Phillip Aoto

Title(s)	ASST PROJ SCIENTIST-FY NEX, Pharmacology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS Biol. 2022 02; 20(2):e3001427. Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. PMID: 35192607; PMCID: PMC8863276.

View in: PubMed Mentions: Fields:
Bio Biology
Translation:Humans Cells
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. PMID: 34088839; PMCID: PMC8201809.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Humans Cells
Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. PLoS Biol. 2020 12; 18(12):e3001018. Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. PMID: 33370777; PMCID: PMC7793292.

View in: PubMed Mentions: 4 Fields:
Bio Biology
Translation:Humans Cells
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Am J Hum Genet. 2020 11 05; 107(5):977-988. Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibæk M, Kristiansen BS, Issa MY, Mehrez MI, Ismail S, Tenorio J, Li G, Skålhegg BS, Otaify GA, Temtamy S, Aglan M, Jønch AE, De Luca A, Mortier G, Cormier-Daire V, Ziegler A, Wallis M, Lapunzina P, Herberg FW, Taylor SS, Ruiz-Perez VL. PMID: 33058759; PMCID: PMC7675002.

View in: PubMed Mentions: 4 Fields:
Gen Genetics
Translation:Humans Animals Cells
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery. Front Mol Neurosci. 2020; 13:538219. Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW. PMID: 33122997; PMCID: PMC7573214.

View in: PubMed Mentions: 2
Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. PLoS Pathog. 2020 03; 16(3):e1008373. Oyen D, Torres JL, Aoto PC, Flores-Garcia Y, Binter Š, Pholcharee T, Carroll S, Reponen S, Wash R, Liang Q, Lemiale F, Locke E, Bradley A, King CR, Emerling D, Kellam P, Zavala F, Ward AB, Wilson IA. PMID: 32150583; PMCID: PMC7082059.

View in: PubMed Mentions: 16 Fields:
Mic Microbiology
Translation:Animals Cells
A Dynamic Switch in Inactive p38γ Leads to an Excited State on the Pathway to an Active Kinase. Biochemistry. 2019 12 24; 58(51):5160-5172. Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE. PMID: 31794659; PMCID: PMC6932632.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Humans Cells
Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16347-16356. Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. PMID: 31363049; PMCID: PMC6697891.

View in: PubMed Mentions: 9 Fields:
Sci Science
Translation:Humans Cells
Dynamic allostery-based molecular workings of kinase:peptide complexes. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15052-15061. Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. PMID: 31285328; PMCID: PMC6660753.

View in: PubMed Mentions: 14 Fields:
Sci Science
Translation:Cells
Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nat Commun. 2019 02 18; 10(1):799. Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. PMID: 30778078; PMCID: PMC6379427.

View in: PubMed Mentions: 11 Fields:
Bio Biology Sci Science
Translation:Cells
Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J Am Chem Soc. 2017 08 16; 139(32):11233-11240. Oyen D, Fenwick RB, Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE. PMID: 28737940; PMCID: PMC5562155.

View in: PubMed Mentions: 13 Fields:
Che Chemistry
Translation:Cells
NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γ. Sci Rep. 2016 06 29; 6:28655. Aoto PC, Martin BT, Wright PE. PMID: 27353957; PMCID: PMC4926091.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Cells
Accurate scoring of non-uniform sampling schemes for quantitative NMR. J Magn Reson. 2014 Sep; 246:31-5. Aoto PC, Fenwick RB, Kroon GJ, Wright PE. PMID: 25063954; PMCID: PMC4165770.

View in: PubMed Mentions: 25 Fields:
Dia Diagnostic Imaging
Probing the non-native H helix translocation in apomyoglobin folding intermediates. Biochemistry. 2014 Jun 17; 53(23):3767-80. Aoto PC, Nishimura C, Dyson HJ, Wright PE. PMID: 24857522; PMCID: PMC4067146.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Animals Cells
Biarsenical-tetracysteine motif as a fluorescent tag for detection in capillary electrophoresis. Anal Chem. 2008 Jul 15; 80(14):5358-66. Kottegoda S, Aoto PC, Sims CE, Allbritton NL. PMID: 18522433; PMCID: PMC2562765.

View in: PubMed Mentions: 4 Fields:
Che Chemistry Techniques
Translation:Cells
Broadening cell selection criteria with micropallet arrays of adherent cells. Cytometry A. 2007 Oct; 71(10):866-74. Wang Y, Young G, Aoto PC, Pai JH, Bachman M, Li GP, Sims CE, Allbritton NL. PMID: 17559133.

View in: PubMed Mentions: 23 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
X-ray diffraction analysis of a crystal of HscA from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 01; 61(Pt 7):715-7. Aoto PC, Ta DT, Cupp-Vickery JR, Vickery LE. PMID: 16511138; PMCID: PMC1952449.

View in: PubMed Mentions: 1 Fields:
Che Chemistry Techniques
Translation:Cells