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Laurent Fattet

Title(s)Assistant Project Scientist, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex. Dev Cell. 2020 Aug 10; 54(3):302-316.e7. Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, Yang J. PMID: 32574556.
      View in: PubMed   Mentions:    Fields:    
    2. A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor. FEBS J. 2020 May 02. Aubol BE, Fattet L, Adams JA. PMID: 32359191.
      View in: PubMed   Mentions:    Fields:    
    3. RREB1 Integrates TGF-ß and RAS Signals to Drive EMT. Dev Cell. 2020 02 10; 52(3):259-260. Fattet L, Yang J. PMID: 32049037.
      View in: PubMed   Mentions: 1     Fields:    
    4. Disordered protein interactions for an ordered cellular transition: Cdc2-like kinase 1 is transported to the nucleus via its Ser-Arg protein substrate. J Biol Chem. 2019 06 14; 294(24):9631-9641. George A, Aubol BE, Fattet L, Adams JA. PMID: 31064840.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2019 03; 21(3):359-371. Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. PMID: 30804505.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3502-3507. Ondeck MG, Kumar A, Placone JK, Plunkett CM, Matte BF, Wong KC, Fattet L, Yang J, Engler AJ. PMID: 30755531.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. Biomaterials to model and measure epithelial cancers. Nat Rev Mater. 2018 Nov; 3(11):418-430. Beri P, Matte BF, Fattet L, Kim D, Yang J, Engler AJ. PMID: 30416759.
      View in: PubMed   Mentions:
    8. Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1. J Biol Chem. 2018 10 26; 293(43):16751-16760. Aubol BE, Serrano P, Fattet L, Wüthrich K, Adams JA. PMID: 30185622.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Mobilization of a splicing factor through a nuclear kinase-kinase complex. Biochem J. 2018 02 14; 475(3):677-690. Aubol BE, Keshwani MM, Fattet L, Adams JA. PMID: 29335301.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform. J Mol Biol. 2017 07 07; 429(14):2178-2191. Aubol BE, Hailey KL, Fattet L, Jennings PA, Adams JA. PMID: 28576472.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 07 21; 63(2):218-228. Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. PMID: 27397683.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. Biochem J. 2015 Dec 15; 472(3):329-38. Keshwani MM, Hailey KL, Aubol BE, Fattet L, McGlone ML, Jennings PA, Adams JA. PMID: 26443864.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-ß-Induced Epithelial to Mesenchymal Transition. PLoS One. 2015; 10(9):e0139179. Ruff M, Leyme A, Le Cann F, Bonnier D, Le Seyec J, Chesnel F, Fattet L, Rimokh R, Baffet G, Théret N. PMID: 26407179.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    14. The forces behind EMT and tumor metastasis. Cell Cycle. 2015 Aug 03; 14(15):2387-8. Wei SC, Fattet L, Yang J. PMID: 26083471.
      View in: PubMed   Mentions:
    15. TIF1? interferes with TGFß1/SMAD4 signaling to promote poor outcome in operable breast cancer patients. BMC Cancer. 2015 Jun 04; 15:453. Kassem L, Deygas M, Fattet L, Lopez J, Goulvent T, Lavergne E, Chabaud S, Carrabin N, Chopin N, Bachelot T, Gillet G, Treilleux I, Rimokh R. PMID: 26040677.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. PMID: 25893917.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    17. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 01; 466(2):311-22. Keshwani MM, Aubol BE, Fattet L, Ma CT, Qiu J, Jennings PA, Fu XD, Adams JA. PMID: 25529026.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. Clin Cancer Res. 2015 Mar 01; 21(5):962-968. Jung HY, Fattet L, Yang J. PMID: 25107915.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    19. Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature. J Proteomics. 2014 Oct 14; 110:183-94. Biarc J, Gonzalo P, Mikaelian I, Fattet L, Deygas M, Gillet G, Lemoine J, Rimokh R. PMID: 25242195.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    20. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep. 2014 Jun 26; 7(6):1900-13. Dardenne E, Polay Espinoza M, Fattet L, Germann S, Lambert MP, Neil H, Zonta E, Mortada H, Gratadou L, Deygas M, Chakrama FZ, Samaan S, Desmet FO, Tranchevent LC, Dutertre M, Rimokh R, Bourgeois CF, Auboeuf D. PMID: 24910439.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    21. TIF1? requires sumoylation to exert its repressive activity on TGFß signaling. J Cell Sci. 2013 Aug 15; 126(Pt 16):3713-23. Fattet L, Ay AS, Bonneau B, Jallades L, Mikaelian I, Treilleux I, Gillet G, Hesling C, Rimokh R. PMID: 23788427.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Tif1? is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition. Development. 2013 Jan 01; 140(1):167-75. Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R. PMID: 23154409.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Dynamic regulation of Tgf-B signaling by Tif1?: a computational approach. PLoS One. 2012; 7(3):e33761. Andrieux G, Fattet L, Le Borgne M, Rimokh R, Théret N. PMID: 22461896.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    24. Antagonistic regulation of EMT by TIF1? and Smad4 in mammary epithelial cells. . 2011 Jul 01; 12(7):665-72. Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, Vanbelle C, Morel AP, Gillet G, Mikaelian I, Rimokh R. PMID: 21597466.
      View in: PubMed   Mentions:
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