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Michael Matthias

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0760
La Jolla CA 92093
Phone858-534-6604
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    Collapse Research 
    Collapse Research Activities and Funding
    B12 Autotrophy as a Virulence Mechanism in Infectious Leptospira
    NIH/NIAID R21AI115273Jul 15, 2015 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fernandez C, Lubar AA, Vinetz JM, Matthias MA. Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae. Am J Trop Med Hyg. 2018 Jun 25. PMID: 29943708.
      View in: PubMed
    2. Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017 02 15; 17(1):133. PMID: 28201999.
      View in: PubMed
    3. Wunder EA, Figueira CP, Santos GR, Lourdault K, Matthias MA, Vinetz JM, Ramos E, Haake DA, Picardeau M, Dos Reis MG, Ko AI. Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters. Infect Immun. 2016 07; 84(7):2105-2115. PMID: 27141082.
      View in: PubMed
    4. Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis. 2016 Feb; 10(2):e0004403. PMID: 26890609; PMCID: PMC4758666.
    5. Lehmann JS, Corey VC, Ricaldi JN, Vinetz JM, Winzeler EA, Matthias MA. Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. Am J Trop Med Hyg. 2016 Feb; 94(2):302-13. PMID: 26711524; PMCID: PMC4751964.
    6. RamachandraRao SP, Matthias MA, Kokoy-Mondrogon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. Correction: Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003718. PMID: 25860882; PMCID: PMC4393270.
    7. RamachandraRao SP, Matthias MA, Kokoy-Mondragon C, Mondrogon CK, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003640. PMID: 25793258; PMCID: PMC4368819.
    8. Lehmann JS, Matthias MA, Vinetz JM, Fouts DE. Leptospiral pathogenomics. Pathogens. 2014 Apr 10; 3(2):280-308. PMID: 25437801; PMCID: PMC4243447.
    9. Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, Perera M, Priyankara S, Weerawansa P, Matthias MA, Vinetz JM. Regional differences of leptospirosis in Sri Lanka: observations from a flood-associated outbreak in 2011. PLoS Negl Trop Dis. 2014; 8(1):e2626. PMID: 24454971; PMCID: PMC3894175.
    10. Lehmann JS, Fouts DE, Haft DH, Cannella AP, Ricaldi JN, Brinkac L, Harkins D, Durkin S, Sanka R, Sutton G, Moreno A, Vinetz JM, Matthias MA. Pathogenomic inference of virulence-associated genes in Leptospira interrogans. PLoS Negl Trop Dis. 2013; 7(10):e2468. PMID: 24098822; PMCID: PMC3789758.
    11. Ricaldi JN, Swancutt MA, Matthias MA. Current trends in translational research in leptospirosis. Curr Opin Infect Dis. 2013 Oct; 26(5):399-403. PMID: 23982231.
      View in: PubMed
    12. Román K, Castillo R, Gilman RH, Calderón M, Vivar A, Céspedes M, Smits HL, Meléndez P, Gotuzzo E, Guerra H, Maves RC, Matthias MA, Vinetz JM, Saito M. A foodborne outbreak of brucellosis at a police station cafeteria, Lima, Peru. Am J Trop Med Hyg. 2013 Mar; 88(3):552-8. PMID: 23382164.
      View in: PubMed
    13. Agampodi SB, Moreno AC, Vinetz JM, Matthias MA. Utility and limitations of direct multi-locus sequence typing on qPCR-positive blood to determine infecting Leptospira strain. Am J Trop Med Hyg. 2013 Jan; 88(1):184-5. PMID: 23208890; PMCID: PMC3541733.
    14. Ricaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA. Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity. PLoS Negl Trop Dis. 2012; 6(10):e1853. PMID: 23145189; PMCID: PMC3493377.
    15. Ricaldi JN, Matthias MA, Vinetz JM, Lewis AL. Expression of sialic acids and other nonulosonic acids in Leptospira. BMC Microbiol. 2012 Aug 01; 12:161. PMID: 22853805; PMCID: PMC3438082.
    16. Kosek M, Yori PP, Gilman RH, Calderon M, Zimic M, Chuquiyauri R, Jeri C, Pinedo-Cancino V, Matthias MA, Llanos-Cuentas A, Vinetz JM. High degree of Plasmodium vivax diversity in the Peruvian Amazon demonstrated by tandem repeat polymorphism analysis. Am J Trop Med Hyg. 2012 Apr; 86(4):580-6. PMID: 22492139; PMCID: PMC3403772.
    17. Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of quantitative polymerase chain reaction in leptospirosis diagnosis: association of level of leptospiremia and clinical manifestations in Sri Lanka. Clin Infect Dis. 2012 May; 54(9):1249-55. PMID: 22354922; PMCID: PMC3404689.
    18. Ganoza CA, Matthias MA, Saito M, Cespedes M, Gotuzzo E, Vinetz JM. Asymptomatic renal colonization of humans in the peruvian Amazon by Leptospira. PLoS Negl Trop Dis. 2010 Feb 23; 4(2):e612. PMID: 20186328; PMCID: PMC2826405.
    19. Matthias MA, Ricaldi JN, Cespedes M, Diaz MM, Galloway RL, Saito M, Steigerwalt AG, Patra KP, Ore CV, Gotuzzo E, Gilman RH, Levett PN, Vinetz JM. Human leptospirosis caused by a new, antigenically unique Leptospira associated with a Rattus species reservoir in the Peruvian Amazon. PLoS Negl Trop Dis. 2008 Apr 02; 2(4):e213. PMID: 18382606; PMCID: PMC2271056.
    20. Barry M, Wisnewski AV, Matthias MA, Inouye SK, Vinetz JM. Suburban leptospirosis: atypical lymphocytosis and gamma-delta T cell response. Clin Infect Dis. 2006 Nov 15; 43(10):1304-7. PMID: 17051497.
      View in: PubMed
    21. Ganoza CA, Matthias MA, Collins-Richards D, Brouwer KC, Cunningham CB, Segura ER, Gilman RH, Gotuzzo E, Vinetz JM. Determining risk for severe leptospirosis by molecular analysis of environmental surface waters for pathogenic Leptospira. PLoS Med. 2006 Aug; 3(8):e308. PMID: 16933963; PMCID: PMC1551915.
    22. Viriyakosol S, Matthias MA, Swancutt MA, Kirkland TN, Vinetz JM. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006 Feb; 74(2):887-95. PMID: 16428731; PMCID: PMC1360355.
    23. Matthias MA, Díaz MM, Campos KJ, Calderon M, Willig MR, Pacheco V, Gotuzzo E, Gilman RH, Vinetz JM. Diversity of bat-associated Leptospira in the Peruvian Amazon inferred by bayesian phylogenetic analysis of 16S ribosomal DNA sequences. Am J Trop Med Hyg. 2005 Nov; 73(5):964-74. PMID: 16282313; PMCID: PMC2270400.
    24. Segura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, Céspedes MJ, Matthias MA, Swancutt MA, López Liñán R, Gotuzzo E, Guerra H, Gilman RH, Vinetz JM. Clinical spectrum of pulmonary involvement in leptospirosis in a region of endemicity, with quantification of leptospiral burden. Clin Infect Dis. 2005 Feb 01; 40(3):343-51. PMID: 15668855; PMCID: PMC2366057.
    25. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis. 2003 Dec; 3(12):757-71. PMID: 14652202.
      View in: PubMed
    26. Klimpel GR, Matthias MA, Vinetz JM. Leptospira interrogans activation of human peripheral blood mononuclear cells: preferential expansion of TCR gamma delta+ T cells vs TCR alpha beta+ T cells. J Immunol. 2003 Aug 01; 171(3):1447-55. PMID: 12874237.
      View in: PubMed