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Lesley Ellies

Title(s)Recall Hcomp, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    NIH K22CA118182Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    Role of SV40 in Salivary Gland Tumorigenesis
    NIH R03DE014638Sep 1, 2002 - Aug 31, 2005
    Role: Principal Investigator
    ADHESION MOLECULES IN NO MODULATED TUMORIGENESIS
    NIH K08CA088035Sep 30, 2000 - Aug 31, 2006
    Role: Principal Investigator
    ALPHA 2,3 SIALYTRANSFERASES IN DEVELOPMENT AND TUMORS
    NIH F32CA079130Mar 27, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nat Commun. 2021 01 25; 12(1):565. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. PMID: 33495474.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations. Clin Cancer Res. 2020 06 15; 26(12):2972-2985. Aguilera TA, Elghonaimy EA, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong AC, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. PMID: 32098769.
      View in: PubMed   Mentions: 1     Fields:    
    3. Degradation of splicing factor SRSF3 contributes to progressive liver disease. J Clin Invest. 2019 08 08; 129(10):4477-4491. Kumar D, Das M, Sauceda C, Ellies LG, Kuo K, Parwal P, Kaur M, Jih L, Bandyopadhyay GK, Burton D, Loomba R, Osborn O, Webster NJ. PMID: 31393851.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    4. Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. PLoS One. 2018; 13(9):e0198464. Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. PMID: 30248101.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene. 2018 04; 37(15):2022-2036. Ireland L, Santos A, Campbell F, Figueiredo C, Hammond D, Ellies LG, Weyer-Czernilofsky U, Bogenrieder T, Schmid M, Mielgo A. PMID: 29367764.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    6. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 12 23; 7:13898. Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. PMID: 28008921.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    7. Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis. Oncoimmunology. 2017; 6(2):e1268310. Gross ET, Han S, Vemu P, Peinado CD, Marsala M, Ellies LG, Bui JD. PMID: 28344881.
      View in: PubMed   Mentions:
    8. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun. 2016 10 06; 7:13007. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W. PMID: 27708283.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    9. Collagen and fibronectin: threads linking obesity and breast cancer. Ann Transl Med. 2016 Oct; 4(Suppl 1):S50. Ellies LG. PMID: 27868018.
      View in: PubMed   Mentions:
    10. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. PMID: 27832862.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    11. A three-dimensional co-culture system to investigate macrophage-dependent tumor cell invasion. J Biol Methods. 2016; 3(3):e49. Dwyer AR, Ellies LG, Holme AL, Pixley FJ. PMID: 31453214.
      View in: PubMed   Mentions:
    12. Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. Xenobiotica. 2017 Jul; 47(7):600-606. Spilker ME, Chung H, Visswanathan R, Bagrodia S, Gernhardt S, Fantin VR, Ellies LG. PMID: 27435693.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity. J Immunol. 2015 Dec 01; 195(11):5237-50. Cimen Bozkus C, Elzey BD, Crist SA, Ellies LG, Ratliff TL. PMID: 26491198.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. Multipotent luminal mammary cancer stem cells model tumor heterogeneity. Breast Cancer Res. 2015 Oct 14; 17(1):137. Bao L, Cardiff RD, Steinbach P, Messer KS, Ellies LG. PMID: 26467658.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    15. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. PMID: 25189770.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    16. Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound. J Surg Res. 2014 Aug; 190(2):391-8. Liberman A, Wu Z, Barback CV, Viveros RD, Wang J, Ellies LG, Mattrey RF, Trogler WC, Kummel AC, Blair SL. PMID: 24972734.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    17. Dual targeting of integrin avß3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. . 2014 Jun; 13(6):1514-25. Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY. PMID: 24737028.
      View in: PubMed   Mentions:
    18. Attenuation of TGF-ß signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett. 2014 Apr 28; 346(1):129-38. Biswas T, Gu X, Yang J, Ellies LG, Sun LZ. PMID: 24368187.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. Color Doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells. ACS Nano. 2013 Jul 23; 7(7):6367-77. Liberman A, Wu Z, Barback CV, Viveros R, Blair SL, Ellies LG, Vera DR, Mattrey RF, Kummel AC, Trogler WC. PMID: 23802554.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-? and elevated secretion of Cxcl10. EMBO Mol Med. 2013 Jul; 5(7):1035-50. Burkart C, Arimoto K, Tang T, Cong X, Xiao N, Liu YC, Kotenko SV, Ellies LG, Zhang DE. PMID: 23681607.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PMID: 23671068.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    22. Correlation of transcription of MALAT-1, a novel noncoding RNA, with deregulated expression of tumor suppressor p53 in small DNA tumor virus models. J Cancer Ther. 2013 May; 4(3). Jeffers LK, Duan K, Ellies LG, Seaman WT, Burger-Calderon RA, Diatchenko LB, Webster-Cyriaque J. PMID: 24163781.
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    23. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjug Chem. 2013 May 15; 24(5):766-71. Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. PMID: 23600997.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Nicotine promotes acquisition of stem cell and epithelial-to-mesenchymal properties in head and neck squamous cell carcinoma. PLoS One. 2012; 7(12):e51967. Yu MA, Kiang A, Wang-Rodriguez J, Rahimy E, Haas M, Yu V, Ellies LG, Chen J, Fan JB, Brumund KT, Weisman RA, Ongkeko WM. PMID: 23300583.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT. PMID: 23188503.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    26. Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan. Breast Cancer Res. 2012 Apr 24; 14(2):R67. Gibby K, You WK, Kadoya K, Helgadottir H, Young LJ, Ellies LG, Chang Y, Cardiff RD, Stallcup WB. PMID: 22531600.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    27. Endothelial cell HIF-1a and HIF-2a differentially regulate metastatic success. Cancer Cell. 2012 Jan 17; 21(1):52-65. Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski DM, Liao D, Ellies L, Johnson RS. PMID: 22264788.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    28. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS One. 2011; 6(12):e29046. Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT. PMID: 22194986.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    29. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. PMID: 21665146.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimals
    30. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res. 2010 Jun 24; 11:87. Niese KA, Chiaramonte MG, Ellies LG, Rothenberg ME, Zimmermann N. PMID: 20576117.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. J Biol Chem. 2010 Jul 16; 285(29):22532-41. Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY. PMID: 20460372.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    32. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. PMID: 20388801.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    33. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. PMID: 20160097.
      View in: PubMed   Mentions: 156     Fields:    Translation:Animals
    34. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. PMID: 20160077.
      View in: PubMed   Mentions: 171     Fields:    Translation:Animals
    35. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb). 2009 Jun; 1(5-6):382-93. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. PMID: 20023745.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    36. Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res. 2008 Sep 01; 68(17):7219-27. Versteeg HH, Schaffner F, Kerver M, Ellies LG, Andrade-Gordon P, Mueller BM, Ruf W. PMID: 18757438.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    37. Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J Exp Med. 2008 Jun 09; 205(6):1435-46. Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M. PMID: 18519646.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    38. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 18; 133(2):223-34. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. PMID: 18423195.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    39. Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. PLoS Pathog. 2008 Mar 14; 4(3):e1000023. Thompson RW, Pesce JT, Ramalingam T, Wilson MS, White S, Cheever AW, Ricklefs SM, Porcella SF, Li L, Ellies LG, Wynn TA. PMID: 18369473.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    40. L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages. Infect Immun. 2007 Jun; 75(6):2802-10. Wanasen N, MacLeod CL, Ellies LG, Soong L. PMID: 17387163.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    41. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res. 2007 Apr; 16(2):193-201. Davie SA, Maglione JE, Manner CK, Young D, Cardiff RD, MacLeod CL, Ellies LG. PMID: 17206489.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    42. Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation. Eur J Immunol. 2006 Dec; 36(12):3207-15. Sperandio M, Frommhold D, Babushkina I, Ellies LG, Olson TS, Smith ML, Fritzsching B, Pauly E, Smith DF, Nobiling R, Linderkamp O, Marth JD, Ley K. PMID: 17111351.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    43. Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14895-900. Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG, Zimmermann N. PMID: 17003120.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    44. A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells. Blood. 2005 Dec 01; 106(12):3867-73. Underhill GH, Zisoulis DG, Kolli KP, Ellies LG, Marth JD, Kansas GS. PMID: 16099875.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    45. Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes. . 2004 Aug; 3(8):941-53. Maglione JE, McGoldrick ET, Young LJ, Namba R, Gregg JP, Liu L, Moghanaki D, Ellies LG, Borowsky AD, Cardiff RD, MacLeod CL. PMID: 15299077.
      View in: PubMed   Mentions:
    46. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer. 2003 Aug 10; 106(1):1-7. Ellies LG, Fishman M, Hardison J, Kleeman J, Maglione JE, Manner CK, Cardiff RD, MacLeod CL. PMID: 12794750.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    47. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol. 2003 Jun; 48(6):415-22. Ellies LG. PMID: 12749913.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    48. Sialyltransferase specificity in selectin ligand formation. Blood. 2002 Nov 15; 100(10):3618-25. Ellies LG, Sperandio M, Underhill GH, Yousif J, Smith M, Priatel JJ, Kansas GS, Ley K, Marth JD. PMID: 12393657.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    49. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10042-7. Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD. PMID: 12097641.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    50. Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. . 2002 Feb; 282(2):L259-66. Broide DH, Miller M, Castaneda D, Nayar J, Cho JY, Roman M, Ellies LG, Sriramarao P. PMID: 11792630.
      View in: PubMed   Mentions:
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