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    Morgan Desantis

    TitlePostdoctoral Scholar
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0694
    CA La Jolla 92093
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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. PMID: 28886386.
        View in: PubMed
      2. Redwine WB, DeSantis ME, Hollyer I, Htet ZM, Tran PT, Swanson SK, Florens L, Washburn MP, Reck-Peterson SL. The human cytoplasmic dynein interactome reveals novel activators of motility. Elife. 2017 Jul 18; 6. PMID: 28718761.
        View in: PubMed
      3. Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. PMID: 26436706; PMCID: PMC4644480 [Available on 11/13/16].
      4. Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol Cell. 2015 Mar 05; 57(5):836-49. PMID: 25620563; PMCID: PMC4623595.
      5. Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 2014 Jan 16; 156(1-2):170-82. PMID: 24439375; PMCID: PMC3909490.
      6. Desantis M, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. J Biol Chem. 2014 Jan 10; 289(2):848-67. PMID: 24280225; PMCID: PMC3887210.
      7. Coelho M, Dereli A, Haese A, Kühn S, Malinovska L, DeSantis ME, Shorter J, Alberti S, Gross T, Tolic-Nørrelykke IM. Fission yeast does not age under favorable conditions, but does so after stress. Curr Biol. 2013 Oct 07; 23(19):1844-52. PMID: 24035542; PMCID: PMC4620659.
      8. DeSantis ME, Shorter J. Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)]. Chem Biol. 2012 Nov 21; 19(11):1400-10. PMID: 23177195; PMCID: PMC3508465.
      9. DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell. 2012 Nov 09; 151(4):778-93. PMID: 23141537; PMCID: PMC3496281.
      10. Acchione M, Lee YC, DeSantis ME, Lipschultz CA, Wlodawer A, Li M, Shanmuganathan A, Walter RL, Smith-Gill S, Barchi JJ. Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics. Biochemistry. 2012 Jul 31; 51(30):6017-27. PMID: 22769726; PMCID: PMC3508667.
      11. Sweeny EA, DeSantis ME, Shorter J. Purification of hsp104, a protein disaggregase. J Vis Exp. 2011 Sep 30; (55). PMID: 21989490; PMCID: PMC3230206.
      12. Desantis M, Shorter J. The elusive middle domain of Hsp104 and ClpB: location and function. Biochim Biophys Acta. 2012 Jan; 1823(1):29-39. PMID: 21843558; PMCID: PMC3219823.
      13. DeSantis ME, Dersh D. Preventing Parkinson's pathology. Dis Model Mech. 2010 Jul-Aug; 3(7-8):399-400. PMID: 20483997.
        View in: PubMed
      14. Acchione M, Lipschultz CA, DeSantis ME, Shanmuganathan A, Li M, Wlodawer A, Tarasov S, Smith-Gill SJ. Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies. Mol Immunol. 2009 Dec; 47(2-3):457-64. PMID: 19781789.
        View in: PubMed
      15. Mohan S, Kourentzi K, Schick KA, Uehara C, Lipschultz CA, Acchione M, Desantis M, Smith-Gill SJ, Willson RC. Association energetics of cross-reactive and specific antibodies. Biochemistry. 2009 Feb 17; 48(6):1390-8. PMID: 19166328; PMCID: PMC2713044.
      16. Lohmeyer M, Harrison PM, Kannan S, DeSantis M, O'Reilly NJ, Sternberg MJ, Salomon DS, Gullick WJ. Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto. Biochemistry. 1997 Apr 01; 36(13):3837-45. PMID: 9092813.
        View in: PubMed