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Lawrence Prince

Title(s)Professor, Pediatrics
SchoolHealth Sciences
Phone858-822-4677
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    Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung Innate Defenses in the Fetus and Newborn Infant
    NIH/NIAID R01AI142864Jul 17, 2019 - Jun 30, 2022
    Role: Principal Investigator
    Impact of Early-in-life Disruption of Lung Development on Adult Lung Progenitor Function
    NIH/NHLBI R01HL143256Sep 1, 2018 - Jun 30, 2022
    Role: Co-Principal Investigator
    Transcriptional Control of Lung Macrophage Development
    NIH/NHLBI R01HL126703May 15, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Imaging Activated Macrophages in the Lungs
    NIH/NHLBI R01HL116358Sep 25, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Confocal Microscope for Live Embryo Imaging in a Shared Resource Facility
    NIH/NCRR S10RR027396Aug 1, 2010 - Jul 31, 2011
    Role: Principal Investigator
    Role of Fetal Lung Macrophages in Bronchopulmonary Dysplasia
    NIH/NHLBI R01HL097195Sep 14, 2009 - Jul 31, 2014
    Role: Principal Investigator
    FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    NIH/NHLBI R01HL086324Jul 1, 2006 - May 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lakhdari O, Yamamura A, Hernandez GE, Anderson KK, Lund SJ, Oppong-Nonterah GO, Hoffman HM, Prince LS. Differential Immune Activation in Fetal Macrophage Populations. Sci Rep. 2019 May 22; 9(1):7677. PMID: 31118442.
      View in: PubMed
    2. Oppong-Nonterah GO, Lakhdari O, Yamamura A, Hoffman HM, Prince LS. TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation. J Innate Immun. 2019; 11(1):99-108. PMID: 30408777.
      View in: PubMed
    3. Prince LS. FGF10 and Human Lung Disease Across the Life Spectrum. Front Genet. 2018; 9:517. PMID: 30429870.
      View in: PubMed
    4. McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS. IKKß Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Dec; 187(12):2635-2644. PMID: 28923684.
      View in: PubMed
    5. Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince LS. The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L861-L872. PMID: 28336813.
      View in: PubMed
    6. Lakhdari O, McAllister CS, Wang M, Minev I, Prince LS, Eckmann L, Kagnoff MF. TLR3 signaling is downregulated by a MAVS isoform in epithelial cells. Cell Immunol. 2016 12; 310:205-210. PMID: 27593154.
      View in: PubMed
    7. Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince LS, Young LR, Blackwell TS. Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development. Am J Pathol. 2016 07; 186(7):1786-1800. PMID: 27181406.
      View in: PubMed
    8. Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS. IL-1ß and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development. J Immunol. 2016 Apr 15; 196(8):3411-20. PMID: 26951798.
      View in: PubMed
    9. Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):50-9. PMID: 25375039.
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    10. Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec; 141(24):4751-62. PMID: 25395457.
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    11. Greer RM, Miller JD, Okoh VO, Halloran BA, Prince LS. Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis. Organogenesis. 2014; 10(4):340-9. PMID: 25482312.
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    12. Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS. I?B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol. 2014 Aug 01; 193(3):1184-93. PMID: 24981452.
      View in: PubMed
    13. Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince LS, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 Jun; 34(6):801-11. PMID: 23505205.
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    14. Carver BJ, Plosa EJ, Stinnett AM, Blackwell TS, Prince LS. Interactions between NF-?B and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013 May 24; 288(21):15318-25. PMID: 23558680.
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    15. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
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    16. Goudy S, Angel P, Jacobs B, Hill C, Mainini V, Smith AL, Kousa YA, Caprioli R, Prince LS, Baldwin S, Schutte BC. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One. 2013; 8(2):e56270. PMID: 23451037.
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    17. Plosa EJ, Gooding KA, Zent R, Prince LS. Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn. 2012 Nov; 241(11):1770-81. PMID: 22972683.
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    18. Fike CD, Sidoryk-Wegrzynowicz M, Aschner M, Summar M, Prince LS, Cunningham G, Kaplowitz M, Zhang Y, Aschner JL. Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation. Cardiovasc Res. 2012 Aug 01; 95(3):375-84. PMID: 22673370.
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    19. Zhang C, Sherman MP, Prince LS, Bader D, Weitkamp JH, Slaughter JC, McElroy SJ. Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech. 2012 Jul; 5(4):522-32. PMID: 22328592.
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    20. Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet. 2012 Mar 15; 21(6):1374-83. PMID: 22156581.
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    21. Yamamoto Y, Baldwin HS, Prince LS. Endothelial differentiation by multipotent fetal mouse lung mesenchymal cells. Stem Cells Dev. 2012 Jun 10; 21(9):1455-65. PMID: 22008017.
      View in: PubMed
    22. Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene. 2012 Jun 28; 31(26):3164-76. PMID: 22002309.
      View in: PubMed
    23. Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS. NF-?B signaling in fetal lung macrophages disrupts airway morphogenesis. J Immunol. 2011 Sep 01; 187(5):2740-7. PMID: 21775686.
      View in: PubMed
    24. McElroy SJ, Prince LS, Weitkamp JH, Reese J, Slaughter JC, Polk DB. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G656-66. PMID: 21737776.
      View in: PubMed
    25. Benjamin JT, Carver BJ, Plosa EJ, Yamamoto Y, Miller JD, Liu JH, van der Meer R, Blackwell TS, Prince LS. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol. 2010 Oct 15; 185(8):4896-903. PMID: 20861353.
      View in: PubMed
    26. Miller JD, Benjamin JT, Kelly DR, Frank DB, Prince LS. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L637-45. PMID: 20172951.
      View in: PubMed
    27. Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol. 2009 Nov 15; 335(2):407-17. PMID: 19769957.
      View in: PubMed
    28. Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008 Jun 01; 318(1):112-25. PMID: 18423437.
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    29. Prince LS. Hyperoxia and EGFL7: saving cells from too much of a good thing. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L15-6. PMID: 17993582.
      View in: PubMed
    30. Benjamin JT, Smith RJ, Halloran BA, Day TJ, Kelly DR, Prince LS. FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L550-8. PMID: 17071719.
      View in: PubMed
    31. Dieperink HI, Blackwell TS, Prince LS. Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatr Res. 2006 Feb; 59(2):185-90. PMID: 16439576.
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    32. Prince LS, Dieperink HI, Okoh VO, Fierro-Perez GA, Lallone RL. Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung. Dev Dyn. 2005 Jun; 233(2):553-61. PMID: 15830384.
      View in: PubMed
    33. Prince LS, Okoh VO, Moninger TO, Matalon S. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L999-1006. PMID: 15475494.
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    34. Carlo WA, Prince LS, St John EB, Ambalavanan N. Care of very low birth weight infants with respiratory distress syndrome: an evidence-based review. Minerva Pediatr. 2004 Aug; 56(4):373-80. PMID: 15457135.
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    35. Prince LS, Karp PH, Moninger TO, Welsh MJ. KGF alters gene expression in human airway epithelia: potential regulation of the inflammatory response. Physiol Genomics. 2001 Jul 17; 6(2):81-9. PMID: 11459923.
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    36. Prince LS, Peter K, Hatton SR, Zaliauskiene L, Cotlin LF, Clancy JP, Marchase RB, Collawn JF. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal. J Biol Chem. 1999 Feb 05; 274(6):3602-9. PMID: 9920908.
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    37. Prince LS, Workman RB, Marchase RB. Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5192-6. PMID: 7515188.
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    38. Prince LS, Tousson A, Marchase RB. Cell surface labeling of CFTR in T84 cells. Am J Physiol. 1993 Feb; 264(2 Pt 1):C491-8. PMID: 7680530.
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    39. Prince LS, Miller SK, Pohost GM, Elgavish GA. The longitudinal relaxation time (T1) of the intracellular 23Na NMR signal in the isolated perfused rat heart during hypoxia and reoxygenation. Magn Reson Med. 1992 Feb; 23(2):376-82. PMID: 1549052.
      View in: PubMed
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