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Nunzio Bottini

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0656
La Jolla CA 92093
Phone858-246-2398
vCardDownload vCard

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    Education
    Dr. Bottini obtained his MD and PhD from the University of Rome, Tor Vergata, where he also completed his medical internship and residency. He then received postdoctoral research training at the Sanford Burnham Medical Research Institute in La Jolla, and completed a clinical fellowship in Rheumatology at the University of California San Diego. Between 2005 and 2009 he held the position of Assistant Professor at the Institute for Genetic Medicine at the University of Southern California in Los Angeles and between 2009 and 2016 he was an Associate Professor at the La Jolla Institute for Allergy and Immunology. Dr. Bottini was recruited to UCSD as full time faculty in 2016.

    Research Interest
    The Bottini laboratory focuses on the control of intracellular signaling by protein phosphorylation with particular interest in the role of protein tyrosine phosphatases. Our goal is to find new biomarkers and therapeutic targets for arthritis and autoimmunity. Active projects in the laboratory include:

    - Functional genetics of protein tyrosine phosphatases in autoimmune diseases
    - Regulation of tyrosine phosphorylation in rheumatoid arthritis synoviocytes
    - Regulation of tyrosine phosphorylation in scleroderma fibroblasts


    Collapse Research 
    Collapse Research Activities and Funding
    Role of PTP4A1 in systemic sclerosis
    NIH/NIAMS R21AR069822Jul 15, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Small Molecule Inhibitors of LMPTP: An Obesity Drug Target
    NIH/NIDDK R01DK106233Jul 1, 2015 - May 31, 2019
    Role: Principal Investigator
    Role of PTPRS in Rheumatoid Artiritis
    NIH/NIAMS R01AR066053Sep 1, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Cell-based functional genetics of autoimmunity through targeted gene integration
    NIH/NIAID R21AI101875Feb 5, 2013 - Jan 31, 2016
    Role: Principal Investigator
    Small molecule inhibitors of LMPTP: an obesity drug target
    NIH/NIDA R03DA033986Feb 1, 2012 - Jan 31, 2014
    Role: Principal Investigator
    Fluorogenic Assays for Cell-based HTS of Tyrosine Phosphatase Inhibitors
    NIH/NIDDK R01DK080165Aug 15, 2008 - May 31, 2014
    Role: Principal Investigator
    Regulation of ZAP-70 by the Low Molecular Weight Protein Tyrosine Phosphatase
    NIH/NIAMS R03AR054053Sep 20, 2006 - Aug 31, 2010
    Role: Principal Investigator
    Lymphoid Tyrosine Phosphatase and Type I Diabetes
    NIH/NIAID R21AI065643Aug 1, 2006 - Jun 1, 2009
    Role: Principal Investigator
    PTPN22 AND AUTOIMMUNITY
    NIH/NIAID R01AI070544Jul 1, 2006 - Jan 31, 2020
    Role: Principal Investigator
    Fluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors
    NIH/NINDS R21NS056945Jul 1, 2006 - Jun 30, 2010
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bhattacharya K, Sacchetti C, Costa PM, Sommertune J, Brandner BD, Magrini A, Rosato N, Bottini N, Bottini M, Fadeel B. Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery. Adv Healthc Mater. 2018 Mar; 7(6):e1700916. PMID: 29334180.
      View in: PubMed
    2. Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. PTP4A1 promotes TGFß signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 10 20; 8(1):1060. PMID: 29057934.
      View in: PubMed
    3. Sacchetti C, Bottini N. Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets. Curr Rheumatol Rep. 2017 May; 19(5):28. PMID: 28397126.
      View in: PubMed
    4. Stanford SM, Bottini N. Targeting Tyrosine Phosphatases: Time to End the Stigma. Trends Pharmacol Sci. 2017 06; 38(6):524-540. PMID: 28412041.
      View in: PubMed
    5. Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 06; 13(6):624-632. PMID: 28346406.
      View in: PubMed
    6. Doody KM, Bottini N, Firestein GS. Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. 2017 Apr; 9(4):479-492. PMID: 28322585.
      View in: PubMed
    7. Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016 Nov 14; 7:13373. PMID: 27841348.
      View in: PubMed
    8. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
      View in: PubMed
    9. Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B. T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. J Allergy Clin Immunol. 2016 Sep; 138(3):839-851.e8. PMID: 27056269.
      View in: PubMed
    10. Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. Receptor Protein Tyrosine Phosphatase a-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Arthritis Rheumatol. 2016 Feb; 68(2):359-69. PMID: 26414708; PMCID: PMC4770259 [Available on 02/01/17].
    11. Bottini M, Bhattacharya K, Fadeel B, Magrini A, Bottini N, Rosato N. Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. Nanomedicine. 2016 Feb; 12(2):255-68. PMID: 26707894.
      View in: PubMed
    12. Doody KM, Bottini N. Chondrocyte clocks make cartilage time-sensitive material. J Clin Invest. 2016 Jan; 126(1):38-9. PMID: 26657854; PMCID: PMC4701534 [Available on 01/04/17].
    13. Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015 Nov 15; 195(10):4841-52. PMID: 26438525.
      View in: PubMed
    14. Bottini N, Firestein GS. Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside. Nat Rev Rheumatol. 2015 Nov; 11(11):623-4. PMID: 26390844.
      View in: PubMed
    15. Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C. Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. J Pathol. 2015 Dec; 237(4):482-94. PMID: 26213100.
      View in: PubMed
    16. Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. PLoS One. 2015; 10(6):e0129264. PMID: 26061731; PMCID: PMC4462581.
    17. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. PMID: 25995222.
      View in: PubMed
    18. Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. ACS Nano. 2014 Dec 23; 8(12):12280-91. PMID: 25415768; PMCID: PMC4373402.
    19. Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. TGFß responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016 Jan; 75(1):295-302. PMID: 25378349.
      View in: PubMed
    20. de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3793-806. PMID: 25083990; PMCID: PMC4151223.
    21. Doody KM, Bottini N. "PEST control": regulation of molecular barcodes by tyrosine phosphatases. Cell Res. 2014 Sep; 24(9):1027-8. PMID: 25081059; PMCID: PMC4152731.
    22. Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol. 2014 Oct; 10(10):602-11. PMID: 25003765; PMCID: PMC4375551.
    23. Stanford SM, Ahmed V, Barrios AM, Bottini N. Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxid Redox Signal. 2014 May 10; 20(14):2160-78. PMID: 24294920; PMCID: PMC3995294.
    24. Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One. 2014; 9(2):e86677. PMID: 24498279; PMCID: PMC3911918.
    25. Ahmed VF, Bottini N, Barrios AM. Covalent inhibition of the lymphoid tyrosine phosphatase. ChemMedChem. 2014 Feb; 9(2):296-9. PMID: 24403103; PMCID: PMC4096870.
    26. Bottini M, Sacchetti C, Pietroiusti A, Bellucci S, Magrini A, Rosato N, Bottini N. Targeted nanodrugs for cancer therapy: prospects and challenges. J Nanosci Nanotechnol. 2014 Jan; 14(1):98-114. PMID: 24730253.
      View in: PubMed
    27. Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol. 2014; 32:83-119. PMID: 24364806.
      View in: PubMed
    28. Bottini N, Firestein GS. Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Curr Rheumatol Rep. 2013 Nov; 15(11):372. PMID: 24072602.
      View in: PubMed
    29. Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem. 2013 Sep 02; 14(13):1640-7. PMID: 23956195; PMCID: PMC3874405.
    30. Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods. 2014 Jan 15; 65(2):165-74. PMID: 23886911; PMCID: PMC3899110.
    31. Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. ChemMedChem. 2013 Sep; 8(9):1561-8. PMID: 23873737; PMCID: PMC3863632.
    32. Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013 Jul 25; 39(1):111-22. PMID: 23871208; PMCID: PMC3830738.
    33. He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. J Med Chem. 2013 Jun 27; 56(12):4990-5008. PMID: 23713581; PMCID: PMC3711248.
    34. Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjug Chem. 2013 Jun 19; 24(6):852-8. PMID: 23682992.
      View in: PubMed
    35. Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum. 2013 May; 65(5):1171-80. PMID: 23335101; PMCID: PMC3636201.
    36. Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance. ACS Nano. 2013 Mar 26; 7(3):1974-89. PMID: 23413928.
      View in: PubMed
    37. Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013 Jan; 9(1):24-33. PMID: 23147896; PMCID: PMC3970924.
    38. Stanford SM, Rapini N, Bottini N. Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology. 2012 Sep; 137(1):1-19. PMID: 22862552; PMCID: PMC3449242.
    39. Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):13972-7. PMID: 22891353; PMCID: PMC3435192.
    40. Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA. PTPN22 alters the development of regulatory T cells in the thymus. J Immunol. 2012 Jun 01; 188(11):5267-75. PMID: 22539785.
      View in: PubMed
    41. Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, Gonzalez-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol. 2012 Jan; 73(1):107-10. PMID: 22064183.
      View in: PubMed
    42. Bottini M, Rosato N, Bottini N. PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromolecules. 2011 Oct 10; 12(10):3381-93. PMID: 21916410.
      View in: PubMed
    43. Teruel M, Martin JE, González-Juanatey C, López-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Fernández-Gutierrez B, Ortiz AM, González-Alvaro I, Gómez-Vaquero C, Bottini N, Llorca J, González-Gay MA, Martin J. Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Arthritis Res Ther. 2011 Jul 18; 13(4):R116. PMID: 21767392; PMCID: PMC3239354.
    44. Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, Neamati N, Bottini N. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011 Mar 24; 54(6):1640-54. PMID: 21341673; PMCID: PMC3086468.
    45. Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis Rheum. 2011 Feb; 63(2):365-72. PMID: 21279993.
      View in: PubMed
    46. Diaz-Gallo LM, Espino-Paisán L, Fransen K, Gómez-García M, van Sommeren S, Cardeña C, Rodrigo L, Mendoza JL, Taxonera C, Nieto A, Alcain G, Cueto I, López-Nevot MA, Bottini N, Barclay ML, Crusius JB, van Bodegraven AA, Wijmenga C, Ponsioen CY, Gearry RB, Roberts RL, Weersma RK, Urcelay E, Merriman TR, Alizadeh BZ, Martin J. Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2011 Nov; 17(11):2287-94. PMID: 21287672.
      View in: PubMed
    47. Delogu LG, Stanford SM, Santelli E, Magrini A, Bergamaschi A, Motamedchaboki K, Rosato N, Mustelin T, Bottini N, Bottini M. Carbon nanotube-based nanocarriers: the importance of keeping it clean. J Nanosci Nanotechnol. 2010 Aug; 10(8):5293-301. PMID: 21125885.
      View in: PubMed
    48. Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N. Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. J Biol Chem. 2010 Aug 20; 285(34):26506-18. PMID: 20538612; PMCID: PMC2924087.
    49. Stanford SM, Mustelin TM, Bottini N. Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol. 2010 Jun; 32(2):127-36. PMID: 20204370; PMCID: PMC2881161.
    50. Karver MR, Krishnamurthy D, Bottini N, Barrios AM. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. J Inorg Biochem. 2010 Mar; 104(3):268-73. PMID: 20083307; PMCID: PMC2873867.
    51. Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. J Med Chem. 2009 Nov 12; 52(21):6912-8. PMID: 19888762; PMCID: PMC2801581.
    52. Saccucci P, Manca Bitti ML, Bottini N, Rapini N, Piccinini S, D'Annibale F, Chiarelli F, Verrotti A, Bottini E, Gloria-Bottini F. Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms. Med Sci Monit. 2009 Oct; 15(10):CR511-517. PMID: 19789510.
      View in: PubMed
    53. Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 2009 Aug 11; 48(31):7525-32. PMID: 19586056; PMCID: PMC3113683.
    54. Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. PMID: 19622628; PMCID: PMC2758733.
    55. Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orrú V, Bottini N, Chen XS. Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry. 2009 Jun 09; 48(22):4838-45. PMID: 19371084; PMCID: PMC2747803.
    56. Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M. Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjug Chem. 2009 Mar 18; 20(3):427-31. PMID: 19243140.
      View in: PubMed
    57. Renzetti G, Silvestre G, D'Amario C, Bottini E, Gloria-Bottini F, Bottini N, Auais A, Perez MK, Piedimonte G. Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children. Pediatrics. 2009 Mar; 123(3):1051-8. PMID: 19255039.
      View in: PubMed
    58. Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet. 2009 Feb 01; 18(3):569-79. PMID: 18981062; PMCID: PMC2722189.
    59. Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. J Med Chem. 2008 Aug 14; 51(15):4790-5. PMID: 18605719.
      View in: PubMed
    60. Banci M, Saccucci P, D'Annibale F, Dofcaci A, Trionfera G, Magrini A, Bottini N, Bottini E, Gloria-Bottini F. Adenosine deaminase genetic polymorphism and coronary artery disease. Cardiology. 2009; 112(1):74-5. PMID: 18560234.
      View in: PubMed
    61. Cato MH, D'Annibale F, Mills DM, Cerignoli F, Dawson MI, Bergamaschi E, Bottini N, Magrini A, Bergamaschi A, Rosato N, Rickert RC, Mustelin T, Bottini M. Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. J Nanosci Nanotechnol. 2008 May; 8(5):2259-69. PMID: 18572636.
      View in: PubMed
    62. Gloria-Bottini F, Bottini N, Magrini A, Renzetti G, Martinoli R, Bergamaschi A, Bottini E. Low birth weight and allergy: possible pleiotropic effect of ACP1. Hum Biol. 2008 Feb; 80(1):65-72. PMID: 18505045.
      View in: PubMed
    63. Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F. Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes. 2008 Jan; 57(1):229-34. PMID: 17934143.
      View in: PubMed
    64. Vang T, Miletic AV, Bottini N, Mustelin T. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity. 2007 Sep; 40(6):453-61. PMID: 17729039.
      View in: PubMed
    65. Gloria-Bottini F, Bottini N, La Torre M, Magrini A, Bergamaschi A, Bottini E. The effects of genetic and seasonal factors on reproductive success. Fertil Steril. 2008 May; 89(5):1090-4. PMID: 17678914.
      View in: PubMed
    66. Ammendola M, Bottini N, Pietropolli A, Saccucci P, Gloria-Bottini F. Association between PTPN22 and endometriosis. Fertil Steril. 2008 Apr; 89(4):993-4. PMID: 17624340.
      View in: PubMed
    67. Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol. 2006 Aug; 18(4):207-13. PMID: 16697661.
      View in: PubMed
    68. Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Mol Cell Biol. 2006 Mar; 26(5):1806-16. PMID: 16479000; PMCID: PMC1430257.
    69. Gloria-Bottini F, Ronchetti F, Ammendola L, Bottini N. Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children. Allergy Asthma Proc. 2006 Mar-Apr; 27(2):115-8. PMID: 16724628.
      View in: PubMed
    70. Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97. PMID: 16330817; PMCID: PMC2213338.
    71. Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet. 2005 Dec; 37(12):1317-9. PMID: 16273109.
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    72. Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, Bergamaschi A, Mustelin T. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett. 2006 Jan 05; 160(2):121-6. PMID: 16125885.
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    73. Wu H, Cantor RM, Graham DS, Lingren CM, Farwell L, Jager PL, Bottini N, Grossman JM, Wallace DJ, Hahn BH, Julkunen H, Hebert LA, Rovin BH, Birmingham DJ, Rioux JD, Yu CY, Kere J, Vyse TJ, Tsao BP. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis Rheum. 2005 Aug; 52(8):2396-402. PMID: 16052563.
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    74. Iannaccone U, Bergamaschi A, Magrini A, Marino G, Bottini N, Lucarelli P, Bottini E, Gloria-Bottini F. Serum glucose concentration and ACP1 genotype in healthy adult subjects. Metabolism. 2005 Jul; 54(7):891-4. PMID: 15988697.
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    75. Musumeci L, Bongiorni C, Tautz L, Edwards RA, Osterman A, Perego M, Mustelin T, Bottini N. Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis. J Bacteriol. 2005 Jul; 187(14):4945-56. PMID: 15995210; PMCID: PMC1169535.
    76. Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N. In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE. J Bacteriol. 2005 May; 187(10):3384-90. PMID: 15866923; PMCID: PMC1112022.
    77. Mijakovic I, Petranovic D, Bottini N, Deutscher J, Ruhdal Jensen P. Protein-tyrosine phosphorylation in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 9(3-4):189-97. PMID: 16415592.
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    78. Mustelin T, Vang T, Bottini N. Protein tyrosine phosphatases and the immune response. Nat Rev Immunol. 2005 Jan; 5(1):43-57. PMID: 15630428.
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    79. Ladner MB, Bottini N, Valdes AM, Noble JA. Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum Immunol. 2005 Jan; 66(1):60-4. PMID: 15620463.
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    80. Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem. 2005 Mar 11; 280(10):9400-8. PMID: 15615724.
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    81. Bottini M, Tautz L, Huynh H, Monosov E, Bottini N, Dawson MI, Bellucci S, Mustelin T. Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles. Chem Commun (Camb). 2005 Feb 14; (6):758-60. PMID: 15685328.
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    82. Bottini N, Magrini A, Cosmi E, Gloria-Bottini F, Saccucci P, Di Iorio R, Bergamaschi A, Bottini E. Genetics of signal transduction and the effect of maternal smoking on sex ratio of offspring. Am J Hum Biol. 2004 Sep-Oct; 16(5):588-92. PMID: 15368606.
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    83. Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol. 2004 Sep; 6(9):831-9. PMID: 15322554.
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    84. Mustelin T, Alonso A, Bottini N, Huynh H, Rahmouni S, Nika K, Louis-dit-Sully C, Tautz L, Togo SH, Bruckner S, Mena-Duran AV, al-Khouri AM. Protein tyrosine phosphatases in T cell physiology. Mol Immunol. 2004 Jul; 41(6-7):687-700. PMID: 15220004.
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    85. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11; 117(6):699-711. PMID: 15186772.
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    86. Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004 Apr; 36(4):337-8. PMID: 15004560.
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    87. Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T. Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Biochem J. 2004 Mar 01; 378(Pt 2):335-42. PMID: 14613483; PMCID: PMC1223964.
    88. Huynh H, Wang X, Li W, Bottini N, Williams S, Nika K, Ishihara H, Godzik A, Mustelin T. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. J Immunol. 2003 Dec 15; 171(12):6661-71. PMID: 14662869.
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    89. Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T. Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem. 2004 Feb 06; 279(6):4922-8. PMID: 14623872.
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    90. Lucarelli P, Palminiello S, Saccucci P, Bottini N, De Luca D, Elia M, Fiumara A, Curatolo P. Association study of autistic disorder and chromosome 16p. Am J Med Genet A. 2003 Jun 01; 119A(2):242-6. PMID: 12749074.
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    91. Meloni G, Bottini N, Borgiani P, Lucarelli P, Meloni T, Bottini E. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. Med Sci Monit. 2003 Mar; 9(3):CR105-8. PMID: 12640337.
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    92. Mustelin T, Rahmouni S, Bottini N, Alonso A. Role of protein tyrosine phosphatases in T cell activation. Immunol Rev. 2003 Feb; 191:139-47. PMID: 12614357.
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    93. Bottini N, Saccucci P, Piciullo A, Iannetti P, Lucarini N, Lucarelli P, Gloria-Bottini F, Curatolo P. Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample. Neurosci Lett. 2002 Nov 29; 333(3):159-62. PMID: 12429372.
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    94. Bottini N, MacMurray J, Peters W, Rostamkhani M, Comings DE. Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. Mol Genet Metab. 2002 Nov; 77(3):226-9. PMID: 12409270.
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    95. Bottini N, MacMurray J, Rostamkani M, McGue M, Iacono WG, Comings DE. Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. Neurosci Lett. 2002 Sep 20; 330(2):198-200. PMID: 12231445.
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    96. Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T. Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol. 2002 Jul 01; 169(1):286-91. PMID: 12077256.
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    97. Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem. 2002 Jul 05; 277(27):24220-4. PMID: 11976341.
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    98. Lucarelli P, Saccucci P, Bottini N, De Luca D, Fiumara A, Elia M, Bottini N, Porfirio MC, Curatolo P. Two-loci ADA haplotypes in autistic disorder. Am J Med Genet. 2002 Apr 01; 108(4):339-40. PMID: 11920843.
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    99. Bottini N, Bottini E, Gloria-Bottini F, Mustelin T. Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms. Arch Immunol Ther Exp (Warsz). 2002; 50(2):95-104. PMID: 12022706.
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    100. Bottini N, Mao XQ, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Shirakawa T, Hopkin JM. Low molecular weight PTP-IL-4RA interaction in atopy predisposition. Allergy. 2002; 57 Suppl 72:10-2. PMID: 12144546.
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    101. Greene LS, Bottini N, Borgiani P, Gloria-Bottini F. Acid phosphatase locus 1 (ACP1): Possible relationship of allelic variation to body size and human population adaptation to thermal stress-A theoretical perspective. Am J Hum Biol. 2000 Sep; 12(5):688-701. PMID: 11534062.
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