Morgan Desantis

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0694
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19; 173(3):677-692.e20. PMID: 29677512.
      View in: PubMed
    2. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. PMID: 28886386.
      View in: PubMed
    3. Redwine WB, DeSantis ME, Hollyer I, Htet ZM, Tran PT, Swanson SK, Florens L, Washburn MP, Reck-Peterson SL. The human cytoplasmic dynein interactome reveals novel activators of motility. Elife. 2017 07 18; 6. PMID: 28718761.
      View in: PubMed
    4. Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. PMID: 26436706; PMCID: PMC4644480 [Available on 11/13/16].
    5. Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol Cell. 2015 Mar 05; 57(5):836-849. PMID: 25620563.
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    6. Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 2014 Jan 16; 156(1-2):170-82. PMID: 24439375; PMCID: PMC3909490.
    7. Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. J Biol Chem. 2014 Jan 10; 289(2):848-67. PMID: 24280225; PMCID: PMC3887210.
    8. Coelho M, Dereli A, Haese A, Kühn S, Malinovska L, DeSantis ME, Shorter J, Alberti S, Gross T, Tolic-Nørrelykke IM. Fission yeast does not age under favorable conditions, but does so after stress. Curr Biol. 2013 Oct 07; 23(19):1844-52. PMID: 24035542; PMCID: PMC4620659.
    9. DeSantis ME, Shorter J. Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)]. Chem Biol. 2012 Nov 21; 19(11):1400-10. PMID: 23177195; PMCID: PMC3508465.
    10. DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell. 2012 Nov 09; 151(4):778-93. PMID: 23141537; PMCID: PMC3496281.
    11. Acchione M, Lee YC, DeSantis ME, Lipschultz CA, Wlodawer A, Li M, Shanmuganathan A, Walter RL, Smith-Gill S, Barchi JJ. Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics. Biochemistry. 2012 Jul 31; 51(30):6017-27. PMID: 22769726.
      View in: PubMed
    12. Sweeny EA, DeSantis ME, Shorter J. Purification of hsp104, a protein disaggregase. J Vis Exp. 2011 Sep 30; (55). PMID: 21989490; PMCID: PMC3230206.
    13. Desantis ME, Shorter J. The elusive middle domain of Hsp104 and ClpB: location and function. Biochim Biophys Acta. 2012 Jan; 1823(1):29-39. PMID: 21843558; PMCID: PMC3219823.
    14. DeSantis ME, Dersh D. Preventing Parkinson's pathology. Dis Model Mech. 2010 Jul-Aug; 3(7-8):399-400. PMID: 20483997.
      View in: PubMed
    15. Acchione M, Lipschultz CA, DeSantis ME, Shanmuganathan A, Li M, Wlodawer A, Tarasov S, Smith-Gill SJ. Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies. Mol Immunol. 2009 Dec; 47(2-3):457-64. PMID: 19781789.
      View in: PubMed
    16. Mohan S, Kourentzi K, Schick KA, Uehara C, Lipschultz CA, Acchione M, Desantis ME, Smith-Gill SJ, Willson RC. Association energetics of cross-reactive and specific antibodies. Biochemistry. 2009 Feb 17; 48(6):1390-8. PMID: 19166328.
      View in: PubMed
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