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    Maurizio Pellecchia

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-646-3159
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wu B, De SK, Kulinich A, Salem AF, Koeppen J, Wang R, Barile E, Wang S, Zhang D, Ethell I, Pellecchia M. Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol. 2017 Mar 16; 24(3):293-305. PMID: 28196613.
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      2. Barile E, Marconi GD, De SK, Baggio C, Gambini L, Salem AF, Kashyap MK, Castro JE, Kipps TJ, Pellecchia M. hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. ACS Chem Biol. 2016 Dec 27. PMID: 28026162.
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      3. Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, Fisher PB. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2016 Dec 23. PMID: 28011764.
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      4. Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J. Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKC?/?. Cell Rep. 2016 Sep 20; 16(12):3297-310. PMID: 27653691.
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      5. Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson CH. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4; 19(2):177-91. PMID: 27292188.
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      6. Baggio C, Barile E, Di Sorbo G, Kipps TJ, Pellecchia M. The Cell Surface Receptor CD44: NMR-Based Characterization of Putative Ligands. ChemMedChem. 2016 May 19; 11(10):1097-106. PMID: 27144715.
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      7. Quinn BA, Wang S, Barile E, Das SK, Emdad L, Sarkar D, De SK, Morvaridi SK, Stebbins JL, Pandol SJ, Fisher PB, Pellecchia M. Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. Oncotarget. 2016 Mar 29; 7(13):17103-10. PMID: 26959746.
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      8. Paasonen L, Sharma S, Braun GB, Kotamraju VR, Chung TD, She ZG, Sugahara KN, Yliperttula M, Wu B, Pellecchia M, Ruoslahti E, Teesalu T. New p32/gC1qR Ligands for Targeted Tumor Drug Delivery. Chembiochem. 2016 Apr 1; 17(7):570-5. PMID: 26895508.
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      9. Feng Y, Pinkerton AB, Hulea L, Zhang T, Davies MA, Grotegut S, Cheli Y, Yin H, Lau E, Kim H, De SK, Barile E, Pellecchia M, Bosenberg M, Li JL, James B, Hassig CA, Brown KM, Topisirovic I, Ronai ZA. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res. 2015 Dec 15; 75(24):5211-8. PMID: 26603897.
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      10. Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M. High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH. ChemMedChem. 2016 Apr 19; 11(8):919-27. PMID: 26592695.
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      11. Sarkar S, Pradhan A, Das SK, Emdad L, Sarkar D, Pellecchia M, Fisher PB. Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic. Oncoimmunology. 2016 Mar; 5(3):e1078059. PMID: 27141334.
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      12. Maji S, Samal SK, Pattanaik L, Panda S, Quinn BA, Das SK, Sarkar D, Pellecchia M, Fisher PB, Dash R. Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. Oncotarget. 2015 Jun 30; 6(18):16623-37. PMID: 26009874.
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      13. Pan R, Ruvolo VR, Wei J, Konopleva M, Reed JC, Pellecchia M, Andreeff M, Ruvolo PP. Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. Blood. 2015 Jul 16; 126(3):363-72. PMID: 26045609.
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      14. Quinn BA, Dash R, Sarkar S, Azab B, Bhoopathi P, Das SK, Emdad L, Wei J, Pellecchia M, Sarkar D, Fisher PB. Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. Cancer Res. 2015 Jun 1; 75(11):2305-15. PMID: 26032425.
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      15. Bacolod MD, Das SK, Sokhi UK, Bradley S, Fenstermacher DA, Pellecchia M, Emdad L, Sarkar D, Fisher PB. Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets. Adv Cancer Res. 2015; 127:49-121. PMID: 26093898.
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      16. Quinn BA, Lee NA, Kegelman TP, Bhoopathi P, Emdad L, Das SK, Pellecchia M, Sarkar D, Fisher PB. The Quest for an Effective Treatment for an Intractable Cancer: Established and Novel Therapies for Pancreatic Adenocarcinoma. Adv Cancer Res. 2015; 127:283-306. PMID: 26093904.
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      17. Sarkar S, Quinn BA, Shen XN, Dash R, Das SK, Emdad L, Klibanov AL, Wang XY, Pellecchia M, Sarkar D, Fisher PB. Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. Oncotarget. 2015 May 10; 6(13):10712-27. PMID: 25926554.
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      18. Bottini A, De SK, Wu B, Tang C, Varani G, Pellecchia M. Targeting Influenza A Virus RNA Promoter. Chem Biol Drug Des. 2015 Oct; 86(4):663-73. PMID: 25676805.
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      19. Moccia M, Picillo M, Erro R, Longo K, Amboni M, Santangelo G, Palladino R, Allocca R, Caporale O, Triassi M, Pellecchia M, Barone P, Vitale C. Increased bilirubin levels in de novo Parkinson's disease. Eur J Neurol. 2015 Jun; 22(6):954-9. PMID: 25740378.
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      20. Scortegagna M, Lau E, Zhang T, Feng Y, Sereduk C, Yin H, De SK, Meeth K, Platt JT, Langdon CG, Halaban R, Pellecchia M, Davies MA, Brown K, Stern DF, Bosenberg M, Ronai ZA. PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets. Cancer Res. 2015 Apr 1; 75(7):1399-412. PMID: 25712345.
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      21. Wu B, Barile E, De SK, Wei J, Purves A, Pellecchia M. High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists. Curr Top Med Chem. 2015; 15(20):2032-42. PMID: 25986689.
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      22. White KM, De Jesus P, Chen Z, Abreu P, Barile E, Mak PA, Anderson P, Nguyen QT, Inoue A, Stertz S, Koenig R, Pellecchia M, Palese P, Kuhen K, García-Sastre A, Chanda SK, Shaw ML. A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein. ACS Infect Dis. 2015 Feb 13; 1(2):98-109. PMID: 25984567.
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      23. Zhang Z, Cellitti J, Teriete P, Pellecchia M, Stec B. New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie. 2015 Jan; 108:186-92. PMID: 25433210.
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      24. Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M. CD and NMR conformational studies of a peptide encompassing the Mid Loop interface of Ship2-Sam. Biopolymers. 2014 Nov; 101(11):1088-98. PMID: 24889333.
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      25. Kegelman TP, Das SK, Emdad L, Hu B, Menezes ME, Bhoopathi P, Wang XY, Pellecchia M, Sarkar D, Fisher PB. Targeting tumor invasion: the roles of MDA-9/Syntenin. Expert Opin Ther Targets. 2015 Jan; 19(1):97-112. PMID: 25219541.
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      26. Moccia M, Picillo M, Erro R, Vitale C, Longo K, Amboni M, Santangelo G, Palladino R, Capo G, Orefice G, Barone P, Pellecchia M. Presence and progression of non-motor symptoms in relation to uric acid in de novo Parkinson's disease. Eur J Neurol. 2015 Jan; 22(1):93-8. PMID: 25104282.
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      27. Barile E, Pellecchia M. NMR-Based Approaches for the Identification and Optimization of Inhibitors of Protein-Protein Interactions. Chem Rev. 2014 May 14; 114(9):4749-63. PMID: 24712885.
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      28. Barile E, Wang S, Das SK, Noberini R, Dahl R, Stebbins JL, Pasquale EB, Fisher PB, Pellecchia M. Design, Synthesis and Bioevaluation of an EphA2 Receptor-Based Targeted Delivery System. ChemMedChem. 2014 Jul; 9(7):1403-12. PMID: 24677792.
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      29. Picillo M, Iavarone A, Pellecchia M, Amboni M, Erro R, Moccia M, Vitale C, Longo K, Santangelo G, Spina E, Scannapieco S, Orefice G, Barone P. Validation of an Italian version of the 40-item University of Pennsylvania Smell Identification Test that is physician administered: Our experience on one hundred and thirty-eight healthy subjects. Clin Otolaryngol. 2014 Feb; 39(1):53-7. PMID: 24373213.
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      30. Azab BM, Dash R, Das SK, Bhutia SK, Sarkar S, Shen XN, Quinn BA, Dent P, Dmitriev IP, Wang XY, Curiel DT, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV). J Cell Physiol. 2014 Jan; 229(1):34-43. PMID: 23868767.
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      31. Kegelman TP, Das SK, Hu B, Bacolod MD, Fuller CE, Menezes ME, Emdad L, Dasgupta S, Baldwin AS, Bruce JN, Dent P, Pellecchia M, Sarkar D, Fisher PB. MDA-9/syntenin is a key regulator of glioma pathogenesis. Neuro Oncol. 2014 Jan; 16(1):50-61. PMID: 24305713.
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      32. Lee MK, Bottini A, Kim M, Bardaro MF, Zhang Z, Pellecchia M, Choi BS, Varani G. A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chem Commun (Camb). 2014 Jan 11; 50(3):368-70. PMID: 24247110.
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      33. Stebbins JL, Santelli E, Feng Y, De SK, Purves A, Motamedchaboki K, Wu B, Ronai ZA, Liddington RC, Pellecchia M. Structure-based design of covalent Siah inhibitors. Chem Biol. 2013 Aug 22; 20(8):973-82. PMID: 23891150.
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      34. Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM. Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. Neoplasia. 2013 May; 15(5):568-78. PMID: 23633928.
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      35. Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One. 2013; 8(2):e56603. PMID: 23457590.
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      36. Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24; 20(1):19-33. PMID: 23352136.
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      37. Goff DJ, Recart AC, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 7; 12(3):316-28. PMID: 23333150.
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      38. Pellecchia M. Antagonists of protein-protein interactions made easy? J Med Chem. 2013 Jan 10; 56(1):13-4. PMID: 23265190.
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      39. Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone EM, Pellecchia M, Leone M. Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights. Chembiochem. 2013 Jan 2; 14(1):100-6. PMID: 23239578.
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      40. Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L, Santhekadur PK, Dasgupta S, Dash R, Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB. MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma. Cancer Res. 2013 Jan 15; 73(2):844-54. PMID: 23233738.
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      41. Thomas S, Quinn BA, Das SK, Dash R, Emdad L, Dasgupta S, Wang XY, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Targeting the Bcl-2 family for cancer therapy. Expert Opin Ther Targets. 2013 Jan; 17(1):61-75. PMID: 23173842.
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      42. Wang S, Noberini R, Stebbins JL, Das S, Zhang Z, Wu B, Mitra S, Billet S, Fernandez A, Bhowmick NA, Kitada S, Pasquale EB, Fisher PB, Pellecchia M. Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clin Cancer Res. 2013 Jan 1; 19(1):128-37. PMID: 23155185.
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      43. Bottini A, De SK, Baaten BJ, Wu B, Barile E, Soonthornvacharin S, Stebbins JL, Bradley LM, Chanda SK, Pellecchia M. Identification of small molecules that interfere with H1N1 influenza A viral replication. ChemMedChem. 2012 Dec; 7(12):2227-35. PMID: 23139022.
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      44. Feng Y, Lau E, Scortegagna M, Ruller C, De SK, Barile E, Krajewski S, Aza-Blanc P, Williams R, Pinkerton AB, Jackson M, Chin L, Pellecchia M, Bosenberg M, Ronai ZA. Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11. Pigment Cell Melanoma Res. 2013 Jan; 26(1):136-42. PMID: 23035722.
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      45. Hedvat M, Emdad L, Das SK, Kim K, Dasgupta S, Thomas S, Hu B, Zhu S, Dash R, Quinn BA, Oyesanya RA, Kegelman TP, Sokhi UK, Sarkar S, Erdogan E, Menezes ME, Bhoopathi P, Wang XY, Pomper MG, Wei J, Wu B, Stebbins JL, Diaz PW, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. Anticancer Agents Med Chem. 2012 Nov; 12(9):1143-55. PMID: 22931411.
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      46. Das SK, Bhutia SK, Sokhi UK, Azab B, Su ZZ, Boukerche H, Anwar T, Moen EL, Chatterjee D, Pellecchia M, Sarkar D, Fisher PB. Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma. Cancer Res. 2012 Dec 1; 72(23):6217-26. PMID: 23066033.
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      47. De Ingeniis J, Ratnikov B, Richardson AD, Scott DA, Aza-Blanc P, De SK, Kazanov M, Pellecchia M, Ronai Z, Osterman AL, Smith JW. Functional specialization in proline biosynthesis of melanoma. PLoS One. 2012; 7(9):e45190. PMID: 23024808.
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      48. Jackson RS, Placzek W, Fernandez A, Ziaee S, Chu CY, Wei J, Stebbins J, Kitada S, Fritz G, Reed JC, Chung LW, Pellecchia M, Bhowmick NA. Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia. 2012 Jul; 14(7):656-65. PMID: 22904682.
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      49. Reed JC, Pellecchia M. Ironing out cell death mechanisms. Cell. 2012 May 25; 149(5):963-5. PMID: 22632964.
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      50. Azab B, Dash R, Das SK, Bhutia SK, Shen XN, Quinn BA, Sarkar S, Wang XY, Hedvat M, Dmitriev IP, Curiel DT, Grant S, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. J Cell Physiol. 2012 May; 227(5):2145-53. PMID: 21780116.
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      51. Barile E, De SK, Pellecchia M. PDK1 inhibitors. Pharm Pat Anal. 2012 May; 1(2):145-63. PMID: 24236780.
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      52. Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 2012 May 1; 72(9):2339-49. PMID: 22406620.
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      53. Mercurio FA, Marasco D, Pirone L, Pedone EM, Pellecchia M, Leone M. Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor. Biochemistry. 2012 Mar 13; 51(10):2136-45. PMID: 22332920.
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      54. Wang S, Placzek WJ, Stebbins JL, Mitra S, Noberini R, Koolpe M, Zhang Z, Dahl R, Pasquale EB, Pellecchia M. Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells. J Med Chem. 2012 Mar 8; 55(5):2427-36. PMID: 22329578.
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      55. Farina B, Fattorusso R, Pellecchia M. Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5. Chembiochem. 2011 Dec 16; 12(18):2837-45. PMID: 22162216.
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      56. Pellecchia M, Antonini A, Bonuccelli U, Fabbrini G, Ferini Strambi L, Stocchi F, Battaglia A, Barone P. Observational study of sleep-related disorders in Italian patients with Parkinson's disease: usefulness of the Italian version of Parkinson's disease sleep scale. Neurol Sci. 2012 Jun; 33(3):689-94. PMID: 22048792.
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      57. Kim K, Lee SG, Kegelman TP, Su ZZ, Das SK, Dash R, Dasgupta S, Barral PM, Hedvat M, Diaz P, Reed JC, Stebbins JL, Pellecchia M, Sarkar D, Fisher PB. Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol. 2011 Oct; 226(10):2484-93. PMID: 21792905.
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      58. Wei J, Stebbins JL, Kitada S, Dash R, Zhai D, Placzek WJ, Wu B, Rega MF, Zhang Z, Barile E, Yang L, Dahl R, Fisher PB, Reed JC, Pellecchia M. An optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic bcl-2 family proteins. Front Oncol. 2011; 1:28. PMID: 22655238.
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      59. Placzek WJ, Sturlese M, Wu B, Cellitti JF, Wei J, Pellecchia M. Identification of a novel Mcl-1 protein binding motif. J Biol Chem. 2011 Nov 18; 286(46):39829-35. PMID: 21953453.
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      60. Pappatà S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia M, Brunetti A, De Michele G, Salvatore M, Barone P. Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism. Neurology. 2011 Oct 4; 77(14):1357-62. PMID: 21940621.
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      61. Noberini R, De SK, Zhang Z, Wu B, Raveendra-Panickar D, Chen V, Vazquez J, Qin H, Song J, Cosford ND, Pellecchia M, Pasquale EB. A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des. 2011 Oct; 78(4):667-78. PMID: 21791013.
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      62. Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14. PMID: 21815634.
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      63. Quinn BA, Dash R, Azab B, Sarkar S, Das SK, Kumar S, Oyesanya RA, Dasgupta S, Dent P, Grant S, Rahmani M, Curiel DT, Dmitriev I, Hedvat M, Wei J, Wu B, Stebbins JL, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Targeting Mcl-1 for the therapy of cancer. Expert Opin Investig Drugs. 2011 Oct; 20(10):1397-411. PMID: 21851287.
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      64. Rega MF, Wu B, Wei J, Zhang Z, Cellitti JF, Pellecchia M. SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1. J Med Chem. 2011 Sep 8; 54(17):6000-13. PMID: 21797225.
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      65. Johnson S, Barile E, Farina B, Purves A, Wei J, Chen LH, Shiryaev S, Zhang Z, Rodionova I, Agrawal A, Cohen SM, Osterman A, Strongin A, Pellecchia M. Targeting metalloproteins by fragment-based lead discovery. Chem Biol Drug Des. 2011 Aug; 78(2):211-23. PMID: 21564556.
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      66. Feng Y, Barile E, De SK, Stebbins JL, Cortez A, Aza-Blanc P, Villanueva J, Heryln M, Krajewski S, Pellecchia M, Ronai ZA, Chiang GG. Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-?B pathways. Pigment Cell Melanoma Res. 2011 Aug; 24(4):703-13. PMID: 21592316.
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      67. Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8785-90. PMID: 21555592.
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      68. De SK, Barile E, Chen V, Stebbins JL, Cellitti JF, Machleidt T, Carlson CB, Yang L, Dahl R, Pellecchia M. Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase. Bioorg Med Chem. 2011 Apr 15; 19(8):2582-8. PMID: 21458276.
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      69. Monfardini I, Huang JW, Beck B, Cellitti JF, Pellecchia M, Dömling A. Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder. J Med Chem. 2011 Feb 10; 54(3):890-900. PMID: 21241056.
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      70. Leone M, Barile E, Dahl R, Pellecchia M. Design and NMR studies of cyclic peptides targeting the N-terminal domain of the protein tyrosine phosphatase YopH. Chem Biol Drug Des. 2011 Jan; 77(1):12-9. PMID: 21118379.
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      71. Barile E, De SK, Carlson CB, Chen V, Knutzen C, Riel-Mehan M, Yang L, Dahl R, Chiang G, Pellecchia M. Design, Synthesis, and Structure-Activity Relationships of 3-Ethynyl-1H-indazoles as Inhibitors of the Phosphatidylinositol 3-Kinase Signaling Pathway. J Med Chem. 2010 Dec 9; 53(23):8368-75. PMID: 21062009.
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      72. Wei J, Kitada S, Stebbins JL, Placzek W, Zhai D, Wu B, Rega MF, Zhang Z, Cellitti J, Yang L, Dahl R, Reed JC, Pellecchia M. Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 Nov 25; 53(22):8000-11. PMID: 21033669.
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      73. Qi J, Pellecchia M, Ronai ZA. The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities. Oncotarget. 2010 Sep; 1(5):379-85. PMID: 21037926.
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      74. Yuan H, Johnson SL, Chen LH, Wei J, Pellecchia M. A novel pharmacophore model for the design of anthrax lethal factor inhibitors. Chem Biol Drug Des. 2010 Sep 1; 76(3):263-8. PMID: 20572812.
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      75. Wei J, Stebbins JL, Kitada S, Dash R, Placzek W, Rega MF, Wu B, Cellitti J, Zhai D, Yang L, Dahl R, Fisher PB, Reed JC, Pellecchia M. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27; 53(10):4166-76. PMID: 20443627.
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      76. Dash R, Richards JE, Su ZZ, Bhutia SK, Azab B, Rahmani M, Dasmahapatra G, Yacoub A, Dent P, Dmitriev IP, Curiel DT, Grant S, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine. Cancer Res. 2010 Jun 15; 70(12):5034-45. PMID: 20501829.
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      77. Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M. NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH. Chem Biol Drug Des. 2010 Jul; 76(1):10-6. PMID: 20456369.
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      78. Radichev IA, Remacle AG, Shiryaev SA, Purves AN, Johnson SL, Pellecchia M, Strongin AY. Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase. J Biol Chem. 2010 May 21; 285(21):16076-86. PMID: 20308072.
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      79. Agrawal A, Johnson SL, Jacobsen JA, Miller MT, Chen LH, Pellecchia M, Cohen SM. Chelator fragment libraries for targeting metalloproteinases. ChemMedChem. 2010 Feb 1; 5(2):195-9. PMID: 20058293.
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      80. De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M. Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2010 Jan 15; 18(2):590-6. PMID: 20045647.
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      81. Di Micco S, Vitale R, Pellecchia M, Rega MF, Riva R, Basso A, Bifulco G. Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach. J Med Chem. 2009 Dec 10; 52(23):7856-67. PMID: 19852471.
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      82. Pellecchia M, Pivonello R, Monsurrò MR, Trojsi F, Longo K, Piccirillo G, Pivonello C, Rocco M, Di Somma C, Colao A, Tedeschi G, Barone P. The GH-IGF system in amyotrophic lateral sclerosis: correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features. Eur J Neurol. 2010 May; 17(5):666-71. PMID: 20002733.
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      83. Wu S, Vossius S, Rahmouni S, Miletic AV, Vang T, Vazquez-Rodriguez J, Cerignoli F, Arimura Y, Williams S, Hayes T, Moutschen M, Vasile S, Pellecchia M, Mustelin T, Tautz L. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12; 52(21):6716-23. PMID: 19888758.
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      84. Leone M, Cellitti J, Pellecchia M. The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam. BMC Struct Biol. 2009; 9:59. PMID: 19765305.
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      85. Shah M, Stebbins JL, Dewing A, Qi J, Pellecchia M, Ronai ZA. Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis. Pigment Cell Melanoma Res. 2009 Dec; 22(6):799-808. PMID: 19712206.
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      86. Cellitti J, Zhang Z, Wang S, Wu B, Yuan H, Hasegawa P, Guiney DG, Pellecchia M. Small molecule DnaK modulators targeting the beta-domain. Chem Biol Drug Des. 2009 Oct; 74(4):349-57. PMID: 19694756.
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      87. Wei J, Kitada S, Rega MF, Stebbins JL, Zhai D, Cellitti J, Yuan H, Emdadi A, Dahl R, Zhang Z, Yang L, Reed JC, Pellecchia M. Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2009 Jul 23; 52(14):4511-23. PMID: 19555126.
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      88. Rozanov DV, Savinov AY, Golubkov VS, Rozanova OL, Postnova TI, Sergienko EA, Vasile S, Aleshin AE, Rega MF, Pellecchia M, Strongin AY. Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells. Mol Cancer Ther. 2009 Jun; 8(6):1515-25. PMID: 19509255.
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      89. Pellecchia M. Fragment-based drug discovery takes a virtual turn. Nat Chem Biol. 2009 May; 5(5):274-5. PMID: 19377449.
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      90. De SK, Stebbins JL, Chen LH, Riel-Mehan M, Machleidt T, Dahl R, Yuan H, Emdadi A, Barile E, Chen V, Murphy R, Pellecchia M. Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. J Med Chem. 2009 Apr 9; 52(7):1943-52. PMID: 19271755.
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      91. Wu B, Rega MF, Wei J, Yuan H, Dahl R, Zhang Z, Pellecchia M. Discovery and binding studies on a series of novel Pin1 ligands. Chem Biol Drug Des. 2009 Apr; 73(4):369-79. PMID: 19291099.
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      92. Wei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, Stebbins JL, Zhai D, Sun J, Yang L, Dahl R, Zhang Z, Wu B, Wang S, Reed TA, Wang HG, Lawrence N, Sebti S, Reed JC, Pellecchia M. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009 Apr; 8(4):904-13. PMID: 19372563.
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      93. Johnson SL, Chen LH, Barile E, Emdadi A, Sabet M, Yuan H, Wei J, Guiney D, Pellecchia M. Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors. Bioorg Med Chem. 2009 May 1; 17(9):3352-68. PMID: 19359184.
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      94. De SK, Chen LH, Stebbins JL, Machleidt T, Riel-Mehan M, Dahl R, Chen V, Yuan H, Barile E, Emdadi A, Murphy R, Pellecchia M. Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2009 Apr 1; 17(7):2712-7. PMID: 19282190.
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      95. Gaitonde S, De SK, Tcherpakov M, Dewing A, Yuan H, Riel-Mehan M, Krajewski S, Robertson G, Pellecchia M, Ronai Z. BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma. Pigment Cell Melanoma Res. 2009 Apr; 22(2):187-95. PMID: 19175524.
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      96. Leone M, Cellitti J, Pellecchia M. NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor. Biochemistry. 2008 Dec 2; 47(48):12721-8. PMID: 18991394.
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      97. Huang JW, Zhang Z, Wu B, Cellitti JF, Zhang X, Dahl R, Shiau CW, Welsh K, Emdadi A, Stebbins JL, Reed JC, Pellecchia M. Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors. J Med Chem. 2008 Nov 27; 51(22):7111-8. PMID: 18956862.
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      98. Bisson WH, Zhang Z, Welsh K, Huang JW, Ryan J, Reed JC, Pellecchia M. Binding properties of the C-terminal domain of VIAF. Chem Biol Drug Des. 2008 Nov; 72(5):331-6. PMID: 19012568.
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      99. Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13. PMID: 18922779.
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      100. Wei J, Rega MF, Kitada S, Yuan H, Zhai D, Risbood P, Seltzman HH, Twine CE, Reed JC, Pellecchia M. Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists. Cancer Lett. 2009 Jan 8; 273(1):107-13. PMID: 18782651.
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      101. Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G. Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov. 2008 Sep; 7(9):738-45. PMID: 19172689.
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      102. Vazquez J, De SK, Chen LH, Riel-Mehan M, Emdadi A, Cellitti J, Stebbins JL, Rega MF, Pellecchia M. Development of paramagnetic probes for molecular recognition studies in protein kinases. J Med Chem. 2008 Jun 26; 51(12):3460-5. PMID: 18494454.
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      103. Johnson SL, Chen LH, Harbach R, Sabet M, Savinov A, Cotton NJ, Strongin A, Guiney D, Pellecchia M. Rhodanine derivatives as selective protease inhibitors against bacterial toxins. Chem Biol Drug Des. 2008 Feb; 71(2):131-9. PMID: 18221310.
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      104. Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood. 2008 Mar 15; 111(6):3211-9. PMID: 18202226.
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      105. Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M. The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies. Biopolymers. 2008 Jan; 89(1):86-92. PMID: 17922498.
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      106. Stebbins JL, Zhang Z, Chen J, Wu B, Emdadi A, Williams ME, Cashman J, Pellecchia M. Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem. 2007 Dec 27; 50(26):6607-17. PMID: 18038971.
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      107. Bottini M, Cerignoli F, Mills DM, D'Annibale F, Leone M, Rosato N, Magrini A, Pellecchia M, Bergamaschi A, Mustelin T. Luminescent silica nanobeads: characterization and evaluation as efficient cytoplasmatic transporters for T-lymphocytes. J Am Chem Soc. 2007 Jun 27; 129(25):7814-23. PMID: 17542582.
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      108. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY. Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20; 282(29):20847-53. PMID: 17537721.
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      109. Rega MF, Leone M, Jung D, Cotton NJ, Stebbins JL, Pellecchia M. Structure-based discovery of a new class of Bcl-xL antagonists. Bioorg Chem. 2007 Aug; 35(4):344-53. PMID: 17512966.
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      110. Chen J, Zhang Z, Stebbins JL, Zhang X, Hoffman R, Moore A, Pellecchia M. A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors. ACS Chem Biol. 2007 May 22; 2(5):329-36. PMID: 17465519.
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      111. Vazquez J, Tautz L, Ryan JJ, Vuori K, Mustelin T, Pellecchia M. Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors. J Med Chem. 2007 May 3; 50(9):2137-43. PMID: 17394300.
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      112. Johnson SL, Chen LH, Pellecchia M. A high-throughput screening approach to anthrax lethal factor inhibition. Bioorg Chem. 2007 Aug; 35(4):306-12. PMID: 17320146.
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      113. Rega MF, Reed JC, Pellecchia M. Robust lanthanide-based assays for the detection of anti-apoptotic Bcl-2-family protein antagonists. Bioorg Chem. 2007 Apr; 35(2):113-20. PMID: 16996562.
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      114. Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M. The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry. 2006 Aug 29; 45(34):10294-302. PMID: 16922504.
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      115. Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell KJ, Rega MF, Landshamer S, Reed JC, Plesnila N, Pellecchia M. Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12602-6. PMID: 16891420.
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      116. Erdogan E, Lamark T, Stallings-Mann M. Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. J Biol Chem. 2006 Sep 22; 281(38):28450-9. PMID: 16861740.
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      117. Leone M, Freeze HH, Chan CS, Pellecchia M. The Nuclear Overhauser Effect in the lead identification process. Curr Drug Discov Technol. 2006 Jun; 3(2):91-100. PMID: 16925517.
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      118. Leone M, Yu EC, Liddington R, Pellecchia M. NMR assignment of the phosphotyrosine binding (PTB) domain of tensin. J Biomol NMR. 2006; 36 Suppl 1:40. PMID: 16705357.
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      119. Stebbins JL, Jung D, Leone M, Zhang XK, Pellecchia M. A structure-based approach to retinoid X receptor-alpha inhibition. J Biol Chem. 2006 Jun 16; 281(24):16643-8. PMID: 16606625.
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      120. Becattini B, Pellecchia M. SAR by ILOEs: an NMR-based approach to reverse chemical genetics. Chemistry. 2006 Mar 20; 12(10):2658-62. PMID: 16121405.
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      121. Schimmer AD, Thomas MP, Hurren R, Gronda M, Pellecchia M, Pond GR, Konopleva M, Gurfinkel D, Mawji IA, Brown E, Reed JC. Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer Res. 2006 Feb 15; 66(4):2367-75. PMID: 16489043.
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      122. Tautz L, Pellecchia M, Mustelin T. Targeting the PTPome in human disease. Expert Opin Ther Targets. 2006 Feb; 10(1):157-77. PMID: 16441235.
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      123. Johnson SL, Jung D, Forino M, Chen Y, Satterthwait A, Rozanov DV, Strongin AY, Pellecchia M. Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies. J Med Chem. 2006 Jan 12; 49(1):27-30. PMID: 16392787.
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      124. Johnson SL, Pellecchia M. Structure- and fragment-based approaches to protease inhibition. Curr Top Med Chem. 2006; 6(4):317-29. PMID: 16611145.
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      125. Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Pellechia M, Blomgren K, Plesnila N. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci. 2005 Nov 2; 25(44):10262-72. PMID: 16267234.
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      126. Pellecchia M. Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions. Chem Biol. 2005 Sep; 12(9):961-71. PMID: 16183020.
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      127. Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S. Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. J Biol Chem. 2005 Oct 7; 280(40):34278-87. PMID: 16085652.
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      128. Geser F, Seppi K, Stampfer-Kountchev M, Köllensperger M, Diem A, Ndayisaba JP, Ostergaard K, Dupont E, Cardozo A, Tolosa E, Abele M, Dodel R, Klockgether T, Ghorayeb I, Yekhlef F, Tison F, Daniels C, Kopper F, Deuschl G, Coelho M, Ferreira J, Rosa MM, Sampaio C, Bozi M, Schrag A, Hooker J, Kim H, Scaravilli T, Mathias CJ, Fowler C, Wood N, Quinn N, Widner H, Nilsson CF, Lindvall O, Schimke N, Eggert KM, Oertel W, del Sorbo F, Carella F, Albanese A, Pellecchia M, Barone P, Djaldetti R, Meco G, Colosimo C, Gonzalez-Mandly A, Berciano J, Gurevich T, Giladi N, Galitzky M, Ory F, Rascol O, Kamm C, Buerk K, Maass S, Gasser T, Poewe W, Wenning GK. The European Multiple System Atrophy-Study Group (EMSA-SG). J Neural Transm. 2005 Dec; 112(12):1677-86. PMID: 16049636.
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      129. Forino M, Johnson S, Wong TY, Rozanov DV, Savinov AY, Li W, Fattorusso R, Becattini B, Orry AJ, Jung D, Abagyan RA, Smith JW, Alibek K, Liddington RC, Strongin AY, Pellecchia M. Efficient synthetic inhibitors of anthrax lethal factor. Proc Natl Acad Sci U S A. 2005 Jul 5; 102(27):9499-504. PMID: 15983377.
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      130. Pellecchia M, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24; 64(10):1810-2. PMID: 15911822.
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      131. Forino M, Jung D, Easton JB, Houghton PJ, Pellecchia M. Virtual docking approaches to protein kinase B inhibition. J Med Chem. 2005 Apr 7; 48(7):2278-81. PMID: 15801821.
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      132. Reed JC, Pellecchia M. Apoptosis-based therapies for hematologic malignancies. Blood. 2005 Jul 15; 106(2):408-18. PMID: 15797997.
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      133. Fattorusso R, Jung D, Crowell KJ, Forino M, Pellecchia M. Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach. J Med Chem. 2005 Mar 10; 48(5):1649-56. PMID: 15743206.
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      134. Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem. 2005 Mar 11; 280(10):9400-8. PMID: 15615724.
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      135. Varrone A, Pellecchia M, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappatà S, Barone P. Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease. Neurology. 2004 Dec 14; 63(11):2097-103. PMID: 15596756.
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      136. Pellecchia M, Becattini B, Crowell KJ, Fattorusso R, Forino M, Fragai M, Jung D, Mustelin T, Tautz L. NMR-based techniques in the hit identification and optimisation processes. Expert Opin Ther Targets. 2004 Dec; 8(6):597-611. PMID: 15584865.
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      137. Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol. 2004 Sep; 6(9):831-9. PMID: 15322554.
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      138. Becattini B, Sareth S, Zhai D, Crowell KJ, Leone M, Reed JC, Pellecchia M. Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules. Chem Biol. 2004 Aug; 11(8):1107-17. PMID: 15324812.
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      139. Brown DM, Pellecchia M, Ruoslahti E. Drug identification through in vivo screening of chemical libraries. Chembiochem. 2004 Jun 7; 5(6):871-5. PMID: 15174173.
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      140. Pellecchia M, Grasso A, Biancardi LG, Squillante M, Bonavita V, Barone P. Physical therapy in Parkinson's disease: an open long-term rehabilitation trial. J Neurol. 2004 May; 251(5):595-8. PMID: 15164194.
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      141. Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004 Apr; 36(4):337-8. PMID: 15004560.
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      142. Becattini B, Kitada S, Leone M, Monosov E, Chandler S, Zhai D, Kipps TJ, Reed JC, Pellecchia M. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). Chem Biol. 2004 Mar; 11(3):389-95. PMID: 15123268.
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      143. Sem DS, Bertolaet B, Baker B, Chang E, Costache AD, Coutts S, Dong Q, Hansen M, Hong V, Huang X, Jack RM, Kho R, Lang H, Ma CT, Meininger D, Pellecchia M, Pierre F, Villar H, Yu L. Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox. Chem Biol. 2004 Feb; 11(2):185-94. PMID: 15123280.
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      144. Pellecchia M, Reed JC. Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy. Curr Pharm Des. 2004; 10(12):1387-98. PMID: 15134489.
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      145. Leone M, Zhai D, Sareth S, Kitada S, Reed JC, Pellecchia M. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res. 2003 Dec 1; 63(23):8118-21. PMID: 14678963.
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      146. Pellecchia M, Criscuolo C, De Joanna G, D'Amico A, Santoro L, Barone P. Pure unilateral hyperhidrosis after pontine infarct. Neurology. 2003 Nov 11; 61(9):1305. PMID: 14610150.
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      147. Stevens SY, Cai S, Pellecchia M, Zuiderweg ER. The solution structure of the bacterial HSP70 chaperone protein domain DnaK(393-507) in complex with the peptide NRLLLTG. Protein Sci. 2003 Nov; 12(11):2588-96. PMID: 14573869.
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      148. Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25; 46(20):4259-64. PMID: 13678404.
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      149. Leone M, Rodriguez-Mias RA, Pellecchia M. Selective incorporation of 19F-labeled Trp side chains for NMR-spectroscopy-based ligand-protein interaction studies. Chembiochem. 2003 Jul 7; 4(7):649-50. PMID: 12851935.
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      150. Rodriguez-Mias RA, Pellecchia M. Use of selective Trp side chain labeling to characterize protein-protein and protein-ligand interactions by NMR spectroscopy. J Am Chem Soc. 2003 Mar 12; 125(10):2892-3. PMID: 12617653.
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      151. Pellecchia M, Criscuolo C, Longo K, Campanella G, Filla A, Barone P. Clinical presentation and treatment of Wilson's disease: a single-centre experience. Eur Neurol. 2003; 50(1):48-52. PMID: 12824712.
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      152. Pellecchia M, Ambrosio G, Salvatore E, Vitale C, De Michele G, Barone P. Possible gluten sensitivity in multiple system atrophy. Neurology. 2002 Oct 8; 59(7):1114-5. PMID: 12370481.
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      153. Pellecchia M, Sem DS, Wüthrich K. NMR in drug discovery. Nat Rev Drug Discov. 2002 Mar; 1(3):211-9. PMID: 12120505.
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      154. Pellecchia M, Meininger D, Dong Q, Chang E, Jack R, Sem DS. NMR-based structural characterization of large protein-ligand interactions. J Biomol NMR. 2002 Feb; 22(2):165-73. PMID: 11883777.
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      155. Perretti A, Pellecchia M, Lanzillo B, Campanella G, Santoro L. Excitatory and inhibitory mechanisms in Wilson's disease: investigation with magnetic motor cortex stimulation. J Neurol Sci. 2001 Nov 15; 192(1-2):35-40. PMID: 11701150.
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      156. Barbieri F, Pellecchia M, Esposito E, Di Stasio E, Castaldo I, Santorelli F, Perretti A, Santoro L, De Michele G. Adult-onset familial laryngeal abductor paralysis, cerebellar ataxia, and pure motor neuropathy. Neurology. 2001 May 22; 56(10):1412-4. PMID: 11376202.
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      157. Vitale C, Pellecchia M, Grossi D, Fragassi N, Cuomo T, Di Maio L, Barone P. Unawareness of dyskinesias in Parkinson's and Huntington's diseases. Neurol Sci. 2001 Feb; 22(1):105-6. PMID: 11487181.
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      158. Pellecchia M, Salvatore E, Pivonello R, Faggiano A, Barone P, De Michele G, Colao AM, Filla A. Stimulation of growth hormone release in multiple system atrophy, Parkinson's disease and idiopathic cerebellar ataxia. Neurol Sci. 2001 Feb; 22(1):79-80. PMID: 11487211.
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      159. Pellecchia M, Scala R, Perretti A, De Michele G, Santoro L, Filla A, Ciacci C, Barone P. Cerebellar ataxia associated with subclinical celiac disease responding to gluten-free diet. Neurology. 1999 Oct 22; 53(7):1606-8. PMID: 10534283.
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