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Marten Hoeksema

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0651
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Neele AE, Gijbels MJJ, van der Velden S, Hoeksema M, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ. Myeloid Kdm6b deficiency results in advanced atherosclerosis. Atherosclerosis. 2018 Jun 01; 275:156-165. PMID: 29908485.
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    2. Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema M, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell. 2018 May 05. PMID: 29779944.
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    3. Fei J, Ishii H, Hoeksema M, Meitinger F, Kassavetis GA, Glass CK, Ren B, Kadonaga JT. NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. Genes Dev. 2018 May 01; 32(9-10):682-694. PMID: 29759984.
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    4. Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema M, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 06; 71(5):527-542. PMID: 29406859.
      View in: PubMed
    5. Van Der Vorst E, Theodorou K, Wu Y, Hoeksema M, Goossens P, Bursill C, Aliyev T, Tas S, Kuijpers M, Gijbels M, Schalkwijk C, Leitges M, Lawrence T, Touqui L, Plat J, Van Eck M, Rye KA, De Winther M, Biessen E, Donners M. High density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-kB/STAT1-IRF1 signaling. Atherosclerosis. 2017 Aug; 263:e6. PMID: 29366163.
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    6. Bernelot Moens SJ, Neele AE, Kroon J, van der Valk FM, Van den Bossche J, Hoeksema M, Hoogeveen RM, Schnitzler JG, Baccara-Dinet MT, Manvelian G, de Winther MPJ, Stroes ESG. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia. Eur Heart J. 2017 May 21; 38(20):1584-1593. PMID: 28329114.
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    7. Neele AE, Prange KH, Hoeksema M, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP. Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells. Epigenomics. 2017 Apr; 9(4):383-391. PMID: 28322580.
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    8. van der Vorst EPC, Theodorou K, Wu Y, Hoeksema M, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners MMPC. High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-?B/STAT1-IRF1 Signaling. Cell Metab. 2017 Jan 10; 25(1):197-207. PMID: 27866837.
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    9. Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema M, de Vos AF, de Winther MP. Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Cell Rep. 2016 10 11; 17(3):684-696. PMID: 27732846.
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    10. Tol MJ, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten SM, Geerts D, van Roomen C, Bierlaagh MC, Scheij S, Hoeksema M, Aerts JM, Bogan JS, Dorn GW, Argmann CA, Verhoeven AJ. A PPAR?-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity. Diabetes. 2016 09; 65(9):2591-605. PMID: 27325287; PMCID: PMC5001173 [Available on 09/01/17].
    11. Hoeksema M, de Winther MP. Epigenetic Regulation of Monocyte and Macrophage Function. Antioxid Redox Signal. 2016 11 10; 25(14):758-774. PMID: 26983461.
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    12. Hoeksema M, Laan LC, Postma JJ, Cummings RD, de Winther MP, Dijkstra CD, van Die I, Kooij G. Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling. FASEB J. 2016 08; 30(8):2826-36. PMID: 27095802.
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    13. Boshuizen MC, Neele AE, Gijbels MJ, van der Velden S, Hoeksema M, Forman RA, Muller W, Van den Bossche J, de Winther MP. Myeloid interferon-? receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice. Atherosclerosis. 2016 Mar; 246:325-33. PMID: 26828750.
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    14. Nelson JK, Cook EC, Loregger A, Hoeksema M, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N. Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake. J Biol Chem. 2016 Feb 26; 291(9):4813-25. PMID: 26719329; PMCID: PMC4813502 [Available on 02/26/17].
    15. Boshuizen MC, Hoeksema M, Neele AE, van der Velden S, Hamers AA, Van den Bossche J, Lutgens E, de Winther MP. Interferon-ß promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms. Cytokine. 2016 Jan; 77:220-6. PMID: 26427927.
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    16. Neele AE, Van den Bossche J, Hoeksema M, de Winther MP. Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis. Eur J Pharmacol. 2015 Sep 15; 763(Pt A):79-89. PMID: 26004034.
      View in: PubMed
    17. Hoeksema M, Scicluna BP, Boshuizen MC, van der Velden S, Neele AE, Van den Bossche J, Matlung HL, van den Berg TK, Goossens P, de Winther MP. IFN-? priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment. J Immunol. 2015 Apr 15; 194(8):3909-16. PMID: 25750432.
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    18. Van den Bossche J, Neele AE, Hoeksema M, de Heij F, Boshuizen MC, van der Velden S, de Boer VC, Reedquist KA, de Winther MP. Inhibiting epigenetic enzymes to improve atherogenic macrophage functions. Biochem Biophys Res Commun. 2014 Dec 12; 455(3-4):396-402. PMID: 25446073.
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    19. Van den Bossche J, Neele AE, Hoeksema M, de Winther MP. Macrophage polarization: the epigenetic point of view. Curr Opin Lipidol. 2014 Oct; 25(5):367-73. PMID: 25188918.
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    20. Hoeksema M, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med. 2014 Sep; 6(9):1124-32. PMID: 25007801; PMCID: PMC4197860.
    21. Seijkens T, Hoeksema M, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E. Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis. FASEB J. 2014 May; 28(5):2202-13. PMID: 24481967.
      View in: PubMed
    22. Wijnands KA, Hoeksema M, Meesters DM, van den Akker NM, Molin DG, Briedé JJ, Ghosh M, Köhler SE, van Zandvoort MA, de Winther MP, Buurman WA, Lamers WH, Poeze M. Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia. PLoS One. 2014; 9(1):e86135. PMID: 24465919; PMCID: PMC3897658.
    23. Hoeksema M, Stöger JL, de Winther MP. Molecular pathways regulating macrophage polarization: implications for atherosclerosis. Curr Atheroscler Rep. 2012 Jun; 14(3):254-63. PMID: 22407286; PMCID: PMC3348484.
    24. Goossens P, Vergouwe MN, Gijbels MJ, Curfs DM, van Woezik JH, Hoeksema M, Xanthoulea S, Leenen PJ, Rupec RA, Hofker MH, de Winther MP. Myeloid I?Ba deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques. PLoS One. 2011; 6(7):e22327. PMID: 21814576; PMCID: PMC3141029.
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