Madeline Luth

Title(s)Postdoctoral Scholar, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science. 2022 06 03; 376(6597):1074-1079. Xie SC, Metcalfe RD, Dunn E, Morton CJ, Huang SC, Puhalovich T, Du Y, Wittlin S, Nie S, Luth MR, Ma L, Kim MS, Pasaje CFA, Kumpornsin K, Giannangelo C, Houghton FJ, Churchyard A, Famodimu MT, Barry DC, Gillett DL, Dey S, Kosasih CC, Newman W, Niles JC, Lee MCS, Baum J, Ottilie S, Winzeler EA, Creek DJ, Williamson N, Parker MW, Brand S, Langston SP, Dick LR, Griffin MDW, Gould AE, Tilley L. PMID: 35653481.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Commun Biol. 2022 02 11; 5(1):128. Ottilie S, Luth MR, Hellemann E, Goldgof GM, Vigil E, Kumar P, Cheung AL, Song M, Godinez-Macias KP, Carolino K, Yang J, Lopez G, Abraham M, Tarsio M, LeBlanc E, Whitesell L, Schenken J, Gunawan F, Patel R, Smith J, Love MS, Williams RM, McNamara CW, Gerwick WH, Ideker T, Suzuki Y, Wirth DF, Lukens AK, Kane PM, Cowen LE, Durrant JD, Winzeler EA. PMID: 35149760; PMCID: PMC8837787.
      View in: PubMed   Mentions: Translation:Animals
    3. The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite. Antimicrob Agents Chemother. 2021 10 18; 65(11):e0031121. Ellis KM, Lucantoni L, Chavchich M, Abraham M, De Paoli A, Luth MR, Zeeman AM, Delves MJ, Terán FS, Straschil U, Baum J, Kocken CHM, Ralph SA, Winzeler EA, Avery VM, Edstein MD, Baell JB, Creek DJ. PMID: 34460304; PMCID: PMC8522748.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chem Biol. 2022 02 17; 29(2):191-201.e8. Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, Rubiano K, Akidil A, Ottilie S, Mittal N, Dilmore AH, Won M, Mandt REK, McGowen K, Owen E, Walpole C, Llinás M, Lee MCS, Winzeler EA, Fidock DA, Gilbert IH, Wirth DF, Niles JC, Baragaña B, Lukens AK. PMID: 34348113; PMCID: PMC8878317.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum. ACS Infect Dis. 2021 04 09; 7(4):811-825. Rocamora F, Gupta P, Istvan ES, Luth MR, Carpenter EF, Kümpornsin K, Sasaki E, Calla J, Mittal N, Carolino K, Owen E, Llinás M, Ottilie S, Goldberg DE, Lee MCS, Winzeler EA. PMID: 33715347; PMCID: PMC8042660.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    6. SnapShot: Antimalarial Drugs. Cell. 2020 10 15; 183(2):554-554.e1. Luth MR, Winzeler EA. PMID: 33064992.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    7. Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. Nat Commun. 2020 04 14; 11(1):1780. LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, Huang J, Williams RM, Zou BY, Cheung AL, Kumar P, Egan TJ, Lee MCS, Siegel D, Cowman AF, Fidock DA, Winzeler EA. PMID: 32286267; PMCID: PMC7156427.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials. ACS Infect Dis. 2020 04 10; 6(4):613-628. Abraham M, Gagaring K, Martino ML, Vanaerschot M, Plouffe DM, Calla J, Godinez-Macias KP, Du AY, Wree M, Antonova-Koch Y, Eribez K, Luth MR, Ottilie S, Fidock DA, McNamara CW, Winzeler EA. PMID: 32078764; PMCID: PMC7155171.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    9. Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii. Proc Natl Acad Sci U S A. 2019 Dec 05. Rosenberg A, Luth MR, Winzeler EA, Behnke M, Sibley LD. PMID: 31806760; PMCID: PMC6936365.
      View in: PubMed   Mentions: 9     Fields:    
    10. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Sci Transl Med. 2019 12 04; 11(521). Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. PMID: 31801884; PMCID: PMC7444640.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    11. Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathog. 2019 06; 15(6):e1007722. Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA. PMID: 31170268; PMCID: PMC6553790.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    12. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science. 2018 12 07; 362(6419). Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA. PMID: 30523084; PMCID: PMC6516198.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    13. Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. J Med Chem. 2018 11 21; 61(22):10053-10066. Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould AE, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, Hutton CA, Burrows JN, Winzeler EA, Avery VM, Dick LR, Tilley L. PMID: 30373366; PMCID: PMC6257627.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    14. Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery. ACS Infect Dis. 2018 03 09; 4(3):301-314. Luth MR, Gupta P, Ottilie S, Winzeler EA. PMID: 29451780; PMCID: PMC5848146.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    15. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. PMID: 29284029; PMCID: PMC5746216.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    16. Efficacy of post-harvest rinsing and bleach disinfection of E. coli O157:H7 on spinach leaf surfaces. Food Microbiol. 2017 Apr; 62:212-220. Kinsinger NM, Mayton HM, Luth MR, Walker SL. PMID: 27889151.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
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