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Olivia Osborn

Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0673
La Jolla CA 92093
Phone8/8-22--6645
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, La JollaPost doc11/2013Obesity/Type 2 Diabetes
    The Scripps Research Institute, La JollaPost doc09/2009Neuroscience/Obesity
    University of Oxford, Oxford, UKDPhil12/2006Neuroscience/Genetics

    Collapse Overview 
    Collapse Overview
    The primary focus of my research is to investigate mechanisms involved in food intake and weight gain. We are using a variety of approaches and model systems to investigate the underlying pathways implicated in feeding and feeding disorders.
    Antipsychotic drugs are highly efficacious treatments for psychiatric disorders a serious side effect of their use is increased food intake, excessive weight gain and subsequent development of metabolic disease. We made the surprising discovery that antipsychotics also induce hyperphagia in C. elegans which allowed us to use an in vivo screening assay to identify potential adjuvant therapies to block antipsychotic-induced food intake. We use mouse models to test potential adjuvant therapies and are beginning to unravel the key pathways involved in antipsychotic-induced food intake. These collaborative studies formed the basis of our R01 grant (1R01DK117872).
    The second area of focus is “why is it so hard to maintain weight loss?” Many people can successfully diet to lose weight but the vast majority will regain this weight within a year. Through a series of transcriptomics and metabolomics studies we made the discovery that “memory” of obesity is predominantly found in the adipose tissue. We identified genes that are persistently elevated in obesity and are studying their role in the food intake and the development of obesity and weight regain.
    These studies have identified novel pathways implicated in food intake with broad implications in in field of obesity, metabolic disease and psychiatry.

    Collapse Research 
    Collapse Research Activities and Funding
    An in vivo screening system for chemical modulators of eating behavior
    NIH/NIDDK R01 DK117872Aug 1, 2018 - Jul 31, 2023
    Role: PI (Multi PI)

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain. Sci Rep. 2020 10 29; 10(1):18581. Zapata RC, Rosenthal SB, Fisch K, Dao K, Jain M, Osborn O. PMID: 33122657.
      View in: PubMed   Mentions:    Fields:    
    2. Positive Reinforcing Mechanisms between GPR120 and PPAR? Modulate Insulin Sensitivity. Cell Metab. 2020 Jun 02; 31(6):1173-1188.e5. Paschoal VA, Walenta E, Talukdar S, Pessentheiner AR, Osborn O, Hah N, Chi TJ, Tye GL, Armando AM, Evans RM, Chi NW, Quehenberger O, Olefsky JM, Oh DY. PMID: 32413335.
      View in: PubMed   Mentions: 3     Fields:    
    3. Susceptibility of male wild type mouse strains to antipsychotic-induced weight gain. Physiol Behav. 2020 06 01; 220:112859. Zapata RC, Osborn O. PMID: 32156556.
      View in: PubMed   Mentions:    Fields:    
    4. Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Sci Rep. 2019 10 14; 9(1):14779. Lackey DE, Reis FCG, Isaac R, Zapata RC, El Ouarrat D, Lee YS, Bandyopadhyay G, Ofrecio JM, Oh DY, Osborn O. PMID: 31611602.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Nat Commun. 2018 12 10; 9(1):5272. Perez-Gomez A, Carretero M, Weber N, Peterka V, To A, Titova V, Solis G, Osborn O, Petrascheck M. PMID: 30532051.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    6. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 08 01; 315(2):E267-E278. Hernandez-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O. PMID: 29634311.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Distinct gene signatures predict insulin resistance in young mice with high fat diet-induced obesity. Physiol Genomics. 2018 03 01; 50(3):144-157. Chen K, Jih A, Osborn O, Kavaler ST, Fu W, Sasik R, Saito R, Kim JJ. PMID: 29341863.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond). 2018 04; 42(4):728-736. Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O. PMID: 29089614.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 01; 127(3):1019-1030. Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. PMID: 28192375.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    11. Distinct Hepatic Macrophage Populations in Lean and Obese Mice. Front Endocrinol (Lausanne). 2016; 7:152. Mayoral Monibas R, Johnson AM, Osborn O, Traves PG, Mahata SK. PMID: 27999564.
      View in: PubMed   Mentions:
    12. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. PMID: 27814523.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    13. The role of dietary fat in obesity-induced insulin resistance. Am J Physiol Endocrinol Metab. 2016 12 01; 311(6):E989-E997. Lackey DE, Lazaro RG, Li P, Johnson A, Hernandez-Carretero A, Weber N, Vorobyova I, Tsukomoto H, Osborn O. PMID: 27802965.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 May; 4(5):378-91. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. PMID: 25973386.
      View in: PubMed   Mentions: 33     Fields:    
    15. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2015 Apr 16; 520(7547):388. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25739500.
      View in: PubMed   Mentions:    Fields:    
    16. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015 Mar; 21(3):239-247. Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM. PMID: 25706874.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    17. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344.
      View in: PubMed   Mentions: 148     Fields:    Translation:Animals
    18. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015 Apr; 64(4):1120-30. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY. PMID: 25315009.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    19. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487. Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. PMID: 25244011.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    20. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. PMID: 25043058.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    21. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-1352. PMID: 24906151.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    22. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 2013 Apr 12; 288(15):10722-35. PMID: 23457303.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. PMID: 22653059.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012 Mar 06; 18(3):363-74. PMID: 22395709.
      View in: PubMed   Mentions: 456     Fields:    Translation:HumansCells
    25. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. PMID: 21985785.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    26. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci. 2011 Sep; 32(9):543-50. Talukdar S, Olefsky JM, Osborn O. PMID: 21663979.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    27. Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem. 2011 Apr 29; 286(17):14983-90. Sanchez-Alavez M, Osborn O, Tabarean IV, Holmberg KH, Eberwine J, Kahn CR, Bartfai T. PMID: 21330367.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    28. Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue. Cytokine. 2011 Mar; 53(3):311-9. Osborn O, Sanchez-Alavez M, Dubins JS, Gonzalez AS, Morrison B, Hadcock JR, Bartfai T. PMID: 21177120.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    29. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. Osborn O, Sears DD, Olefsky JM. PMID: 21109185.
      View in: PubMed   Mentions: 5     Fields:    
    30. Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes. 2010 Jan; 59(1):43-50. Sanchez-Alavez M, Tabarean IV, Osborn O, Mitsukawa K, Schaefer J, Dubins J, Holmberg KH, Klein I, Klaus J, Gomez LF, Kolb H, Secrest J, Jochems J, Myashiro K, Buckley P, Hadcock JR, Eberwine J, Conti B, Bartfai T. PMID: 19846801.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    31. Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cell Mol Neurobiol. 2010 Jan; 30(1):23-33. Osborn O, Sanchez-Alavez M, Brownell SE, Ross B, Klaus J, Dubins J, Beutler B, Conti B, Bartfai T. PMID: 19582570.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly. 2008 Nov 15; 138(45-46):665-73. Osborn O, Gram H, Zorrilla EP, Conti B, Bartfai T. PMID: 18855149.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    33. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine. 2008 Oct; 44(1):141-8. Osborn O, Brownell SE, Sanchez-Alavez M, Salomon D, Gram H, Bartfai T. PMID: 18723371.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    34. A locus for autosomal dominant "pure" hereditary spastic paraplegia maps to chromosome 19q13. Am J Hum Genet. 2000 Feb; 66(2):728-32. Reid E, Dearlove AM, Osborn O, Rogers MT, Rubinsztein DC. PMID: 10677333.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
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