Michael Croft

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Immune Regulation by Deubiquitination
    NIH R01AI140130Sep 19, 2018 - Aug 31, 2023
    Role: Principal Investigator
    TWEAK and Skin Inflammation
    NIH R01AR072640Jul 18, 2018 - Apr 30, 2023
    Role: Principal Investigator
    LIGHT/TNFSF14 in allergic esophagitis remodeling
    NIH R01DK114457Apr 1, 2018 - Feb 28, 2022
    Role: Principal Investigator
    Training in Immunological Mechanisms
    NIH T32AI125179Aug 1, 2016 - Jul 31, 2026
    Role: Principal Investigator
    Novel PTPRD interaction Controlling T cell Responsiveness
    NIH R21AI123134Jan 15, 2016 - Dec 31, 2017
    Role: Principal Investigator
    Structural Characterization of 4-1BB-Galectin-9 Complexes
    NIH R03AI110929Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Control of Airway Tolerance
    NIH R01AI103021May 15, 2013 - Apr 30, 2018
    Role: Principal Investigator
    TNF Family Members and Control of Fibrotic Disease
    NIH R21AI100905Jul 2, 2012 - Jun 30, 2014
    Role: Principal Investigator
    FACSAria II Cell Sorter
    NIH S10RR027366Mar 7, 2011 - Mar 6, 2012
    Role: Principal Investigator
    Induction and maintenance of regulatory T cells
    NIH P01AI089624Jul 16, 2010 - Jun 30, 2015
    Role: Co-Investigator
    Tolerogenic Interactions of 4-1BB
    NIH R21AI085291Feb 10, 2010 - Jan 31, 2011
    Role: Principal Investigator
    Airway Inflammation and Airway Remodeling in Severe Asthma
    NIH U19AI070535Jul 1, 2006 - Jun 30, 2026
    Role: Co-Investigator
    TNFR Members in T Cell Immunity to Vaccinia
    NIH R01AI067341Jun 15, 2006 - May 31, 2011
    Role: Principal Investigator
    TNFR Members in T Cell Immunity to Vaccinia
    NIH R56AI067341Dec 1, 2005 - Aug 31, 2013
    Role: Principal Investigator
    NIH P01AI050498Sep 10, 2001 - Jun 30, 2007
    Role: Co-Investigator
    Regulation of T Cell Tolerance by OX40
    NIH R01CA091837Jul 1, 2001 - May 31, 2013
    Role: Principal Investigator
    The molecular basis of OX40 on CD4 T cells
    NIH R01AI049453Apr 1, 2001 - Nov 30, 2012
    Role: Principal Investigator
    NIH R03AI043298Aug 1, 1998 - Jul 31, 2001
    Role: Principal Investigator
    NIH R03AG015638Jul 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    The Role of 4-1BB in T Cell and APC Interactions
    NIH R01AI042944Apr 1, 1998 - Apr 30, 2011
    Role: Principal Investigator
    NIH U19AI042244Sep 30, 1997 - Oct 15, 2001
    Role: Co-Investigator
    NIH R29AI036259Aug 15, 1994 - Jul 31, 1999
    Role: Principal Investigator
    NIH P60AR040770Aug 1, 1991 - Feb 28, 2002
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. J Immunol. 2022 Oct 26. Manresa MC, Miki H, Miller J, Okamoto K, Dobaczewska K, Herro R, Gupta RK, Kurten R, Aceves SS, Croft M. PMID: 36426994.
      View in: PubMed   Mentions: 1     Fields:    
    2. A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. J Immunol. 2022 Oct 26. Manresa MC, Miki H, Miller J, Okamoto K, Dobaczewska K, Herro R, Gupta RK, Kurten R, Aceves SS, Croft M. PMID: 36288906; PMCID: PMC10130236.
      View in: PubMed   Mentions: 4     Fields:    
    3. LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms. Mucosal Immunol. 2022 02; 15(2):327-337. Manresa MC, Wu A, Nhu QM, Chiang AWT, Okamoto K, Miki H, Kurten R, Pham E, Duong LD, Lewis NE, Akuthota P, Croft M, Aceves SS. PMID: 34903876; PMCID: PMC8866113.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Gastroenterology. 2020 11; 159(5):1778-1792.e13. Manresa MC, Chiang AWT, Kurten RC, Dohil R, Brickner H, Dohil L, Herro R, Akuthota P, Lewis NE, Croft M, Aceves SS. PMID: 32712105; PMCID: PMC7726704.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    5. Unconventional ST2- and CD127-negative lung ILC2 populations are induced by the fungal allergen Alternaria alternata. J Allergy Clin Immunol. 2019 11; 144(5):1432-1435.e9. Cavagnero KJ, Badrani JH, Naji LH, Amadeo MB, Shah VS, Gasparian S, Pham A, Wang AW, Seumois G, Croft M, Broide DH, Doherty TA. PMID: 31369800; PMCID: PMC6938690.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    6. Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation. J Immunol. 2017 10 01; 199(7):2215-2224. Song DJ, Miller M, Beppu A, Rosenthal P, Das S, Karta M, Vuong C, Mehta AK, Croft M, Broide DH. PMID: 28827284; PMCID: PMC5605463.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017 08 01; 199(3):1096-1104. Lund SJ, Portillo A, Cavagnero K, Baum RE, Naji LH, Badrani JH, Mehta A, Croft M, Broide DH, Doherty TA. PMID: 28667163; PMCID: PMC5531601.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    8. Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases. Nat Rev Rheumatol. 2017 Apr; 13(4):217-233. Croft M, Siegel RM. PMID: 28275260; PMCID: PMC5486401.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    9. Accessory Molecule and Costimulation Requirements for CD4 T Cell Response. Crit Rev Immunol. 2017; 37(2-6):261-290. Croft M, Dubey C. PMID: 29773023.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. How Mouse Macrophages Sense What Is Going On. Front Immunol. 2016; 7:204. Ley K, Pramod AB, Croft M, Ravichandran KS, Ting JP. PMID: 27313577; PMCID: PMC4890338.
      View in: PubMed   Mentions: 47     Fields:    
    11. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 2015 Oct 15; 195(8):3546-56. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH. PMID: 26355153; PMCID: PMC4811198.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol. 2013 Jul; 132(1):205-13. Doherty TA, Khorram N, Lund S, Mehta AK, Croft M, Broide DH. PMID: 23688412; PMCID: PMC3704056.
      View in: PubMed   Mentions: 209     Fields:    Translation:AnimalsCells
    13. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 01; 303(7):L577-88. Doherty TA, Khorram N, Chang JE, Kim HK, Rosenthal P, Croft M, Broide DH. PMID: 22865552; PMCID: PMC3469584.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    14. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9. Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. PMID: 22327070; PMCID: PMC3294141.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    15. Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J Immunol. 2009 Oct 15; 183(8):5333-41. Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide DH. PMID: 19783675; PMCID: PMC2788790.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    16. CD4 T cell priming in dendritic cell-deficient mice. Int Immunol. 2003 Jan; 15(1):127-36. Castiglioni P, Lu C, Lo D, Croft M, Langlade-Demoyen P, Zanetti M, Gerloni M. PMID: 12502733.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Microchimerism does not induce tolerance and sustains immunity after in utero transplantation. Transplantation. 2001 Feb 15; 71(3):359-68. Donahue J, Gilpin E, Lee TH, Busch MP, Croft M, Carrier E. PMID: 11233894.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Functional cooperation between T helper cell determinants. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13269-74. Gerloni M, Xiong S, Mukerjee S, Schoenberger SP, Croft M, Zanetti M. PMID: 11069291; PMCID: PMC27214.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    19. Activation of CD4 T cells by somatic transgenesis induces generalized immunity of uncommitted T cells and immunologic memory. J Immunol. 1999 Apr 01; 162(7):3782-9. Gerloni M, Miner KT, Xiong S, Croft M, Zanetti M. PMID: 10201894.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Accessory molecule and costimulation requirements for CD4 T cell response. Crit Rev Immunol. 1997; 17(1):89-118. Croft M, Dubey C. PMID: 9034725.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    21. From naive to memory T cells. Immunol Rev. 1996 Apr; 150:143-67. Swain SL, Croft M, Dubey C, Haynes L, Rogers P, Zhang X, Bradley LM. PMID: 8782706.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    22. Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. Int Immunol. 1996 Feb; 8(2):275-85. Jaiswal AI, Dubey C, Swain SL, Croft M. PMID: 8671613.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    23. Accessory molecule regulation of naive CD4 T cell activation. Immunol Res. 1996; 15(2):114-25. Dubey C, Croft M. PMID: 8839780.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J Immunol. 1995 Jul 01; 155(1):45-57. Dubey C, Croft M, Swain SL. PMID: 7541426.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    25. Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol. 1995 May 01; 154(9):4269-82. Croft M, Swain SL. PMID: 7536767.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    26. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med. 1994 Nov 01; 180(5):1715-28. Croft M, Carter L, Swain SL, Dutton RW. PMID: 7525836; PMCID: PMC2191720.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    27. Activation of naive, memory and effector T cells. Curr Opin Immunol. 1994 Jun; 6(3):431-7. Croft M. PMID: 7917111.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    28. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol. 1994 Mar 15; 152(6):2675-85. Croft M, Bradley LM, Swain SL. PMID: 7908301.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    29. T-cell memory: new perspectives. Immunol Today. 1993 May; 14(5):197-9. Bradley LM, Croft M, Swain SL. PMID: 8100135.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    30. Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells. J Immunol. 1992 Nov 15; 149(10):3157-65. Croft M, Swain SL. PMID: 1358966.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements. J Exp Med. 1992 Nov 01; 176(5):1431-7. Croft M, Duncan DD, Swain SL. PMID: 1357074; PMCID: PMC2119425.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    32. B cell response to T helper cell subsets. II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity. J Immunol. 1991 Dec 01; 147(11):3679-89. Croft M, Swain SL. PMID: 1682380.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev. 1991 Oct; 123:115-44. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RW, Huston G. PMID: 1684776.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    34. B cell response to fresh and effector T helper cells. Role of cognate T-B interaction and the cytokines IL-2, IL-4, and IL-6. J Immunol. 1991 Jun 15; 146(12):4055-64. Croft M, Swain SL. PMID: 1828258.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. Critical role of cognate interactions in the response of small, high-density B cells. Res Immunol. 1990 May-Jun; 141(4-5):431-40. Swain SL, Croft M. PMID: 2148429.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells