Marcus Kaul

Title(s)Associate Adjunct Professor, Psychiatry
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Cysteinyl Leukotrienes in HIV Brain Injury
    NIH R01MH105330Apr 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Lipocalin-2 in HIV-Associated Neuronal Injury
    NIH R01MH104131Dec 15, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Combined effect of Methamphetamine, HIV and HAART on neurons and macrophages
    NIH R03DA029480May 1, 2010 - Apr 30, 2012
    Role: Principal Investigator
    Neuroprotection by IFN-beta in AIDS
    NIH R01MH087332Jul 1, 2009 - Jun 30, 2020
    Role: Principal Investigator
    Translational Methamphetamine AIDS Research Center (TMARC)
    NIH/NIDA P50DA026306Dec 1, 2008 - May 31, 2019
    Role: Co-Investigator
    Chemokine Receptor Signaling in HIV Neuropathology
    NIH R01NS050621May 3, 2004 - Apr 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yuan NY, Kaul M. Beneficial and Adverse Effects of cART Affect Neurocognitive Function in HIV-1 Infection: Balancing Viral Suppression against Neuronal Stress and Injury. J Neuroimmune Pharmacol. 2019 Aug 06. PMID: 31385157.
      View in: PubMed
    2. Thaney VE, Sanchez AB, Fields JA, Minassian A, Young JW, Maung R, Kaul M. Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol. 2018 Apr; 24(2):156-167. PMID: 29075998.
      View in: PubMed
    3. Kaul M. The 23rd Scientific Conference of the Society on Neuroimmune Pharmacology. J Neuroimmune Pharmacol. 2017 04; 12(Suppl 1):1-2. PMID: 28286912.
      View in: PubMed
    4. Noel RJ, Kaul M. The 22nd Scientific Conference of the Society on Neuroimmune Pharmacology. J Neuroimmune Pharmacol. 2016 Apr; 11 Suppl 1:S1-2. PMID: 26968848.
      View in: PubMed
    5. Maung R, Hoefer MM, Sanchez AB, Sejbuk NE, Medders KE, Desai MK, Catalan IC, Dowling CC, de Rozieres CM, Garden GA, Russo R, Roberts AJ, Williams R, Kaul M. CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J Immunol. 2014 Aug 15; 193(4):1895-910. PMID: 25031461; PMCID: PMC4370188.
    6. Kang Y, Tiziani S, Park G, Kaul M, Paternostro G. Cellular protection using Flt3 and PI3Ka inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity. Nat Commun. 2014 Apr 17; 5:3672. PMID: 24739485.
      View in: PubMed
    7. Wang RG, Kaul M, Zhang DX. Interferon-stimulated gene 15 as a general marker for acute and chronic neuronal injuries. Sheng Li Xue Bao. 2012 Oct 25; 64(5):577-83. PMID: 23090498; PMCID: PMC3587786.
    8. Maung R, Medders KE, Sejbuk NE, Desai MK, Russo R, Kaul M. Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury. J Neuroimmune Pharmacol. 2012 Jun; 7(2):306-18. PMID: 22124968; PMCID: PMC3690779.
    9. Medders KE, Kaul M. Mitogen-activated protein kinase p38 in HIV infection and associated brain injury. J Neuroimmune Pharmacol. 2011 Jun; 6(2):202-15. PMID: 21286833; PMCID: PMC3690763.
    10. Letendre SL, Zheng JC, Kaul M, Yiannoutsos CT, Ellis RJ, Taylor MJ, Marquie-Beck J, Navia B. Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals. J Neurovirol. 2011 Feb; 17(1):63-9. PMID: 21246320; PMCID: PMC3032187.
    11. Medders KE, Sejbuk NE, Maung R, Desai MK, Kaul M. Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity. J Immunol. 2010 Oct 15; 185(8):4883-95. PMID: 20855878; PMCID: PMC3848867.
    12. Kang YJ, Digicaylioglu M, Russo R, Kaul M, Achim CL, Fletcher L, Masliah E, Lipton SA. Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Ann Neurol. 2010 Sep; 68(3):342-52. PMID: 20818790; PMCID: PMC3733362.
    13. Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med. 2009 Dec; 15(12):1407-13. PMID: 19915593; PMCID: PMC2789858.
    14. Roberts AJ, Maung R, Sejbuk NE, Ake C, Kaul M. Alteration of Methamphetamine-induced stereotypic behaviour in transgenic mice expressing HIV-1 envelope protein gp120. J Neurosci Methods. 2010 Feb 15; 186(2):222-5. PMID: 19917310; PMCID: PMC3432271.
    15. Tatro ET, Everall IP, Kaul M, Achim CL. Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder. Brain Res. 2009 Aug 25; 1286:1-12. PMID: 19545546; PMCID: PMC2724600.
    16. Kaul M. HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches. Curr Opin Neurol. 2009 Jun; 22(3):315-20. PMID: 19300249; PMCID: PMC2779773.
    17. Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton SA, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J Neurosci. 2007 Oct 10; 27(41):11047-55. PMID: 17928446.
      View in: PubMed
    18. Okamoto S, Kang YJ, Brechtel CW, Siviglia E, Russo R, Clemente A, Harrop A, McKercher S, Kaul M, Lipton SA. HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. Cell Stem Cell. 2007 Aug 16; 1(2):230-6. PMID: 18371353.
      View in: PubMed
    19. Kaul M, Lipton SA. Mechanisms of neuronal injury and death in HIV-1 associated dementia. Curr HIV Res. 2006 Jul; 4(3):307-18. PMID: 16842083.
      View in: PubMed
    20. Kaul M, Lipton SA. Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. J Neuroimmune Pharmacol. 2006 Jun; 1(2):138-51. PMID: 18040780.
      View in: PubMed
    21. Digicaylioglu M, Kaul M, Fletcher L, Dowen R, Lipton SA. Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage. Neuroreport. 2004 Apr 09; 15(5):761-3. PMID: 15073510.
      View in: PubMed
    22. Kaul M, Lipton SA. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. J Neurovirol. 2004; 10 Suppl 1:97-101. PMID: 14982746.
      View in: PubMed
    23. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science. 2002 Aug 16; 297(5584):1186-90. PMID: 12183632.
      View in: PubMed