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Neville Bethel

Title(s)Assistant Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bond-centric modular design of protein assemblies. Nat Mater. 2025 Oct; 24(10):1644-1652. Wang S, Favor A, Kibler RD, Lubner JM, Borst AJ, Coudray N, Redler RL, Chiang HT, Sheffler W, Hsia Y, Bethel NP, Li Z, Ekiert DC, Bhabha G, Pozzo LD, Baker D. PMID: 40745093; PMCID: PMC12484077.
      View in: PubMed   Mentions: 3     Fields:    
    2. Local structural flexibility drives oligomorphism in computationally designed protein assemblies. Nat Struct Mol Biol. 2025 Jun; 32(6):1050-1060. Khmelinskaia A, Bethel NP, Fatehi F, Mallik BB, Antanasijevic A, Borst AJ, Lai SH, Chim HY, Wang JY', Miranda MC, Watkins AM, Ogohara C, Caldwell S, Wu M, Heck AJR, Veesler D, Ward AB, Baker D, Twarock R, King NP. PMID: 40011747; PMCID: PMC12170342.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    3. Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. Cell. 2024 Jul 11; 187(14):3726-3740.e43. Edman NI, Phal A, Redler RL, Schlichthaerle T, Srivatsan SR, Ehnes DD, Etemadi A, An SJ, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry CE, Schweppe DK, Freedman BS, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. PMID: 38861993; PMCID: PMC11246234.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    4. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024 Mar; 627(8005):898-904. Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. PMID: 38480887; PMCID: PMC10972742.
      View in: PubMed   Mentions: 19     Fields:    
    5. Local structural flexibility drives oligomorphism in computationally designed protein assemblies. bioRxiv. 2023 Oct 19. Khmelinskaia A, Bethel NP, Fatehi F, Antanasijevic A, Borst AJ, Lai SH, Wang JYJ, Mallik BB, Miranda MC, Watkins AM, Ogohara C, Caldwell S, Wu M, Heck AJR, Veesler D, Ward AB, Baker D, Twarock R, King NP. PMID: 37905007; PMCID: PMC10614843.
      View in: PubMed   Mentions:
    6. Precisely patterned nanofibres made from extendable protein multiplexes. Nat Chem. 2023 12; 15(12):1664-1671. Bethel NP, Borst AJ, Parmeggiani F, Bick MJ, Brunette TJ, Nguyen H, Kang A, Bera AK, Carter L, Miranda MC, Kibler RD, Lamb M, Li X, Sankaran B, Baker D. PMID: 37667012; PMCID: PMC10695826.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    7. Blueprinting expandable nanomaterials with standardized protein building blocks. bioRxiv. 2023 Jun 09. Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Weidle C, Han HL, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. PMID: 37333359; PMCID: PMC10274926.
      View in: PubMed   Mentions:
    8. Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. bioRxiv. 2023 Mar 15. Edman NI, Redler RL, Phal A, Schlichthaerle T, Srivatsan SR, Etemadi A, An SJ, Favor A, Ehnes D, Li Z, Praetorius F, Gordon M, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. PMID: 36993355; PMCID: PMC10055045.
      View in: PubMed   Mentions:
    9. Robust deep learning-based protein sequence design using ProteinMPNN. Science. 2022 10 07; 378(6615):49-56. Dauparas J, Anishchenko I, Bennett N, Bai H, Ragotte RJ, Milles LF, Wicky BIM, Courbet A, de Haas RJ, Bethel N, Leung PJY, Huddy TF, Pellock S, Tischer D, Chan F, Koepnick B, Nguyen H, Kang A, Sankaran B, Bera AK, King NP, Baker D. PMID: 36108050; PMCID: PMC9997061.
      View in: PubMed   Mentions: 602     Fields:    Translation:Cells
    10. Computational design of mechanically coupled axle-rotor protein assemblies. Science. 2022 04 22; 376(6591):383-390. Courbet A, Hansen J, Hsia Y, Bethel N, Park YJ, Xu C, Moyer A, Boyken SE, Ueda G, Nattermann U, Nagarajan D, Silva DA, Sheffler W, Quispe J, Nord A, King N, Bradley P, Veesler D, Kollman J, Baker D. PMID: 35446645; PMCID: PMC10712554.
      View in: PubMed   Mentions: 21     Fields:    
    11. Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells. ACS Synth Biol. 2022 03 18; 11(3):1292-1302. Veling MT, Nguyen DT, Thadani NN, Oster ME, Rollins NJ, Brock KP, Bethel NP, Lim S, Baker D, Way JC, Marks DS, Chang RL, Silver PA. PMID: 35176859; PMCID: PMC9651988.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    12. A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel. J Gen Physiol. 2019 03 04; 151(3):316-327. Argudo D, Capponi S, Bethel NP, Grabe M. PMID: 30728217; PMCID: PMC6400526.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    13. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. PMID: 30622179; PMCID: PMC6347726.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    14. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 03 07; 97(5):1063-1077.e4. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. PMID: 29478917; PMCID: PMC5860880.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    15. Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell. 2017 Jul 15; 28(15):2076-2090. Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL. PMID: 28539401; PMCID: PMC5509421.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    16. New Continuum Approaches for Determining Protein-Induced Membrane Deformations. Biophys J. 2017 May 23; 112(10):2159-2172. Argudo D, Bethel NP, Marcoline FV, Wolgemuth CW, Grabe M. PMID: 28538153; PMCID: PMC5448241.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    17. Atomistic insight into lipid translocation by a TMEM16 scramblase. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):14049-14054. Bethel NP, Grabe M. PMID: 27872308; PMCID: PMC5150362.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    18. Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models. Biochim Biophys Acta. 2016 Jul; 1858(7 Pt B):1619-34. Argudo D, Bethel NP, Marcoline FV, Grabe M. PMID: 26853937; PMCID: PMC4877259.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    19. Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations. Structure. 2015 Aug 04; 23(8):1526-1537. Marcoline FV, Bethel N, Guerriero CJ, Brodsky JL, Grabe M. PMID: 26118532; PMCID: PMC4527966.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    20. Interrelation between external oscillatory muscle coupling amplitude and in vivo intramedullary pressure related bone adaptation. Bone. 2014 Sep; 66:178-81. Hu M, Cheng J, Bethel N, Serra-Hsu F, Ferreri S, Lin L, Qin YX. PMID: 24947450; PMCID: PMC4125428.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. Dynamic hydraulic fluid stimulation regulated intramedullary pressure. Bone. 2013 Nov; 57(1):137-41. Hu M, Serra-Hsu F, Bethel N, Lin L, Ferreri S, Cheng J, Qin YX. PMID: 23895997; PMCID: PMC3832679.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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