Omar Lakhdari

TitleAssistant Project Scientist
InstitutionUniversity of California San Diego
Address200 W. Arbor Drive #8774D
San Diego CA 92103
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    1. McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS. IKKß Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Dec; 187(12):2635-2644. PMID: 28923684.
      View in: PubMed
    2. Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince LS. The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 01; 312(6):L861-L872. PMID: 28336813.
      View in: PubMed
    3. Lakhdari O, McAllister CS, Wang M, Minev I, Prince LS, Eckmann L, Kagnoff MF. TLR3 signaling is downregulated by a MAVS isoform in epithelial cells. Cell Immunol. 2016 Dec; 310:205-210. PMID: 27593154.
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    4. Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS. IL-1ß and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development. J Immunol. 2016 Apr 15; 196(8):3411-20. PMID: 26951798.
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    5. Solaymani-Mohammadi S, Lakhdari O, Minev I, Shenouda S, Frey BF, Billeskov R, Singer SM, Berzofsky JA, Eckmann L, Kagnoff MF. Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules. J Leukoc Biol. 2016 Mar; 99(3):475-82. PMID: 26467188.
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    6. Tap J, Furet JP, Bensaada M, Philippe C, Roth H, Rabot S, Lakhdari O, Lombard V, Henrissat B, Corthier G, Fontaine E, Doré J, Leclerc M. Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults. Environ Microbiol. 2015 Dec; 17(12):4954-64. PMID: 26235304.
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    7. Cultrone A, de Wouters T, Lakhdari O, Kelly D, Mulder I, Logan E, Lapaque N, Doré J, Blottière HM. The NF-?B binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells. Eur J Immunol. 2013 Apr; 43(4):1053-62. PMID: 23310954.
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    8. Egea L, McAllister CS, Lakhdari O, Minev I, Shenouda S, Kagnoff MF. GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa. J Immunol. 2013 Feb 15; 190(4):1702-13. PMID: 23325885; PMCID: PMC3563922.
    9. McAllister CS, Lakhdari O, Pineton de Chambrun G, Gareau MG, Broquet A, Lee GH, Shenouda S, Eckmann L, Kagnoff MF. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. J Immunol. 2013 Jan 01; 190(1):418-27. PMID: 23209324; PMCID: PMC3551582.
    10. Santos Rocha C, Lakhdari O, Blottière HM, Blugeon S, Sokol H, Bermúdez-Humarán LG, Azevedo V, Miyoshi A, Doré J, Langella P, Maguin E, van de Guchte M. Anti-inflammatory properties of dairy lactobacilli. Inflamm Bowel Dis. 2012 Apr; 18(4):657-66. PMID: 21837773.
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    11. Lakhdari O, Tap J, Béguet-Crespel F, Le Roux K, de Wouters T, Cultrone A, Nepelska M, Lefèvre F, Doré J, Blottière HM. Identification of NF-?B modulation capabilities within human intestinal commensal bacteria. J Biomed Biotechnol. 2011; 2011:282356. PMID: 21765633; PMCID: PMC3134244.
    12. Kaci G, Lakhdari O, Doré J, Ehrlich SD, Renault P, Blottière HM, Delorme C. Inhibition of the NF-kappaB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius. Appl Environ Microbiol. 2011 Jul; 77(13):4681-4. PMID: 21602373; PMCID: PMC3127691.
    13. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J. Enterotypes of the human gut microbiome. Nature. 2011 May 12; 473(7346):174-80. PMID: 21508958.
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    14. Lakhdari O, Cultrone A, Tap J, Gloux K, Bernard F, Ehrlich SD, Lefèvre F, Doré J, Blottière HM. Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-?B modulation in the human gut. PLoS One. 2010 Sep 30; 5(9). PMID: 20927194; PMCID: PMC2948039.
    15. Madi A, Lakhdari O, Blottière HM, Guyard-Nicodème M, Le Roux K, Groboillot A, Svinareff P, Doré J, Orange N, Feuilloley MG, Connil N. The clinical Pseudomonas fluorescens MFN1032 strain exerts a cytotoxic effect on epithelial intestinal cells and induces Interleukin-8 via the AP-1 signaling pathway. BMC Microbiol. 2010 Aug 10; 10:215. PMID: 20698984; PMCID: PMC2933668.
    16. Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16731-6. PMID: 18936492; PMCID: PMC2575488.
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