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Lesley Ellies

Title(s)Recall Faculty, Pathology
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    NIH/NCI K22CA118182Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    Role of SV40 in Salivary Gland Tumorigenesis
    NIH/NIDCR R03DE014638Sep 1, 2002 - Aug 31, 2005
    Role: Principal Investigator
    ADHESION MOLECULES IN NO MODULATED TUMORIGENESIS
    NIH/NCI K08CA088035Sep 30, 2000 - Aug 31, 2006
    Role: Principal Investigator
    ALPHA 2,3 SIALYTRANSFERASES IN DEVELOPMENT AND TUMORS
    NIH/NCI F32CA079130Mar 27, 1999
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ireland L, Santos A, Campbell F, Figueiredo C, Hammond D, Ellies LG, Weyer-Czernilofsky U, Bogenrieder T, Schmid M, Mielgo A. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene. 2018 Apr; 37(15):2022-2036. PMID: 29367764.
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    2. Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 12 23; 7:13898. PMID: 28008921.
      View in: PubMed
    3. Gross ET, Han S, Vemu P, Peinado CD, Marsala M, Ellies LG, Bui JD. Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis. Oncoimmunology. 2017; 6(2):e1268310. PMID: 28344881.
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    4. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun. 2016 10 06; 7:13007. PMID: 27708283.
      View in: PubMed
    5. Ellies LG. Collagen and fibronectin: threads linking obesity and breast cancer. Ann Transl Med. 2016 Oct; 4(Suppl 1):S50. PMID: 27868018.
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    6. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. PMID: 27832862.
      View in: PubMed
    7. Spilker ME, Chung H, Visswanathan R, Bagrodia S, Gernhardt S, Fantin VR, Ellies LG. Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. Xenobiotica. 2017 Jul; 47(7):600-606. PMID: 27435693.
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    8. Cimen Bozkus C, Elzey BD, Crist SA, Ellies LG, Ratliff TL. Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity. J Immunol. 2015 Dec 01; 195(11):5237-50. PMID: 26491198; PMCID: PMC4655170 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    9. Bao L, Cardiff RD, Steinbach P, Messer KS, Ellies LG. Multipotent luminal mammary cancer stem cells model tumor heterogeneity. Breast Cancer Res. 2015 Oct 14; 17(1):137. PMID: 26467658; PMCID: PMC4606989.
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    10. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. PMID: 25220417; PMCID: PMC4362785.
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    11. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770; PMCID: PMC4183333.
      View in: PubMed, PubMed Central
    12. Zhou JZ, Riquelme MA, Gao X, Ellies LG, Sun LZ, Jiang JX. Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis. Oncogene. 2015 Apr 02; 34(14):1831-42. PMID: 24837364; PMCID: PMC4315766.
      View in: PubMed, PubMed Central
    13. Liberman A, Wu Z, Barback CV, Viveros RD, Wang J, Ellies LG, Mattrey RF, Trogler WC, Kummel AC, Blair SL. Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound. J Surg Res. 2014 Aug; 190(2):391-8. PMID: 24972734; PMCID: PMC4141695.
      View in: PubMed, PubMed Central
    14. Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY. Dual targeting of integrin avß3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. Mol Cancer Ther. 2014 Jun; 13(6):1514-25. PMID: 24737028; PMCID: PMC4051287.
      View in: PubMed, PubMed Central
    15. Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. J Thromb Haemost. 2014 Jan; 12(1):71-81. PMID: 24175924; PMCID: PMC3947224.
      View in: PubMed, PubMed Central
    16. Biswas T, Gu X, Yang J, Ellies LG, Sun LZ. Attenuation of TGF-ß signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett. 2014 Apr 28; 346(1):129-38. PMID: 24368187; PMCID: PMC3947668.
      View in: PubMed, PubMed Central
    17. Liberman A, Wu Z, Barback CV, Viveros R, Blair SL, Ellies LG, Vera DR, Mattrey RF, Kummel AC, Trogler WC. Color Doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells. ACS Nano. 2013 Jul 23; 7(7):6367-77. PMID: 23802554; PMCID: PMC3777724.
      View in: PubMed, PubMed Central
    18. Burkart C, Arimoto K, Tang T, Cong X, Xiao N, Liu YC, Kotenko SV, Ellies LG, Zhang DE. Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-? and elevated secretion of Cxcl10. EMBO Mol Med. 2013 Jul; 5(7):1035-50. PMID: 23681607; PMCID: PMC3721472.
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    19. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. PMID: 23671068.
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    20. Jeffers LK, Duan K, Ellies LG, Seaman WT, Burger-Calderon RA, Diatchenko LB, Webster-Cyriaque J. Correlation of transcription of MALAT-1, a novel noncoding RNA, with deregulated expression of tumor suppressor p53 in small DNA tumor virus models. J Cancer Ther. 2013 May; 4(3). PMID: 24163781.
      View in: PubMed
    21. Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjug Chem. 2013 May 15; 24(5):766-71. PMID: 23600997; PMCID: PMC3658552.
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    22. Yu MA, Kiang A, Wang-Rodriguez J, Rahimy E, Haas M, Yu V, Ellies LG, Chen J, Fan JB, Brumund KT, Weisman RA, Ongkeko WM. Nicotine promotes acquisition of stem cell and epithelial-to-mesenchymal properties in head and neck squamous cell carcinoma. PLoS One. 2012; 7(12):e51967. PMID: 23300583; PMCID: PMC3530520.
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    23. Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. PMID: 23188503; PMCID: PMC3799878.
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    24. Gibby K, You WK, Kadoya K, Helgadottir H, Young LJ, Ellies LG, Chang Y, Cardiff RD, Stallcup WB. Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan. Breast Cancer Res. 2012 Apr 24; 14(2):R67. PMID: 22531600; PMCID: PMC3446402.
      View in: PubMed, PubMed Central
    25. Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski DM, Liao D, Ellies L, Johnson RS. Endothelial cell HIF-1a and HIF-2a differentially regulate metastatic success. Cancer Cell. 2012 Jan 17; 21(1):52-65. PMID: 22264788.
      View in: PubMed
    26. Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS One. 2011; 6(12):e29046. PMID: 22194986; PMCID: PMC3237590.
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    27. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146; PMCID: PMC3144144.
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    28. Shu X, Lev-Ram V, Olson ES, Aguilera TA, Jiang T, Whitney M, Crisp JL, Steinbach P, Deerinck T, Ellisman MH, Ellies LG, Nguyen QT, Tsien RY. Spiers Memorial Lecture. Breeding and building molecular spies. Faraday Discuss. 2011; 149:9; discussion 63-77. PMID: 21413170.
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    29. Hebbard L, Cecena G, Golas J, Sawada J, Ellies LG, Charbono A, Williams R, Jimenez RE, Wankell M, Arndt KT, DeJoy SQ, Rollins RA, Diesl V, Follettie M, Chen L, Rosfjord E, Cardiff RD, Komatsu M, Boschelli F, Oshima RG. Control of mammary tumor differentiation by SKI-606 (bosutinib). Oncogene. 2011 Jan 20; 30(3):301-12. PMID: 20818417; PMCID: PMC3000443.
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    30. Niese KA, Chiaramonte MG, Ellies LG, Rothenberg ME, Zimmermann N. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res. 2010 Jun 24; 11:87. PMID: 20576117; PMCID: PMC2906447.
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    31. Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY. Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. J Biol Chem. 2010 Jul 16; 285(29):22532-41. PMID: 20460372; PMCID: PMC2903386.
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    32. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. PMID: 20388801; PMCID: PMC2856096.
      View in: PubMed, PubMed Central
    33. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. PMID: 20160097; PMCID: PMC2840114.
      View in: PubMed, PubMed Central
    34. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. PMID: 20160077; PMCID: PMC2840175.
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    35. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb). 2009 Jun; 1(5-6):382-93. PMID: 20023745; PMCID: PMC2796841.
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    36. Versteeg HH, Schaffner F, Kerver M, Ellies LG, Andrade-Gordon P, Mueller BM, Ruf W. Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res. 2008 Sep 01; 68(17):7219-27. PMID: 18757438; PMCID: PMC2596617.
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    37. Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M. Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J Exp Med. 2008 Jun 09; 205(6):1435-46. PMID: 18519646; PMCID: PMC2413039.
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    38. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 18; 133(2):223-34. PMID: 18423195; PMCID: PMC2849644.
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    39. Thompson RW, Pesce JT, Ramalingam T, Wilson MS, White S, Cheever AW, Ricklefs SM, Porcella SF, Li L, Ellies LG, Wynn TA. Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. PLoS Pathog. 2008 Mar 14; 4(3):e1000023. PMID: 18369473; PMCID: PMC2265428.
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    40. Wanasen N, MacLeod CL, Ellies LG, Soong L. L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages. Infect Immun. 2007 Jun; 75(6):2802-10. PMID: 17387163; PMCID: PMC1932894.
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    41. Davie SA, Maglione JE, Manner CK, Young D, Cardiff RD, MacLeod CL, Ellies LG. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res. 2007 Apr; 16(2):193-201. PMID: 17206489; PMCID: PMC1829418.
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    42. Sperandio M, Frommhold D, Babushkina I, Ellies LG, Olson TS, Smith ML, Fritzsching B, Pauly E, Smith DF, Nobiling R, Linderkamp O, Marth JD, Ley K. Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation. Eur J Immunol. 2006 Dec; 36(12):3207-15. PMID: 17111351.
      View in: PubMed
    43. Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG, Zimmermann N. Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14895-900. PMID: 17003120; PMCID: PMC1595447.
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    44. Underhill GH, Zisoulis DG, Kolli KP, Ellies LG, Marth JD, Kansas GS. A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells. Blood. 2005 Dec 01; 106(12):3867-73. PMID: 16099875; PMCID: PMC1895099.
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    45. Maglione JE, McGoldrick ET, Young LJ, Namba R, Gregg JP, Liu L, Moghanaki D, Ellies LG, Borowsky AD, Cardiff RD, MacLeod CL. Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes. Mol Cancer Ther. 2004 Aug; 3(8):941-53. PMID: 15299077.
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    46. Ellies LG, Fishman M, Hardison J, Kleeman J, Maglione JE, Manner CK, Cardiff RD, MacLeod CL. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer. 2003 Aug 10; 106(1):1-7. PMID: 12794750.
      View in: PubMed
    47. Ellies LG. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol. 2003 Jun; 48(6):415-22. PMID: 12749913.
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    48. Ellies LG, Sperandio M, Underhill GH, Yousif J, Smith M, Priatel JJ, Kansas GS, Ley K, Marth JD. Sialyltransferase specificity in selectin ligand formation. Blood. 2002 Nov 15; 100(10):3618-25. PMID: 12393657.
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    49. Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10042-7. PMID: 12097641; PMCID: PMC126621.
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    50. Broide DH, Miller M, Castaneda D, Nayar J, Cho JY, Roman M, Ellies LG, Sriramarao P. Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L259-66. PMID: 11792630.
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    51. Maglione JE, Moghanaki D, Young LJ, Manner CK, Ellies LG, Joseph SO, Nicholson B, Cardiff RD, MacLeod CL. Transgenic Polyoma middle-T mice model premalignant mammary disease. Cancer Res. 2001 Nov 15; 61(22):8298-305. PMID: 11719463.
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    52. Sperandio M, Forlow SB, Thatte J, Ellies LG, Marth JD, Ley K. Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo. J Immunol. 2001 Aug 15; 167(4):2268-74. PMID: 11490014.
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    53. Yeh JC, Hiraoka N, Petryniak B, Nakayama J, Ellies LG, Rabuka D, Hindsgaul O, Marth JD, Lowe JB, Fukuda M. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. Cell. 2001 Jun 29; 105(7):957-69. PMID: 11439191.
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    54. Sperandio M, Thatte A, Foy D, Ellies LG, Marth JD, Ley K. Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice. Blood. 2001 Jun 15; 97(12):3812-9. PMID: 11389021.
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    55. Snapp KR, Heitzig CE, Ellies LG, Marth JD, Kansas GS. Differential requirements for the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin. Blood. 2001 Jun 15; 97(12):3806-11. PMID: 11389020.
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    56. Shafi R, Iyer SP, Ellies LG, O'Donnell N, Marek KW, Chui D, Hart GW, Marth JD. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5735-9. PMID: 10801981; PMCID: PMC18502.
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    57. Ellies LG, Tsuboi S, Petryniak B, Lowe JB, Fukuda M, Marth JD. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity. 1998 Dec; 9(6):881-90. PMID: 9881978.
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    58. Ellies LG, Tao W, Fellinger W, Teh HS, Ziltener HJ. The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection. Blood. 1996 Sep 01; 88(5):1725-32. PMID: 8781428.
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