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Randall Johnson

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0377
La Jolla CA 92093
Phone858-822-0509
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic Regulation of T cell Immunity
    NIH/NIAID R01AI096852Aug 1, 2012 - Jul 31, 2016
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    NIH/NIAID R01AI093451Apr 5, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Myeloid Vascular Endothelial Growth Factor Expression &its Role in Tumorigenesis
    NIH/NCI R01CA153983Jan 6, 2011 - Dec 31, 2015
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
    NIH/NIAID R56AI090863Aug 2, 2010 - Jul 31, 2011
    Role: Principal Investigator
    Hypoxia-induced Responses and Innate Immunity
    NIH/NIAID R01AI060840May 1, 2005 - Jan 31, 2009
    Role: Principal Investigator
    Biology of Hypoxia
    NIH/NIA R13AG023493Apr 1, 2004 - Mar 31, 2005
    Role: Principal Investigator
    Hypoxia Response in the Stroma During Tumorigenesis
    NIH/NCI R01CA082515Jul 1, 1999 - Apr 30, 2013
    Role: Principal Investigator
    GENETIC ANALYSIS OF RAS TRANSFORMATION AND JUN FUNCTION
    NIH/NCI R01CA074100Apr 20, 1997 - Jan 31, 2002
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson R. HIF-2a is essential for carotid body development and function. Elife. 2018 Apr 19; 7. PMID: 29671738.
      View in: PubMed
    2. Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson R. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metab. 2018 Apr 03; 27(4):898-913.e7. PMID: 29617647.
      View in: PubMed
    3. Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson R. An HIF-1a/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 2017 Nov 13; 32(5):669-683.e5. PMID: 29136509.
      View in: PubMed
    4. Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson R. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. Elife. 2017 Oct 19; 6. PMID: 29049022.
      View in: PubMed
    5. Giaccia A, Johnson R. Lorenz Poellinger. Exp Cell Res. 2017 07 15; 356(2):115. PMID: 28622772.
      View in: PubMed
    6. Luecke-Johansson S, Gralla M, Rundqvist H, Ho JC, Johnson R, Gradin K, Poellinger L. A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase. Mol Cell Biol. 2017 Jul 01; 37(13). PMID: 28416634.
      View in: PubMed
    7. Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl PO, Belting M, Von Euler L, Rundqvist H, Johnson R, Branco C. Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis. Biol Open. 2017 May 15; 6(5):688-697. PMID: 28302670.
      View in: PubMed
    8. Branco C, Johnson R. To PFKFB3 or Not to PFKFB3, That Is the Question. Cancer Cell. 2016 12 12; 30(6):831. PMID: 27960081.
      View in: PubMed
    9. Bleymehl K, Pérez-Gómez A, Omura M, Moreno-Pérez A, Macías D, Bai Z, Johnson R, Leinders-Zufall T, Zufall F, Mombaerts P. A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium. Neuron. 2016 Dec 21; 92(6):1196-1203. PMID: 27916458.
      View in: PubMed
    10. Johnson R. Profile of William Kaelin, Peter Ratcliffe, and Greg Semenza, 2016 Albert Lasker Basic Medical Research Awardees. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):13938-13940. PMID: 27911834.
      View in: PubMed
    11. Phan AT, Doedens AL, Palazon A, Tyrakis PA, Cheung KP, Johnson R, Goldrath AW. Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection. Immunity. 2016 11 15; 45(5):1024-1037. PMID: 27836431.
      View in: PubMed
    12. Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson R. S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate. Nature. 2016 12 08; 540(7632):236-241. PMID: 27798602.
      View in: PubMed
    13. Yamamoto H, Rundqvist H, Branco C, Johnson R. Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior. Front Cell Dev Biol. 2016; 4:99. PMID: 27709112.
      View in: PubMed
    14. Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson R. HIF2a-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8801-6. PMID: 27432976; PMCID: PMC4978263.
    15. Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson R, Manabe I, Nagai R, Komuro I. HIF-1a-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016 May 18; 7:11635. PMID: 27189088; PMCID: PMC4873978.
    16. Johnson R, Titze J, Weller R. Cutaneous control of blood pressure. Curr Opin Nephrol Hypertens. 2016 Jan; 25(1):11-5. PMID: 26625865.
      View in: PubMed
    17. Evans CE, Bendahl PO, Belting M, Branco C, Johnson R. Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation. Blood. 2016 Mar 10; 127(10):1355-60. PMID: 26702059.
      View in: PubMed
    18. Ashmore T, Roberts LD, Morash AJ, Kotwica AO, Finnerty J, West JA, Murfitt SA, Fernandez BO, Branco C, Cowburn AS, Clarke K, Johnson R, Feelisch M, Griffin JL, Murray AJ. Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. BMC Biol. 2015 Dec 22; 13:110. PMID: 26694920; PMCID: PMC4688964.
    19. Hong J, Tobin NP, Rundqvist H, Li T, Lavergne M, García-Ibáñez Y, Qin H, Paulsson J, Zeitelhofer M, Adzemovic MZ, Nilsson I, Roswall P, Hartman J, Johnson R, Östman A, Bergh J, Poljakovic M, Genové G. Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells. J Natl Cancer Inst. 2015 Oct; 107(10). PMID: 26296362.
      View in: PubMed
    20. Sim J, Johnson R. Through a Clear Cell, Darkly: HIF2a/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress. Cancer Discov. 2015 Jun; 5(6):584-5. PMID: 26037916.
      View in: PubMed
    21. Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson R, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC. HIF1a Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08; 33(5):507-21. PMID: 26028220; PMCID: PMC4509618.
    22. Koh HS, Chang CY, Jeon SB, Yoon HJ, Ahn YH, Kim HS, Kim IH, Jeon SH, Johnson R, Park EJ. The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. Nat Commun. 2015 Mar 20; 6:6340. PMID: 25790768; PMCID: PMC4383004.
    23. Kalucka J, Schley G, Georgescu A, Klanke B, Rössler S, Baumgartl J, Velden J, Amann K, Willam C, Johnson R, Eckardt KU, Weidemann A. Kidney injury is independent of endothelial HIF-1a. J Mol Med (Berl). 2015 Aug; 93(8):891-904. PMID: 25754172.
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    24. Arai T, Kato Y, Ishimoto K, Kanai M, Shinjo S, Sayama K, Suzuki T, Doi T, Johnson R, Suematsu M, Goda N. WITHDRAWN: Loss of hepatic HIF-1a accelerates lipid accumulation by inhibiting peroxisomal fatty acid oxidation in nonalcoholic fatty liver disease. J Hepatol. 2015 Feb 10. PMID: 25681160.
      View in: PubMed
    25. Ashmore T, Fernandez BO, Evans CE, Huang Y, Branco-Price C, Griffin JL, Johnson R, Feelisch M, Murray AJ. Suppression of erythropoiesis by dietary nitrate. FASEB J. 2015 Mar; 29(3):1102-12. PMID: 25422368; PMCID: PMC4422362.
    26. Palazon A, Goldrath AW, Nizet V, Johnson R. HIF transcription factors, inflammation, and immunity. Immunity. 2014 Oct 16; 41(4):518-28. PMID: 25367569; PMCID: PMC4346319.
    27. Ashmore T, Fernandez BO, Branco-Price C, West JA, Cowburn AS, Heather LC, Griffin JL, Johnson R, Feelisch M, Murray AJ. Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. J Physiol. 2014 Nov 01; 592(21):4715-31. PMID: 25172947; PMCID: PMC4253472.
    28. Sim J, Johnson R. A whiter shade of gray: HIF and coordination of angiogenesis with postnatal myelination. Dev Cell. 2014 Jul 28; 30(2):116-7. PMID: 25073152.
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    29. Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson R, Elenius K. Hypoxia-inducible factor-1a induces ErbB4 signaling in the differentiating mammary gland. J Biol Chem. 2014 Aug 08; 289(32):22459-69. PMID: 24966332; PMCID: PMC4139252.
    30. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson R, Olefsky JM. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-52. PMID: 24906151.
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    31. O'Reilly VC, Lopes Floro K, Shi H, Chapman BE, Preis JI, James AC, Chapman G, Harvey RP, Johnson R, Grieve SM, Sparrow DB, Dunwoodie SL. Gene-environment interaction demonstrates the vulnerability of the embryonic heart. Dev Biol. 2014 Jul 01; 391(1):99-110. PMID: 24657234.
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    32. Lin Q, Huang Y, Booth CJ, Haase VH, Johnson R, Celeste Simon M, Giordano FJ, Yun Z. Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc. 2013 Dec 10; 2(6):e000548. PMID: 24326162.
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    33. Branco-Price C, Evans CE, Johnson R. Endothelial hypoxic metabolism in carcinogenesis and dissemination: HIF-A isoforms are a NO metastatic phenomenon. Oncotarget. 2013 Dec; 4(12):2567-76. PMID: 24318195.
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    34. Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson R, Renshaw SA, Whyte MK, Walmsley SR. Hypoxia-inducible factor 2a regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014 Jan 16; 123(3):366-76. PMID: 24196071.
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    35. Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson R. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17570-5. PMID: 24101470.
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    36. Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson R, Goldrath AW. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol. 2013 Nov; 14(11):1173-82. PMID: 24076634.
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    37. Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson R. Epidermal deletion of HIF-2a stimulates wound closure. J Invest Dermatol. 2014 Mar; 134(3):801-808. PMID: 24037341.
      View in: PubMed
    38. Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson R, Kato S, Toyama Y, Miyamoto T. HIF1a is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16568-73. PMID: 24023068.
      View in: PubMed
    39. Tsukada K, Tajima T, Hori S, Matsuura T, Johnson R, Goda N, Suematsu M. Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver. Microcirculation. 2013 Jul; 20(5):385-93. PMID: 23252463.
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    40. Scheerer N, Dehne N, Stockmann C, Swoboda S, Baba HA, Neugebauer A, Johnson R, Fandrey J. Myeloid hypoxia-inducible factor-1a is essential for skeletal muscle regeneration in mice. J Immunol. 2013 Jul 01; 191(1):407-14. PMID: 23729446.
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    41. Bhandari T, Olson J, Johnson R, Nizet V. HIF-1a influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med (Berl). 2013 Oct; 91(10):1199-205. PMID: 23686259.
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    42. Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson R, Soga T, Hirao A, Suematsu M, Suda T. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013 Jan 03; 12(1):49-61. PMID: 23290136.
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    43. Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson R, Broide DH, Nizet V. Myeloid cell HIF-1a regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. PMID: 23250618.
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    44. Huang Y, Lei L, Liu D, Jovin I, Russell R, Johnson R, Di Lorenzo A, Giordano FJ. Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1a-dependent function. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17478-83. PMID: 23047702; PMCID: PMC3491491.
    45. Peng H, Kaplan N, Hamanaka RB, Katsnelson J, Blatt H, Yang W, Hao L, Bryar PJ, Johnson R, Getsios S, Chandel NS, Lavker RM. microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14030-4. PMID: 22891326; PMCID: PMC3435188.
    46. Evans CE, Branco-Price C, Johnson R. HIF-mediated endothelial response during cancer progression. Int J Hematol. 2012 May; 95(5):471-7. PMID: 22562456.
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    47. Kim JW, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, Johnson R. Loss of fibroblast HIF-1a accelerates tumorigenesis. Cancer Res. 2012 Jul 01; 72(13):3187-95. PMID: 22556263.
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    48. Köhler T, Reizis B, Johnson R, Weighardt H, Förster I. Influence of hypoxia-inducible factor 1a on dendritic cell differentiation and migration. Eur J Immunol. 2012 May; 42(5):1226-36. PMID: 22539295.
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    49. Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, Schrödter K, Zimmermann A, Helfrich I, Rundqvist H, Theegarten D, Anhenn O, Orian-Rousseau V, Johnson R, Alitalo K, Fischer JW, Fandrey J, Stockmann C. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood. 2012 Jun 14; 119(24):5931-42. PMID: 22547584.
      View in: PubMed
    50. Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson R, Nizet V. A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl). 2012 Sep; 90(9):1079-89. PMID: 22371073; PMCID: PMC3606899.
    51. Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski DM, Liao D, Ellies L, Johnson R. Endothelial cell HIF-1a and HIF-2a differentially regulate metastatic success. Cancer Cell. 2012 Jan 17; 21(1):52-65. PMID: 22264788.
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    52. Keith B, Johnson R, Simon MC. HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 2011 Dec 15; 12(1):9-22. PMID: 22169972; PMCID: PMC3401912.
    53. Kurihara T, Westenskow PD, Krohne TU, Aguilar E, Johnson R, Friedlander M. Astrocyte pVHL and HIF-a isoforms are required for embryonic-to-adult vascular transition in the eye. J Cell Biol. 2011 Nov 14; 195(4):689-701. PMID: 22084310; PMCID: PMC3257537.
    54. Ochiai D, Goda N, Hishiki T, Kanai M, Senoo-Matsuda N, Soga T, Johnson R, Yoshimura Y, Suematsu M. Disruption of HIF-1a in hepatocytes impairs glucose metabolism in diet-induced obesity mice. Biochem Biophys Res Commun. 2011 Nov 25; 415(3):445-9. PMID: 22051049.
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    55. Nishiyama Y, Goda N, Kanai M, Niwa D, Osanai K, Yamamoto Y, Senoo-Matsuda N, Johnson R, Miura S, Kabe Y, Suematsu M. HIF-1a induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. J Hepatol. 2012 Feb; 56(2):441-7. PMID: 21896344.
      View in: PubMed
    56. Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson R, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest. 2011 Mar; 121(3):1053-63. PMID: 21317538; PMCID: PMC3049381.
    57. Stockmann C, Kirmse S, Helfrich I, Weidemann A, Takeda N, Doedens A, Johnson R. A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing. J Invest Dermatol. 2011 Mar; 131(3):797-801. PMID: 21107350.
      View in: PubMed
    58. Mazumdar J, O'Brien WT, Johnson R, LaManna JC, Chavez JC, Klein PS, Simon MC. O2 regulates stem cells through Wnt/ß-catenin signalling. Nat Cell Biol. 2010 Oct; 12(10):1007-13. PMID: 20852629; PMCID: PMC3144143.
    59. Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson R. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010 Oct 01; 70(19):7465-75. PMID: 20841473; PMCID: PMC2948598.
    60. Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson R, Hirao A, Suematsu M, Suda T. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 2010 Sep 03; 7(3):391-402. PMID: 20804974.
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    61. Weidemann A, Krohne TU, Aguilar E, Kurihara T, Takeda N, Dorrell MI, Simon MC, Haase VH, Friedlander M, Johnson R. Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia. 2010 Aug; 58(10):1177-85. PMID: 20544853; PMCID: PMC2993327.
    62. Scott A, Powner MB, Gandhi P, Clarkin C, Gutmann DH, Johnson R, Ferrara N, Fruttiger M. Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. PLoS One. 2010 Jul 29; 5(7):e11863. PMID: 20686684.
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    63. Branco-Price C, Johnson R. Tumor vessels are Eph-ing complicated. Cancer Cell. 2010 Jun 15; 17(6):533-4. PMID: 20541698.
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    64. Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson R, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H. von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010 May; 137(9):1563-71. PMID: 20388654; PMCID: PMC3224975.
    65. Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson R. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 05; 11(5):364-78. PMID: 20399150; PMCID: PMC2893150.
    66. Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson R. VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol. 2010 May; 176(5):2269-82. PMID: 20382704; PMCID: PMC2861092.
    67. Takeda N, O'Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, Asagiri M, Simon MC, Hoffmann A, Johnson R. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev. 2010 Mar 01; 24(5):491-501. PMID: 20194441; PMCID: PMC2827844.
    68. Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson R, Schipani E, Clemens TL. Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci. 2010 Mar; 1192:322-6. PMID: 20392254; PMCID: PMC3047468.
    69. Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson R. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4329-34. PMID: 20142499; PMCID: PMC2840078.
    70. Rundqvist H, Johnson R. Hypoxia and metastasis in breast cancer. Curr Top Microbiol Immunol. 2010; 345:121-39. PMID: 20549469.
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    71. Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson R. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest. 2009 Nov; 119(11):3373-83. PMID: 19809162.
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    72. Nizet V, Johnson R. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol. 2009 Sep; 9(9):609-17. PMID: 19704417; PMCID: PMC4343208.
    73. Tajima T, Goda N, Fujiki N, Hishiki T, Nishiyama Y, Senoo-Matsuda N, Shimazu M, Soga T, Yoshimura Y, Johnson R, Suematsu M. HIF-1alpha is necessary to support gluconeogenesis during liver regeneration. Biochem Biophys Res Commun. 2009 Oct 02; 387(4):789-94. PMID: 19643083.
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    74. Kim JW, Johnson R. You don't need a PHD to grow a tumor. Dev Cell. 2009 Jun; 16(6):781-2. PMID: 19531349.
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    75. Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson R, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009 Jul 23; 114(4):844-59. PMID: 19454749; PMCID: PMC2882173.
    76. Weidemann A, Johnson R. Nonrenal regulation of EPO synthesis. Kidney Int. 2009 Apr; 75(7):682-8. PMID: 19165176.
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    77. Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg JI, Cheresh DA, Johnson R. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature. 2008 Dec 11; 456(7223):814-8. PMID: 18997773; PMCID: PMC3103772.
    78. Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson R, Angle N, Cheresh DA. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 2008 Dec 11; 456(7223):809-13. PMID: 18997771; PMCID: PMC2605188.
    79. Bray S, Johnson R. Putting the tissue and environmental 'context' into differentiation and gene regulation. Curr Opin Genet Dev. 2008 Oct; 18(5):395-6. PMID: 18992338.
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    80. Garcia CM, Shui YB, Kamath M, DeVillar J, Johnson R, Gerber HP, Ferrara N, Robinson ML, Beebe DC. The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts. Exp Eye Res. 2009 Feb; 88(2):270-6. PMID: 18782574; PMCID: PMC2656580.
    81. Chen Y, Doughman YQ, Gu S, Jarrell A, Aota S, Cvekl A, Watanabe M, Dunwoodie SL, Johnson R, van Heyningen V, Kleinjan DA, Beebe DC, Yang YC. Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development. 2008 Sep; 135(17):2939-48. PMID: 18653562; PMCID: PMC2654719.
    82. Shui YB, Arbeit JM, Johnson R, Beebe DC. HIF-1: an age-dependent regulator of lens cell proliferation. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4961-70. PMID: 18586877; PMCID: PMC2585414.
    83. Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson R, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene. 2008 Sep 11; 27(40):5354-8. PMID: 18490920; PMCID: PMC2575082.
    84. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson R, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. PMID: 18432192; PMCID: PMC2669289.
    85. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson R. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 18; 133(2):223-34. PMID: 18423195; PMCID: PMC2849644.
    86. Peyssonnaux C, Boutin AT, Zinkernagel AS, Datta V, Nizet V, Johnson R. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol. 2008 Aug; 128(8):1964-8. PMID: 18323789.
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    87. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson R, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425; PMCID: PMC2643426.
    88. Lei L, Mason S, Liu D, Huang Y, Marks C, Hickey R, Jovin IS, Pypaert M, Johnson R, Giordano FJ. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol. 2008 Jun; 28(11):3790-803. PMID: 18285456; PMCID: PMC2423296.
    89. Zinkernagel AS, Peyssonnaux C, Johnson R, Nizet V. Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis. 2008 Jan 15; 197(2):214-7. PMID: 18173364.
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    90. Peyssonnaux C, Nizet V, Johnson R. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle. 2008 Jan 01; 7(1):28-32. PMID: 18212530.
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    91. Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson R, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest. 2007 Dec; 117(12):3810-20. PMID: 18037992; PMCID: PMC2082142.
    92. Zinkernagel AS, Johnson R, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med (Berl). 2007 Dec; 85(12):1339-46. PMID: 18030436.
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    93. Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson R, Zelzer E. HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007 Nov; 134(21):3917-28. PMID: 17913788.
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    94. Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson R. HIF-1alpha in endurance training: suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol. 2007 Nov; 293(5):R2059-69. PMID: 17855495.
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    95. Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson R, Blackwell JM, Nizet V, Srai SK. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007 Oct 15; 110(8):3039-48. PMID: 17606764.
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    96. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson R. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest. 2007 Jul; 117(7):1926-32. PMID: 17557118; PMCID: PMC1884690.
    97. Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson R, Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol. 2007 Jun 15; 178(12):7516-9. PMID: 17548584.
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    98. Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson R, Chavez JC. Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci. 2007 Jun 06; 27(23):6320-32. PMID: 17554006.
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    99. Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson R, Schipani E, Clemens TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest. 2007 Jun; 117(6):1616-26. PMID: 17549257; PMCID: PMC1878533.
    100. Liao D, Johnson R. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 2007 Jun; 26(2):281-90. PMID: 17603752.
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    101. Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg HM, Johnson R, Longaker MT, Giaccia AJ, Schipani E. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol. 2007 May 07; 177(3):451-64. PMID: 17470636; PMCID: PMC2064828.
    102. Johnson R, Huang LE. Can irradiated tumors take NO for an answer? Mol Cell. 2007 Apr 27; 26(2):157-8. PMID: 17466616.
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    103. Rempe DA, Lelli KM, Vangeison G, Johnson R, Federoff HJ. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem. 2007 Jun 01; 282(22):16187-201. PMID: 17420250.
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    104. Boutin AT, Johnson R. Waiting to inhale: HIF-1 modulates aerobic respiration. Cell. 2007 Apr 06; 129(1):29-30. PMID: 17418782.
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    105. Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson R, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007 Apr; 117(4):1068-77. PMID: 17404621; PMCID: PMC1838939.
    106. Gruber M, Hu CJ, Johnson R, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2301-6. PMID: 17284606; PMCID: PMC1892942.
    107. Park SK, Haase VH, Johnson R. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol. 2007 Feb; 30(2):341-8. PMID: 17203215.
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    108. Liao D, Corle C, Seagroves TN, Johnson R. Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res. 2007 Jan 15; 67(2):563-72. PMID: 17234764.
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    109. Mason S, Johnson R. The role of HIF-1 in hypoxic response in the skeletal muscle. Adv Exp Med Biol. 2007; 618:229-44. PMID: 18269201.
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    110. Doedens A, Johnson R. Transgenic models to understand hypoxia-inducible factor function. Methods Enzymol. 2007; 435:87-105. PMID: 17998050.
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    111. Lim JH, Park JW, Kim SJ, Kim MS, Park SK, Johnson R, Chun YS. ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1. Mol Pharmacol. 2007 Mar; 71(3):942-8. PMID: 17178925.
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    112. Allen JW, Khetani SR, Johnson R, Bhatia SN. In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression. Tissue Eng. 2006 Nov; 12(11):3135-47. PMID: 17518628.
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    113. Lim JH, Park JW, Kim MS, Park SK, Johnson R, Chun YS. Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha. Mol Pharmacol. 2006 Dec; 70(6):1856-65. PMID: 16940187.
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    114. Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson R, Yancopoulos GD, Mulligan RC, Kuo CJ. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med. 2006 Jul; 12(7):793-800. PMID: 16799557.
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    115. Tang N, Mack F, Haase VH, Simon MC, Johnson R. pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol. 2006 Apr; 26(7):2519-30. PMID: 16537898; PMCID: PMC1430327.
    116. Spear W, Chan D, Coppens I, Johnson R, Giaccia A, Blader IJ. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol. 2006 Feb; 8(2):339-52. PMID: 16441443.
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    117. Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson R, Nizet V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood. 2006 May 01; 107(9):3727-32. PMID: 16391018; PMCID: PMC1895778.
    118. Neumann AK, Yang J, Biju MP, Joseph SK, Johnson R, Haase VH, Freedman BD, Turka LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17071-6. PMID: 16286658; PMCID: PMC1287984.
    119. Cejudo-Martin P, Johnson R. A new notch in the HIF belt: how hypoxia impacts differentiation. Dev Cell. 2005 Nov; 9(5):575-6. PMID: 16256731.
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    120. Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson R. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest. 2005 Jul; 115(7):1806-15. PMID: 16007254; PMCID: PMC1159132.
    121. Mialon A, Sankinen M, Söderström H, Junttila TT, Holmström T, Koivusalo R, Papageorgiou AC, Johnson R, Hietanen S, Elenius K, Westermarck J. DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Mol Cell Biol. 2005 Jun; 25(12):5040-51. PMID: 15923621; PMCID: PMC1140586.
    122. Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson R, Lipton SA, Barlow C. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci. 2005 Apr 20; 25(16):4099-107. PMID: 15843612.
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    123. Rankin EB, Higgins DF, Walisser JA, Johnson R, Bradfield CA, Haase VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr; 25(8):3163-72. PMID: 15798202; PMCID: PMC1069599.
    124. Xie L, Johnson R, Freeman RS. Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. J Cell Biol. 2005 Mar 14; 168(6):911-20. PMID: 15767462; PMCID: PMC2171791.
    125. Allen JW, Johnson R, Bhatia SN. Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha. Toxicol Lett. 2005 Jan 15; 155(1):151-9. PMID: 15585370.
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    126. Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson R, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med. 2005 Jan 03; 201(1):105-15. PMID: 15630139.
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    127. Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson R. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 2004 Nov; 6(5):485-95. PMID: 15542432.
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    128. Karhausen J, Furuta GT, Tomaszewski JE, Johnson R, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest. 2004 Oct; 114(8):1098-106. PMID: 15489957; PMCID: PMC522241.
    129. Biju MP, Neumann AK, Bensinger SJ, Johnson R, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol. 2004 Oct; 24(20):9038-47. PMID: 15456877; PMCID: PMC517905.
    130. Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, Sasik R, Rose DW, Johnson R, Rosenfeld MG, Glass CK. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14461-6. PMID: 15452344; PMCID: PMC521940.
    131. Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson R. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004 Oct; 2(10):e288. PMID: 15328538; PMCID: PMC514537.
    132. Higgins DF, Biju MP, Akai Y, Wutz A, Johnson R, Haase VH. Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol. 2004 Dec; 287(6):F1223-32. PMID: 15315937.
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    133. Huang Y, Hickey RP, Yeh JL, Liu D, Dadak A, Young LH, Johnson R, Giordano FJ. Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J. 2004 Jul; 18(10):1138-40. PMID: 15132980.
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    134. Laderoute KR, Calaoagan JM, Knapp M, Johnson R. Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun. Mol Cell Biol. 2004 May; 24(10):4128-37. PMID: 15121835; PMCID: PMC400476.
    135. Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson R, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004 May; 131(10):2497-508. PMID: 15128677.
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    136. Zelzer E, Mamluk R, Ferrara N, Johnson R, Schipani E, Olsen BR. VEGFA is necessary for chondrocyte survival during bone development. Development. 2004 May; 131(9):2161-71. PMID: 15073147.
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    137. Peyssonaux C, Johnson R. An unexpected role for hypoxic response: oxygenation and inflammation. Cell Cycle. 2004 Feb; 3(2):168-71. PMID: 14712083.
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    138. Poellinger L, Johnson R. HIF-1 and hypoxic response: the plot thickens. Curr Opin Genet Dev. 2004 Feb; 14(1):81-5. PMID: 15108809.
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    139. Giaccia A, Siim BG, Johnson R. HIF-1 as a target for drug development. Nat Rev Drug Discov. 2003 Oct; 2(10):803-11. PMID: 14526383.
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    140. Goda N, Dozier SJ, Johnson R. HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid Redox Signal. 2003 Aug; 5(4):467-73. PMID: 13678535.
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    141. Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson R, Bergers G. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 2003 Aug; 4(2):133-46. PMID: 12957288.
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    142. Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson R. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol. 2003 Jul; 23(14):4959-71. PMID: 12832481; PMCID: PMC162224.
    143. Li G, Gustafson-Brown C, Hanks SK, Nason K, Arbeit JM, Pogliano K, Wisdom RM, Johnson R. c-Jun is essential for organization of the epidermal leading edge. Dev Cell. 2003 Jun; 4(6):865-77. PMID: 12791271.
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    144. Unruh A, Ressel A, Mohamed HG, Johnson R, Nadrowitz R, Richter E, Katschinski DM, Wenger RH. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene. 2003 May 22; 22(21):3213-20. PMID: 12761491.
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    145. Pfander D, Cramer T, Schipani E, Johnson R. HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci. 2003 May 01; 116(Pt 9):1819-26. PMID: 12665562.
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    146. Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson R, Rockwell S, Glazer PM. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol. 2003 May; 23(9):3265-73. PMID: 12697826; PMCID: PMC153206.
    147. Cramer T, Johnson R. A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function. Cell Cycle. 2003 May-Jun; 2(3):192-3. PMID: 12734422.
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    148. Seagroves TN, Hadsell D, McManaman J, Palmer C, Liao D, McNulty W, Welm B, Wagner KU, Neville M, Johnson R. HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development. 2003 Apr; 130(8):1713-24. PMID: 12620994.
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    149. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson R. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 07; 112(5):645-57. PMID: 12628185; PMCID: PMC4480774.
    150. Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson R. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol. 2003 Jan; 23(1):359-69. PMID: 12482987; PMCID: PMC140666.
    151. Vengellur A, Woods BG, Ryan HE, Johnson R, LaPres JJ. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr. 2003; 11(3-4):181-97. PMID: 14686790.
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    152. Putkey FR, Cramer T, Morphew MK, Silk AD, Johnson R, McIntosh JR, Cleveland DW. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell. 2002 Sep; 3(3):351-65. PMID: 12361599.
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    153. Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li GC, Mendonca HL, Ryan HE, Wang Z, Johnson R. The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Mol Cell Biol. 2002 Apr; 22(8):2515-23. PMID: 11909946; PMCID: PMC133718.
    154. Seagroves T, Johnson R. Two HIFs may be better than one. Cancer Cell. 2002 Apr; 1(3):211-3. PMID: 12086854.
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    155. Yun Z, Maecker HL, Johnson R, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2002 Mar; 2(3):331-41. PMID: 11879638.
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    156. Scheid A, Wenger RH, Schäffer L, Camenisch I, Distler O, Ferenc A, Cristina H, Ryan HE, Johnson R, Wagner KF, Stauffer UG, Bauer C, Gassmann M, Meuli M. Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3. FASEB J. 2002 Mar; 16(3):411-3. PMID: 11790723.
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    157. Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson R, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 2002 Jan-Feb; 8(1):47-54. PMID: 11895203.
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