Olivia Kim Mcmanus

Title(s)Associate Clinical Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4785-7795 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia University , New York, NYB.A. Neurosciences
    Georgetown University , Washington, D.C.M.S.Physiology & Biophysics
    George Washington University School of Medicine/Children's National Medical Center, Washington, D.C.M.D.
    University of Southern California (USC)/Children's Hospital Los Angeles, Los Angeles, C.A.Pediatric Neurology
    University of California, Irvine, Irvine, C.A.Clinical Neurophysiology Fellowship
    University of California, Irvine, Irvine, C.A.Epilepsy Fellowship
    Collapse Awards and Honors
    Epilepsy Foundation of Greater Los Angeles2010  - 2015Care & Cure Award
    National Institutes of Health2004  - 2005Postbaccalaureate Intramural Research Training Award
    UC San Diego 2022  - 2022National Center of Leadership in Academic Medicine: Individualized antisense oligonucleotide therapy

    Collapse Overview 
    Collapse Overview
    Dr. Olivia Kim-McManus is an Associate Clinical Professor at UC San Diego School of Medicine Department of Neurosciences and a pediatric neurologist and epileptologist at Rady Children's Hospital Division of Pediatric Neurology.

    Dr. Olivia Kim-McManus is Board certified in Neurology with special qualifications in Child Neurology and a Board-certified epileptologist with additional expertise in Pediatric Epilepsy and Clinical Neurophysiology.

    Dr. Kim-McManus completed undergraduate studies at Columbia University in New York City with a degree in Neurosciences. She received a National Institutes of Health Postbaccalaureate Intramural Research Training Award and subsequently trained at Children's National Medical Center, earning her medical doctorate from the George Washington University School of Medicine in Washington, D.C. She completed residencies in pediatrics and neurology at Children's Hospital Los Angeles/University of Southern California. Subsequently, she completed two additional fellowships at UC Irvine School of Medicine/Children's Hospital Orange County to further specialize in pediatric epilepsy and clinical neurophysiology.

    She specializes in treating infants, children and adolescents with pediatric neurological conditions including neurological conditions related to brain malformations, underlying genetic etiologies, intellectual disabilities and neurodevelopmental problems of childhood. Her primary expertise and interests include pediatric epilepsy, epilepsy genetics, and epilepsy surgery. She performs invasive intracranial electroencephalography monitoring with stereotactic depth electrodes or grid electrodes and intraoperative electrocorticography. She treats medically intractable epilepsy patients with ketogenic diet therapy in addition to surgical procedures including resective brain surgery, hemispherectomy, minimally invasive laser ablation therapy and/or implantable neuromodulation devices such as responsive neurostimulation (RNS), deep brain stimulation (DBS) and vagal nerve stimulation (VNS) as alternative therapies to medications.

    Dr. Kim-McManus primarily sees pediatric patients with epilepsy at Rady Children's Hospital in the Division of Pediatric Neurology. She also monitors infants with neonatal seizures on continuous EEG in the neonatal intensive care unit at UC San Diego Jacobs Medical Center.

    Her research activities include site principal investigator in a multicenter research study with UC Irvine and UC Berkeley/UCSF involving memory and cognition in pediatric epilepsy surgery patients undergoing intracranial EEG monitoring. She is a principal investigator and co-investigator in multiple additional epilepsy trials involving antisense oligonucleotide drugs in rare developmental epileptic encephalopathies (Dravet Syndrome, SCN2A, Angelman Syndrome), mitochondrial epilepsies and software development for absence epilepsy. She is a PI for n=1 individualized antisense oligonucleotide therapies for children at Rady Children's Hospital with severe developmental epileptic encephalopathies due to rare genetic causes. She serves on the Rady Children's Institute of Genomic Medicine Task Force for Clinical Whole Genome Sequencing and The N=1 Collaborative Institutional Implementations and Clinical Outcomes Task Forces to bring forward rare disease therapies for children with unmet need.

    Dr. Kim-McManus established and directs the Neuro-Infusion Program for Batten's Disease (Late infantile ceroid neuronal lipofuscinosis type 2) at Rady Children's Hospital, a bi-weekly cerliponase alfa enzyme replacement delivered intraventricularly via Ommaya reservoir, a disease-modifying therapy for rare, pediatric neurodegenerative disease.

    Dr. Olivia Kim-McManus is also the director of the Pediatric Epilepsy Fellowship Program at UC San Diego, Rady Children's Hospital where she trains medical students, residents and fellows.

    She is also the Neurology Section Vice Chief of Medical Staff at Rady Children's Hospital and a Professional Advisory Board member of the Epilepsy Foundation of San Diego.

    Dr. Kim-McManus is a member of the American Epilepsy Society, Child Neurology Society and American Academy of Neurology.

    In her spare time, she enjoys spending time with her husband and three children.
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Skelin I, Zhang H, Zheng J, Ma S, Mander BA, Kim McManus O, Vadera S, Knight RT, McNaughton BL, Lin JJ. PMID: 34001599; PMCID: PMC8166184.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    2. Strength and stability of EEG functional connectivity predict treatment response in infants with epileptic spasms. Clin Neurophysiol. 2018 10; 129(10):2137-2148. Shrey DW, Kim McManus O, Rajaraman R, Ombao H, Hussain SA, Lopour BA. PMID: 30114662; PMCID: PMC6193760.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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