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Matthias Von Herrath

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0673
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Integrated Functional Histopathology of the Diabetic Human Pancreas
    NIH/NIAID R01AI134971Dec 7, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Specificity, Phenotype and Function of Pancreatic CD8 T Cells in Human Type 1 Diabetes
    NIH/NIAID R01AI092453May 2, 2011 - Nov 30, 2021
    Role: Principal Investigator
    How IL-10R blockade can resolve persistent viral infections
    NIH/NIAID R01AI068818Sep 1, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Animal Models in Type 1 Diabetes and Multiple Sclerosis
    NIH/NIDDK R13DK076554Sep 30, 2006 - Aug 31, 2007
    Role: Principal Investigator
    Assessment of cytokines in human islets from patients with diabetes
    NIH/NIAID U01AI102370Sep 20, 2006 - Jun 30, 2017
    Role: Principal Investigator
    Achieving Therapeutic Antigent-Specific Tolerance in Type 1 Diabetes
    NIH/NIDDK U01DK078013Sep 20, 2006 - Jun 30, 2012
    Role: Principal Investigator
    FASEB Summer Conference on 'Autoimmunity'
    NIH/NIAID R13AI065123Jun 1, 2005 - May 31, 2010
    Role: Principal Investigator
    Viruses and Autoimmunity POI
    NIH/NIAID P01AI058105Jul 1, 2004 - Jun 30, 2010
    Role: Principal Investigator
    IMMUNE TOLERANCE INDUCTION BY APOPTOTIC BODIES
    NIH/NIAID R21AI059850May 1, 2004 - Apr 30, 2007
    Role: Principal Investigator
    CXCR3 Chemokines in Type I Diabetes
    NIH/NIDDK R01DK066346Mar 5, 2004 - Nov 30, 2009
    Role: Principal Investigator
    How Does blockade of CD40/CD40L Prevent Autoimmunity?
    NIH/NIAID U19AI051973Sep 30, 2001 - Jul 31, 2006
    Role: Principal Investigator
    Role of a Non-Tolerant Autoantigen in Autoimmunity
    NIH/NIAID R01AI044451Sep 30, 1998 - Dec 31, 2008
    Role: Principal Investigator
    DNA Vaccination &Regulatory Cells in Type I Diabetes
    NIH/NIDDK R01DK051091Jun 1, 1996 - Nov 30, 2007
    Role: Principal Investigator
    PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DIABETES
    NIH/NIDDK R29DK051091Jun 1, 1996 - May 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coppieters K, von Herrath M. The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes. Front Med (Lausanne). 2018; 5:283. PMID: 30356664.
      View in: PubMed
    2. Anquetil F, Mondanelli G, Gonzalez N, Rodriguez Calvo T, Zapardiel Gonzalo J, Krogvold L, Dahl-Jørgensen K, Van den Eynde B, Orabona C, Grohmann U, von Herrath MG. Loss of IDO1 Expression From Human Pancreatic ß-Cells Precedes Their Destruction During the Development of Type 1 Diabetes. Diabetes. 2018 Jun 26. PMID: 29945890.
      View in: PubMed
    3. Sbierski-Kind J, Kath J, Brachs S, Streitz M, von Herrath MG, Kühl AA, Schmidt-Bleek K, Mai K, Spranger J, Volk HD. Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes. Front Immunol. 2018; 9:1069. PMID: 29892281.
      View in: PubMed
    4. Kihl P, Krych L, Buschard K, Wesley JD, Kot W, Hansen AK, Nielsen DS, von Herrath MG. Oral insulin does not alter gut microbiota composition of NOD mice. Diabetes Metab Res Rev. 2018 Apr 10; e3010. PMID: 29637693.
      View in: PubMed
    5. Christoffersson G, Chodaczek G, Ratliff SS, Coppieters K, von Herrath MG. Suppression of diabetes by accumulation of non-islet-specific CD8+ effector T cells in pancreatic islets. Sci Immunol. 2018 Mar 23; 3(21). PMID: 29572238.
      View in: PubMed
    6. Sidney J, Vela JL, Friedrich D, Kolla R, von Herrath M, Wesley JD, Sette A. Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications. BMC Immunol. 2018 Mar 21; 19(1):12. PMID: 29562882.
      View in: PubMed
    7. Sabouri S, Mikulski Z, von Herrath MG. OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration. Clin Immunol. 2018 Jun; 191:34-36. PMID: 29551703.
      View in: PubMed
    8. Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC. a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. Cell Rep. 2018 Mar 06; 22(10):2667-2676. PMID: 29514095.
      View in: PubMed
    9. Pettus J, Von Herrath M. The shifting paradigm of a "cure" for type 1 diabetes: is technology replacing immune-based therapies? Acta Diabetol. 2018 Feb; 55(2):117-120. PMID: 29188386.
      View in: PubMed
    10. Coppieters K, von Herrath M. Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy. Cell Metab. 2017 Oct 03; 26(4):595-597. PMID: 28978425.
      View in: PubMed
    11. Rodriguez-Calvo T, Atkinson M, von Herrath MG. Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of ß-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345. Diabetes. 2017 09; 66(9):e10-e11. PMID: 28830918.
      View in: PubMed
    12. Rydén AK, Perdue NR, Pagni PP, Gibson CB, Ratliff SS, Kirk RK, Friesen TJ, Haase C, Coppieters K, von Herrath MG, Boursalian TE. Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes. J Autoimmun. 2017 Nov; 84:65-74. PMID: 28711285.
      View in: PubMed
    13. Rodriguez-Calvo T, Atkinson M, von Herrath M. ß-Cell mass versus function in type 1 diabetes mellitus: truth or dare? Nat Rev Endocrinol. 2017 Sep; 13(9):1. PMID: 28685769.
      View in: PubMed
    14. Grönholm J, Pagni PP, Pham MN, Gibson CB, Macomber PF, Vela JL, von Herrath M, Lenardo MJ. Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice. Diabetologia. 2017 08; 60(8):1475-1482. PMID: 28455654.
      View in: PubMed
    15. Anquetil F, Sabouri S, Thivolet C, Rodriguez-Calvo T, Zapardiel-Gonzalo J, Amirian N, Schneider D, Castillo E, Lajevardi Y, von Herrath MG. Alpha cells, the main source of IL-1ß in human pancreas. J Autoimmun. 2017 Jul; 81:68-73. PMID: 28325643.
      View in: PubMed
    16. Kirk RK, Pyke C, von Herrath MG, Hasselby JP, Pedersen L, Mortensen PG, Knudsen LB, Coppieters K. Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes. Diabetes Obes Metab. 2017 05; 19(5):705-712. PMID: 28094469.
      View in: PubMed
    17. Rodriguez-Calvo T, Zapardiel-Gonzalo J, Amirian N, Castillo E, Lajevardi Y, Krogvold L, Dahl-Jørgensen K, von Herrath MG. Increase in Pancreatic Proinsulin and Preservation of ß-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes. 2017 05; 66(5):1334-1345. PMID: 28137793.
      View in: PubMed
    18. Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA. Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary? Diabetologia. 2017 04; 60(4):753-755. PMID: 28070616.
      View in: PubMed
    19. Kolb H, von Herrath M. Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process? Cell Metab. 2017 Feb 07; 25(2):233-241. PMID: 27839907.
      View in: PubMed
    20. Durlanik S, Loyal L, Stark R, Sercan Alp Ö, Hartung A, Radbruch A, von Herrath M, Matzmohr N, Frentsch M, Thiel A. CD40L expression by CD4+ but not CD8+ T cells regulates antiviral immune responses in acute LCMV infection in mice. Eur J Immunol. 2016 11; 46(11):2566-2573. PMID: 27562840.
      View in: PubMed
    21. Christoffersson G, von Herrath MG. A Deeper Look into Type 1 Diabetes - Imaging Immune Responses during Onset of Disease. Front Immunol. 2016; 7:313. PMID: 27574523; PMCID: PMC4983548.
    22. Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, von Herrath M, Pugliese A, Atkinson MA, Morgan NG. Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia. 2016 11; 59(11):2448-2458. PMID: 27506584.
      View in: PubMed
    23. Rodriguez-Calvo T, Sabouri S, Anquetil F, von Herrath MG. The viral paradigm in type 1 diabetes: Who are the main suspects? Autoimmun Rev. 2016 Oct; 15(10):964-9. PMID: 27491567.
      View in: PubMed
    24. Christoffersson G, Rodriguez-Calvo T, von Herrath M. Recent advances in understanding Type 1 Diabetes. F1000Res. 2016; 5. PMID: 26918165; PMCID: PMC4755393.
    25. Pham MN, Gibson C, Rydén AK, Perdue N, Boursalian TE, Pagni PP, Coppieters K, Skonberg C, Porsgaard T, von Herrath M, Vela JL. Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse. Clin Immunol. 2016 Mar; 164:28-33. PMID: 26821303.
      View in: PubMed
    26. Pham MN, von Herrath MG, Vela JL. Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes. Front Immunol. 2015; 6:651. PMID: 26793191; PMCID: PMC4707297.
    27. Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardiel-Gonzalo J, von Herrath MG. Erratum. Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes. Diabetes 2014;63:3880-3890. Diabetes. 2016 Jan; 65(1):303. PMID: 26696640; PMCID: PMC4877679.
    28. Gill RG, Pagni PP, Kupfer T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Bel Hani A, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT. A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. Diabetes. 2016 05; 65(5):1310-6. PMID: 26718498.
      View in: PubMed
    29. Von Herrath M, Jarjour WN. New horizons in biomarker research. Clin Immunol. 2015 Nov; 161(1):1. PMID: 26383133.
      View in: PubMed
    30. Boettler T, Schneider D, Cheng Y, Kadoya K, Brandon EP, Martinson L, von Herrath M. Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes. Cell Transplant. 2016; 25(3):609-14. PMID: 26300527.
      View in: PubMed
    31. Rodriguez-Calvo T, Suwandi JS, Amirian N, Zapardiel-Gonzalo J, Anquetil F, Sabouri S, von Herrath MG. Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase. J Histochem Cytochem. 2015 08; 63(8):626-36. PMID: 26216138; PMCID: PMC4530397.
    32. Rekers NV, von Herrath MG, Wesley JD. Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success. Clin Immunol. 2015 Nov; 161(1):37-43. PMID: 26122172.
      View in: PubMed
    33. Atkinson MA, von Herrath M, Powers AC, Clare-Salzler M. Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease. Diabetes Care. 2015 Jun; 38(6):979-88. PMID: 25998290; PMCID: PMC4439528.
    34. Rodriguez-Calvo T, von Herrath MG. Enterovirus infection and type 1 diabetes: closing in on a link? Diabetes. 2015 May; 64(5):1503-5. PMID: 25908875.
      View in: PubMed
    35. Sarikonda G, Sachithanantham S, Miller JF, Pagni PP, Coppieters KT, von Herrath M. The Hsp60 peptide p277 enhances anti-CD3 mediated diabetes remission in non-obese diabetic mice. J Autoimmun. 2015 May; 59:61-6. PMID: 25772283.
      View in: PubMed
    36. Drescher KM, von Herrath M, Tracy S. Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine. Rev Med Virol. 2015 Jan; 25(1):19-32. PMID: 25430610.
      View in: PubMed
    37. Sarikonda G, Fousteri G, Sachithanantham S, Miller JF, Dave A, Juntti T, Coppieters KT, von Herrath M. BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells. PLoS One. 2014; 9(11):e112242. PMID: 25393309; PMCID: PMC4231041.
    38. Coppieters KT, von Herrath MG. The type 1 diabetes signature: hardwired to trigger inflammation? Diabetes. 2014 Nov; 63(11):3581-3. PMID: 25342729.
      View in: PubMed
    39. Yip L, Fuhlbrigge R, Taylor C, Creusot RJ, Nishikawa-Matsumura T, Whiting CC, Schartner JM, Akter R, von Herrath M, Fathman CG. Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes. Diabetes. 2015 Feb; 64(2):604-17. PMID: 25187368; PMCID: PMC4303971.
    40. Sarikonda G, Sachithanantham S, Pettus J, Rodriguez-Calvo T, Phatak S, Edelman S, von Herrath M. Higher proinflammatory cytokine production and spontaneous activation in some type 1 and type 2 diabetic subjects. Clin Immunol. 2014 Nov; 155(1):27-9. PMID: 25173803.
      View in: PubMed
    41. Schneider DA, von Herrath MG. Potential viral pathogenic mechanism in human type 1 diabetes. Diabetologia. 2014 Oct; 57(10):2009-18. PMID: 25073445; PMCID: PMC4153966.
    42. Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. CTSH regulates ß-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10305-10. PMID: 24982147; PMCID: PMC4104872.
    43. Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardiel-Gonzalo J, von Herrath MG. Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes. Diabetes. 2014 Nov; 63(11):3880-90. PMID: 24947367; PMCID: PMC4207385.
    44. Jones CB, Pagni PP, Fousteri G, Sachithanantham S, Dave A, Rodriguez-Calvo T, Miller J, von Herrath M. Regulatory T cells control diabetes without compromising acute anti-viral defense. Clin Immunol. 2014 Aug; 153(2):298-307. PMID: 24858581; PMCID: PMC4889438.
    45. Baca Jones C, Filippi C, Sachithanantham S, Rodriguez-Calvo T, Ehrhardt K, von Herrath M. Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells. PLoS One. 2014; 9(3):e90855. PMID: 24613988; PMCID: PMC3948950.
    46. Van Belle TL, Pagni PP, Liao J, Sachithanantham S, Dave A, Bel Hani A, Manenkova Y, Amirian N, Yang C, Morin B, Zhang H, Campbell IL, von Herrath MG. Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes. J Autoimmun. 2014 Dec; 55:24-32. PMID: 24582317; PMCID: PMC4143487.
    47. Pagni PP, Bresson D, Rodriguez-Calvo T, Bel Hani A, Manenkova Y, Amirian N, Blaszczak A, Faton S, Sachithanantham S, von Herrath MG. Combination therapy with an anti-IL-1ß antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model. Diabetes. 2014 Jun; 63(6):2015-25. PMID: 24520125; PMCID: PMC4030110.
    48. Coppieters KT, von Herrath MG. Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapies. Mol Metab. 2014 Jun; 3(3):275-83. PMID: 24749057; PMCID: PMC3986497.
    49. Sarikonda G, Pettus J, Phatak S, Sachithanantham S, Miller JF, Wesley JD, Cadag E, Chae J, Ganesan L, Mallios R, Edelman S, Peters B, von Herrath M. CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes. J Autoimmun. 2014 May; 50:77-82. PMID: 24387802.
      View in: PubMed
    50. Sarikonda G, Pettus J, Sachithanantham S, Phatak S, Miller JF, Ganesan L, Chae J, Mallios R, Edelman S, Peters B, von Herrath M. Temporal intra-individual variation of immunological biomarkers in type 1 diabetes patients: implications for future use in cross-sectional assessment. PLoS One. 2013; 8(11):e79383. PMID: 24223938; PMCID: PMC3817042.
    51. Rydén AK, Wesley JD, Coppieters KT, Von Herrath MG. Non-antigenic and antigenic interventions in type 1 diabetes. Hum Vaccin Immunother. 2014; 10(4):838-46. PMID: 24165565; PMCID: PMC4896560.
    52. Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M. Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. J Immunol. 2013 Nov 15; 191(10):5026-35. PMID: 24101548; PMCID: PMC3915873.
    53. Schneider DA, Sarikonda G, Montero E, von Herrath MG. Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance. Clin Immunol. 2013 Dec; 149(3):440-1. PMID: 24211845.
      View in: PubMed
    54. Pettus J, von Herrath M. Keeping the patient perspective: Where are we in the world of type 1 diabetes? Clin Immunol. 2013 Dec; 149(3):265-7. PMID: 24012473.
      View in: PubMed
    55. Roep BO, Solvason N, Gottlieb PA, Abreu JRF, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, Garren H. Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8? T cells in type 1 diabetes. Sci Transl Med. 2013 Jun 26; 5(191):191ra82. PMID: 23803704; PMCID: PMC4516024.
    56. Boettler T, Pagni PP, Jaffe R, Cheng Y, Zerhouni P, von Herrath M. The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. J Autoimmun. 2013 Aug; 44:40-8. PMID: 23770292.
      View in: PubMed
    57. Schneider DA, von Herrath MG. Viruses and Type 1 diabetes: a dynamic labile equilibrium. Diabetes Manag (Lond). 2013 May; 3(3):217-223. PMID: 24634696.
      View in: PubMed
    58. Coppieters KT, von Herrath M. Antibody cross-reactivity and the viral aetiology of type 1 diabetes. J Pathol. 2013 May; 230(1):1-3. PMID: 23389883.
      View in: PubMed
    59. Coppieters KT, Amirian N, Pagni PP, Baca Jones C, Wiberg A, Lasch S, Hintermann E, Christen U, von Herrath MG. Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model. Diabetes. 2013 Jul; 62(7):2492-9. PMID: 23434930; PMCID: PMC3712024.
    60. Coppieters KT, Harrison LC, von Herrath MG. Trials in type 1 diabetes: Antigen-specific therapies. Clin Immunol. 2013 Dec; 149(3):345-55. PMID: 23490422.
      View in: PubMed
    61. Sarikonda G, Sachithanantham S, Manenkova Y, Kupfer T, Posgai A, Wasserfall C, Bernstein P, Straub L, Pagni PP, Schneider D, Calvo TR, Coulombe M, Herold K, Gill RG, Atkinson M, Nepom G, Ehlers M, Staeva T, Garren H, Steinman L, Chan AC, von Herrath M. Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice. PLoS One. 2013; 8(2):e54712. PMID: 23405091; PMCID: PMC3566105.
    62. Christen S, Coppieters K, Rose K, Holdener M, Bayer M, Pfeilschifter JM, Hintermann E, von Herrath MG, Aurrand-Lions M, Imhof BA, Christen U. Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice. PLoS One. 2013; 8(1):e54675. PMID: 23372751; PMCID: PMC3556033.
    63. Vaughan K, Peters B, Mallone R, von Herrath M, Roep BO, Sette A. Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB). Immunome Res. 2013; 9(1). PMID: 25140192.
      View in: PubMed
    64. Coppieters KT, Sehested Hansen B, von Herrath MG. Clinical potential of antigen-specific therapies in type 1 diabetes. Rev Diabet Stud. 2012; 9(4):328-37. PMID: 23804270; PMCID: PMC3740700.
    65. Coppieters KT, Wiberg A, von Herrath MG. Viral infections and molecular mimicry in type 1 diabetes. APMIS. 2012 Dec; 120(12):941-9. PMID: 23051179.
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    66. Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG. OX40 facilitates control of a persistent virus infection. PLoS Pathog. 2012 Sep; 8(9):e1002913. PMID: 22969431; PMCID: PMC3435255.
    67. Van Belle TL, Ling E, Haase C, Bresson D, Ursø B, von Herrath MG. NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes. J Autoimmun. 2013 Feb; 40:66-73. PMID: 22944096.
      View in: PubMed
    68. Boettler T, von Herrath M. IL-7 receptor a blockade, an off-switch for autoreactive T cells. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12270-1. PMID: 22826232; PMCID: PMC3412005.
    69. Christen U, Bender C, von Herrath MG. Infection as a cause of type 1 diabetes? Curr Opin Rheumatol. 2012 Jul; 24(4):417-23. PMID: 22504578; PMCID: PMC4828240.
    70. Chapman NM, Coppieters K, von Herrath M, Tracy S. The microbiology of human hygiene and its impact on type 1 diabetes. Islets. 2012 Jul-Aug; 4(4):253-61. PMID: 22996796; PMCID: PMC3496651.
    71. Boettler T, Cheng Y, Ehrhardt K, von Herrath M. TGF-ß blockade does not improve control of an established persistent viral infection. Viral Immunol. 2012 Jun; 25(3):232-8. PMID: 22620718; PMCID: PMC3366339.
    72. Van Belle TL, Nierkens S, Arens R, von Herrath MG. Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets. Immunity. 2012 Jun 29; 36(6):1060-72. PMID: 22579473; PMCID: PMC3810457.
    73. Fousteri G, Jasinski J, Dave A, Nakayama M, Pagni P, Lambolez F, Juntti T, Sarikonda G, Cheng Y, Croft M, Cheroutre H, Eisenbarth G, von Herrath M. Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes. 2012 May; 61(5):1169-79. PMID: 22403296; PMCID: PMC3331775.
    74. Boettler T, Cunha-Neto E, Kalil J, von Herrath M. Can an immune-regulatory vaccine prevent HIV infection? Expert Rev Anti Infect Ther. 2012 Mar; 10(3):299-305. PMID: 22397564; PMCID: PMC3318911.
    75. Mamchak AA, Manenkova Y, Leconet W, Zheng Y, Chan JR, Stokes CL, Shoda LK, von Herrath M, Bresson D. Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3. Diabetes. 2012 Jun; 61(6):1490-9. PMID: 22362174; PMCID: PMC3357270.
    76. Coppieters KT, von Herrath MG. Motifs for a deadly encounter. Nat Immunol. 2012 Feb 16; 13(3):205-6. PMID: 22344274.
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    77. Blumberg RS, Dittel B, Hafler D, von Herrath M, Nestle FO. Unraveling the autoimmune translational research process layer by layer. Nat Med. 2012 Jan 06; 18(1):35-41. PMID: 22227670; PMCID: PMC4592149.
    78. Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TW, Atkinson MA, Roep BO, von Herrath MG. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med. 2012 Jan 16; 209(1):51-60. PMID: 22213807; PMCID: PMC3260877.
    79. Coppieters KT, Boettler T, von Herrath M. Virus infections in type 1 diabetes. Cold Spring Harb Perspect Med. 2012 Jan; 2(1):a007682. PMID: 22315719; PMCID: PMC3253029.
    80. Schneider DA, Sarikonda G, von Herrath MG. Combination therapy with InsB9-23 peptide immunization and CTLA4-IgG does not reverse diabetes in NOD mice. Clin Immunol. 2012 Mar; 142(3):402-3. PMID: 22239953.
      View in: PubMed
    81. Coppieters K, Amirian N, von Herrath M. Intravital imaging of CTLs killing islet cells in diabetic mice. J Clin Invest. 2012 Jan; 122(1):119-31. PMID: 22133877; PMCID: PMC3248300.
    82. Bresson D, Fousteri G, Manenkova Y, Croft M, von Herrath M. Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun. 2011 Dec; 37(4):342-51. PMID: 22063316; PMCID: PMC3811160.
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