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    Mario Chojkier

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #9111-D
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      Fellowship1979Yale University
      Residency1977Yale University
      Residency1975Instituto Nacional de la Salud, Argentina
      Internship 1972Buenos Aires University
      MD, Magna Cum Laude1970Buenos Aires University

      Collapse Research 
      Collapse Research Activities and Funding
      Targeting C/EBP-beta Phosphorylation for the Treatment of Lung Fibrosis
      NIH/NHLBI R41HL127919Apr 25, 2015 - Mar 31, 2016
      Role: Principal Investigator
      NIH/NHLBI R41HL122022Sep 1, 2014 - Aug 31, 2015
      Role: Principal Investigator
      NIH/NIDDK R41DK100189Sep 5, 2013 - Aug 31, 2014
      Role: Principal Investigator
      Liver Inflammation and Injury: Molecular Mechanisms
      VA I01BX000525Oct 1, 2010 - Sep 30, 2014
      Role: Principal Investigator
      C/EBP beta Peptides for the Treatment of Hepatic Fibrosis
      NIH/NIDDK RC1DK087031Sep 30, 2009 - Aug 31, 2012
      Role: Co-Principal Investigator
      NIH/NIDDK R37DK046971Jul 15, 1993 - May 31, 2013
      Role: Principal Investigator
      NIH/NIDDK R01DK046971Jul 15, 1993 - Aug 31, 2003
      Role: Principal Investigator
      Hepatic Fibrosis: Molecular Mechanisms
      NIH/NIDDK R01DK038652Jul 1, 1987 - May 31, 2011
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Traykova D, Schneider B, Chojkier M, Buck M. Blood Microbiome Quantity and the Hyperdynamic Circulation in Decompensated Cirrhotic Patients. PLoS One. 2017; 12(2):e0169310. PMID: 28146577.
        View in: PubMed
      2. Buck M, Solis-Herruzo J, Chojkier M. C/EBPß-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury. Sci Rep. 2016 Apr 12; 6:24268. PMID: 27067260; PMCID: PMC4828658.
      3. Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, Romero-Gomez M, Zarski JP, Agarwal K, Buggisch P, Foster GR, Bräu N, Buti M, Jacobson IM, Subramanian GM, Ding X, Mo H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Mangia A, Marcellin P. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15; 370(20):1889-98. PMID: 24725239.
        View in: PubMed
      4. Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, Shiffman ML, Schiff E, Ghalib R, Ryan M, Rustgi V, Chojkier M, Herring R, Di Bisceglie AM, Pockros PJ, Subramanian GM, An D, Svarovskaia E, Hyland RH, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Pound D, Fried MW. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014 May 15; 370(20):1879-88. PMID: 24720702.
        View in: PubMed
      5. Buck M, Garcia-Tsao G, Groszmann RJ, Stalling C, Grace ND, Burroughs AK, Patch D, Matloff DS, Clopton P, Chojkier M. Novel inflammatory biomarkers of portal pressure in compensated cirrhosis patients. Hepatology. 2014 Mar; 59(3):1052-9. PMID: 24115225.
        View in: PubMed
      6. Chojkier M, Elkhayat H, Sabry D, Donohue M, Buck M. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. PLoS One. 2012; 7(3):e31516. PMID: 22412837; PMCID: PMC3296686.
      7. Ratziu V, Sheikh MY, Sanyal AJ, Lim JK, Conjeevaram H, Chalasani N, Abdelmalek M, Bakken A, Renou C, Palmer M, Levine RA, Bhandari BR, Cornpropst M, Liang W, King B, Mondou E, Rousseau FS, McHutchison J, Chojkier M. A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis. Hepatology. 2012 Feb; 55(2):419-28. PMID: 22006541; PMCID: PMC3779694.
      8. Buck M, Chojkier M. C/EBPß-Thr217 phosphorylation signaling contributes to the development of lung injury and fibrosis in mice. PLoS One. 2011; 6(10):e25497. PMID: 21998664; PMCID: PMC3187778.
      9. Buck M, Chojkier M. A ribosomal S-6 kinase-mediated signal to C/EBP-beta is critical for the development of liver fibrosis. PLoS One. 2007 Dec 26; 2(12):e1372. PMID: 18159255; PMCID: PMC2137951.
      10. Buck M, Chojkier M. C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells. J Clin Gastroenterol. 2007 Nov-Dec; 41 Suppl 3:S295-9. PMID: 17975479.
        View in: PubMed
      11. Buck M, Chojkier M. C/EBPbeta phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin. Am J Physiol Cell Physiol. 2007 Dec; 293(6):C1788-96. PMID: 17855774.
        View in: PubMed
      12. Ghosh P, Miyai K, Chojkier M. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14; 13(6):960-3. PMID: 17352032; PMCID: PMC4065938.
      13. Chojkier M. Inhibition of albumin synthesis in chronic diseases: molecular mechanisms. J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S143-6. PMID: 15758650.
        View in: PubMed
      14. Chojkier M. Troglitazone and liver injury: in search of answers. Hepatology. 2005 Feb; 41(2):237-46. PMID: 15657914.
        View in: PubMed
      15. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol. 2003 Sep; 39(3):437-46. PMID: 12927933.
        View in: PubMed
      16. Buck M, Chojkier M. Signal transduction in the liver: C/EBPbeta modulates cell proliferation and survival. Hepatology. 2003 Apr; 37(4):731-8. PMID: 12668962.
        View in: PubMed
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