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    Lesley Ellies

    TitleRecall Faculty
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0717
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
      NIH/NCI K22CA118182Aug 1, 2006 - Jul 31, 2009
      Role: Principal Investigator
      Role of SV40 in Salivary Gland Tumorigenesis
      NIH/NIDCR R03DE014638Sep 1, 2002 - Aug 31, 2005
      Role: Principal Investigator
      NIH/NCI K08CA088035Sep 30, 2000 - Aug 31, 2006
      Role: Principal Investigator
      NIH/NCI F32CA079130Mar 27, 1999
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Gross ET, Han S, Vemu P, Peinado CD, Marsala M, Ellies L, Bui JD. Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis. Oncoimmunology. 2017; 6(2):e1268310. PMID: 28344881.
        View in: PubMed
      2. Ellies L. Collagen and fibronectin: threads linking obesity and breast cancer. Ann Transl Med. 2016 Oct; 4(Suppl 1):S50. PMID: 27868018.
        View in: PubMed
      3. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies L. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. PMID: 27832862.
        View in: PubMed
      4. Spilker ME, Chung H, Visswanathan R, Bagrodia S, Gernhardt S, Fantin VR, Ellies L. Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. Xenobiotica. 2017 Jul; 47(7):600-606. PMID: 27435693.
        View in: PubMed
      5. Cimen Bozkus C, Elzey BD, Crist SA, Ellies L, Ratliff TL. Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity. J Immunol. 2015 Dec 01; 195(11):5237-50. PMID: 26491198; PMCID: PMC4655170 [Available on 12/01/16].
      6. Bao L, Cardiff RD, Steinbach P, Messer KS, Ellies L. Multipotent luminal mammary cancer stem cells model tumor heterogeneity. Breast Cancer Res. 2015 Oct 14; 17(1):137. PMID: 26467658; PMCID: PMC4606989.
      7. Crisp JL, Savariar EN, Glasgow HL, Ellies L, Whitney MA, Tsien RY. Dual targeting of integrin avß3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. Mol Cancer Ther. 2014 Jun; 13(6):1514-25. PMID: 24737028; PMCID: PMC4051287.
      8. Biswas T, Gu X, Yang J, Ellies L, Sun LZ. Attenuation of TGF-ß signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett. 2014 Apr 28; 346(1):129-38. PMID: 24368187; PMCID: PMC3947668.
      9. Liberman A, Wu Z, Barback CV, Viveros R, Blair SL, Ellies L, Vera DR, Mattrey RF, Kummel AC, Trogler WC. Color Doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells. ACS Nano. 2013 Jul 23; 7(7):6367-77. PMID: 23802554; PMCID: PMC3777724.
      10. Burkart C, Arimoto K, Tang T, Cong X, Xiao N, Liu YC, Kotenko SV, Ellies L, Zhang DE. Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-? and elevated secretion of Cxcl10. EMBO Mol Med. 2013 Jul; 5(7):1035-50. PMID: 23681607; PMCID: PMC3721472.
      11. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies L, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. PMID: 23671068; PMCID: PMC3670313.
      12. Weinstain R, Kanter J, Friedman B, Ellies L, Baker ME, Tsien RY. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjug Chem. 2013 May 15; 24(5):766-71. PMID: 23600997; PMCID: PMC3658552.
      13. Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies L, Steinbach P, Tsien RY, Nguyen QT. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. PMID: 23188503; PMCID: PMC3799878.
      14. Gibby K, You WK, Kadoya K, Helgadottir H, Young LJ, Ellies L, Chang Y, Cardiff RD, Stallcup WB. Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan. Breast Cancer Res. 2012 Apr 24; 14(2):R67. PMID: 22531600; PMCID: PMC3446402.
      15. Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski DM, Liao D, Ellies L, Johnson RS. Endothelial cell HIF-1a and HIF-2a differentially regulate metastatic success. Cancer Cell. 2012 Jan 17; 21(1):52-65. PMID: 22264788; PMCID: PMC3334270.
      16. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies L, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146; PMCID: PMC3144144.
      17. Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies L, Tsien RY. Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. J Biol Chem. 2010 Jul 16; 285(29):22532-41. PMID: 20460372; PMCID: PMC2903386.
      18. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies L, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. PMID: 20388801; PMCID: PMC2856096.
      19. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies L, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. PMID: 20160077; PMCID: PMC2840175.
      20. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies L, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. PMID: 20160097; PMCID: PMC2840114.
      21. Versteeg HH, Schaffner F, Kerver M, Ellies L, Andrade-Gordon P, Mueller BM, Ruf W. Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res. 2008 Sep 01; 68(17):7219-27. PMID: 18757438; PMCID: PMC2596617.
      22. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies L, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 18; 133(2):223-34. PMID: 18423195; PMCID: PMC2849644.
      23. Wanasen N, MacLeod CL, Ellies L, Soong L. L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages. Infect Immun. 2007 Jun; 75(6):2802-10. PMID: 17387163; PMCID: PMC1932894.
      24. Davie SA, Maglione JE, Manner CK, Young D, Cardiff RD, MacLeod CL, Ellies L. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res. 2007 Apr; 16(2):193-201. PMID: 17206489; PMCID: PMC1829418.
      25. Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies L, Zimmermann N. Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14895-900. PMID: 17003120; PMCID: PMC1595447.
      26. Maglione JE, McGoldrick ET, Young LJ, Namba R, Gregg JP, Liu L, Moghanaki D, Ellies L, Borowsky AD, Cardiff RD, MacLeod CL. Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes. Mol Cancer Ther. 2004 Aug; 3(8):941-53. PMID: 15299077.
        View in: PubMed
      27. Ellies L, Fishman M, Hardison J, Kleeman J, Maglione JE, Manner CK, Cardiff RD, MacLeod CL. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer. 2003 Aug 10; 106(1):1-7. PMID: 12794750.
        View in: PubMed
      28. Ellies L. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol. 2003 Jun; 48(6):415-22. PMID: 12749913.
        View in: PubMed
      29. Ellies L, Sperandio M, Underhill GH, Yousif J, Smith M, Priatel JJ, Kansas GS, Ley K, Marth JD. Sialyltransferase specificity in selectin ligand formation. Blood. 2002 Nov 15; 100(10):3618-25. PMID: 12393657.
        View in: PubMed
      30. Ellies L, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10042-7. PMID: 12097641; PMCID: PMC126621.
      31. Broide DH, Miller M, Castaneda D, Nayar J, Cho JY, Roman M, Ellies L, Sriramarao P. Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L259-66. PMID: 11792630.
        View in: PubMed