-
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proc Natl Acad Sci U S A. 2021 Jun 08; 118(23).
Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. PMID: 34088839.
View in:
PubMed Mentions: Fields:
-
Structural analyses of the PKA RIIß holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. PLoS Biol. 2020 12; 18(12):e3001018.
Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. PMID: 33370777.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Am J Hum Genet. 2020 11 05; 107(5):977-988.
Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibæk M, Kristiansen BS, Issa MY, Mehrez MI, Ismail S, Tenorio J, Li G, Skålhegg BS, Otaify GA, Temtamy S, Aglan M, Jønch AE, De Luca A, Mortier G, Cormier-Daire V, Ziegler A, Wallis M, Lapunzina P, Herberg FW, Taylor SS, Ruiz-Perez VL. PMID: 33058759.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery. Front Mol Neurosci. 2020; 13:538219.
Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW. PMID: 33122997.
View in:
PubMed Mentions:
-
Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. PLoS Pathog. 2020 03; 16(3):e1008373.
Oyen D, Torres JL, Aoto PC, Flores-Garcia Y, Binter Š, Pholcharee T, Carroll S, Reponen S, Wash R, Liang Q, Lemiale F, Locke E, Bradley A, King CR, Emerling D, Kellam P, Zavala F, Ward AB, Wilson IA. PMID: 32150583.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
A Dynamic Switch in Inactive p38? Leads to an Excited State on the Pathway to an Active Kinase. Biochemistry. 2019 12 24; 58(51):5160-5172.
Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE. PMID: 31794659.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Two PKA RIa holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16347-16356.
Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. PMID: 31363049.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Dynamic allostery-based molecular workings of kinase:peptide complexes. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15052-15061.
Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. PMID: 31285328.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nat Commun. 2019 02 18; 10(1):799.
Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. PMID: 30778078.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
-
Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J Am Chem Soc. 2017 08 16; 139(32):11233-11240.
Oyen D, Fenwick RB, Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE. PMID: 28737940.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38?. Sci Rep. 2016 06 29; 6:28655.
Aoto PC, Martin BT, Wright PE. PMID: 27353957.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Accurate scoring of non-uniform sampling schemes for quantitative NMR. J Magn Reson. 2014 Sep; 246:31-5.
Aoto PC, Fenwick RB, Kroon GJ, Wright PE. PMID: 25063954.
View in:
PubMed Mentions:
22 Fields:
-
Probing the non-native H helix translocation in apomyoglobin folding intermediates. Biochemistry. 2014 Jun 17; 53(23):3767-80.
Aoto PC, Nishimura C, Dyson HJ, Wright PE. PMID: 24857522.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Biarsenical-tetracysteine motif as a fluorescent tag for detection in capillary electrophoresis. Anal Chem. 2008 Jul 15; 80(14):5358-66.
Kottegoda S, Aoto PC, Sims CE, Allbritton NL. PMID: 18522433.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Broadening cell selection criteria with micropallet arrays of adherent cells. Cytometry A. 2007 Oct; 71(10):866-74.
Wang Y, Young G, Aoto PC, Pai JH, Bachman M, Li GP, Sims CE, Allbritton NL. PMID: 17559133.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
-
X-ray diffraction analysis of a crystal of HscA from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 01; 61(Pt 7):715-7.
Aoto PC, Ta DT, Cupp-Vickery JR, Vickery LE. PMID: 16511138.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells