 282(6):L1198-208. PMID: 12003775.
        View in: PubMed
      34. Hastings R, Auger WR, Kerr KM, Quintana RA, Deftos LJ. Parathyroid hormone-related protein and lung injury after pulmonary thromboendarterectomy. Regul Pept. 2001 Oct 15; 102(1):1-7. PMID: 11600204.
        View in: PubMed
      35. Hastings R, Burton DW, Quintana RA, Biederman E, Gujral A, Deftos LJ. Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice. Cancer. 2001 Sep 15; 92(6):1402-10. PMID: 11745216.
        View in: PubMed
      36. Hook VY, Burton D, Yasothornsrikul S, Hastings R, Deftos LJ. Proteolysis of ProPTHrP(1-141) by "prohormone thiol protease" at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells. Biochem Biophys Res Commun. 2001 Jul 27; 285(4):932-8. PMID: 11467841.
        View in: PubMed
      37. Deftos LJ, Burton D, Hastings R, Terkeltaub R, Hook VY. Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues. Endocrine. 2001 Jul; 15(2):217-24. PMID: 11720250.
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      38. Hastings R, Burton DW, Summers-Torres D, Quintana R, Biederman E, Deftos LJ. Splenic, thymic, bony and lymph node metastases from orthotopic human lung carcinomas in immunocompromised mice. Anticancer Res. 2000 Sep- Oct; 20(5B):3625-9. PMID: 11131672.
        View in: PubMed
      39. Hastings R, Berg JT, Summers-Torres D, Burton DW, Deftos LJ. Parathyroid hormone-related protein reduces alveolar epithelial cell proliferation during lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L194-200. PMID: 10893218.
        View in: PubMed
      40. Hastings R. Monitoring alveolar epithelial function in acute lung injury. J Clin Monit Comput. 2000; 16(5-6):385-92. PMID: 12580221.
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      41. Hastings R, Summers-Torres D. Direct Laryngoscopy in Mice. Contemp Top Lab Anim Sci. 1999 Nov; 38(6):33-35. PMID: 12086445.
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      42. Hastings R, Summers-Torres D, Burton D, Deftos L. Growth factor control of type II cell apoptosis. Chest. 1999 Jul; 116(1 Suppl):68S. PMID: 10424598.
        View in: PubMed
      43. Ng M, Hastings R. Successful direct laryngoscopy assisted by posture in a patient with ankylosing spondylitis. Anesth Analg. 1998 Dec; 87(6):1436-7. PMID: 9842844.
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      44. Speziale MV, Mannino FL, Hastings R, Deftos LJ. Parathyroid hormone-related protein in tracheal aspirates of newborn infants. Pediatr Res. 1998 May; 43(5):660-5. PMID: 9585013.
        View in: PubMed
      45. Hastings R, Summers-Torres D, Yaszay B, LeSueur J, Burton DW, Deftos LJ. Parathyroid hormone-related protein, an autocrine growth inhibitor of alveolar type II cells. Am J Physiol. 1997 Mar; 272(3 Pt 1):L394-9. PMID: 9124594.
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      46. Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings R. Alveolar epithelial clearance of protein. J Appl Physiol (1985). 1996 May; 80(5):1431-45. PMID: 8727524.
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      47. Hastings R, Hon ED, Nghiem C, Wahrenbrock EA. Force, torque, and stress relaxation with direct laryngoscopy. Anesth Analg. 1996 Mar; 82(3):456-61. PMID: 8623942.
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      48. Hastings R, Hon ED, Nghiem C, Wahrenbrock EA. Force and torque vary between laryngoscopists and laryngoscope blades. Anesth Analg. 1996 Mar; 82(3):462-8. PMID: 8623943.
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      49. Hastings R, Summers-Torres D, Cheung TC, Ditmer LS, Petrin EM, Burton DW, Spragg RG, Li J, Deftos LJ. Parathyroid hormone-related protein, an autocrine regulatory factor in alveolar epithelial cells. Am J Physiol. 1996 Mar; 270(3 Pt 1):L353-61. PMID: 8638727.
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      50. Hastings R, Hua XY. Expression of calcitonin gene-related peptide by cultured rat alveolar type II cells. Am J Respir Cell Mol Biol. 1995 Nov; 13(5):563-9. PMID: 7576692.
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      51. Hastings R, Folkesson HG, Petersen V, Ciriales R, Matthay MA. Cellular uptake of albumin from lungs of anesthetized rabbits. Am J Physiol. 1995 Oct; 269(4 Pt 1):L453-62. PMID: 7485517.
        View in: PubMed
      52. Hastings R, Vigil AC, Hanna R, Yang BY, Sartoris DJ. Cervical spine movement during laryngoscopy with the Bullard, Macintosh, and Miller laryngoscopes. Anesthesiology. 1995 Apr; 82(4):859-69. PMID: 7717556.
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      53. Hastings R, Duong H, Burton DW, Deftos LJ. Alveolar epithelial cells express and secrete parathyroid hormone-related protein. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):701-6. PMID: 7946399.
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      54. Wilson WC, Frankville DD, Maxwell W, Carpenter T, Hastings R. Massive intraoperative pulmonary embolus diagnosed by transesophageal echocardiography. Anesthesiology. 1994 Aug; 81(2):504-8. PMID: 8053601.
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      55. Hastings R, Wright JR, Albertine KH, Ciriales R, Matthay MA. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol. 1994 May; 266(5 Pt 1):L544-52. PMID: 8203547.
        View in: PubMed
      56. Hastings R, Wood PR. Head extension and laryngeal view during laryngoscopy with cervical spine stabilization maneuvers. Anesthesiology. 1994 Apr; 80(4):825-31. PMID: 8024137.
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      57. Hastings R, Kelley SD. Neurologic deterioration associated with airway management in a cervical spine-injured patient. Anesthesiology. 1993 Mar; 78(3):580-3. PMID: 8457057.
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      58. Hastings R, Grady M, Sakuma T, Matthay MA. Clearance of different-sized proteins from the alveolar space in humans and rabbits. J Appl Physiol (1985). 1992 Oct; 73(4):1310-6. PMID: 1447074.
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      59. Hastings R, Marks JD. Airway management for trauma patients with potential cervical spine injuries. Anesth Analg. 1991 Oct; 73(4):471-82. PMID: 1897772.
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      60. Hastings R, McKay WR. Treatment of benign chronic abdominal pain with neurolytic celiac plexus block. Anesthesiology. 1991 Jul; 75(1):156-8. PMID: 2064045.
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      61. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA. Alveolar and lung liquid clearance in anesthetized rabbits. J Appl Physiol (1985). 1991 Apr; 70(4):1827-35. PMID: 2055861.
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      62. Powell FL, Hastings R, Mazzone RW. Pulmonary vascular resistance during unilateral pulmonary arterial occlusion in ducks. Am J Physiol. 1985 Jul; 249(1 Pt 2):R39-43. PMID: 4014495.
        View in: PubMed
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