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    Marc Montminy

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
    Phone858-453-4100
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      Collapse Research 
      Collapse Research Activities and Funding
      Cross-talk between the circadian clock and the cAMP signaling pathway
      NIH/NIDDK R01DK091618Apr 15, 2011 - Mar 31, 2016
      Role: Principal Investigator
      FINR: A Novel Modulator of Insulin Signaling
      NIH/NIDDK R01DK064142Apr 1, 2003 - May 31, 2011
      Role: Principal Investigator
      Role of the TORC/CRTC Family of Coactivators in Energy Balance
      NIH/NIDDK R01DK049777Jun 15, 1995 - Dec 31, 2014
      Role: Principal Investigator
      Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
      NIH/NIDDK R37DK083834Dec 1, 1986 - Feb 28, 2019
      Role: Principal Investigator
      Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
      NIH/NIDDK R01DK083834Dec 1, 1986 - Feb 28, 2014
      Role: Principal Investigator
      REGULATION OF SOMATOSTATIN GENE EXPRESSION
      NIH/NIGMS R37GM037828Dec 1, 1986 - Feb 28, 2009
      Role: Principal Investigator
      REGULATION OF SOMATOSTATIN GENE EXPRESSION
      NIH/NIGMS R01GM037828Dec 1, 1986 - Nov 30, 1998
      Role: Principal Investigator
      REGULATION OF NEUROPEPTIDE BIOSYNTHESIS
      NIH/NINDS F32NS007523Sep 12, 1985
      Role: Principal Investigator
      Biology of Neuroendocrine Peptides
      NIH/NIDDK P01DK026741Jun 1, 1980 - May 31, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sonntag T, Moresco JJ, Vaughan JM, Matsumura S, Yates JR, Montminy M. Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. PLoS One. 2017; 12(2):e0173013. PMID: 28235073.
        View in: PubMed
      2. Shen R, Wang B, Giribaldi MG, Ayres J, Thomas JB, Montminy M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. Proc Natl Acad Sci U S A. 2016 Jun 7; 113(23):E3307-14. PMID: 27208092.
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      3. Ravnskjaer K, Madiraju A, Montminy M. Role of the cAMP Pathway in Glucose and Lipid Metabolism. Handb Exp Pharmacol. 2016; 233:29-49. PMID: 26721678.
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      4. Luan B, Yoon YS, Le Lay J, Kaestner KH, Hedrick S, Montminy M. CREB pathway links PGE2 signaling with macrophage polarization. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15642-7. PMID: 26644581.
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      5. Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M. Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. J Biol Chem. 2015 Oct 23; 290(43):25997-6006. PMID: 26342077.
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      6. Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, Montminy M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nat Commun. 2015; 6:7216. PMID: 26031354.
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      7. Blanchet E, Van de Velde S, Matsumura S, Hao E, LeLay J, Kaestner K, Montminy M. Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance. Cell Rep. 2015 Feb 24; 10(7):1149-57. PMID: 25704817.
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      8. Tsai WW, Matsumura S, Liu W, Phillips NG, Sonntag T, Hao E, Lee S, Hai T, Montminy M. ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis. Proc Natl Acad Sci U S A. 2015 Mar 3; 112(9):2699-704. PMID: 25730876.
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      9. Paz JC, Park SH, Phillips N, Matsumura S, Tsai WW, Kasper L, Brindle PK, Zhang G, Zhou MM, Wright PE, Montminy M. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proc Natl Acad Sci U S A. 2014 Dec 2; 111(48):17116-21. PMID: 25404345.
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      10. Luan B, Goodarzi MO, Phillips NG, Guo X, Chen YD, Yao J, Allison M, Rotter JI, Shaw R, Montminy M. Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4. Cell Metab. 2014 Jun 3; 19(6):1058-65. PMID: 24768298.
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      11. Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013 Oct 1; 123(10):4318-28. PMID: 24051374.
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      12. Tsai WW, Niessen S, Goebel N, Yates JR, Guccione E, Montminy M. PRMT5 modulates the metabolic response to fasting signals. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):8870-5. PMID: 23671120.
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      13. Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013 Feb 8; 288(6):3823-30. PMID: 23269672.
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      14. Luo Q, Viste K, Urday-Zaa JC, Senthil Kumar G, Tsai WW, Talai A, Mayo KE, Montminy M, Radhakrishnan I. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20865-70. PMID: 23213254.
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      15. Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature. 2012 May 3; 485(7396):128-32. PMID: 22495310.
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      16. Montminy M, Lee KF, Rivier JE, Rivier C, Reichlin S. Wylie Vale: neuroendocrine master. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3604-5. PMID: 22355104.
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      17. Van de Velde S, Hogan MF, Montminy M. mTOR links incretin signaling to HIF induction in pancreatic beta cells. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16876-82. PMID: 21949366.
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      18. Stewart R, Flechner L, Montminy M, Berdeaux R. CREB is activated by muscle injury and promotes muscle regeneration. PLoS One. 2011; 6(9):e24714. PMID: 21931825.
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      19. Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR, Fischer WH, Thomas JB, Montminy M. A hormone-dependent module regulating energy balance. Cell. 2011 May 13; 145(4):596-606. PMID: 21565616.
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      20. Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011 May 13; 145(4):607-21. PMID: 21565617.
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      21. Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol. 2011 Mar; 12(3):141-51. PMID: 21346730.
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      22. Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011 Feb 17; 470(7334):404-8. PMID: 21331044.
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      23. Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR. CRTC3 links catecholamine signalling to energy balance. Nature. 2010 Dec 16; 468(7326):933-9. PMID: 21164481.
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      24. Yoon YS, Lee MW, Ryu D, Kim JH, Ma H, Seo WY, Kim YN, Kim SS, Lee CH, Hunter T, Choi CS, Montminy M, Koo SH. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17704-9. PMID: 20876121.
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      25. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. PMID: 20852621.
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      26. Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy M, Hai T. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol. 2010 Jul; 24(7):1423-33. PMID: 20519332.
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      27. Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3087-92. PMID: 20133702.
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      28. Wang Y, Vera L, Fischer WH, Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature. 2009 Jul 23; 460(7254):534-7. PMID: 19543265.
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      29. Qi L, Saberi M, Zmuda E, Wang Y, Altarejos J, Zhang X, Dentin R, Hedrick S, Bandyopadhyay G, Hai T, Olefsky J, Montminy M. Adipocyte CREB promotes insulin resistance in obesity. Cell Metab. 2009 Mar; 9(3):277-86. PMID: 19254572.
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      30. Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 2009 Mar; 9(3):240-51. PMID: 19254569.
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      31. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73. PMID: 18849969.
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      32. Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, Sawchenko PE, Montminy M. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med. 2008 Oct; 14(10):1112-7. PMID: 18758446.
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      33. Wang B, Goode J, Best J, Meltzer J, Schilman PE, Chen J, Garza D, Thomas JB, Montminy M. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 2008 May; 7(5):434-44. PMID: 18460334.
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      34. Dentin R, Hedrick S, Xie J, Yates J, Montminy M. Hepatic glucose sensing via the CREB coactivator CRTC2. Science. 2008 Mar 7; 319(5868):1402-5. PMID: 18323454.
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      35. Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J, Montminy M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature. 2007 Sep 20; 449(7160):366-9. PMID: 17805301.
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      36. Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 2007 Jun 20; 26(12):2880-9. PMID: 17476304.
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      37. Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, Shelton GD, Montminy M. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 2007 May; 13(5):597-603. PMID: 17468767.
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      38. Koo SH, Montminy M. In vino veritas: a tale of two sirt1s? Cell. 2006 Dec 15; 127(6):1091-3. PMID: 17174885.
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      39. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 2006 Jun 23; 312(5781):1763-6. PMID: 16794074.
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      40. Liu Y, Montminy M. CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5. Cell Metab. 2006 Jun; 3(6):387-8. PMID: 16753572.
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      41. Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, Schultz PG, Chanda SK. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metab. 2006 May; 3(5):367-78. PMID: 16679294.
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      42. Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich KA, Sajan MP, Farese RV, Stolz DB, Tso P, Koo SH, Montminy M, Unterman TG. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem. 2006 Apr 14; 281(15):10105-17. PMID: 16492665.
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      43. Koo SH, Montminy M. Fatty acids and insulin resistance: a perfect storm. Mol Cell. 2006 Feb 17; 21(4):449-50. PMID: 16483925.
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      44. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 9; 310(5754):1642-6. PMID: 16308421.
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      45. Canettieri G, Koo SH, Berdeaux R, Heredia J, Hedrick S, Zhang X, Montminy M. Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab. 2005 Nov; 2(5):331-8. PMID: 16271533.
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      46. Lebrun P, Montminy M, Van Obberghen E. Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase. J Biol Chem. 2005 Nov 18; 280(46):38203-10. PMID: 16166097.
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      47. Gardner KH, Montminy M. Can you hear me now? Regulating transcriptional activators by phosphorylation. Sci STKE. 2005 Sep 13; 2005(301):pe44. PMID: 16160121.
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      48. Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005 Oct 20; 437(7062):1109-11. PMID: 16148943.
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      49. Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29. PMID: 16169504.
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      50. Conkright MD, Montminy M. CREB: the unindicted cancer co-conspirator. Trends Cell Biol. 2005 Sep; 15(9):457-9. PMID: 16084096.
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      51. Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, Young RA, Montminy M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4459-64. PMID: 15753290.
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      52. Mayr BM, Guzman E, Montminy M. Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. J Biol Chem. 2005 Apr 15; 280(15):15103-10. PMID: 15703171.
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      53. Montminy M, Koo SH. Diabetes: outfoxing insulin resistance? Nature. 2004 Dec 23; 432(7020):958-9. PMID: 15616540.
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      54. Best JL, Amezcua CA, Mayr B, Flechner L, Murawsky CM, Emerson B, Zor T, Gardner KH, Montminy M. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17622-7. PMID: 15585582.
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      55. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell. 2004 Oct 1; 119(1):61-74. PMID: 15454081.
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      56. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36. PMID: 15372107.
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      57. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. PMID: 15107844.
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      58. Montminy M, Koo SH, Zhang X. The CREB family: key regulators of hepatic metabolism. Ann Endocrinol (Paris). 2004 Feb; 65(1):73-5. PMID: 15122096.
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      59. Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature. 2003 Nov 13; 426(6963):190-3. PMID: 14614508.
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      60. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M. TORCs: transducers of regulated CREB activity. Mol Cell. 2003 Aug; 12(2):413-23. PMID: 14536081.
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      61. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 1; 17(13):1575-80. PMID: 12842910.
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      62. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003 Jun 6; 300(5625):1574-7. PMID: 12791994.
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      63. Conkright MD, Guzmán E, Flechner L, Su AI, Hogenesch JB, Montminy M. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell. 2003 Apr; 11(4):1101-8. PMID: 12718894.
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      64. Canettieri G, Morantte I, Guzmán E, Asahara H, Herzig S, Anderson SD, Yates JR, Montminy M. Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat Struct Biol. 2003 Mar; 10(3):175-81. PMID: 12567184.
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      65. Zor T, Mayr BM, Dyson HJ, Montminy M, Wright PE. Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem. 2002 Nov 1; 277(44):42241-8. PMID: 12196545.
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      66. Asahara H, Tartare-Deckert S, Nakagawa T, Ikehara T, Hirose F, Hunter T, Ito T, Montminy M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol. 2002 May; 22(9):2974-83. PMID: 11940655.
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      67. Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy M, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest. 2002 May; 109(9):1193-201. PMID: 11994408.
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      68. Asahara H, Santoso B, Guzman E, Du K, Cole PA, Davidson I, Montminy M. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Mol Cell Biol. 2001 Dec; 21(23):7892-900. PMID: 11689682.
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      69. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson BM, Montminy M, Evans RM. A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21; 294(5551):2507-11. PMID: 11701890.
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      70. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. PMID: 11557984.
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      71. Mayr BM, Canettieri G, Montminy M. Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10936-41. PMID: 11535812.
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      72. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol. 2001 Aug; 2(8):599-609. PMID: 11483993.
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      73. Long F, Schipani E, Asahara H, Kronenberg H, Montminy M. The CREB family of activators is required for endochondral bone development. Development. 2001 Feb; 128(4):541-50. PMID: 11171337.
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      74. Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1065-70. PMID: 11158595.
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      75. Frangioni JV, LaRiccia LM, Cantley LC, Montminy M. Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening. Nat Biotechnol. 2000 Oct; 18(10):1080-5. PMID: 11017047.
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      76. von Mikecz A, Zhang S, Montminy M, Tan EM, Hemmerich P. CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. J Cell Biol. 2000 Jul 10; 150(1):265-73. PMID: 10893273.
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      77. Du K, Asahara H, Jhala US, Wagner BL, Montminy M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol. 2000 Jun; 20(12):4320-7. PMID: 10825195.
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      78. Wagner BL, Bauer A, Schütz G, Montminy M. Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific antiserum. J Biol Chem. 2000 Mar 24; 275(12):8263-6. PMID: 10722651.
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      79. Michael LF, Asahara H, Shulman AI, Kraus WL, Montminy M. The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. Mol Cell Biol. 2000 Mar; 20(5):1596-603. PMID: 10669737.
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      80. Asahara H, Dutta S, Kao HY, Evans RM, Montminy M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol. 1999 Dec; 19(12):8219-25. PMID: 10567547.
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      81. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8. PMID: 10545951.
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      82. Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Mol Cell Biol. 1999 Aug; 19(8):5601-7. PMID: 10409749.
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      83. Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy M, Wright PE. Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains. J Mol Biol. 1999 Apr 16; 287(5):859-65. PMID: 10222196.
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      84. Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4; 273(49):32377-9. PMID: 9829964.
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      85. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. PMID: 9774973.
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      86. Dutta S, Bonner-Weir S, Montminy M, Wright C. Regulatory factor linked to late-onset diabetes? Nature. 1998 Apr 9; 392(6676):560. PMID: 9560151.
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      87. Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A. 1998 Mar 3; 95(5):2061-6. PMID: 9482838.
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      88. Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy M, Wright PE. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997 Dec 12; 91(6):741-52. PMID: 9413984.
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      89. Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD, Montminy M. RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 1997 Sep 19; 90(6):1107-12. PMID: 9323138.
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      90. Montminy M. Transcriptional activation. Something new to hang your HAT on. Nature. 1997 Jun 12; 387(6634):654-5. PMID: 9192883.
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      91. Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol. 1997 May; 17(5):2598-604. PMID: 9111329.
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      92. Mayall TP, Sheridan PL, Montminy M, Jones KA. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. Genes Dev. 1997 Apr 1; 11(7):887-99. PMID: 9106660.
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      93. Nakajima T, Uchida C, Anderson SF, Parvin JD, Montminy M. Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. Genes Dev. 1997 Mar 15; 11(6):738-47. PMID: 9087428.
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      94. Montminy M. Transcriptional regulation by cyclic AMP. Annu Rev Biochem. 1997; 66:807-22. PMID: 9242925.
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      95. Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, Montminy M, Evans RM. Role of CBP/P300 in nuclear receptor signalling. Nature. 1996 Sep 5; 383(6595):99-103. PMID: 8779723.
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      96. Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy M. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 1996 Aug 9; 86(3):465-74. PMID: 8756728.
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      97. Montminy M, Brindle P, Arias J, Ferreri K, Armstrong R. Regulation of somatostatin gene transcription by cyclic adenosine monophosphate. Metabolism. 1996 Aug; 45(8 Suppl 1):4-7. PMID: 8769368.
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      98. Kee BL, Arias J, Montminy M. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J Biol Chem. 1996 Feb 2; 271(5):2373-5. PMID: 8576192.
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      99. Parker D, Ferreri K, Nakajima T, LaMorte VJ, Evans R, Koerber SC, Hoeger C, Montminy M. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol Cell Biol. 1996 Feb; 16(2):694-703. PMID: 8552098.
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      100. Sharma S, Leonard J, Lee S, Chapman HD, Leiter EH, Montminy M. Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF. J Biol Chem. 1996 Jan 26; 271(4):2294-9. PMID: 8567692.
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      101. Montminy M, Brindle P, Arias J, Ferreri K, Armstrong R. Regulation of somatostatin gene transcription by cAMP. Adv Pharmacol. 1996; 36:1-13. PMID: 8783551.
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      102. Peers B, Sharma S, Johnson T, Kamps M, Montminy M. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol Cell Biol. 1995 Dec; 15(12):7091-7. PMID: 8524276.
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      103. Brindle P, Nakajima T, Montminy M. Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. Proc Natl Acad Sci U S A. 1995 Nov 7; 92(23):10521-5. PMID: 7479832.
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      104. Bertherat J, Chanson P, Montminy M. The cyclic adenosine 3',5'-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol. 1995 Jul; 9(7):777-83. PMID: 7476961.
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      105. Armstrong R, Wen W, Meinkoth J, Taylor S, Montminy M. A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A. Mol Cell Biol. 1995 Mar; 15(3):1826-32. PMID: 7862172.
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      106. Montminy M, Brindle P, Arias J, Ferreri K, Armstrong R. Regulation of somatostatin gene transcription by cAMP. Ciba Found Symp. 1995; 190:7-20; discussion 20-5. PMID: 7587654.
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      107. Guz Y, Montminy M, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development. 1995 Jan; 121(1):11-8. PMID: 7867492.
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      108. Peers B, Leonard J, Sharma S, Teitelman G, Montminy M. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol. 1994 Dec; 8(12):1798-806. PMID: 7708065.
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      109. Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994 Jul 21; 370(6486):226-9. PMID: 8028671.
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      110. Alberts AS, Montminy M, Shenolikar S, Feramisco JR. Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. Mol Cell Biol. 1994 Jul; 14(7):4398-407. PMID: 7516466.
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      111. Alberts AS, Arias J, Hagiwara M, Montminy M, Feramisco JR. Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J Biol Chem. 1994 Mar 11; 269(10):7623-30. PMID: 8125987.
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      112. Ferreri K, Gill G, Montminy M. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1210-3. PMID: 7906413.
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      113. Meinkoth JL, Alberts AS, Went W, Fantozzi D, Taylor SS, Hagiwara M, Montminy M, Feramisco JR. Signal transduction through the cAMP-dependent protein kinase. Mol Cell Biochem. 1993 Nov; 127-128:179-86. PMID: 7935349.
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      114. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy M, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28; 365(6449):855-9. PMID: 8413673.
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      115. Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy M. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol. 1993 Oct; 7(10):1275-83. PMID: 7505393.
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      116. Montminy M. Trying on a new pair of SH2s. Science. 1993 Sep 24; 261(5129):1694-5. PMID: 8397444.
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      117. Brindle P, Linke S, Montminy M. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. Nature. 1993 Aug 26; 364(6440):821-4. PMID: 8102791.
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      118. Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy M. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol. 1993 Aug; 13(8):4852-9. PMID: 8336722.
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      119. Montminy M. Cell differentiation. The road not taken. Nature. 1993 Jul 15; 364(6434):190-1. PMID: 8321314.
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      120. Armstrong RC, Montminy M. Transsynaptic control of gene expression. Annu Rev Neurosci. 1993; 16:17-29. PMID: 8384807.
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      121. Leonard J, Serup P, Gonzalez G, Edlund T, Montminy M. The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6247-51. PMID: 1352885.
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      122. Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell. 1992 Jul 10; 70(1):105-13. PMID: 1352481.
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      123. Brindle PK, Montminy M. The CREB family of transcription activators. Curr Opin Genet Dev. 1992 Apr; 2(2):199-204. PMID: 1386267.
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      124. Leonard J, Montminy M. Control of gene expression by transmitters and peptide hormones. Curr Opin Neurobiol. 1991 Jun; 1(1):74-8. PMID: 1688009.
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      125. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy M. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature. 1991 Apr 18; 350(6319):622-4. PMID: 1826763.
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      126. Meinkoth JL, Montminy M, Fink JS, Feramisco JR. Induction of a cyclic AMP-responsive gene in living cells requires the nuclear factor CREB. Mol Cell Biol. 1991 Mar; 11(3):1759-64. PMID: 1847503.
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      127. Gonzalez GA, Menzel P, Leonard J, Fischer WH, Montminy M. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol Cell Biol. 1991 Mar; 11(3):1306-12. PMID: 1671708.
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      128. Montminy M, Gonzalez GA, Yamamoto KK. Characteristics of the cAMP response unit. Metabolism. 1990 Sep; 39(9 Suppl 2):6-12. PMID: 2169573.
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      129. Lamph WW, Dwarki VJ, Ofir R, Montminy M, Verma IM. Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4320-4. PMID: 2140898.
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      130. Montminy M, Gonzalez GA, Yamamoto KK. Regulation of cAMP-inducible genes by CREB. Trends Neurosci. 1990 May; 13(5):184-8. PMID: 1693237.
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      131. Yamamoto KK, Gonzalez GA, Menzel P, Rivier J, Montminy M. Characterization of a bipartite activator domain in transcription factor CREB. Cell. 1990 Feb 23; 60(4):611-7. PMID: 2137373.
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      132. Dwarki VJ, Montminy M, Verma IM. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J. 1990 Jan; 9(1):225-32. PMID: 2136830.
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      133. Montminy M, Gonzalez GA, Yamamoto KK. Characteristics of the cAMP response unit. Recent Prog Horm Res. 1990; 46:219-29; discussion 29-30. PMID: 2177907.
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      134. Gonzalez GA, Montminy M. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 1989 Nov 17; 59(4):675-80. PMID: 2573431.
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      135. Gonzalez GA, Yamamoto KK, Fischer WH, Karr D, Menzel P, Biggs W, Vale WW, Montminy M. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature. 1989 Feb 23; 337(6209):749-52. PMID: 2521922.
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      136. Montminy M. Regulation of eukaryotic genes by cyclic-AMP. Nihon Naibunpi Gakkai Zasshi. 1988 Dec 20; 64(12):1233-5. PMID: 2907881.
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      137. Yamamoto KK, Gonzalez GA, Biggs WH, Montminy M. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature. 1988 Aug 11; 334(6182):494-8. PMID: 2900470.
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      138. Montminy M, Bilezikjian LM. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature. 1987 Jul 9-15; 328(6126):175-8. PMID: 2885756.
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      139. Sevarino KA, Felix R, Banks CM, Low MJ, Montminy M, Mandel G, Goodman RH. Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells. J Biol Chem. 1987 Apr 15; 262(11):4987-93. PMID: 2881926.
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      140. Goodman RH, Leiter A, Low MJ, Montminy M, Tsukada T, Fink JS, Mandel G. Biosynthesis of pancreatic islet hormones. Hepatology. 1987 Jan-Feb; 7(1 Suppl):36S-41S. PMID: 2879784.
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      141. Höfler H, Childers H, Montminy M, Goodman RH, Lechan RM, DeLellis RA, Tischler AS, Wolfe HJ. Localization of somatostatin mRNA in the gut, pancreas and thyroid gland of the rat using antisense RNA probes for in situ hybridization. Acta Histochem Suppl. 1987; 34:101-5. PMID: 2437612.
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      142. Hoefler H, Childers H, Montminy M, Lechan RM, Goodman RH, Wolfe HJ. In situ hybridization methods for the detection of somatostatin mRNA in tissue sections using antisense RNA probes. Histochem J. 1986 Nov-Dec; 18(11-12):597-604. PMID: 2435682.
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      143. Montminy M, Sevarino KA, Wagner JA, Mandel G, Goodman RH. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6682-6. PMID: 2875459.
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      144. Montminy M, Low MJ, Tapia-Arancibia L, Reichlin S, Mandel G, Goodman RH. Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells. J Neurosci. 1986 Apr; 6(4):1171-6. PMID: 2871140.
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      145. Leiter AB, Montminy M, Jamieson E, Goodman RH. Exons of the human pancreatic polypeptide gene define functional domains of the precursor. J Biol Chem. 1985 Oct 25; 260(24):13013-7. PMID: 2997153.
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      146. Tsukada T, Horovitch SJ, Montminy M, Mandel G, Goodman RH. Structure of the human vasoactive intestinal polypeptide gene. DNA. 1985 Aug; 4(4):293-300. PMID: 3899557.
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      147. Goodman RH, Montminy M, Low MJ, Habener JF. Biosynthesis of rat preprosomatostatin. Adv Exp Med Biol. 1985; 188:31-47. PMID: 2863939.
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      148. Montminy M, Goodman RH, Horovitch SJ, Habener JF. Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci U S A. 1984 Jun; 81(11):3337-40. PMID: 6145156.
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      149. Lund PK, Goodman RH, Montminy M, Dee PC, Habener JF. Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA. J Biol Chem. 1983 Mar 10; 258(5):3280-4. PMID: 6338015.
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      150. Montminy M, Teres D. Shock after phenothiazine administration in a pregnant patient with a pheochromocytoma. A case report and literature review. J Reprod Med. 1983 Feb; 28(2):159-62. PMID: 6834356.
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      151. Montminy M, Gagnon PA. [Dysplasia epiphysialis hemimelica (tarsomegaly)]. Union Med Can. 1972 Sep; 101(9):1822-6. PMID: 5075013.
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