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    Lawrence Prince

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0760
    CA La Jolla 92093
    Phone858-822-4677
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      Collapse Research 
      Collapse Research Activities and Funding
      Transcriptional Control of Lung Macrophage Development
      NIH/NHLBI R01HL126703May 15, 2015 - Mar 31, 2019
      Role: Principal Investigator
      Imaging Activated Macrophages in the Lungs
      NIH/NHLBI R01HL116358Sep 25, 2012 - Jun 30, 2015
      Role: Principal Investigator
      Confocal Microscope for Live Embryo Imaging in a Shared Resource Facility
      NIH/NCRR S10RR027396Aug 1, 2010 - Jul 31, 2011
      Role: Principal Investigator
      Role of Fetal Lung Macrophages in Bronchopulmonary Dysplasia
      NIH/NHLBI R01HL097195Sep 14, 2009 - Jul 31, 2014
      Role: Principal Investigator
      FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
      NIH/NHLBI R01HL086324Jul 1, 2006 - May 31, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince L. IKKß Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Sep 15. PMID: 28923684.
        View in: PubMed
      2. Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince L. The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 01; 312(6):L861-L872. PMID: 28336813.
        View in: PubMed
      3. Lakhdari O, McAllister CS, Wang M, Minev I, Prince L, Eckmann L, Kagnoff MF. TLR3 signaling is downregulated by a MAVS isoform in epithelial cells. Cell Immunol. 2016 Dec; 310:205-210. PMID: 27593154.
        View in: PubMed
      4. Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince L, Young LR, Blackwell TS. Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development. Am J Pathol. 2016 Jul; 186(7):1786-800. PMID: 27181406; PMCID: PMC4929391 [Available on 07/01/17].
        View in: PubMed, PubMed Central
      5. Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince L. IL-1ß and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development. J Immunol. 2016 Apr 15; 196(8):3411-20. PMID: 26951798.
        View in: PubMed
      6. Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince L, Blackwell TS. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):50-9. PMID: 25375039; PMCID: PMC4566110.
        View in: PubMed, PubMed Central
      7. Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince L, Blackwell TS, Zent R. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec; 141(24):4751-62. PMID: 25395457; PMCID: PMC4299273.
        View in: PubMed, PubMed Central
      8. Greer RM, Miller JD, Okoh VO, Halloran BA, Prince L. Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis. Organogenesis. 2014; 10(4):340-9. PMID: 25482312; PMCID: PMC4594603.
        View in: PubMed, PubMed Central
      9. Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince L. I?B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol. 2014 Aug 01; 193(3):1184-93. PMID: 24981452; PMCID: PMC4108541.
        View in: PubMed, PubMed Central
      10. Greer RM, Miller JD, Okoh VO, Halloran BA, Prince L. Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis. Organogenesis. 2014 May 14; 10(3). PMID: 24827973.
        View in: PubMed
      11. Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince L, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 Jun; 34(6):801-11. PMID: 23505205; PMCID: PMC3663886.
        View in: PubMed, PubMed Central
      12. Carver BJ, Plosa EJ, Stinnett AM, Blackwell TS, Prince L. Interactions between NF-?B and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013 May 24; 288(21):15318-25. PMID: 23558680; PMCID: PMC3663551.
        View in: PubMed, PubMed Central
      13. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince L, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856; PMCID: PMC3955361.
        View in: PubMed, PubMed Central
      14. Goudy S, Angel P, Jacobs B, Hill C, Mainini V, Smith AL, Kousa YA, Caprioli R, Prince L, Baldwin S, Schutte BC. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One. 2013; 8(2):e56270. PMID: 23451037; PMCID: PMC3579850.
        View in: PubMed, PubMed Central
      15. Plosa EJ, Gooding KA, Zent R, Prince L. Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn. 2012 Nov; 241(11):1770-81. PMID: 22972683; PMCID: PMC3484380.
        View in: PubMed, PubMed Central
      16. Fike CD, Sidoryk-Wegrzynowicz M, Aschner M, Summar M, Prince L, Cunningham G, Kaplowitz M, Zhang Y, Aschner JL. Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation. Cardiovasc Res. 2012 Aug 01; 95(3):375-84. PMID: 22673370; PMCID: PMC3400357.
        View in: PubMed, PubMed Central
      17. Zhang C, Sherman MP, Prince L, Bader D, Weitkamp JH, Slaughter JC, McElroy SJ. Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech. 2012 Jul; 5(4):522-32. PMID: 22328592; PMCID: PMC3380715.
        View in: PubMed, PubMed Central
      18. Humphreys R, Zheng W, Prince L, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet. 2012 Mar 15; 21(6):1374-83. PMID: 22156581; PMCID: PMC3465692.
        View in: PubMed, PubMed Central
      19. Yamamoto Y, Baldwin HS, Prince L. Endothelial differentiation by multipotent fetal mouse lung mesenchymal cells. Stem Cells Dev. 2012 Jun 10; 21(9):1455-65. PMID: 22008017; PMCID: PMC3359627.
        View in: PubMed, PubMed Central
      20. Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince L, Yull FE, Blackwell TS. Epithelial nuclear factor-?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene. 2012 Jun 28; 31(26):3164-76. PMID: 22002309; PMCID: PMC3266969.
        View in: PubMed, PubMed Central
      21. Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince L. NF-?B signaling in fetal lung macrophages disrupts airway morphogenesis. J Immunol. 2011 Sep 01; 187(5):2740-7. PMID: 21775686; PMCID: PMC3159744.
        View in: PubMed, PubMed Central
      22. McElroy SJ, Prince L, Weitkamp JH, Reese J, Slaughter JC, Polk DB. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G656-66. PMID: 21737776; PMCID: PMC3191555.
        View in: PubMed, PubMed Central
      23. Benjamin JT, Carver BJ, Plosa EJ, Yamamoto Y, Miller JD, Liu JH, van der Meer R, Blackwell TS, Prince L. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol. 2010 Oct 15; 185(8):4896-903. PMID: 20861353; PMCID: PMC4399641.
        View in: PubMed, PubMed Central
      24. Miller JD, Benjamin JT, Kelly DR, Frank DB, Prince L. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L637-45. PMID: 20172951; PMCID: PMC2867403.
        View in: PubMed, PubMed Central
      25. Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince L. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol. 2009 Nov 15; 335(2):407-17. PMID: 19769957; PMCID: PMC2783258.
        View in: PubMed, PubMed Central
      26. Wang H, Ding T, Brown N, Yamamoto Y, Prince L, Reese J, Paria BC. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008 Jun 01; 318(1):112-25. PMID: 18423437; PMCID: PMC2442465.
        View in: PubMed, PubMed Central
      27. Prince L. Hyperoxia and EGFL7: saving cells from too much of a good thing. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L15-6. PMID: 17993582.
        View in: PubMed
      28. Benjamin JT, Smith RJ, Halloran BA, Day TJ, Kelly DR, Prince L. FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L550-8. PMID: 17071719.
        View in: PubMed
      29. Dieperink HI, Blackwell TS, Prince L. Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatr Res. 2006 Feb; 59(2):185-90. PMID: 16439576.
        View in: PubMed
      30. Prince L, Dieperink HI, Okoh VO, Fierro-Perez GA, Lallone RL. Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung. Dev Dyn. 2005 Jun; 233(2):553-61. PMID: 15830384.
        View in: PubMed
      31. Prince L, Okoh VO, Moninger TO, Matalon S. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L999-1006. PMID: 15475494.
        View in: PubMed
      32. Carlo WA, Prince L, St John EB, Ambalavanan N. Care of very low birth weight infants with respiratory distress syndrome: an evidence-based review. Minerva Pediatr. 2004 Aug; 56(4):373-80. PMID: 15457135.
        View in: PubMed
      33. Prince L, Karp PH, Moninger TO, Welsh MJ. KGF alters gene expression in human airway epithelia: potential regulation of the inflammatory response. Physiol Genomics. 2001 Jul 17; 6(2):81-9. PMID: 11459923.
        View in: PubMed
      34. Prince L, Peter K, Hatton SR, Zaliauskiene L, Cotlin LF, Clancy JP, Marchase RB, Collawn JF. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal. J Biol Chem. 1999 Feb 05; 274(6):3602-9. PMID: 9920908.
        View in: PubMed
      35. Prince L, Workman RB, Marchase RB. Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5192-6. PMID: 7515188; PMCID: PMC43958.
        View in: PubMed, PubMed Central
      36. Prince L, Tousson A, Marchase RB. Cell surface labeling of CFTR in T84 cells. Am J Physiol. 1993 Feb; 264(2 Pt 1):C491-8. PMID: 7680530.
        View in: PubMed
      37. Prince L, Miller SK, Pohost GM, Elgavish GA. The longitudinal relaxation time (T1) of the intracellular 23Na NMR signal in the isolated perfused rat heart during hypoxia and reoxygenation. Magn Reson Med. 1992 Feb; 23(2):376-82. PMID: 1549052.
        View in: PubMed
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