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Louis-Felix Nothias-Scaglia

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0719
La Jolla CA 92093
Phone858-822-5347
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    Collapse Biography 
    Collapse Education and Training
    University of Corsica , FrancePhD12/2015Organic and Analytical Chemistry
    University of Corsica, FranceMaster06/2011Analytical Chemistry applied to Phytochemistry
    Collapse Awards and Honors
    CNRS (France) and UC San Diego (USA)2016  - 2017MSCA GF H2020 Fellowship

    Collapse Overview 
    Collapse Overview
    Louis Felix Nothias had a PhD degree in Organic and Analytical Chemistry (2015), applied to the study of antiviral metabolites from Euphorbia plants found in Corsica (France). Co-mentored by the Pr. Jean Costa (University of Corsica), and the Dr. Marc Litaudon (University Paris-Saclay, France), he has been trained in bioassay-guided fractionation, isolation, structural elucidation by NMR, and metabolite profiling by tandem mass spectrometry and molecular networking.

    He joined the Prof. Pieter Dorrestein lab (UC San Diego) as a post-doctoral researcher in March 2016, where he performs mass spectrometry-based metabolomics, and bioinformatics data analysis. Since its arrival, he contributed to the development of new methods, such as 3D-molecular cartography (collaboration between P. Dorrestein and T. Alexandrov, at EMBL Heidelberg), or feature-based molecular networking, as well as generated multiple public spectral libraries available on GNPS (NIH natural products, pesticides). Currently, he is participating to a research project on the molecular cartography of skin psoriasis, and lead a study on the influence of biotic factors and abiotic factors on plant metabolome and microbiome, such as endophyte or pesticides (MSCA fellow). Louis Felix has a strong interest in computational tools for the annotation of tandem mass spectrometry data (collaboration Dorrestein-Boecker at University of Jena, Germany), especially its integration with molecular networking on GNPS.


    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Galtier d'Auriac I, Quinn RA, Maughan H, Nothias LF, Little M, Kapono CA, Cobian A, Reyes BT, Green K, Quistad SD, Leray M, Smith JE, Dorrestein PC, Rohwer F, Deheyn DD, Hartmann AC. Before platelets: the production of platelet-activating factor during growth and stress in a basal marine organism. Proc Biol Sci. 2018 Aug 15; 285(1884). PMID: 30111600.
      View in: PubMed
    2. Olivon F, Nothias LF, Dumontet V, Retailleau P, Berger S, Ferry G, Cohen W, Pfeiffer B, Boutin JA, Scalbert E, Roussi F, Litaudon M. Natural Inhibitors of the RhoA-p115 Complex from the Bark of Meiogyne baillonii. J Nat Prod. 2018 Jul 27; 81(7):1610-1618. PMID: 29969260.
      View in: PubMed
    3. da Silva RR, Wang M, Nothias LF, van der Hooft JJJ, Caraballo-Rodríguez AM, Fox E, Balunas MJ, Klassen JL, Lopes NP, Dorrestein PC. Propagating annotations of molecular networks using in silico fragmentation. PLoS Comput Biol. 2018 Apr; 14(4):e1006089. PMID: 29668671.
      View in: PubMed
    4. Nothias LF, Nothias-Esposito M, da Silva R, Wang M, Protsyuk I, Zhang Z, Sarvepalli A, Leyssen P, Touboul D, Costa J, Paolini J, Alexandrov T, Litaudon M, Dorrestein PC. Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation. J Nat Prod. 2018 Apr 27; 81(4):758-767. PMID: 29498278.
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    5. Protsyuk I, Melnik AV, Nothias LF, Rappez L, Phapale P, Aksenov AA, Bouslimani A, Ryazanov S, Dorrestein PC, Alexandrov T. 3D molecular cartography using LC-MS facilitated by Optimus and 'ili software. Nat Protoc. 2018 Jan; 13(1):134-154. PMID: 29266099.
      View in: PubMed
    6. Scheubert K, Hufsky F, Petras D, Wang M, Nothias LF, Dührkop K, Bandeira N, Dorrestein PC, Böcker S. Significance estimation for large scale metabolomics annotations by spectral matching. Nat Commun. 2017 Nov 14; 8(1):1494. PMID: 29133785.
      View in: PubMed
    7. Nothias LF, Boutet-Mercey S, Cachet X, De La Torre E, Laboureur L, Gallard JF, Retailleau P, Brunelle A, Dorrestein PC, Costa J, Bedoya LM, Roussi F, Leyssen P, Alcami J, Paolini J, Litaudon M, Touboul D. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata. J Nat Prod. 2017 Oct 27; 80(10):2620-2629. PMID: 28925702.
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    8. Olivon F, Allard PM, Koval A, Righi D, Genta-Jouve G, Neyts J, Apel C, Pannecouque C, Nothias LF, Cachet X, Marcourt L, Roussi F, Katanaev VL, Touboul D, Wolfender JL, Litaudon M. Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks. ACS Chem Biol. 2017 10 20; 12(10):2644-2651. PMID: 28829118.
      View in: PubMed
    9. Esposito M, Nothias LF, Retailleau P, Costa J, Roussi F, Neyts J, Leyssen P, Touboul D, Litaudon M, Paolini J. Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking. J Nat Prod. 2017 Jul 28; 80(7):2051-2059. PMID: 28671832.
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    10. Esposito M, Nim S, Nothias LF, Gallard JF, Rawal MK, Costa J, Roussi F, Prasad R, Di Pietro A, Paolini J, Litaudon M. Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters. J Nat Prod. 2017 Feb 24; 80(2):479-487. PMID: 28106996.
      View in: PubMed
    11. Nothias LF, Knight R, Dorrestein PC. Antibiotic discovery is a walk in the park. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14477-14479. PMID: 27940910.
      View in: PubMed
    12. Quinn RA, Nothias LF, Vining O, Meehan M, Esquenazi E, Dorrestein PC. Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy. Trends Pharmacol Sci. 2017 02; 38(2):143-154. PMID: 27842887.
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    13. Mohimani H, Gurevich A, Mikheenko A, Garg N, Nothias LF, Ninomiya A, Takada K, Dorrestein PC, Pevzner PA. Dereplication of peptidic natural products through database search of mass spectra. Nat Chem Biol. 2017 Jan; 13(1):30-37. PMID: 27820803.
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    14. Esposito M, Nothias LF, Nedev H, Gallard JF, Leyssen P, Retailleau P, Costa J, Roussi F, Iorga BI, Paolini J, Litaudon M. Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity. J Nat Prod. 2016 11 23; 79(11):2873-2882. PMID: 27786472.
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    15. Petras D, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook V, Garg N, Hoffner N, Jiang Y, Kapono CA, Koester I, Knight R, Leber CA, Ling TJ, Luzzatto-Knaan T, McCall LI, McGrath AP, Meehan MJ, Merritt JK, Mills RH, Morton J, Podvin S, Protsyuk I, Purdy T, Satterfield K, Searles S, Shah S, Shires S, Steffen D, White M, Todoric J, Tuttle R, Wojnicz A, Sapp V, Vargas F, Yang J, Zhang C, Dorrestein PC. Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Anal Chem. 2016 Nov 15; 88(22):10775-10784. PMID: 27732780.
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    16. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. PMID: 27504778.
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