Martyn Goulding

TitleAdjunct Professor
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0932
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Revealing the connectivity and functionality of brain stem circuits
    NIH/NINDS U01NS090595Sep 30, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Spinal cord neural circuits for left-right and flexor-extensor coordination
    NIH/NINDS R01NS090919Sep 15, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Intersectional genetic dissection of spinal circuits processing pain and itch
    NIH/NINDS R01NS086372Sep 30, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Sensory and Supraspinal Control of Locomotion
    NIH/NINDS R01NS080586Feb 15, 2013 - Jan 31, 2018
    Role: Principal Investigator
    Tools for Mapping Mammalian Nervous System Connections with Modified Rabies Virus
    NIH/NINDS RC2NS069464Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Diversification and Function of Spinal V2b-Derived Neurons
    NIH/FIC R03TW008026Aug 1, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Functional Analysis of Inhibitory Spinal Cord Interneurons
    NIH/NINDS R37NS037075Apr 1, 1998 - Mar 31, 2013
    Role: Principal Investigator
    Functional Analysis of Spinal Cord Interneurons
    NIH/NINDS R01NS037075Apr 1, 1998 - Aug 14, 2006
    Role: Principal Investigator
    Specification of Dorsal Lbx1-Derived Interneurons
    NIH/NINDS R01NS031978Aug 1, 1993 - Apr 30, 2008
    Role: Principal Investigator
    Molecular Determinants of Neural Development
    NIH/NINDS P01NS031249Jan 1, 1993 - Mar 31, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang Y, Liu S, Zhang YQ, Goulding M, Wang YQ, Ma Q. Timing Mechanisms Underlying Gate Control by Feedforward Inhibition. Neuron. 2018 Aug 07. PMID: 30122375.
      View in: PubMed
    2. Gatto G, Goulding M. Locomotion Control: Brainstem Circuits Satisfy the Need for Speed. Curr Biol. 2018 Mar 19; 28(6):R256-R259. PMID: 29558639.
      View in: PubMed
    3. Koch SC, Del Barrio MG, Dalet A, Gatto G, Günther T, Zhang J, Seidler B, Saur D, Schüle R, Goulding M. RORß Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait. Neuron. 2017 Dec 20; 96(6):1419-1431.e5. PMID: 29224725.
      View in: PubMed
    4. Koch SC, Acton D, Goulding M. Spinal Circuits for Touch, Pain, and Itch. Annu Rev Physiol. 2018 Feb 10; 80:189-217. PMID: 28961064.
      View in: PubMed
    5. Cheng L, Duan B, Huang T, Zhang Y, Chen Y, Britz O, Garcia-Campmany L, Ren X, Vong L, Lowell BB, Goulding M, Wang Y, Ma Q. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. Nat Neurosci. 2017 Jun; 20(6):804-814. PMID: 28436981.
      View in: PubMed
    6. Sternfeld MJ, Hinckley CA, Moore NJ, Pankratz MT, Hilde KL, Driscoll SP, Hayashi M, Amin ND, Bonanomi D, Gifford WD, Sharma K, Goulding M, Pfaff SL. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. Elife. 2017 Feb 14; 6. PMID: 28195039.
      View in: PubMed
    7. Flynn JR, Conn VL, Boyle KA, Hughes DI, Watanabe M, Velasquez T, Goulding MD, Callister RJ, Graham BA. Anatomical and Molecular Properties of Long Descending Propriospinal Neurons in Mice. Front Neuroanat. 2017; 11:5. PMID: 28220062.
      View in: PubMed
    8. Tuncdemir SN, Wamsley B, Stam FJ, Osakada F, Goulding M, Callaway EM, Rudy B, Fishell G. Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits. Neuron. 2016 Feb 03; 89(3):521-35. PMID: 26844832.
      View in: PubMed
    9. Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. Correction: A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. Elife. 2015 Nov 25; 4:e13038. PMID: 26606138; PMCID: PMC4657252.
    10. Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, Goulding M. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science. 2015 Oct 30; 350(6260):550-4. PMID: 26516282; PMCID: PMC4700934.
    11. Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. Elife. 2015 Oct 14; 4. PMID: 26465208; PMCID: PMC4604447.
    12. Bourane S, Grossmann KS, Britz O, Dalet A, Del Barrio MG, Stam FJ, Garcia-Campmany L, Koch S, Goulding M. Identification of a spinal circuit for light touch and fine motor control. Cell. 2015 Jan 29; 160(3):503-15. PMID: 25635458; PMCID: PMC4431637.
    13. Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross S, Lowell BB, Wang Y, Goulding M, Ma Q. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014 Dec 04; 159(6):1417-1432. PMID: 25467445; PMCID: PMC4258511.
    14. Carcagno AL, Di Bella DJ, Goulding M, Guillemot F, Lanuza GM. Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain. J Neurosci. 2014 Nov 12; 34(46):15223-33. PMID: 25392491.
      View in: PubMed
    15. Hatori M, Gill S, Mure LS, Goulding M, O'Leary DD, Panda S. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife. 2014 Jul 17; 3:e03357. PMID: 25035422; PMCID: PMC4137275.
    16. Goulding M, Bourane S, Garcia-Campmany L, Dalet A, Koch S. Inhibition downunder: an update from the spinal cord. Curr Opin Neurobiol. 2014 Jun; 26:161-6. PMID: 24743058; PMCID: PMC4059017.
    17. Zhang J, Lanuza GM, Britz O, Wang Z, Siembab VC, Zhang Y, Velasquez T, Alvarez FJ, Frank E, Goulding M. V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion. Neuron. 2014 Apr 02; 82(1):138-50. PMID: 24698273; PMCID: PMC4096991.
    18. Borowska J, Jones CT, Zhang H, Blacklaws J, Goulding M, Zhang Y. Functional subpopulations of V3 interneurons in the mature mouse spinal cord. J Neurosci. 2013 Nov 20; 33(47):18553-65. PMID: 24259577; PMCID: PMC3894417.
    19. Del Barrio MG, Bourane S, Grossmann K, Schüle R, Britsch S, O'Leary DD, Goulding M. A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord. PLoS One. 2013; 8(11):e77928. PMID: 24223744; PMCID: PMC3817166.
    20. Francius C, Harris A, Rucchin V, Hendricks TJ, Stam FJ, Barber M, Kurek D, Grosveld FG, Pierani A, Goulding M, Clotman F. Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord. PLoS One. 2013; 8(8):e70325. PMID: 23967072; PMCID: PMC3744532.
    21. Li Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage FH. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9106-11. PMID: 23671081; PMCID: PMC3670356.
    22. Goulding M. Motor neurons that multitask. Neuron. 2012 Nov 21; 76(4):669-70. PMID: 23177952; PMCID: PMC3754894.
    23. Ikrar T, Shi Y, Velasquez T, Goulding M, Xu X. Cell-type specific regulation of cortical excitability through the allatostatin receptor system. Front Neural Circuits. 2012; 6:2. PMID: 22319474; PMCID: PMC3262160.
    24. Stam FJ, Hendricks TJ, Zhang J, Geiman EJ, Francius C, Labosky PA, Clotman F, Goulding M. Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Development. 2012 Jan; 139(1):179-90. PMID: 22115757; PMCID: PMC3231776.
    25. Garcia-Campmany L, Stam FJ, Goulding M. From circuits to behaviour: motor networks in vertebrates. Curr Opin Neurobiol. 2010 Feb; 20(1):116-25. PMID: 20138753; PMCID: PMC2847443.
    26. Grossmann KS, Giraudin A, Britz O, Zhang J, Goulding M. Genetic dissection of rhythmic motor networks in mice. Prog Brain Res. 2010; 187:19-37. PMID: 21111198; PMCID: PMC3056116.
    27. Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol. 2009 Sep 15; 333(2):386-96. PMID: 19607821.
      View in: PubMed
    28. Goulding M. Circuits controlling vertebrate locomotion: moving in a new direction. Nat Rev Neurosci. 2009 Jul; 10(7):507-18. PMID: 19543221; PMCID: PMC2847453.
    29. Pagliardini S, Ren J, Gray PA, Vandunk C, Gross M, Goulding M, Greer JJ. Central respiratory rhythmogenesis is abnormal in lbx1- deficient mice. J Neurosci. 2008 Oct 22; 28(43):11030-41. PMID: 18945911.
      View in: PubMed
    30. Zhang Y, Narayan S, Geiman E, Lanuza GM, Velasquez T, Shanks B, Akay T, Dyck J, Pearson K, Gosgnach S, Fan CM, Goulding M. V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron. 2008 Oct 09; 60(1):84-96. PMID: 18940590; PMCID: PMC2753604.
    31. Wang Z, Li L, Goulding M, Frank E. Early postnatal development of reciprocal Ia inhibition in the murine spinal cord. J Neurophysiol. 2008 Jul; 100(1):185-96. PMID: 18463181; PMCID: PMC2493495.
    32. Xu Y, Lopes C, Qian Y, Liu Y, Cheng L, Goulding M, Turner EE, Lima D, Ma Q. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci. 2008 Apr 09; 28(15):4037-46. PMID: 18400903; PMCID: PMC2681187.
    33. Pillai A, Mansouri A, Behringer R, Westphal H, Goulding M. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development. 2007 Jan; 134(2):357-66. PMID: 17166926.
      View in: PubMed
    34. Tan EM, Yamaguchi Y, Horwitz GD, Gosgnach S, Lein ES, Goulding M, Albright TD, Callaway EM. Selective and quickly reversible inactivation of mammalian neurons in vivo using the Drosophila allatostatin receptor. Neuron. 2006 Jul 20; 51(2):157-70. PMID: 16846851.
      View in: PubMed
    35. Mizuguchi R, Kriks S, Cordes R, Gossler A, Ma Q, Goulding M. Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci. 2006 Jun; 9(6):770-8. PMID: 16715081.
      View in: PubMed
    36. Gosgnach S, Lanuza GM, Butt SJ, Saueressig H, Zhang Y, Velasquez T, Riethmacher D, Callaway EM, Kiehn O, Goulding M. V1 spinal neurons regulate the speed of vertebrate locomotor outputs. Nature. 2006 Mar 09; 440(7081):215-9. PMID: 16525473.
      View in: PubMed
    37. Quina LA, Pak W, Lanier J, Banwait P, Gratwick K, Liu Y, Velasquez T, O'Leary DD, Goulding M, Turner EE. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci. 2005 Dec 14; 25(50):11595-604. PMID: 16354917.
      View in: PubMed
    38. Alvarez FJ, Jonas PC, Sapir T, Hartley R, Berrocal MC, Geiman EJ, Todd AJ, Goulding M. Postnatal phenotype and localization of spinal cord V1 derived interneurons. J Comp Neurol. 2005 Dec 12; 493(2):177-92. PMID: 16255029; PMCID: PMC2997483.
    39. Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, Goulding M, Ma Q. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat Neurosci. 2005 Nov; 8(11):1510-5. PMID: 16234809.
      View in: PubMed
    40. Kriks S, Lanuza GM, Mizuguchi R, Nakafuku M, Goulding M. Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development. 2005 Jul; 132(13):2991-3002. PMID: 15930101.
      View in: PubMed
    41. Goulding M, Pfaff SL. Development of circuits that generate simple rhythmic behaviors in vertebrates. Curr Opin Neurobiol. 2005 Feb; 15(1):14-20. PMID: 15721739.
      View in: PubMed
    42. Goulding M. How early is firing required for wiring? Neuron. 2004 Sep 02; 43(5):601-3. PMID: 15339640.
      View in: PubMed
    43. Goulding M. Neurobiology: a matter of balance. Nature. 2004 Jun 03; 429(6991):515-7. PMID: 15175736.
      View in: PubMed
    44. Lanuza GM, Gosgnach S, Pierani A, Jessell TM, Goulding M. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron. 2004 May 13; 42(3):375-86. PMID: 15134635.
      View in: PubMed
    45. Sapir T, Geiman EJ, Wang Z, Velasquez T, Mitsui S, Yoshihara Y, Frank E, Alvarez FJ, Goulding M. Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development. J Neurosci. 2004 Feb 04; 24(5):1255-64. PMID: 14762144; PMCID: PMC2997484.
    46. Goulding M, Lanuza G, Sapir T, Narayan S. The formation of sensorimotor circuits. Curr Opin Neurobiol. 2002 Oct; 12(5):508-15. PMID: 12367629.
      View in: PubMed
    47. Gross MK, Dottori M, Goulding M. Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16; 34(4):535-49. PMID: 12062038.
      View in: PubMed
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