Loading...

Mark Valasek

Title(s)Associate Professor, Pathology
SchoolHealth Sciences
Address200 W. Arbor Drive #8720
San Diego CA 92103
Phone619-543-3265
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Research Interests
    My clinical focus and sub-specialization is in gastrointestinal, hepatic, and pancreatic pathology, which dovetails with my primary research interest in pre-cancerous lesions of the gastrointestinal tract. Broadly defined, pre-cancerous lesions include not only dysplastic lesions, but also such disease entities as Barrett esophagus, fatty liver disease, and inflammatory bowel disease that can lead to esophageal carcinoma, hepatocellular carcinoma, and colonic adenocarcinoma, respectively. A key question in this field is what determines progression at each step of carcinogenesis. What distinguishes progressors from non-progressors? To help accomplish some of our research goals, we are developing "high-resolution" molecular and digital pathology techniques (including artificial intelligence) for the evaluation of gastrointestinal tissues utilizing emerging technologies. Therefore, my laboratory and collaborative work is focused on understanding the mechanisms underlying these pathophysiologic states to help define practical diagnostic and therapeutic clinical applications with the ultimate goal of improving patient care.

    Biography
    Dr. Valasek was accepted into the Medical Scientist Training Program at the University of Texas Southwestern Medical Center at Dallas (UTSW), completing his Ph.D. work in 2006 in the field of Integrative Biology studying gastrointestinal physiology, then receiving his M.D. thereafter. While at UTSW, he earned the prestigious Vernie A. Stembridge Scholarship Award for Excellence in Pathology. Dr. Valasek entered into residency in Anatomic Pathology at the University of Washington in Seattle (UW), where he also completed a fellowship in Gastrointestinal and Hepatic Pathology. He gained additional training in general surgical pathology sign-out as an Assistant Instructor in Surgical Pathology at Parkland Memorial Hospital/University of Texas Southwestern Medical Center. Dr. Valasek started as an Assistant Professor for the Division of Anatomic/Surgical Pathology in the UCSD Department of Pathology in 2013. He was awarded San Diego Medical Society's "2014 Top Doctors" — Physicians of Exceptional Excellence in the Field of Pathology and was an American Society for Clinical Pathology (ASCP) "40 Under Forty" Honoree in 2015. He is currently Director of the Gastrointestinal Pathology Fellowship.

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evaluating the optimum number of biopsies to assess histological inflammation in ulcerative colitis: a retrospective cohort study. Aliment Pharmacol Ther. 2020 Sep 27. Battat R, Vande Casteele N, Pai RK, Wang Z, Zou G, McDonald JWD, Duijvestein M, Jeyarajah J, Parker CE, Van Viegen T, Nelson SA, Boland BS, Singh S, Dulai PS, Valasek MA, Feagan BG, Jairath V, Sandborn WJ. PMID: 32981088.
      View in: PubMed   Mentions:    Fields:    
    2. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci Immunol. 2020 08 21; 5(50). Boland BS, He Z, Tsai MS, Olvera JG, Omilusik KD, Duong HG, Kim ES, Limary AE, Jin W, Milner JJ, Yu B, Patel SA, Louis TL, Tysl T, Kurd NS, Bortnick A, Quezada LK, Kanbar JN, Miralles A, Huylebroeck D, Valasek MA, Dulai PS, Singh S, Lu LF, Bui JD, Murre C, Sandborn WJ, Goldrath AW, Yeo GW, Chang JT. PMID: 32826341.
      View in: PubMed   Mentions: 2     Fields:    
    3. Predictors and outcomes of histological remission in ulcerative colitis treated to endoscopic healing. Aliment Pharmacol Ther. 2020 09; 52(6):1008-1016. Jangi S, Yoon H, Dulai PS, Valasek M, Boland BS, Jairath V, Feagan BG, Sandborn WJ, Singh S. PMID: 33119168.
      View in: PubMed   Mentions:    Fields:    
    4. Assessment of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease by Using Quantitative US. Radiology. 2020 04; 295(1):106-113. Han A, Zhang YN, Boehringer AS, Montes V, Andre MP, Erdman JW, Loomba R, Valasek MA, Sirlin CB, O'Brien WD. PMID: 32013792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Clinical Utility of an Increase in Magnetic Resonance Elastography in Predicting Fibrosis Progression in Nonalcoholic Fatty Liver Disease. Hepatology. 2020 Mar; 71(3):849-860. Ajmera VH, Liu A, Singh S, Yachoa G, Ramey M, Bhargava M, Zamani A, Lopez S, Mangla N, Bettencourt R, Rizo E, Valasek M, Behling C, Richards L, Sirlin C, Loomba R. PMID: 31556124.
      View in: PubMed   Mentions: 6     Fields:    
    6. Mutation profile of high-grade appendiceal mucinous neoplasm. Histopathology. 2020 Feb; 76(3):461-469. Liao X, Vavinskaya V, Sun K, Hao Y, Li X, Valasek M, Xu R, Polydorides AD, Houldsworth J, Harpaz N. PMID: 31491041.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Development and Validation of a Test to Monitor Endoscopic Activity in Patients With Crohn's Disease Based on Serum Levels of Proteins. Gastroenterology. 2020 02; 158(3):515-526.e10. D'Haens G, Kelly O, Battat R, Silverberg MS, Laharie D, Louis E, Savarino E, Bodini G, Yarur A, Boland BS, Afif W, Li XJ, Hale M, Ho J, Kondragunta V, Huang B, Kuy C, Okada L, Hester KD, Bray KR, Mimms L, Jain A, Singh S, Collins A, Valasek MA, Sandborn WJ, Vermeire S, Dulai PS. PMID: 31711925.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials. Aliment Pharmacol Ther. 2019 11; 50(10):1100-1111. Pai RK, Kleiner DE, Hart J, Adeyi OA, Clouston AD, Behling CA, Jain D, Kakar S, Brahmania M, Burgart L, Batts KP, Valasek MA, Torbenson MS, Guindi M, Wang HL, Ajmera V, Adams LA, Parker CE, Feagan BG, Loomba R, Jairath V. PMID: 31583739.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. The California Telepathology Service: UCLA's Experience in Deploying a Regional Digital Pathology Subspecialty Consultation Network. J Pathol Inform. 2019; 10:31. Chong T, Palma-Diaz MF, Fisher C, Gui D, Ostrzega NL, Sempa G, Sisk AE, Valasek M, Wang BY, Zuckerman J, Khacherian C, Binder S, Wallace WD. PMID: 31620310.
      View in: PubMed   Mentions:
    10. Histopathology Scoring Systems of Stenosis Associated With Small Bowel Crohn's Disease: A Systematic Review. Gastroenterology. 2020 01; 158(1):137-150.e1. Gordon IO, Bettenworth D, Bokemeyer A, Srivastava A, Rosty C, de Hertogh G, Robert ME, Valasek MA, Mao R, Kurada S, Harpaz N, Borralho P, Pai RK, Pai RK, Odze R, Feakins R, Parker CE, Nguyen T, Jairath V, Baker ME, Bruining DH, Fletcher JG, Feagan BG, Rieder F. PMID: 31476299.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Reader agreement and accuracy of ultrasound features for hepatic steatosis. Abdom Radiol (NY). 2019 01; 44(1):54-64. Hong CW, Marsh A, Wolfson T, Paige J, Dekhordy SF, Schlein AN, Housman E, Deiranieh LH, Li CQ, Wasnik AP, Jang HJ, Dietrich CF, Piscaglia F, Casola G, O'Boyle M, Richman KM, Valasek MA, Andre M, Loomba R, Sirlin CB. PMID: 29951900.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Gut. 2019 10; 68(10):1884-1892. Caussy C, Ajmera VH, Puri P, Hsu CL, Bassirian S, Mgdsyan M, Singh S, Faulkner C, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Sanyal AJ, Loomba R. PMID: 30567742.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther. 2019 01; 49(2):183-193. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R. PMID: 30506692.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Serum Concentrations of 7a-hydroxy-4-cholesten-3-one Are Associated With Bile Acid Diarrhea in Patients With Crohn's Disease. Clin Gastroenterol Hepatol. 2019 12; 17(13):2722-2730.e4. Battat R, Duijvestein M, Vande Casteele N, Singh S, Dulai PS, Valasek MA, Mimms L, McFarland J, Hester KD, Renshaw M, Jain A, Sandborn WJ, Boland BS. PMID: 30448597.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Race/Ethnicity-, Socioeconomic Status-, and Anatomic Subsite-Specific Risks for Gastric Cancer. Gastroenterology. 2019 01; 156(1):59-62.e4. Gupta S, Tao L, Murphy JD, Camargo MC, Oren E, Valasek MA, Gomez SL, Martinez ME. PMID: 30267713.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Responsiveness of histological disease activity indices in ulcerative colitis: a post hoc analysis using data from the TOUCHSTONE randomised controlled trial. Gut. 2019 07; 68(7):1162-1168. Jairath V, Peyrin-Biroulet L, Zou G, Mosli M, Vande Casteele N, Pai RK, Valasek MA, Marchal-Bressenot A, Stitt LW, Shackelton LM, Khanna R, D'Haens GR, Sandborn WJ, Olson A, Feagan BG, Pai RK. PMID: 30076171.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    17. Biallelic Mismatch Repair Deficiency in an Adolescent Female. Case Rep Genet. 2018; 2018:8657823. Hildreth A, Valasek MA, Thung I, Savides T, Sivagnanam M, Ramamoorthy S, Huang SC. PMID: 30155321.
      View in: PubMed   Mentions:
    18. Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient. Case Rep Transplant. 2018; 2018:7410508. Patel S, Mendler MH, Valasek MA, Tsunoda SM. PMID: 30105113.
      View in: PubMed   Mentions:
    19. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 08; 155(2):307-310.e2. Ajmera V, Park CC, Caussy C, Singh S, Hernandez C, Bettencourt R, Hooker J, Sy E, Behling C, Xu R, Middleton MS, Valasek MA, Faulkner C, Rizo E, Richards L, Sirlin CB, Loomba R. PMID: 29660324.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    21. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol. 2018 12; 16(12):1974-1982.e7. Caussy C, Chen J, Alquiraish MH, Cepin S, Nguyen P, Hernandez C, Yin M, Bettencourt R, Cachay ER, Jayakumar S, Fortney L, Hooker J, Sy E, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Ehman RL, Loomba R. PMID: 29104128.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. An Update on the Diagnosis, Grading, and Staging of Appendiceal Mucinous Neoplasms. Adv Anat Pathol. 2018 Jan; 25(1):38-60. Valasek MA, Pai RK. PMID: 29016471.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC. Ann Surg Oncol. 2018 Mar; 25(3):702-708. Reghunathan M, Kelly KJ, Valasek MA, Lowy AM, Baumgartner JM. PMID: 29282599.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    24. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. PMID: 29273451.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Nonuterine Lipoleiomyoma. Am Surg. 2017 Dec 01; 83(12):e474-475. Bommakanti K, Valasek MA, Sicklick JK. PMID: 29336739.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. PMID: 29153842.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    27. Vedolizumab in Patients With Common Variable Immune Deficiency and Gut Inflammation. Am J Gastroenterol. 2017 10; 112(10):1621. Boland BS, Riedl MA, Valasek MA, Crowe SE, Sandborn WJ. PMID: 28978958.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a TP53 R273C Mutation: An Unusual Case with Wild-Type BRAF. Case Rep Pathol. 2017; 2017:3427343. Lowenthal BM, Chan TW, Thorson JA, Kelly KJ, Savides TJ, Valasek MA. PMID: 28840050.
      View in: PubMed   Mentions:
    29. Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PLoS One. 2017; 12(6):e0179216. Valasek MA, Thung I, Gollapalle E, Hodkoff AA, Kelly KJ, Baumgartner JM, Vavinskaya V, Lin GY, Tipps AP, Hosseini MV, Lowy AM. PMID: 28591173.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Bullet fragment fiducials in stereotactic body radiotherapy as a bridge to transplant for hepatocellular carcinoma. Acta Oncol. 2017 10; 56(10):1324-1327. Takayesu JSK, Tringale KR, Marshall DC, Burkeen J, Valasek MA, Hemming A, Atwood T, Simpson D, Hattangadi-Gluth J. PMID: 28497999.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. A Pilot Comparative Study of Quantitative Ultrasound, Conventional Ultrasound, and MRI for Predicting Histology-Determined Steatosis Grade in Adult Nonalcoholic Fatty Liver Disease. AJR Am J Roentgenol. 2017 May; 208(5):W168-W177. Paige JS, Bernstein GS, Heba E, Costa EAC, Fereirra M, Wolfson T, Gamst AC, Valasek MA, Lin GY, Han A, Erdman JW, O'Brien WD, Andre MP, Loomba R, Sirlin CB. PMID: 28267360.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    32. Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging. Aliment Pharmacol Ther. 2017 03; 45(6):844-854. Lin SC, Heba E, Bettencourt R, Lin GY, Valasek MA, Lunde O, Hamilton G, Sirlin CB, Loomba R. PMID: 28116801.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017 02; 152(3):598-607.e2. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. PMID: 27911262.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    34. Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge. Case Rep Obstet Gynecol. 2016; 2016:6841989. Vavinskaya V, Baumgartner JM, Ko A, Saenz CC, Valasek MA. PMID: 27843660.
      View in: PubMed   Mentions:
    35. Metastatic Gastrointestinal Adenocarcinoma with Osteoblastic Activity: A Case Report of Esophageal and Colonic Primaries. Case Rep Pathol. 2016; 2016:1934759. Lowenthal BM, Shabaik AS, Valasek MA. PMID: 27738541.
      View in: PubMed   Mentions:
    36. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2016 Sep; 9(5):692-701. Patel J, Bettencourt R, Cui J, Salotti J, Hooker J, Bhatt A, Hernandez C, Nguyen P, Aryafar H, Valasek M, Haufe W, Hooker C, Richards L, Sirlin CB, Loomba R. PMID: 27582882.
      View in: PubMed   Mentions:
    37. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Aliment Pharmacol Ther. 2016 08; 44(3):287-99. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, Minocha J, Valasek MA, Aryafar H, Brenner DA, Sirlin CB, Loomba R. PMID: 27279429.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. PMID: 27281208.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    39. Letter: global emergence of Helicobacter pylori antibiotic resistance - unanswered questions. Authors' reply. Aliment Pharmacol Ther. 2016 06; 43(11):1249-50. Thung I, Crowe SE, Valasek MA. PMID: 27137739.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 27211490.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    41. Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. PMID: 27179037.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    42. Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis. Am J Gastroenterol. 2016 05; 111(5):746-8. Boland BS, Bagi P, Valasek MA, Chang JT, Bustamante R, Madlensky L, Sandborn WJ, Harismendy O, Gupta S. PMID: 27151126.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    43. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 07; 111(7):986-94. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner DA, Yin M, Glaser KJ, Ehman RL, Sirlin CB. PMID: 27002798.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    44. Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial. Therap Adv Gastroenterol. 2016 Mar; 9(2):152-61. Lin SC, Ang B, Hernandez C, Bettencourt R, Jain R, Salotti J, Richards L, Kono Y, Bhatt A, Aryafar H, Lin GY, Valasek MA, Sirlin CB, Brouha S, Loomba R. PMID: 26929777.
      View in: PubMed   Mentions:
    45. Helicobacter pylori Clarithromycin Resistance and Treatment Failure Are Common in the USA. Dig Dis Sci. 2016 08; 61(8):2373-2380. Park JY, Dunbar KB, Mitui M, Arnold CA, Lam-Himlin DM, Valasek MA, Thung I, Okwara C, Coss E, Cryer B, Doern CD. PMID: 26923948.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    46. Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment Pharmacol Ther. 2016 Feb; 43(4):514-33. Thung I, Aramin H, Vavinskaya V, Gupta S, Park JY, Crowe SE, Valasek MA. PMID: 26694080.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    47. Magnetic resonance elastography is superior to acoustic radiation force impulse for the Diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: A prospective study. Hepatology. 2016 Feb; 63(2):453-61. Cui J, Heba E, Hernandez C, Haufe W, Hooker J, Andre MP, Valasek MA, Aryafar H, Sirlin CB, Loomba R. PMID: 26560734.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    48. Development and validation of a histological index for UC. Gut. 2017 01; 66(1):50-58. Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Shackelton LM, Walker CW, Nelson S, Vandervoort MK, Frisbie V, Samaan MA, Jairath V, Driman DK, Geboes K, Valasek MA, Pai RK, Lauwers GY, Riddell R, Stitt LW, Levesque BG. PMID: 26475633.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    49. Update on the Liver Imaging Reporting and Data System: What the Pathologist Needs to Know. Adv Anat Pathol. 2015 Sep; 22(5):314-22. Tang A, Valasek MA, Sirlin CB. PMID: 26262514.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    50. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    51. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2015 Sep; 42(5):582-90. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T, Brenner DA, Loomba R. PMID: 26119353.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    52. Successful combined liver/kidney transplantation from a donor with Pompe disease. Mol Genet Metab. 2015 Aug; 115(4):141-4. Halldorson J, Kazi Z, Mekeel K, Kuo A, Hassanein T, Loomba R, Austin S, Valasek MA, Kishnani P, Hemming AW. PMID: 26031770.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L. PMID: 25482832.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    54. Association Between Quantity of Liver Fat and Cardiovascular Risk in Patients With Nonalcoholic Fatty Liver Disease Independent of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2015 Aug; 13(8):1513-20.e1. Arulanandan A, Ang B, Bettencourt R, Hooker J, Behling C, Lin GY, Valasek MA, Ix JH, Schnabl B, Sirlin CB, Loomba R. PMID: 25661453.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    55. Clinical, biochemical and histological differences between HIV-associated NAFLD and primary NAFLD: a case-control study. Aliment Pharmacol Ther. 2015 Feb; 41(4):368-78. Vodkin I, Valasek MA, Bettencourt R, Cachay E, Loomba R. PMID: 25496369.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    56. Assessment of histologic disease activity in Crohn's disease: a systematic review. Inflamm Bowel Dis. 2014 Nov; 20(11):2092-103. Mojtahed A, Khanna R, Sandborn WJ, D'Haens GR, Feagan BG, Shackelton LM, Baker KA, Dubcenco E, Valasek MA, Geboes K, Levesque BG. PMID: 25137418.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    57. Reproducibility of histological assessments of disease activity in UC. Gut. 2015 Nov; 64(11):1765-73. Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Behling C, Kaplan K, Driman DK, Shackelton LM, Baker KA, MacDonald JK, Vandervoort MK, Samaan MA, Geboes K, Valasek MA, Pai R, Langner C, Riddell R, Harpaz N, Sewitch M, Peterson M, Stitt LW, Levesque BG. PMID: 25360036.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    58. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014 Dec; 60(6):1920-8. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. PMID: 25103310.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCTClinical Trials
    59. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. PMID: 25132496.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    60. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. PMID: 24910242.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    61. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nat Med. 2014 Jun; 20(6):596-8. Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo WC, Zuo M, Valasek MA, Javle M, Wilkinson MF, Lu Y. PMID: 24859531.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    62. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 01; 88(3):351-63. Chuang JC, Valasek MA, Lopez AM, Posey KS, Repa JJ, Turley SD. PMID: 24486573.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    63. A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. J Biol Chem. 2014 Feb 14; 289(7):4417-31. Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek MA, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, Sturley SL. PMID: 24273168.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    64. Paraneoplastic diarrhea in a patient with lung adenocarcinoma. Clin J Gastroenterol. 2013 Oct; 6(5):357-60. Nguyen AD, Valasek MA, Burstein E. PMID: 26181831.
      View in: PubMed   Mentions: 1     Fields:    
    65. Prevalence of stimulant use in a sample of US medical students. Ann Clin Psychiatry. 2013 Feb; 25(1):27-32. Webb JR, Valasek MA, North CS. PMID: 23376867.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    66. Panniculitis in alpha-1 antitrypsin deficiency treated with enzyme replacement. J Am Acad Dermatol. 2012 Apr; 66(4):e139-41. Olson JM, Moore EC, Valasek MA, Williams LH, Vary JC. PMID: 22421127.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    67. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1012-22. Turley SD, Valasek MA, Repa JJ, Dietschy JM. PMID: 20724527.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    68. Contemplating cognitive enhancement in medical students and residents. Perspect Biol Med. 2010; 53(2):200-14. Webb JR, Thomas JW, Valasek MA. PMID: 20495258.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    69. Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G813-22. Valasek MA, Repa JJ, Quan G, Dietschy JM, Turley SD. PMID: 18718997.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    70. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci. 2007 Dec 26; 27(52):14470-80. Repa JJ, Li H, Frank-Cannon TC, Valasek MA, Turley SD, Tansey MG, Dietschy JM. PMID: 18160655.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    71. Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res. 2007 Dec; 48(12):2725-35. Valasek MA, Clarke SL, Repa JJ. PMID: 17726195.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    72. The power of real-time PCR. Adv Physiol Educ. 2005 Sep; 29(3):151-9. Valasek MA, Repa JJ. PMID: 16109794.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    73. Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem. 2005 Jul 29; 280(30):28103-9. Valasek MA, Weng J, Shaul PW, Anderson RG, Repa JJ. PMID: 15919660.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    74. Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol. 2005 Apr; 64(4):323-33. Li H, Repa JJ, Valasek MA, Beltroy EP, Turley SD, German DC, Dietschy JM. PMID: 15835268.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    75. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1045-50. Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M. PMID: 14722361.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells