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Mark Valasek

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentPathology
Address200 W. Arbor Drive #8720
San Diego CA 92103
Phone619-543-3265
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    Research Interests
    My clinical focus and sub-specialization is in gastrointestinal, hepatic, and pancreatic pathology, which dovetails with my primary research interest in pre-cancerous lesions of the gastrointestinal tract. Broadly defined, pre-cancerous lesions include not only dysplastic lesions, but also such disease entities as Barrett esophagus, fatty liver disease, and inflammatory bowel disease that can lead to esophageal carcinoma, hepatocellular carcinoma, and colonic adenocarcinoma, respectively. A key question in this field is what determines progression at each step of carcinogenesis. What distinguishes progressors from non-progressors? To help accomplish some of our research goals, we are developing "high-resolution" molecular and digital pathology techniques (including artificial intelligence) for the evaluation of gastrointestinal tissues utilizing emerging technologies. Therefore, my laboratory and collaborative work is focused on understanding the mechanisms underlying these pathophysiologic states to help define practical diagnostic and therapeutic clinical applications with the ultimate goal of improving patient care.

    Biography
    Dr. Valasek was accepted into the Medical Scientist Training Program at the University of Texas Southwestern Medical Center at Dallas (UTSW), completing his Ph.D. work in 2006 in the field of Integrative Biology studying gastrointestinal physiology, then receiving his M.D. thereafter. While at UTSW, he earned the prestigious Vernie A. Stembridge Scholarship Award for Excellence in Pathology. Dr. Valasek entered into residency in Anatomic Pathology at the University of Washington in Seattle (UW), where he also completed a fellowship in Gastrointestinal and Hepatic Pathology. He gained additional training in general surgical pathology sign-out as an Assistant Instructor in Surgical Pathology at Parkland Memorial Hospital/University of Texas Southwestern Medical Center. Dr. Valasek started as an Assistant Professor for the Division of Anatomic/Surgical Pathology in the UCSD Department of Pathology in 2013. He was awarded San Diego Medical Society's "2014 Top Doctors" — Physicians of Exceptional Excellence in the Field of Pathology and was an American Society for Clinical Pathology (ASCP) "40 Under Forty" Honoree in 2015. He is currently Director of the Gastrointestinal Pathology Fellowship.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Battat R, Duijvestein M, Vande Casteele N, Singh S, Dulai PS, Valasek MA, Mimms L, McFarland J, Hester KD, Renshaw M, Jain A, Sandborn WJ, Boland BS. Serum Concentrations of 7a-hydroxy-4-cholesten-3-one are Associated with Bile Acid Diarrhea in Patients with Crohn's Disease. Clin Gastroenterol Hepatol. 2018 Nov 15. PMID: 30448597.
      View in: PubMed
    2. Gupta S, Tao L, Murphy JD, Camargo MC, Oren E, Valasek MA, Gomez SL, Martinez ME. Race/Ethnicity-, Socioeconomic Status-, and Anatomic Subsite-specific Risks for Gastric Cancer. Gastroenterology. 2018 Sep 26. PMID: 30267713.
      View in: PubMed
    3. Jairath V, Peyrin-Biroulet L, Zou G, Mosli M, Vande Casteele N, Pai RK, Valasek MA, Marchal-Bressenot A, Stitt LW, Shackelton LM, Khanna R, D'Haens GR, Sandborn WJ, Olson A, Feagan BG, Pai RK. Responsiveness of histological disease activity indices in ulcerative colitis: a post hoc analysis using data from the TOUCHSTONE randomised controlled trial. Gut. 2018 Aug 03. PMID: 30076171.
      View in: PubMed
    4. Hildreth A, Valasek MA, Thung I, Savides T, Sivagnanam M, Ramamoorthy S, Huang SC. Biallelic Mismatch Repair Deficiency in an Adolescent Female. Case Rep Genet. 2018; 2018:8657823. PMID: 30155321.
      View in: PubMed
    5. Patel S, Mendler MH, Valasek MA, Tsunoda SM. Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient. Case Rep Transplant. 2018; 2018:7410508. PMID: 30105113.
      View in: PubMed
    6. Hong CW, Marsh A, Wolfson T, Paige J, Dekhordy SF, Schlein AN, Housman E, Deiranieh LH, Li CQ, Wasnik AP, Jang HJ, Dietrich CF, Piscaglia F, Casola G, O'Boyle M, Richman KM, Valasek MA, Andre M, Loomba R, Sirlin CB. Reader agreement and accuracy of ultrasound features for hepatic steatosis. Abdom Radiol (NY). 2018 Jun 28. PMID: 29951900.
      View in: PubMed
    7. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 Jun 11; 33(6):1061-1077.e6. PMID: 29894692.
      View in: PubMed
    8. Ajmera V, Park CC, Caussy C, Singh S, Hernandez C, Bettencourt R, Hooker J, Sy E, Behling C, Xu R, Middleton MS, Valasek MA, Faulkner C, Rizo E, Richards L, Sirlin CB, Loomba R. Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 Apr 13. PMID: 29660324.
      View in: PubMed
    9. Caussy C, Chen J, Alquiraish MH, Cepin S, Nguyen P, Hernandez C, Yin M, Bettencourt R, Cachay ER, Jayakumar S, Fortney L, Hooker J, Sy E, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Ehman RL, Loomba R. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol. 2018 Jan 17. PMID: 29104128.
      View in: PubMed
    10. Valasek MA, Pai RK. An Update on the Diagnosis, Grading, and Staging of Appendiceal Mucinous Neoplasms. Adv Anat Pathol. 2018 Jan; 25(1):38-60. PMID: 29016471.
      View in: PubMed
    11. Reghunathan M, Kelly KJ, Valasek MA, Lowy AM, Baumgartner JM. Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC. Ann Surg Oncol. 2018 Mar; 25(3):702-708. PMID: 29282599.
      View in: PubMed
    12. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. PMID: 29273451.
      View in: PubMed
    13. Bommakanti K, Valasek MA, Sicklick JK. Nonuterine Lipoleiomyoma. Am Surg. 2017 Dec 01; 83(12):e474-e475. PMID: 30454410.
      View in: PubMed
    14. Bommakanti K, Valasek MA, Sicklick JK. Nonuterine Lipoleiomyoma. Am Surg. 2017 12 01; 83(12):e474-475. PMID: 29336739.
      View in: PubMed
    15. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. PMID: 29153842.
      View in: PubMed
    16. Boland BS, Riedl MA, Valasek MA, Crowe SE, Sandborn WJ. Vedolizumab in Patients With Common Variable Immune Deficiency and Gut Inflammation. Am J Gastroenterol. 2017 Oct; 112(10):1621. PMID: 28978958.
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    17. Lowenthal BM, Chan TW, Thorson JA, Kelly KJ, Savides TJ, Valasek MA. Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a TP53 R273C Mutation: An Unusual Case with Wild-Type BRAF. Case Rep Pathol. 2017; 2017:3427343. PMID: 28840050.
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    18. Valasek MA, Thung I, Gollapalle E, Hodkoff AA, Kelly KJ, Baumgartner JM, Vavinskaya V, Lin GY, Tipps AP, Hosseini MV, Lowy AM. Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PLoS One. 2017; 12(6):e0179216. PMID: 28591173.
      View in: PubMed
    19. Takayesu JSK, Tringale KR, Marshall DC, Burkeen J, Valasek MA, Hemming A, Atwood T, Simpson D, Hattangadi-Gluth J. Bullet fragment fiducials in stereotactic body radiotherapy as a bridge to transplant for hepatocellular carcinoma. Acta Oncol. 2017 Oct; 56(10):1324-1327. PMID: 28497999.
      View in: PubMed
    20. Paige JS, Bernstein GS, Heba E, Costa EAC, Fereirra M, Wolfson T, Gamst AC, Valasek MA, Lin GY, Han A, Erdman JW, O'Brien WD, Andre MP, Loomba R, Sirlin CB. A Pilot Comparative Study of Quantitative Ultrasound, Conventional Ultrasound, and MRI for Predicting Histology-Determined Steatosis Grade in Adult Nonalcoholic Fatty Liver Disease. AJR Am J Roentgenol. 2017 May; 208(5):W168-W177. PMID: 28267360.
      View in: PubMed
    21. Lin SC, Heba E, Bettencourt R, Lin GY, Valasek MA, Lunde O, Hamilton G, Sirlin CB, Loomba R. Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging. Aliment Pharmacol Ther. 2017 03; 45(6):844-854. PMID: 28116801.
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    22. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017 02; 152(3):598-607.e2. PMID: 27911262.
      View in: PubMed
    23. Vavinskaya V, Baumgartner JM, Ko A, Saenz CC, Valasek MA. Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge. Case Rep Obstet Gynecol. 2016; 2016:6841989. PMID: 27843660.
      View in: PubMed
    24. Lowenthal BM, Shabaik AS, Valasek MA. Metastatic Gastrointestinal Adenocarcinoma with Osteoblastic Activity: A Case Report of Esophageal and Colonic Primaries. Case Rep Pathol. 2016; 2016:1934759. PMID: 27738541.
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    25. Patel J, Bettencourt R, Cui J, Salotti J, Hooker J, Bhatt A, Hernandez C, Nguyen P, Aryafar H, Valasek M, Haufe W, Hooker C, Richards L, Sirlin CB, Loomba R. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2016 Sep; 9(5):692-701. PMID: 27582882; PMCID: PMC4984335.
    26. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, Minocha J, Valasek MA, Aryafar H, Brenner DA, Sirlin CB, Loomba R. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Aliment Pharmacol Ther. 2016 08; 44(3):287-99. PMID: 27279429.
      View in: PubMed
    27. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
    28. Thung I, Crowe SE, Valasek MA. Letter: global emergence of Helicobacter pylori antibiotic resistance - unanswered questions. Authors' reply. Aliment Pharmacol Ther. 2016 06; 43(11):1249-50. PMID: 27137739.
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    29. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. PMID: 27211490; PMCID: PMC4907799 [Available on 06/13/17].
    30. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. PMID: 27179037.
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    31. Boland BS, Bagi P, Valasek MA, Chang JT, Bustamante R, Madlensky L, Sandborn WJ, Harismendy O, Gupta S. Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis. Am J Gastroenterol. 2016 05; 111(5):746-8. PMID: 27151126.
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    32. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner DA, Yin M, Glaser KJ, Ehman RL, Sirlin CB. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 Jul; 111(7):986-94. PMID: 27002798; PMCID: PMC5001170 [Available on 01/01/17].
    33. Lin SC, Ang B, Hernandez C, Bettencourt R, Jain R, Salotti J, Richards L, Kono Y, Bhatt A, Aryafar H, Lin GY, Valasek MA, Sirlin CB, Brouha S, Loomba R. Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial. Therap Adv Gastroenterol. 2016 Mar; 9(2):152-61. PMID: 26929777; PMCID: PMC4749859.
    34. Park JY, Dunbar KB, Mitui M, Arnold CA, Lam-Himlin DM, Valasek MA, Thung I, Okwara C, Coss E, Cryer B, Doern CD. Helicobacter pylori Clarithromycin Resistance and Treatment Failure Are Common in the USA. Dig Dis Sci. 2016 08; 61(8):2373-80. PMID: 26923948.
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    35. Thung I, Aramin H, Vavinskaya V, Gupta S, Park JY, Crowe SE, Valasek MA. Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment Pharmacol Ther. 2016 Feb; 43(4):514-33. PMID: 26694080.
      View in: PubMed
    36. Cui J, Heba E, Hernandez C, Haufe W, Hooker J, Andre MP, Valasek MA, Aryafar H, Sirlin CB, Loomba R. Magnetic resonance elastography is superior to acoustic radiation force impulse for the Diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: A prospective study. Hepatology. 2016 Feb; 63(2):453-61. PMID: 26560734; PMCID: PMC4818645 [Available on 02/01/17].
    37. Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Shackelton LM, Walker CW, Nelson S, Vandervoort MK, Frisbie V, Samaan MA, Jairath V, Driman DK, Geboes K, Valasek MA, Pai RK, Lauwers GY, Riddell R, Stitt LW, Levesque BG. Development and validation of a histological index for UC. Gut. 2017 01; 66(1):50-58. PMID: 26475633.
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    38. Tang A, Valasek MA, Sirlin CB. Update on the Liver Imaging Reporting and Data System: What the Pathologist Needs to Know. Adv Anat Pathol. 2015 Sep; 22(5):314-22. PMID: 26262514.
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    39. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. PMID: 26276631; PMCID: PMC4545590.
    40. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T, Brenner DA, Loomba R. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2015 Sep; 42(5):582-90. PMID: 26119353.
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    41. Halldorson J, Kazi Z, Mekeel K, Kuo A, Hassanein T, Loomba R, Austin S, Valasek MA, Kishnani P, Hemming AW. Successful combined liver/kidney transplantation from a donor with Pompe disease. Mol Genet Metab. 2015 Aug; 115(4):141-4. PMID: 26031770.
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    42. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. PMID: 25482832; PMCID: PMC4407930.
    43. Arulanandan A, Ang B, Bettencourt R, Hooker J, Behling C, Lin GY, Valasek MA, Ix JH, Schnabl B, Sirlin CB, Loomba R. Association Between Quantity of Liver Fat and Cardiovascular Risk in Patients With Nonalcoholic Fatty Liver Disease Independent of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2015 Aug; 13(8):1513-20.e1. PMID: 25661453.
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    44. Vodkin I, Valasek MA, Bettencourt R, Cachay E, Loomba R. Clinical, biochemical and histological differences between HIV-associated NAFLD and primary NAFLD: a case-control study. Aliment Pharmacol Ther. 2015 Feb; 41(4):368-78. PMID: 25496369.
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    45. Mojtahed A, Khanna R, Sandborn WJ, D'Haens GR, Feagan BG, Shackelton LM, Baker KA, Dubcenco E, Valasek MA, Geboes K, Levesque BG. Assessment of histologic disease activity in Crohn's disease: a systematic review. Inflamm Bowel Dis. 2014 Nov; 20(11):2092-103. PMID: 25137418.
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    46. Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Behling C, Kaplan K, Driman DK, Shackelton LM, Baker KA, MacDonald JK, Vandervoort MK, Samaan MA, Geboes K, Valasek MA, Pai R, Langner C, Riddell R, Harpaz N, Sewitch M, Peterson M, Stitt LW, Levesque BG. Reproducibility of histological assessments of disease activity in UC. Gut. 2015 Nov; 64(11):1765-73. PMID: 25360036.
      View in: PubMed
    47. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014 Dec; 60(6):1920-8. PMID: 25103310; PMCID: PMC4245360.
    48. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. PMID: 25132496; PMCID: PMC4165611.
    49. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. PMID: 24910242; PMCID: PMC4079758.
    50. Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo WC, Zuo M, Valasek MA, Javle M, Wilkinson MF, Lu Y. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nat Med. 2014 Jun; 20(6):596-8. PMID: 24859531; PMCID: PMC4048332.
    51. Chuang JC, Valasek MA, Lopez AM, Posey KS, Repa JJ, Turley SD. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 01; 88(3):351-63. PMID: 24486573; PMCID: PMC3989900.
    52. Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek MA, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, Sturley SL. A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. J Biol Chem. 2014 Feb 14; 289(7):4417-31. PMID: 24273168; PMCID: PMC3924304.
    53. Nguyen AD, Valasek MA, Burstein E. Paraneoplastic diarrhea in a patient with lung adenocarcinoma. Clin J Gastroenterol. 2013 Oct; 6(5):357-60. PMID: 26181831.
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    54. Webb JR, Valasek MA, North CS. Prevalence of stimulant use in a sample of US medical students. Ann Clin Psychiatry. 2013 Feb; 25(1):27-32. PMID: 23376867.
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    55. Olson JM, Moore EC, Valasek MA, Williams LH, Vary JC. Panniculitis in alpha-1 antitrypsin deficiency treated with enzyme replacement. J Am Acad Dermatol. 2012 Apr; 66(4):e139-41. PMID: 22421127.
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    56. Turley SD, Valasek MA, Repa JJ, Dietschy JM. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1012-22. PMID: 20724527; PMCID: PMC2993165.
    57. Webb JR, Thomas JW, Valasek MA. Contemplating cognitive enhancement in medical students and residents. Perspect Biol Med. 2010; 53(2):200-14. PMID: 20495258.
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    58. Valasek MA, Repa JJ, Quan G, Dietschy JM, Turley SD. Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G813-22. PMID: 18718997; PMCID: PMC2575918.
    59. Repa JJ, Li H, Frank-Cannon TC, Valasek MA, Turley SD, Tansey MG, Dietschy JM. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci. 2007 Dec 26; 27(52):14470-80. PMID: 18160655.
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    60. Valasek MA, Clarke SL, Repa JJ. Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res. 2007 Dec; 48(12):2725-35. PMID: 17726195.
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    61. Valasek MA, Repa JJ. The power of real-time PCR. Adv Physiol Educ. 2005 Sep; 29(3):151-9. PMID: 16109794.
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    62. Valasek MA, Weng J, Shaul PW, Anderson RG, Repa JJ. Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem. 2005 Jul 29; 280(30):28103-9. PMID: 15919660.
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    63. Li H, Repa JJ, Valasek MA, Beltroy EP, Turley SD, German DC, Dietschy JM. Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol. 2005 Apr; 64(4):323-33. PMID: 15835268.
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    64. Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1045-50. PMID: 14722361; PMCID: PMC327148.