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    Mark Valasek

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address200 W. Arbor Drive #8720
    CA San Diego 92103
    Phone619-543-3265
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lowenthal BM, Chan TW, Thorson JA, Kelly KJ, Savides TJ, Valasek M. Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a TP53 R273C Mutation: An Unusual Case with Wild-Type BRAF. Case Rep Pathol. 2017; 2017:3427343. PMID: 28840050.
        View in: PubMed
      2. Valasek M, Thung I, Gollapalle E, Hodkoff AA, Kelly KJ, Baumgartner JM, Vavinskaya V, Lin GY, Tipps AP, Hosseini MV, Lowy AM. Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PLoS One. 2017; 12(6):e0179216. PMID: 28591173.
        View in: PubMed
      3. Takayesu JSK, Tringale KR, Marshall DC, Burkeen J, Valasek M, Hemming A, Atwood T, Simpson D, Hattangadi-Gluth J. Bullet fragment fiducials in stereotactic body radiotherapy as a bridge to transplant for hepatocellular carcinoma. Acta Oncol. 2017 May 12; 1-4. PMID: 28497999.
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      4. Paige JS, Bernstein GS, Heba E, Costa EA, Fereirra M, Wolfson T, Gamst AC, Valasek M, Lin GY, Han A, Erdman JW, O'Brien WD, Andre MP, Loomba R, Sirlin CB. A Pilot Comparative Study of Quantitative Ultrasound, Conventional Ultrasound, and MRI for Predicting Histology-Determined Steatosis Grade in Adult Nonalcoholic Fatty Liver Disease. AJR Am J Roentgenol. 2017 Mar 07; W1-W10. PMID: 28267360.
        View in: PubMed
      5. Lin SC, Heba E, Bettencourt R, Lin GY, Valasek M, Lunde O, Hamilton G, Sirlin CB, Loomba R. Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging. Aliment Pharmacol Ther. 2017 Jan 24. PMID: 28116801.
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      6. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Alquiraish MH, Valasek M, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2016 Oct 27. PMID: 27911262.
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      7. Vavinskaya V, Baumgartner JM, Ko A, Saenz CC, Valasek M. Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge. Case Rep Obstet Gynecol. 2016; 2016:6841989. PMID: 27843660.
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      8. Lowenthal BM, Shabaik AS, Valasek M. Metastatic Gastrointestinal Adenocarcinoma with Osteoblastic Activity: A Case Report of Esophageal and Colonic Primaries. Case Rep Pathol. 2016; 2016:1934759. PMID: 27738541.
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      9. Patel J, Bettencourt R, Cui J, Salotti J, Hooker J, Bhatt A, Hernandez C, Nguyen P, Aryafar H, Valasek M, Haufe W, Hooker C, Richards L, Sirlin CB, Loomba R. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2016 Sep; 9(5):692-701. PMID: 27582882.
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      10. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, Minocha J, Valasek M, Aryafar H, Brenner DA, Sirlin CB, Loomba R. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Aliment Pharmacol Ther. 2016 Aug; 44(3):287-99. PMID: 27279429.
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      11. Thung I, Crowe SE, Valasek M. Letter: global emergence of Helicobacter pylori antibiotic resistance - unanswered questions. Authors' reply. Aliment Pharmacol Ther. 2016 Jun; 43(11):1249-50. PMID: 27137739.
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      12. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek M, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 Jun 13; 29(6):935-48. PMID: 27211490.
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      13. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek M, Sasik R, Novelli F, Hirsch E, Varner JA. Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 Aug; 6(8):870-85. PMID: 27179037.
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      14. Boland BS, Bagi P, Valasek M, Chang JT, Bustamante R, Madlensky L, Sandborn WJ, Harismendy O, Gupta S. Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis. Am J Gastroenterol. 2016 May; 111(5):746-8. PMID: 27151126.
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      15. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek M, Lin GY, Gamst A, Brenner DA, Yin M, Glaser KJ, Ehman RL, Sirlin CB. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 Jul; 111(7):986-94. PMID: 27002798.
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      16. Lin SC, Ang B, Hernandez C, Bettencourt R, Jain R, Salotti J, Richards L, Kono Y, Bhatt A, Aryafar H, Lin GY, Valasek M, Sirlin CB, Brouha S, Loomba R. Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial. Therap Adv Gastroenterol. 2016 Mar; 9(2):152-61. PMID: 26929777.
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      17. Park JY, Dunbar KB, Mitui M, Arnold CA, Lam-Himlin DM, Valasek M, Thung I, Okwara C, Coss E, Cryer B, Doern CD. Helicobacter pylori Clarithromycin Resistance and Treatment Failure Are Common in the USA. Dig Dis Sci. 2016 Aug; 61(8):2373-80. PMID: 26923948.
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      18. Thung I, Aramin H, Vavinskaya V, Gupta S, Park JY, Crowe SE, Valasek M. Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment Pharmacol Ther. 2016 Feb; 43(4):514-33. PMID: 26694080.
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      19. Cui J, Heba E, Hernandez C, Haufe W, Hooker J, Andre MP, Valasek M, Aryafar H, Sirlin CB, Loomba R. Magnetic resonance elastography is superior to acoustic radiation force impulse for the Diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: A prospective study. Hepatology. 2016 Feb; 63(2):453-61. PMID: 26560734.
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      20. Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Shackelton LM, Walker CW, Nelson S, Vandervoort MK, Frisbie V, Samaan MA, Jairath V, Driman DK, Geboes K, Valasek M, Pai RK, Lauwers GY, Riddell R, Stitt LW, Levesque BG. Development and validation of a histological index for UC. Gut. 2017 Jan; 66(1):50-58. PMID: 26475633.
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      21. Tang A, Valasek M, Sirlin CB. Update on the Liver Imaging Reporting and Data System: What the Pathologist Needs to Know. Adv Anat Pathol. 2015 Sep; 22(5):314-22. PMID: 26262514.
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      22. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek M, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. PMID: 26276631.
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      23. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek M, Kisselva T, Brenner DA, Loomba R. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2015 Sep; 42(5):582-90. PMID: 26119353.
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      24. Halldorson J, Kazi Z, Mekeel K, Kuo A, Hassanein T, Loomba R, Austin S, Valasek M, Kishnani P, Hemming AW. Successful combined liver/kidney transplantation from a donor with Pompe disease. Mol Genet Metab. 2015 Aug; 115(4):141-4. PMID: 26031770.
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      25. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek M, Brenner DA, Richards L. Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. PMID: 25482832.
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      26. Arulanandan A, Ang B, Bettencourt R, Hooker J, Behling C, Lin GY, Valasek M, Ix JH, Schnabl B, Sirlin CB, Loomba R. Association Between Quantity of Liver Fat and Cardiovascular Risk in Patients With Nonalcoholic Fatty Liver Disease Independent of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2015 Aug; 13(8):1513-1520.e1. PMID: 25661453.
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      27. Vodkin I, Valasek M, Bettencourt R, Cachay E, Loomba R. Clinical, biochemical and histological differences between HIV-associated NAFLD and primary NAFLD: a case-control study. Aliment Pharmacol Ther. 2015 Feb; 41(4):368-78. PMID: 25496369.
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      28. Mojtahed A, Khanna R, Sandborn WJ, D'Haens GR, Feagan BG, Shackelton LM, Baker KA, Dubcenco E, Valasek M, Geboes K, Levesque BG. Assessment of histologic disease activity in Crohn's disease: a systematic review. Inflamm Bowel Dis. 2014 Nov; 20(11):2092-103. PMID: 25137418.
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      29. Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Behling C, Kaplan K, Driman DK, Shackelton LM, Baker KA, MacDonald JK, Vandervoort MK, Samaan MA, Geboes K, Valasek M, Pai R, Langner C, Riddell R, Harpaz N, Sewitch M, Peterson M, Stitt LW, Levesque BG. Reproducibility of histological assessments of disease activity in UC. Gut. 2015 Nov; 64(11):1765-73. PMID: 25360036.
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      30. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: A prospective study. Hepatology. 2014 Dec; 60(6):1920-8. PMID: 25103310.
        View in: PubMed
      31. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek M, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development. Cancer Cell. 2014 Sep 8; 26(3):331-43. PMID: 25132496.
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      32. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek M, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition. Cell Metab. 2014 Jul 1; 20(1):133-44. PMID: 24910242.
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      33. Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo WC, Zuo M, Valasek M, Javle M, Wilkinson MF, Lu Y. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nat Med. 2014 Jun; 20(6):596-8. PMID: 24859531.
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      34. Chuang JC, Valasek M, Lopez AM, Posey KS, Repa JJ, Turley SD. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 1; 88(3):351-63. PMID: 24486573.
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      35. Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek M, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, Sturley SL. A Functional, Genome-wide Evaluation of Liposensitive Yeast Identifies the "ARE2 Required for Viability" (ARV1) Gene Product as a Major Component of Eukaryotic Fatty Acid Resistance. J Biol Chem. 2014 Feb 14; 289(7):4417-31. PMID: 24273168.
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      36. Nguyen AD, Valasek M, Burstein E. Paraneoplastic diarrhea in a patient with lung adenocarcinoma. Clin J Gastroenterol. 2013 Oct; 6(5):357-60. PMID: 26181831.
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      37. Webb JR, Valasek M, North CS. Prevalence of stimulant use in a sample of US medical students. Ann Clin Psychiatry. 2013 Feb; 25(1):27-32. PMID: 23376867.
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      38. Olson JM, Moore EC, Valasek M, Williams LH, Vary JC. Panniculitis in alpha-1 antitrypsin deficiency treated with enzyme replacement. J Am Acad Dermatol. 2012 Apr; 66(4):e139-41. PMID: 22421127.
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      39. Turley SD, Valasek M, Repa JJ, Dietschy JM. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1012-22. PMID: 20724527.
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      40. Webb JR, Thomas JW, Valasek M. Contemplating cognitive enhancement in medical students and residents. Perspect Biol Med. 2010; 53(2):200-14. PMID: 20495258.
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      41. Valasek M, Repa JJ, Quan G, Dietschy JM, Turley SD. Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G813-22. PMID: 18718997.
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      42. Repa JJ, Li H, Frank-Cannon TC, Valasek M, Turley SD, Tansey MG, Dietschy JM. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci. 2007 Dec 26; 27(52):14470-80. PMID: 18160655.
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      43. Valasek M, Clarke SL, Repa JJ. Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res. 2007 Dec; 48(12):2725-35. PMID: 17726195.
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      44. Valasek M, Repa JJ. The power of real-time PCR. Adv Physiol Educ. 2005 Sep; 29(3):151-9. PMID: 16109794.
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      45. Valasek M, Weng J, Shaul PW, Anderson RG, Repa JJ. Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem. 2005 Jul 29; 280(30):28103-9. PMID: 15919660.
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      46. Li H, Repa JJ, Valasek M, Beltroy EP, Turley SD, German DC, Dietschy JM. Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol. 2005 Apr; 64(4):323-33. PMID: 15835268.
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      47. Xiong Y, Miyamoto N, Shibata K, Valasek M, Motoike T, Kedzierski RM, Yanagisawa M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1045-50. PMID: 14722361.
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