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Mario Chojkier

Title(s)Professor In Residence, Medicine
SchoolHealth Sciences
Phone858-552-8585
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    Collapse Biography 
    Collapse Education and Training
    Fellowship1979Yale University
    Residency1977Yale University
    Residency1975Instituto Nacional de la Salud, Argentina
    Internship 1972Buenos Aires University
    MD, Magna Cum Laude1970Buenos Aires University

    Collapse Research 
    Collapse Research Activities and Funding
    TREATMENT OF LUNG FIBROSIS : IND PHARMACOLOGY AND TOXICOLOGY
    NIH/NHLBI R44HL147724Aug 1, 2019 - Jan 31, 2020
    Role: Co-Principal Investigator
    TREATMENT OF LIVER INJURY AND FIBROSIS: SAFETY PHARMACOLOGY AND TOXICOLOGY
    NIH/NIDDK R44DK122903Aug 1, 2019 - Jan 30, 2020
    Role: Co-Principal Investigator
    Targeting C/EBP-beta Phosphorylation for the Treatment of Lung Fibrosis
    NIH/NHLBI R41HL127919Apr 25, 2015 - Mar 31, 2016
    Role: Principal Investigator
    C/EBP-beta PEPTIDES FOR THE TREATMENT OF LUNG INJURY AND FIBROSIS
    NIH/NHLBI R41HL122022Sep 1, 2014 - Aug 31, 2015
    Role: Principal Investigator
    C/EBP-beta PEPTIDES FOR THE TREATMENT OF LIVER INJURY AND FIBROSIS
    NIH/NIDDK R41DK100189Sep 5, 2013 - Aug 31, 2014
    Role: Principal Investigator
    Liver Inflammation and Injury: Molecular Mechanisms
    VA I01BX000525Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    C/EBP beta Peptides for the Treatment of Hepatic Fibrosis
    NIH/NIDDK RC1DK087031Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    NIH/NIDDK R37DK046971Jul 15, 1993 - May 31, 2013
    Role: Principal Investigator
    C/EBP BETA IN HEPATOCYTE GENE EXPRESSION &PROLIFERATION
    NIH/NIDDK R01DK046971Jul 15, 1993 - Aug 31, 2003
    Role: Principal Investigator
    Hepatic Fibrosis: Molecular Mechanisms
    NIH/NIDDK R01DK038652Jul 1, 1987 - May 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Traykova D, Schneider B, Chojkier M, Buck M. Blood Microbiome Quantity and the Hyperdynamic Circulation in Decompensated Cirrhotic Patients. PLoS One. 2017; 12(2):e0169310. PMID: 28146577.
      View in: PubMed
    2. Buck M, Solis-Herruzo J, Chojkier M. C/EBPß-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury. Sci Rep. 2016 Apr 12; 6:24268. PMID: 27067260; PMCID: PMC4828658.
    3. Sanyal AJ, Abdelmalek MF, Suzuki A, Cummings OW, Chojkier M. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology. 2014 Aug; 147(2):377-84.e1. PMID: 24818764.
      View in: PubMed
    4. Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, Romero-Gomez M, Zarski JP, Agarwal K, Buggisch P, Foster GR, Bräu N, Buti M, Jacobson IM, Subramanian GM, Ding X, Mo H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Mangia A, Marcellin P. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15; 370(20):1889-98. PMID: 24725239.
      View in: PubMed
    5. Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, Shiffman ML, Schiff E, Ghalib R, Ryan M, Rustgi V, Chojkier M, Herring R, Di Bisceglie AM, Pockros PJ, Subramanian GM, An D, Svarovskaia E, Hyland RH, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Pound D, Fried MW. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014 May 15; 370(20):1879-88. PMID: 24720702.
      View in: PubMed
    6. Buck M, Garcia-Tsao G, Groszmann RJ, Stalling C, Grace ND, Burroughs AK, Patch D, Matloff DS, Clopton P, Chojkier M. Novel inflammatory biomarkers of portal pressure in compensated cirrhosis patients. Hepatology. 2014 Mar; 59(3):1052-9. PMID: 24115225.
      View in: PubMed
    7. Chojkier M, Elkhayat H, Sabry D, Donohue M, Buck M. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. PLoS One. 2012; 7(3):e31516. PMID: 22412837; PMCID: PMC3296686.
    8. Ratziu V, Sheikh MY, Sanyal AJ, Lim JK, Conjeevaram H, Chalasani N, Abdelmalek M, Bakken A, Renou C, Palmer M, Levine RA, Bhandari BR, Cornpropst M, Liang W, King B, Mondou E, Rousseau FS, McHutchison J, Chojkier M. A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis. Hepatology. 2012 Feb; 55(2):419-28. PMID: 22006541; PMCID: PMC3779694.
    9. Buck M, Chojkier M. C/EBPß-Thr217 phosphorylation signaling contributes to the development of lung injury and fibrosis in mice. PLoS One. 2011; 6(10):e25497. PMID: 21998664.
      View in: PubMed
    10. Buck M, Chojkier M. A ribosomal S-6 kinase-mediated signal to C/EBP-beta is critical for the development of liver fibrosis. PLoS One. 2007 Dec 26; 2(12):e1372. PMID: 18159255; PMCID: PMC2137951.
    11. Chojkier M. [Portal Hypertension symposium dedicated to Dr Roberto Groszmann]. Rev Esp Enferm Dig. 2007 Dec; 99(12):740-1. PMID: 18290708.
      View in: PubMed
    12. Buck M, Chojkier M. C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells. J Clin Gastroenterol. 2007 Nov-Dec; 41 Suppl 3:S295-9. PMID: 17975479.
      View in: PubMed
    13. Buck M, Chojkier M. C/EBPbeta phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin. Am J Physiol Cell Physiol. 2007 Dec; 293(6):C1788-96. PMID: 17855774.
      View in: PubMed
    14. Ghosh P, Miyai K, Chojkier M. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14; 13(6):960-3. PMID: 17352032; PMCID: PMC4065938.
    15. Carr RA, André AK, Chen P, Grabowski BA, Chang MS, Locke CS, Williams LA, Chojkier M. The effect of hepatic insufficiency on the safety and pharmacokinetics of paricalcitol (Zemplar). Nephron Clin Pract. 2006; 103(3):c100-5. PMID: 16534233.
      View in: PubMed
    16. Chojkier M. Inhibition of albumin synthesis in chronic diseases: molecular mechanisms. J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S143-6. PMID: 15758650.
      View in: PubMed
    17. Chojkier M. Troglitazone and liver injury: in search of answers. Hepatology. 2005 Feb; 41(2):237-46. PMID: 15657914.
      View in: PubMed
    18. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol. 2003 Sep; 39(3):437-46. PMID: 12927933.
      View in: PubMed
    19. Buck M, Chojkier M. Signal transduction in the liver: C/EBPbeta modulates cell proliferation and survival. Hepatology. 2003 Apr; 37(4):731-8. PMID: 12668962.
      View in: PubMed
    20. Buck M, Zhang L, Halasz NA, Hunter T, Chojkier M. Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha. EMBO J. 2001 Dec 03; 20(23):6712-23. PMID: 11726507.
      View in: PubMed
    21. Buck M, Poli V, Hunter T, Chojkier M. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell. 2001 Oct; 8(4):807-16. PMID: 11684016.
      View in: PubMed
    22. Buck M, Kim DJ, Houglum K, Hassanein T, Chojkier M. c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2000 Feb; 278(2):G321-8. PMID: 10666057.
      View in: PubMed
    23. Buck M, Poli V, van der Geer P, Chojkier M, Hunter T. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell. 1999 Dec; 4(6):1087-92. PMID: 10635333.
      View in: PubMed
    24. Chojkier M, Houglum K, Lee KS, Buck M. Long- and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression. Am J Physiol. 1998 12; 275(6):G1480-5. PMID: 9843787.
      View in: PubMed
    25. Houglum K, Buck M, Kim DJ, Chojkier M. TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region. Am J Physiol. 1998 05; 274(5):G840-7. PMID: 9612264.
      View in: PubMed
    26. Lee KS, Cottam HB, Houglum K, Wasson DB, Carson D, Chojkier M. Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity. Am J Physiol. 1997 11; 273(5):G1094-100. PMID: 9374707.
      View in: PubMed
    27. Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology. 1997 Oct; 113(4):1069-73. PMID: 9322499.
      View in: PubMed
    28. Houglum K, Ramm GA, Crawford DH, Witztum JL, Powell LW, Chojkier M. Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis. Hepatology. 1997 Sep; 26(3):605-10. PMID: 9303489.
      View in: PubMed
    29. Houglum K, Lee KS, Chojkier M. Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest. 1997 Mar 15; 99(6):1322-8. PMID: 9077542.
      View in: PubMed
    30. Buck M, Houglum K, Chojkier M. Tumor necrosis factor-alpha inhibits collagen alpha1(I) gene expression and wound healing in a murine model of cachexia. Am J Pathol. 1996 Jul; 149(1):195-204. PMID: 8686743.
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    31. Buck M, Chojkier M. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J. 1996 Apr 15; 15(8):1753-65. PMID: 8617220.
      View in: PubMed
    32. Houglum K, Buck M, Alcorn J, Contreras S, Bornstein P, Chojkier M. Two different cis-acting regulatory regions direct cell-specific transcription of the collagen alpha 1(I) gene in hepatic stellate cells and in skin and tendon fibroblasts. J Clin Invest. 1995 Nov; 96(5):2269-76. PMID: 7593613.
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    33. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest. 1995 Nov; 96(5):2461-8. PMID: 7593635.
      View in: PubMed
    34. Assil KK, Saperstein D, Weinreb RN, Chojkier M. Inhibition of collagen synthesis in human episcleral fibroblasts by calcium ionophore a23187. J Glaucoma. 1995 Feb; 4(1):41-4. PMID: 19920636.
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    35. Chojkier M. Regulation of liver-specific gene expression. Prog Liver Dis. 1995; 13:37-61. PMID: 9224497.
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    36. Houglum K, Bedossa P, Chojkier M. TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload. Am J Physiol. 1994 Nov; 267(5 Pt 1):G908-13. PMID: 7977754.
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    37. Houglum K, Buck M, Adir V, Chojkier M. LAP (NF-IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region. J Clin Invest. 1994 Aug; 94(2):808-14. PMID: 8040336.
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    38. Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J Clin Invest. 1994 Jun; 93(6):2554-61. PMID: 8200992.
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    39. Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology. 1994 May; 19(5):1262-71. PMID: 8175151.
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    40. Buck M, Turler H, Chojkier M. LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation. EMBO J. 1994 Feb 15; 13(4):851-60. PMID: 7906646.
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    41. Holstege A, Bedossa P, Poynard T, Kollinger M, Chaput JC, Houglum K, Chojkier M. Acetaldehyde-modified epitopes in liver biopsy specimens of alcoholic and nonalcoholic patients: localization and association with progression of liver fibrosis. Hepatology. 1994 Feb; 19(2):367-74. PMID: 7507463.
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    42. Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M, Chojkier M. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature. 1993 Aug 05; 364(6437):544-7. PMID: 8336793.
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    43. Chojkier M. Contribution of hepatocytes and nonparenchymal cells to hepatic collagen production. Hepatology. 1992 Apr; 15(4):744-5. PMID: 1551653.
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    44. Alcorn JM, Fierer J, Chojkier M. The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-alpha. Hepatology. 1992 Jan; 15(1):122-9. PMID: 1727788.
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    45. Houglum KP, Brenner DA, Chojkier M. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Am J Clin Nutr. 1991 12; 54(6 Suppl):1141S-1143S. PMID: 1962560.
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    46. Houglum K, Brenner DA, Chojkier M. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation. J Clin Invest. 1991 Jun; 87(6):2230-5. PMID: 2040703.
      View in: PubMed
    47. Houglum K, Filip M, Witztum JL, Chojkier M. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J Clin Invest. 1990 Dec; 86(6):1991-8. PMID: 2123889.
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    48. Descombes P, Chojkier M, Lichtsteiner S, Falvey E, Schibler U. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 1990 Sep; 4(9):1541-51. PMID: 2253878.
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    49. Brenner DA, Alcorn JM, Feitelberg SP, Leffert HL, Chojkier M. Expression of collagen genes in the liver. Mol Biol Med. 1990 Apr; 7(2):105-15. PMID: 2342427.
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    50. Brenner DA, Buck M, Feitelberg SP, Chojkier M. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. J Clin Invest. 1990 Jan; 85(1):248-55. PMID: 2295699.
      View in: PubMed
    51. Leffert HL, Koch KS, Lu XP, Brenner DA, Karin M, Skelly HF, Rippe RA, Fey G, Chojkier M. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Adv Second Messenger Phosphoprotein Res. 1990; 24:352-8. PMID: 2169815.
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    52. Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J Biol Chem. 1989 Oct 05; 264(28):16957-62. PMID: 2777815.
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    53. Chojkier M, Brenner DA, Leffert HL. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. J Biol Chem. 1989 Jun 05; 264(16):9583-91. PMID: 2542314.
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    54. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 1989 Feb 16; 337(6208):661-3. PMID: 2537468.
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    55. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG, Brenner DA. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Hepatology. 1988 Sep-Oct; 8(5):1040-5. PMID: 3047035.
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    56. Chojkier M, Lyche KD, Filip M. Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis. Hepatology. 1988 Jul-Aug; 8(4):808-14. PMID: 3391508.
      View in: PubMed
    57. Solis-Herruzo JA, Brenner DA, Chojkier M. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J Biol Chem. 1988 Apr 25; 263(12):5841-5. PMID: 3258601.
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    58. Chojkier M, Brenner DA. Therapeutic strategies for hepatic fibrosis. Hepatology. 1988 Jan-Feb; 8(1):176-82. PMID: 3276587.
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    59. Brenner DA, Chojkier M. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J Biol Chem. 1987 Dec 25; 262(36):17690-5. PMID: 3693368.
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    60. Chojkier M, Holderman W, Bateman JF. A [4,5-3H]lysine:[14C]lysine dual-label method to measure lysine hydroxylation in collagen. Anal Biochem. 1986 Oct; 158(1):151-7. PMID: 3799961.
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    61. Flaherty M, Chojkier M. Selective inhibition of collagen synthesis by the Ca2+ ionophore A23187 in cultured human fibroblasts. J Biol Chem. 1986 Sep 15; 261(26):12060-5. PMID: 3091597.
      View in: PubMed
    62. Chojkier M. Hepatocyte collagen production in vivo in normal rats. J Clin Invest. 1986 Aug; 78(2):333-9. PMID: 3734095.
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    63. Laine L, Chojkier M. Hepatic collagen production in the rat is unaffected by methotrexate. Proc Soc Exp Biol Med. 1986 Jun; 182(2):194-200. PMID: 3703871.
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    64. Holt KM, Miyai K, Chojkier M. Asymptomatic primary biliary cirrhosis in an old man. J Clin Gastroenterol. 1986 Apr; 8(2):203-6. PMID: 3745858.
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    65. Chojkier M, Laine L, Conn HO, Lerner E. Predictors of outcome in massive upper gastrointestinal hemorrhage. J Clin Gastroenterol. 1986 Feb; 8(1):16-22. PMID: 3486206.
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    66. Chojkier M, Fierer J. D-Galactosamine hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. Gastroenterology. 1985 Jan; 88(1 Pt 1):115-21. PMID: 3880554.
      View in: PubMed
    67. Flaherty M, Chojkier M. [3H]tryptophan-[14C]proline dual label method for the simultaneous determination of collagen and noncollagen protein production. Anal Biochem. 1984 Nov 01; 142(2):386-94. PMID: 6528975.
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    68. Holt K, Bennett M, Chojkier M. Acetaldehyde stimulates collagen and noncollagen protein production by human fibroblasts. Hepatology. 1984 Sep-Oct; 4(5):843-8. PMID: 6479853.
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    69. Schölmerich J, DeLuca M, Chojkier M. Bioluminescence assays for bile acids in the detection and follow-up of experimental liver injury. Hepatology. 1984 Jul-Aug; 4(4):639-43. PMID: 6745852.
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    70. Chojkier M, Spanheimer R, Peterkofsky B. Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. In vitro studies in guinea pig calvarial bones. J Clin Invest. 1983 Sep; 72(3):826-35. PMID: 6309911.
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    71. Chojkier M, Bateman J, Phang JM, Peterkofsky B. Formation of proline metabolites in chick embryo bone: interference with the measurement of free hydroxyproline by ion-exchange chromatography. Anal Biochem. 1982 Mar 01; 120(2):330-8. PMID: 6124177.
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    72. Chojkier M, Groszmann RJ. Measurement of portal-systemic shunting in the rat by using gamma-labeled microspheres. Am J Physiol. 1981 May; 240(5):G371-5. PMID: 7235023.
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    73. Chojkier M, Peterkofsky B, Bateman J. New method for determining the extent of proline hydroxylation by measuring changes in the ratio of [4-3H]:[14C]proline in collagenase digests. Anal Biochem. 1980 Nov 01; 108(2):385-93. PMID: 6257145.
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    74. Chojkier M, Conn HO. Esophageal tamponade in the treatment of bleeding varices. A decadel progress report. Dig Dis Sci. 1980 Apr; 25(4):267-72. PMID: 6967005.
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    75. Chojkier M, Groszmann RJ, Atterbury CE, Bar-Meir S, Blei AT, Frankel J, Glickman MG, Kniaz JL, Schade R, Taggart GJ, Conn HO. A controlled comparison of continuous intraarterial and intravenous infusions of vasopressin in hemorrhage from esophageal varices. Gastroenterology. 1979 Sep; 77(3):540-6. PMID: 313353.
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    76. Bar-Meir S, Chojkier M, Groszmann RJ, Atterbury CE, Conn HO. Spontaneous meningococcal peritonitis: a report of two cases. Am J Dig Dis. 1978 Feb; 23(2):119-22. PMID: 414618.
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