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Lawrence Prince

Title(s)Professor, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0760
La Jolla CA 92093
Phone858-822-4677
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    Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung Innate Defenses in the Fetus and Newborn Infant
    NIH/NIAID R01AI142864Jul 17, 2019 - Jun 30, 2022
    Role: Principal Investigator
    Impact of Early-in-life Disruption of Lung Development on Adult Lung Progenitor Function
    NIH/NHLBI R01HL143256Sep 1, 2018 - Jun 30, 2022
    Role: Co-Principal Investigator
    Transcriptional Control of Lung Macrophage Development
    NIH/NHLBI R01HL126703May 15, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Imaging Activated Macrophages in the Lungs
    NIH/NHLBI R01HL116358Sep 25, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Confocal Microscope for Live Embryo Imaging in a Shared Resource Facility
    NIH/NCRR S10RR027396Aug 1, 2010 - Jul 31, 2011
    Role: Principal Investigator
    Role of Fetal Lung Macrophages in Bronchopulmonary Dysplasia
    NIH/NHLBI R01HL097195Sep 14, 2009 - Jul 31, 2014
    Role: Principal Investigator
    FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    NIH/NHLBI R01HL086324Apr 15, 2008 - May 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection. iScience. 2020 Jun 26; 23(6):101207. Lund SJ, Patras KA, Kimmey JM, Yamamura A, Butcher LD, Del Rosario PGB, Hernandez GE, McCoy AM, Lakhdari O, Nizet V, Prince LS. PMID: 32535023.
      View in: PubMed   Mentions:
    2. Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants. Commun Biol. 2020 May 22; 3(1):259. Sahoo D, Zaramela LS, Hernandez GE, Mai U, Taheri S, Dang D, Stouch AN, Medal RM, McCoy AM, Aschner JL, Blackwell TS, Zengler K, Prince LS. PMID: 32444859.
      View in: PubMed   Mentions:
    3. Computational Approach to Identifying Universal Macrophage Biomarkers. Front Physiol. 2020; 11:275. Dang D, Taheri S, Das S, Ghosh P, Prince LS, Sahoo D. PMID: 32322218.
      View in: PubMed   Mentions:
    4. Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung. Nat Immunol. 2020 02; 21(2):221-231. Sajti E, Link VM, Ouyang Z, Spann NJ, Westin E, Romanoski CE, Fonseca GJ, Prince LS, Glass CK. PMID: 31959980.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Differential Immune Activation in Fetal Macrophage Populations. Sci Rep. 2019 05 22; 9(1):7677. Lakhdari O, Yamamura A, Hernandez GE, Anderson KK, Lund SJ, Oppong-Nonterah GO, Hoffman HM, Prince LS. PMID: 31118442.
      View in: PubMed   Mentions: 1     Fields:    
    6. TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation. J Innate Immun. 2019; 11(1):99-108. Oppong-Nonterah GO, Lakhdari O, Yamamura A, Hoffman HM, Prince LS. PMID: 30408777.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. FGF10 and Human Lung Disease Across the Life Spectrum. Front Genet. 2018; 9:517. Prince LS. PMID: 30429870.
      View in: PubMed   Mentions:
    8. IKKß Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Dec; 187(12):2635-2644. McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS. PMID: 28923684.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L861-L872. Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince LS. PMID: 28336813.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. TLR3 signaling is downregulated by a MAVS isoform in epithelial cells. Cell Immunol. 2016 12; 310:205-210. Lakhdari O, McAllister CS, Wang M, Minev I, Prince LS, Eckmann L, Kagnoff MF. PMID: 27593154.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development. Am J Pathol. 2016 07; 186(7):1786-1800. Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince LS, Young LR, Blackwell TS. PMID: 27181406.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. IL-1ß and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development. J Immunol. 2016 Apr 15; 196(8):3411-20. Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS. PMID: 26951798.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):50-9. Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. PMID: 25375039.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec; 141(24):4751-62. Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R. PMID: 25395457.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis. Organogenesis. 2014; 10(4):340-9. Greer RM, Miller JD, Okoh VO, Halloran BA, Prince LS. PMID: 25482312.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. I?B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol. 2014 Aug 01; 193(3):1184-93. Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS. PMID: 24981452.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 Jun; 34(6):801-11. Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince LS, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P. PMID: 23505205.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    18. Interactions between NF-?B and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013 May 24; 288(21):15318-25. Carver BJ, Plosa EJ, Stinnett AM, Blackwell TS, Prince LS. PMID: 23558680.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    19. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. PMID: 23607856.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    20. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One. 2013; 8(2):e56270. Goudy S, Angel P, Jacobs B, Hill C, Mainini V, Smith AL, Kousa YA, Caprioli R, Prince LS, Baldwin S, Schutte BC. PMID: 23451037.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn. 2012 Nov; 241(11):1770-81. Plosa EJ, Gooding KA, Zent R, Prince LS. PMID: 22972683.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation. Cardiovasc Res. 2012 Aug 01; 95(3):375-84. Fike CD, Sidoryk-Wegrzynowicz M, Aschner M, Summar M, Prince LS, Cunningham G, Kaplowitz M, Zhang Y, Aschner JL. PMID: 22673370.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    23. Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech. 2012 Jul; 5(4):522-32. Zhang C, Sherman MP, Prince LS, Bader D, Weitkamp JH, Slaughter JC, McElroy SJ. PMID: 22328592.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    24. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet. 2012 Mar 15; 21(6):1374-83. Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S. PMID: 22156581.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Endothelial differentiation by multipotent fetal mouse lung mesenchymal cells. Stem Cells Dev. 2012 Jun 10; 21(9):1455-65. Yamamoto Y, Baldwin HS, Prince LS. PMID: 22008017.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Epithelial nuclear factor-?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene. 2012 Jun 28; 31(26):3164-76. Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. PMID: 22002309.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    27. NF-?B signaling in fetal lung macrophages disrupts airway morphogenesis. J Immunol. 2011 Sep 01; 187(5):2740-7. Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS. PMID: 21775686.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    28. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G656-66. McElroy SJ, Prince LS, Weitkamp JH, Reese J, Slaughter JC, Polk DB. PMID: 21737776.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    29. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol. 2010 Oct 15; 185(8):4896-903. Benjamin JT, Carver BJ, Plosa EJ, Yamamoto Y, Miller JD, Liu JH, van der Meer R, Blackwell TS, Prince LS. PMID: 20861353.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L637-45. Miller JD, Benjamin JT, Kelly DR, Frank DB, Prince LS. PMID: 20172951.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    31. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol. 2009 Nov 15; 335(2):407-17. Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. PMID: 19769957.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    32. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008 Jun 01; 318(1):112-25. Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC. PMID: 18423437.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    33. Hyperoxia and EGFL7: saving cells from too much of a good thing. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L15-6. Prince LS. PMID: 17993582.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L550-8. Benjamin JT, Smith RJ, Halloran BA, Day TJ, Kelly DR, Prince LS. PMID: 17071719.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    35. Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatr Res. 2006 Feb; 59(2):185-90. Dieperink HI, Blackwell TS, Prince LS. PMID: 16439576.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    36. Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung. Dev Dyn. 2005 Jun; 233(2):553-61. Prince LS, Dieperink HI, Okoh VO, Fierro-Perez GA, Lallone RL. PMID: 15830384.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L999-1006. Prince LS, Okoh VO, Moninger TO, Matalon S. PMID: 15475494.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    38. Care of very low birth weight infants with respiratory distress syndrome: an evidence-based review. Minerva Pediatr. 2004 Aug; 56(4):373-80. Carlo WA, Prince LS, St John EB, Ambalavanan N. PMID: 15457135.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. KGF alters gene expression in human airway epithelia: potential regulation of the inflammatory response. Physiol Genomics. 2001 Jul 17; 6(2):81-9. Prince LS, Karp PH, Moninger TO, Welsh MJ. PMID: 11459923.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal. J Biol Chem. 1999 Feb 05; 274(6):3602-9. Prince LS, Peter K, Hatton SR, Zaliauskiene L, Cotlin LF, Clancy JP, Marchase RB, Collawn JF. PMID: 9920908.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    41. Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5192-6. Prince LS, Workman RB, Marchase RB. PMID: 7515188.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    42. Cell surface labeling of CFTR in T84 cells. Am J Physiol. 1993 Feb; 264(2 Pt 1):C491-8. Prince LS, Tousson A, Marchase RB. PMID: 7680530.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    43. The longitudinal relaxation time (T1) of the intracellular 23Na NMR signal in the isolated perfused rat heart during hypoxia and reoxygenation. Magn Reson Med. 1992 Feb; 23(2):376-82. Prince LS, Miller SK, Pohost GM, Elgavish GA. PMID: 1549052.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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