Mei Yueh

TitleAssociate Project Scientist
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0722
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    The antimicrobial triclosan is a potent liver tumor promoter
    NIH R21ES023906Jan 21, 2015 - Dec 31, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lu W, Rettenmeier E, Paszek M, Yueh M, Tukey RH, Trottier J, Barbier O, Chen S. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 07; 45(7):748-754. PMID: 28468837.
      View in: PubMed
    2. Yueh M, Chen S, Nguyen N, Tukey RH. Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553. PMID: 28283555.
      View in: PubMed
    3. Chen S, Lu W, Yueh M, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. PMID: 28167773.
      View in: PubMed
    4. Liu M, Chen S, Yueh M, Fujiwara R, Konopnicki C, Hao H, Tukey RH. Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46. PMID: 27060662; PMCID: PMC5010383 [Available on 06/15/17].
    5. Yueh M, Tukey RH. Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annu Rev Pharmacol Toxicol. 2016; 56:251-72. PMID: 26738475; PMCID: PMC4774862 [Available on 01/06/17].
    6. Barateiro A, Chen S, Yueh M, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93. PMID: 26480925; PMCID: PMC4702100 [Available on 01/01/17].
    7. Liu M, Chen S, Yueh M, Wang G, Hao H, Tukey RH. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5. PMID: 26807433.
      View in: PubMed
    8. Yueh M, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. PMID: 25404284; PMCID: PMC4260592.
    9. Yueh M, Chen S, Nguyen N, Tukey RH. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709. PMID: 24403077; PMCID: PMC3931032.
    10. Chen S, Yueh M, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. PMID: 24191041; PMCID: PMC3839688.
    11. Yueh M, Li T, Evans RM, Hammock B, Tukey RH. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 2012; 7(6):e37705. PMID: 22761658; PMCID: PMC3376094.
    12. Chen S, Yueh M, Evans RM, Tukey RH. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. PMID: 22371261; PMCID: PMC3383890.
    13. Chouinard S, Yueh M, Tukey RH, Giton F, Fiet J, Pelletier G, Barbier O, BĂ©langer A. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008 Apr; 109(3-5):247-53. PMID: 18467088.
      View in: PubMed
    14. Yueh M, Tukey RH. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem. 2007 Mar 23; 282(12):8749-58. PMID: 17259171.
      View in: PubMed
    15. Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh M, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27. PMID: 17151188.
      View in: PubMed
    16. Trubetskoy O, Marks B, Zielinski T, Yueh M, Raucy J. A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. AAPS J. 2005 Mar 04; 7(1):E6-13. PMID: 16146350; PMCID: PMC2751492.
    17. Yueh M, Kawahara M, Raucy J. Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol In Vitro. 2005 Mar; 19(2):275-87. PMID: 15649641.
      View in: PubMed
    18. Yueh M, Bonzo JA, Tukey RH. The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1. Methods Enzymol. 2005; 400:75-91. PMID: 16399344.
      View in: PubMed
    19. Yueh M, Kawahara M, Raucy J. High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. Drug Metab Dispos. 2005 Jan; 33(1):38-48. PMID: 15466163.
      View in: PubMed
    20. Yueh M, Huang YH, Hiller A, Chen S, Nguyen N, Tukey RH. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003 Apr 25; 278(17):15001-6. PMID: 12566446.
      View in: PubMed
    21. Raucy J, Warfe L, Yueh M, Allen SW. A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. J Pharmacol Exp Ther. 2002 Oct; 303(1):412-23. PMID: 12235278.
      View in: PubMed
    22. Krueger SK, Williams DE, Yueh M, Martin SR, Hines RN, Raucy JL, Dolphin CT, Shephard EA, Phillips IR. Genetic polymorphisms of flavin-containing monooxygenase (FMO). Drug Metab Rev. 2002 Aug; 34(3):523-32. PMID: 12214664.
      View in: PubMed
    23. Larsen-Su SA, Krueger SK, Yueh M, Pereira CB, Williams DE. Developmental regulation of flavin-containing monooxygenase form 1 in the liver and kidney of fetal and neonatal rabbits. Biochem Pharmacol. 2002 Apr 01; 63(7):1353-9. PMID: 11960612.
      View in: PubMed
    24. Krueger SK, Martin SR, Yueh M, Pereira CB, Williams DE. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. Drug Metab Dispos. 2002 Jan; 30(1):34-41. PMID: 11744609.
      View in: PubMed