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Olga Chaim

TitleVisiting Assistant Project Scientist
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0636
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 Jun 11. PMID: 29887596.
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    2. Boia-Ferreira M, Basílio AB, Hamasaki AE, Matsubara FH, Appel MH, Da Costa CRV, Amson R, Telerman A, Chaim OM, Veiga SS, Senff-Ribeiro A. TCTP as a therapeutic target in melanoma treatment. Br J Cancer. 2017 Aug 22; 117(5):656-665. PMID: 28751755.
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    3. Chaves-Moreira D, Senff-Ribeiro A, Wille ACM, Gremski LH, Chaim OM, Veiga SS. Highlights in the knowledge of brown spider toxins. J Venom Anim Toxins Incl Trop Dis. 2017; 23:6. PMID: 28194160.
      View in: PubMed
    4. Chaves-Moreira D, de Moraes FR, Caruso ÍP, Chaim OM, Senff-Ribeiro A, Ullah A, da Silva LS, Chahine J, Arni RK, Veiga SS. Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D. J Cell Biochem. 2017 04; 118(4):726-738. PMID: 27563734.
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    5. Matsubara FH, Meissner GO, Herzig V, Justa HC, Dias BC, Trevisan-Silva D, Gremski LH, Gremski W, Senff-Ribeiro A, Chaim OM, King GF, Veiga SS. Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus. Insect Mol Biol. 2017 02; 26(1):25-34. PMID: 27743460.
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    6. Meissner GO, de Resende Lara PT, Scott LP, Braz AS, Chaves-Moreira D, Matsubara FH, Soares EM, Trevisan-Silva D, Gremski LH, Veiga SS, Chaim OM. Molecular cloning and in silico characterization of knottin peptide, U2-SCRTX-Lit2, from brown spider (Loxosceles intermedia) venom glands. J Mol Model. 2016 Sep; 22(9):196. PMID: 27488102.
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    7. Morgon AM, Belisario-Ferrari MR, Trevisan-Silva D, Meissner GO, Vuitika L, Marin B, Tashima AK, Gremski LH, Gremski W, Senff-Ribeiro A, Veiga SS, Chaim OM. Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom. Biochimie. 2016 Sep-Oct; 128-129:8-19. PMID: 27343628.
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    8. Vuitika L, Chaves-Moreira D, Caruso I, Lima MA, Matsubara FH, Murakami MT, Takahashi HK, Toledo MS, Coronado MA, Nader HB, Senff-Ribeiro A, Chaim OM, Arni RK, Veiga SS. Active site mapping of Loxosceles phospholipases D: Biochemical and biological features. Biochim Biophys Acta. 2016 09; 1861(9 Pt A):970-979. PMID: 27233517.
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    9. Buch DR, Souza FN, Meissner GO, Morgon AM, Gremski LH, Ferrer VP, Trevisan-Silva D, Matsubara FH, Boia-Ferreira M, Sade YB, Chaves-Moreira D, Gremski W, Veiga SS, Chaim OM, Senff-Ribeiro A. Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity. Toxicon. 2015 Dec 15; 108:154-66. PMID: 26474948.
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    10. Bednaski AV, Trevisan-Silva D, Matsubara FH, Boia-Ferreira M, Olivério MM, Gremski LH, Cavalheiro RP, De Paula DM, Paredes-Gamero EJ, Takahashi HK, Toledo MS, Nader HB, Veiga SS, Chaim OM, Senff-Ribeiro A. Characterization of Brown spider (Loxosceles intermedia) hemolymph: cellular and biochemical analyses. Toxicon. 2015 May; 98:62-74. PMID: 25720299.
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    11. Coronado MA, Ullah A, da Silva LS, Chaves-Moreira D, Vuitika L, Chaim OM, Veiga SS, Chahine J, Murakami MT, Arni RK. Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D. Curr Protein Pept Sci. 2015; 16(8):768-74. PMID: 25961401.
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    12. Gremski LH, Trevisan-Silva D, Ferrer VP, Matsubara FH, Meissner GO, Wille AC, Vuitika L, Dias-Lopes C, Ullah A, de Moraes FR, Chávez-Olórtegui C, Barbaro KC, Murakami MT, Arni RK, Senff-Ribeiro A, Chaim OM, Veiga SS. Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins. Toxicon. 2014 Jun; 83:91-120. PMID: 24631373.
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    13. Vuitika L, Gremski LH, Belisário-Ferrari MR, Chaves-Moreira D, Ferrer VP, Senff-Ribeiro A, Chaim OM, Veiga SS. Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization. J Cell Biochem. 2013 Nov; 114(11):2479-92. PMID: 23733617.
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    14. Trevisan-Silva D, Bednaski AV, Gremski LH, Chaim OM, Veiga SS, Senff-Ribeiro A. Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches. Toxicon. 2013 Dec 15; 76:11-22. PMID: 24018360.
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    15. Matsubara FH, Gremski LH, Meissner GO, Constantino Lopes ES, Gremski W, Senff-Ribeiro A, Chaim OM, Veiga SS. A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: cloning, heterologous expression and immunological cross-reactivity approaches. Toxicon. 2013 Sep; 71:147-58. PMID: 23751278.
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    16. Ferrer VP, de Mari TL, Gremski LH, Trevisan Silva D, da Silveira RB, Gremski W, Chaim OM, Senff-Ribeiro A, Nader HB, Veiga SS. A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization. PLoS Negl Trop Dis. 2013; 7(5):e2206. PMID: 23658852; PMCID: PMC3642055.
    17. Wille AC, Chaves-Moreira D, Trevisan-Silva D, Magnoni MG, Boia-Ferreira M, Gremski LH, Gremski W, Chaim OM, Senff-Ribeiro A, Veiga SS. Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom. Toxicon. 2013 Jun 01; 67:17-30. PMID: 23462381.
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    18. Sade YB, Bóia-Ferreira M, Gremski LH, da Silveira RB, Gremski W, Senff-Ribeiro A, Chaim OM, Veiga SS. Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom. Int J Biochem Cell Biol. 2012 Jan; 44(1):170-7. PMID: 22051631.
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    19. Chaves-Moreira D, Souza FN, Fogaça RT, Mangili OC, Gremski W, Senff-Ribeiro A, Chaim OM, Veiga SS. The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin. J Cell Biochem. 2011 Sep; 112(9):2529-40. PMID: 21590705.
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    20. de Giuseppe PO, Ullah A, Silva DT, Gremski LH, Wille AC, Chaves Moreira D, Ribeiro AS, Chaim OM, Murakami MT, Veiga SS, Arni RK. Structure of a novel class II phospholipase D: catalytic cleft is modified by a disulphide bridge. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):622-7. PMID: 21616057.
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    21. Chaim OM, Trevisan-Silva D, Chaves-Moreira D, Wille AC, Ferrer VP, Matsubara FH, Mangili OC, da Silveira RB, Gremski LH, Gremski W, Senff-Ribeiro A, Veiga SS. Brown spider (Loxosceles genus) venom toxins: tools for biological purposes. Toxins (Basel). 2011 03; 3(3):309-44. PMID: 22069711; PMCID: PMC3202818.
    22. Ullah A, de Giuseppe PO, Murakami MT, Trevisan-Silva D, Wille AC, Chaves-Moreira D, Gremski LH, da Silveira RB, Sennf-Ribeiro A, Chaim OM, Veiga SS, Arni RK. Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D from Loxosceles intermedia venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 01; 67(Pt 2):234-6. PMID: 21301094; PMCID: PMC3034616.
    23. Gomes MT, Guimarães G, Frézard F, Kalapothakis E, Minozzo JC, Chaim OM, Veiga SS, Oliveira SC, Chávez-Olórtegui C. Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase. Toxicon. 2011 Mar 15; 57(4):574-9. PMID: 21236288.
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    24. Chaim OM, da Silveira RB, Trevisan-Silva D, Ferrer VP, Sade YB, Bóia-Ferreira M, Gremski LH, Gremski W, Senff-Ribeiro A, Takahashi HK, Toledo MS, Nader HB, Veiga SS. Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity. Biochim Biophys Acta. 2011 Feb; 1811(2):84-96. PMID: 21094694.
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    25. Gremski LH, da Silveira RB, Chaim OM, Probst CM, Ferrer VP, Nowatzki J, Weinschutz HC, Madeira HM, Gremski W, Nader HB, Senff-Ribeiro A, Veiga SS. A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis. Mol Biosyst. 2010 Dec; 6(12):2403-16. PMID: 20644878.
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    26. Trevisan-Silva D, Gremski LH, Chaim OM, da Silveira RB, Meissner GO, Mangili OC, Barbaro KC, Gremski W, Veiga SS, Senff-Ribeiro A. Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles). Biochimie. 2010 Jan; 92(1):21-32. PMID: 19879318.
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    27. Chaves-Moreira D, Chaim OM, Sade YB, Paludo KS, Gremski LH, Donatti L, de Moura J, Mangili OC, Gremski W, da Silveira RB, Senff-Ribeiro A, Veiga SS. Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom. J Cell Biochem. 2009 Jul 01; 107(4):655-66. PMID: 19455508.
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    28. Pauli I, Minozzo JC, da Silva PH, Chaim OM, Veiga SS. Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia). Toxicon. 2009 May; 53(6):660-71. PMID: 19673081.
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    29. Paludo KS, Biscaia SM, Chaim OM, Otuki MF, Naliwaiko K, Dombrowski PA, Franco CR, Veiga SS. Inflammatory events induced by brown spider venom and its recombinant dermonecrotic toxin: a pharmacological investigation. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Apr; 149(3):323-33. PMID: 19041422.
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    30. de Oliveira Christoff A, de Oliveira A, Chaim OM, Lugarini D, Bastos Pereira AL, Paludo KS, Queiroz Telles JE, Bracht A, Veiga SS, Acco A. Effects of the venom and the dermonecrotic toxin LiRecDT1 of Loxosceles intermedia in the rat liver. Toxicon. 2008 Nov; 52(6):695-704. PMID: 18765244.
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    31. Kusma J, Chaim OM, Wille AC, Ferrer VP, Sade YB, Donatti L, Gremski W, Mangili OC, Veiga SS. Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity. Biochimie. 2008 Nov-Dec; 90(11-12):1722-36. PMID: 18760322.
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    32. Senff-Ribeiro A, Henrique da Silva P, Chaim OM, Gremski LH, Paludo KS, Bertoni da Silveira R, Gremski W, Mangili OC, Veiga SS. Biotechnological applications of brown spider (Loxosceles genus) venom toxins. Biotechnol Adv. 2008 May-Jun; 26(3):210-8. PMID: 18207690.
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    33. Appel MH, da Silveira RB, Chaim OM, Paludo KS, Silva DT, Chaves DM, da Silva PH, Mangili OC, Senff-Ribeiro A, Gremski W, Nader HB, Veiga SS. Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom. Biochim Biophys Acta. 2008 Feb; 1780(2):167-78. PMID: 18082635.
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    34. da Silveira RB, Wille AC, Chaim OM, Appel MH, Silva DT, Franco CR, Toma L, Mangili OC, Gremski W, Dietrich CP, Nader HB, Veiga SS. Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom. Biochem J. 2007 Sep 01; 406(2):355-63. PMID: 17535156; PMCID: PMC1948970.
    35. Ribeiro RO, Chaim OM, da Silveira RB, Gremski LH, Sade YB, Paludo KS, Senff-Ribeiro A, de Moura J, Chávez-Olórtegui C, Gremski W, Nader HB, Veiga SS. Biological and structural comparison of recombinant phospholipase D toxins from Loxosceles intermedia (brown spider) venom. Toxicon. 2007 Dec 15; 50(8):1162-74. PMID: 17900646.
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    36. Gremski LH, Chaim OM, Paludo KS, Sade YB, Otuki MF, Richardson M, Gremski W, Sanchez EF, Veiga SS. Cytotoxic, thrombolytic and edematogenic activities of leucurolysin-a, a metalloproteinase from Bothrops leucurus snake venom. Toxicon. 2007 Jul; 50(1):120-34. PMID: 17482228.
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    37. da Silveira RB, Pigozzo RB, Chaim OM, Appel MH, Silva DT, Dreyfuss JL, Toma L, Dietrich CP, Nader HB, Veiga SS, Gremski W. Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization. Biochimie. 2007 Mar; 89(3):289-300. PMID: 17296256.
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    38. da Silveira RB, Chaim OM, Mangili OC, Gremski W, Dietrich CP, Nader HB, Veiga SS. Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-beta-N-acetyl-d-hexosaminidases hydrolases. Toxicon. 2007 May; 49(6):758-68. PMID: 17210169.
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    39. da Silveira RB, Pigozzo RB, Chaim OM, Appel MH, Dreyfuss JL, Toma L, Mangili OC, Gremski W, Dietrich CP, Nader HB, Veiga SS. Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland. Biochimie. 2006 Sep; 88(9):1241-53. PMID: 16581177.
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    40. Paludo KS, Gremski LH, Veiga SS, Chaim OM, Gremski W, de Freitas Buchi D, Nader HB, Dietrich CP, Franco CR. The effect of brown spider venom on endothelial cell morphology and adhesive structures. Toxicon. 2006 Jun 15; 47(8):844-53. PMID: 16737725.
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    41. Chaim OM, Sade YB, da Silveira RB, Toma L, Kalapothakis E, Chávez-Olórtegui C, Mangili OC, Gremski W, von Dietrich CP, Nader HB, Sanches Veiga S. Brown spider dermonecrotic toxin directly induces nephrotoxicity. Toxicol Appl Pharmacol. 2006 Feb 15; 211(1):64-77. PMID: 16005484.
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    42. Luciano MN, da Silva PH, Chaim OM, dos Santos VL, Franco CR, Soares MF, Zanata SM, Mangili OC, Gremski W, Veiga SS. Experimental evidence for a direct cytotoxicity of Loxosceles intermedia (brown spider) venom in renal tissue. J Histochem Cytochem. 2004 Apr; 52(4):455-67. PMID: 15033997.
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