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    Maya Kunkel

    TitleAssociate Project Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0721
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Coordination of signaling at the NHERF scaffold
      NIH R03CA178524Apr 2, 2014 - Mar 31, 2016
      Role: Principal Investigator
      NIH F32GM019822Jun 15, 1999
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel M, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-73. PMID: 27226531; PMCID: PMC4933157 [Available on 07/01/17].
      2. Dusaban SS, Kunkel M, Smrcka AV, Brown JH. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C?. J Biol Chem. 2015 Oct 30; 290(44):26776-83. PMID: 26350460; PMCID: PMC4646330 [Available on 10/30/16].
      3. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel M, Newton AC, Ghosh P. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E937-46. PMID: 25713130; PMCID: PMC4352799.
      4. Kunkel M, Newton AC. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chem Biol. 2015 Jan 22; 22(1):98-106. PMID: 25556943; PMCID: PMC4311772.
      5. Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel M, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E3957-65. PMID: 25201979; PMCID: PMC4183331.
      6. Antal CE, Violin JD, Kunkel M, Skovsø S, Newton AC. Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol. 2014 Apr 24; 21(4):459-469. PMID: 24631122; PMCID: PMC4020788.
      7. Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel M, Newton AC, Sosinsky GE. Protein kinase Cd-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem. 2014 Mar 28; 289(13):8781-98. PMID: 24500718; PMCID: PMC3979370.
      8. Kunkel M, Newton AC. Imaging kinase activity at protein scaffolds. Methods Mol Biol. 2014; 1071:129-37. PMID: 24052385; PMCID: PMC4043534.
      9. Bossuyt J, Chang CW, Helmstadter K, Kunkel M, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. PMID: 21795686; PMCID: PMC3190922.
      10. Gould CM, Antal CE, Reyes G, Kunkel M, Adams RA, Ziyar A, Riveros T, Newton AC. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem. 2011 Aug 19; 286(33):28922-30. PMID: 21715334; PMCID: PMC3190699.
      11. Kunkel M, Newton AC. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes. J Biol Chem. 2010 Jul 23; 285(30):22748-52. PMID: 20519514; PMCID: PMC2906264.
      12. Kunkel M, Newton AC. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Curr Protoc Chem Biol. 2009 Dec 01; 1(1):17-18. PMID: 21804950.
        View in: PubMed
      13. Kunkel M, Garcia EL, Kajimoto T, Hall RA, Newton AC. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem. 2009 Sep 04; 284(36):24653-61. PMID: 19581308; PMCID: PMC2782054.
      14. Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel M, Newton AC, Langeberg LK, Scott JD. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008 Oct 24; 32(2):169-79. PMID: 18951085; PMCID: PMC3169907.
      15. Kunkel M, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem. 2007 Mar 02; 282(9):6733-42. PMID: 17189263; PMCID: PMC2921767.
      16. Gallegos LL, Kunkel M, Newton AC. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem. 2006 Oct 13; 281(41):30947-56. PMID: 16901905.
        View in: PubMed
      17. Kunkel M, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005 Feb 18; 280(7):5581-7. PMID: 15583002; PMCID: PMC2913970.
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