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Marshall Orloff

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentSurgery
Address200 W. Arbor Drive #8999
San Diego CA 92103
Phone619-543-5866
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    Marshall J. Orloff, MD has been a member of the UCSD School of Medicine faculty for 45 years. In June 1965, Dr. Orloff accepted the position of Chair of Surgery at UCSD. He was the first faculty member and first departmental chair appointed to the UCSD School of Medicine and was one of the founders of the medical school.

    Dr. Orloff received BS, MS, and MD degrees from the University of Illinois, all with high honors, and was a PhD candidate in pharmacology at the University of Colorado. He was the valedictorian of each of the graduating classes of which he was a member. He served an internship at the University of California, San Francisco, and a residency in general surgery and in thoracic surgery at the Hospital of the University of Pennsylvania. He also served research fellowships in pharmacology and in surgery, and was a trainee of the National Cancer Institute. His residency was interrupted by a two-year stint in Germany in the U.S. Army Medical Corps. He has been certified by the American Board of Surgery and the Board of Thoracic Surgery.

    Dr. Orloff’s first full-time academic post was as an Assistant Professor of Surgery at the University of Colorado, where he was honored by being made a Markle Scholar in Medical Science. In 1961, at the age of 34, he was made Professor of Surgery at UCLA School of Medicine and Chief of Surgery at Harbor General Hospital. At Harbor General, he recruited a faculty of young surgeons, four of whom subsequently became chairmen of departments of surgery at major universities. During his tenure at Harbor General, he was offered the position of chairman of surgery at Yale University, University of Chicago, Columbia University, and University of Texas, but he elected to accept the position at the new and very promising UCSD. He was 37 years old when he accepted the Chair of Surgery at UCSD, the youngest surgical chair in the United States.

    Research
    Dr. Orloff’s research activities have been among the most productive of his endeavors. He competed for and was awarded continuous NIH grant support from 1956 to 2004, amounting to approximately $22 million. His research and clinical studies have resulted in 408 publications in peer-reviewed scientific journals and books. He is widely known for his contributions in liver physiology and disease, portal hypertension, diabetes, liver transplantation, pancreas transplantation, gastrointestinal disease, cancer, metabolism, immunology, disease of bile ducts and gallbladder, pancreatic disease, medical education, and morbid obesity.


    Collapse Research 
    Collapse Research Activities and Funding
    BLEEDING ESOPHAGEAL VARICES STUDY
    NIH/NIDDK R01DK041920Jul 15, 1990 - Dec 31, 1997
    Role: Principal Investigator
    EFFECT OF PANCREAS TRANSPLANTS ON PATHOLOGY OF DIABETES
    NIH/NIDDK R01DK030825Apr 1, 1987 - Jun 30, 1996
    Role: Principal Investigator
    EFFECT OF PANCREAS TRANSPLANTS ON PATHOLOGY OF DIABETES
    NIH/NIADDK R01AM030825Apr 1, 1983 - Mar 31, 1987
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Orloff M, Hye RJ, Wheeler HO, Isenberg JI, Haynes KS, Vaida F, Girard B, Orloff KJ. Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis. Surgery. 2015 Jun; 157(6):1028-45. PMID: 25957003.
      View in: PubMed
    2. Orloff M. Fifty-three years' experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in Cirrhosis: 1958-2011. JAMA Surg. 2014 Feb; 149(2):155-69. PMID: 24402314.
      View in: PubMed
    3. Orloff MJ, Orloff M, Orloff SL, Orloff LA, Daily PO, Girard B, Isenberg JI, Wheeler HO. Unshuntable extrahepatic portal hypertension revisited: 43 years' experience with radical esophagogastrectomy treatment of bleeding esophagogastric varices. Am J Surg. 2014 Jan; 207(1):46-52. PMID: 24070666.
      View in: PubMed
    4. Orloff M, Vaida F, Haynes KS, Hye RJ, Isenberg JI, Jinich-Brook H. Randomized controlled trial of emergency transjugular intrahepatic portosystemic shunt versus emergency portacaval shunt treatment of acute bleeding esophageal varices in cirrhosis. J Gastrointest Surg. 2012 Nov; 16(11):2094-111. PMID: 23007280.
      View in: PubMed
    5. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ, Orloff SL. Disability index in a randomized controlled trial of emergency sclerotherapy versus portacaval shunt for bleeding varices in cirrhosis. Am J Surg. 2012 Aug; 204(2):157-66. PMID: 22575398.
      View in: PubMed
    6. Orloff M, Vaida F, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Hye RJ, Orloff SL. Child-Turcotte score versus MELD for prognosis in a randomized controlled trial of emergency treatment of bleeding esophageal varices in cirrhosis. J Surg Res. 2012 Nov; 178(1):139-46. PMID: 22480831.
      View in: PubMed
    7. Orloff M, Isenberg JI, Wheeler HO, Daily PO, Girard B. Budd-Chiari syndrome revisited: 38 years' experience with surgical portal decompression. J Gastrointest Surg. 2012 Feb; 16(2):286-300; discussion 300. PMID: 22065317.
      View in: PubMed
    8. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ, Orloff SL. A randomized controlled trial of emergency treatment of bleeding esophageal varices in cirrhosis for hepatocellular carcinoma. Am J Surg. 2012 Feb; 203(2):182-90. PMID: 21679921.
      View in: PubMed
    9. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ, Orloff SL. Alcoholic versus nonalcoholic cirrhosis in a randomized controlled trial of emergency therapy of bleeding varices. J Surg Res. 2012 May 01; 174(1):98-105. PMID: 21195430; PMCID: PMC3084337.
    10. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ, Orloff SL. Liver transplantation in a randomized controlled trial of emergency treatment of acutely bleeding esophageal varices in cirrhosis. Transplant Proc. 2010 Dec; 42(10):4101-8. PMID: 21168637; PMCID: PMC3032417.
    11. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ. Direct costs of care in a randomized controlled trial of endoscopic sclerotherapy versus emergency portacaval shunt for bleeding esophageal varices in cirrhosis--Part 4. J Gastrointest Surg. 2011 Jan; 15(1):38-47. PMID: 20824373; PMCID: PMC3023018.
    12. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ. Emergency portacaval shunt versus rescue portacaval shunt in a randomized controlled trial of emergency treatment of acutely bleeding esophageal varices in cirrhosis--part 3. J Gastrointest Surg. 2010 Nov; 14(11):1782-95. PMID: 20658205; PMCID: PMC2956038.
    13. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Horacio JB, Rapier R, Vaida F, Hye RJ. Portal-systemic encephalopathy in a randomized controlled trial of endoscopic sclerotherapy versus emergency portacaval shunt treatment of acutely bleeding esophageal varices in cirrhosis. Ann Surg. 2009 Oct; 250(4):598-610. PMID: 19730244.
      View in: PubMed
    14. Orloff M, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ. Randomized trial of emergency endoscopic sclerotherapy versus emergency portacaval shunt for acutely bleeding esophageal varices in cirrhosis. J Am Coll Surg. 2009 Jul; 209(1):25-40. PMID: 19651060.
      View in: PubMed
    15. Orloff M. Prophylactic portasystemic shunt in non-cirrhotic portal fibrosis: is it worthwhile? Nobody knows. Indian J Gastroenterol. 2005 Nov-Dec; 24(6):233-5. PMID: 16424616.
      View in: PubMed
    16. Orloff MJ, Orloff M, Girard B, Orloff SL. Bleeding esophagogastric varices from extrahepatic portal hypertension: 40 years' experience with portal-systemic shunt. J Am Coll Surg. 2002 Jun; 194(6):717-28; discussion 728-30. PMID: 12081062.
      View in: PubMed
    17. Orloff MJ, Daily PO, Orloff SL, Girard B, Orloff M. A 27-year experience with surgical treatment of Budd-Chiari syndrome. Ann Surg. 2000 Sep; 232(3):340-52. PMID: 10973384; PMCID: PMC1421148.
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