 Laurent Fattet
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| Title(s) | Assistant Project Scientist, Pharmacology |
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| School | Health Sciences |
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| vCard | Download vCard |
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 Bibliographic
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George A, Aubol BE, Fattet L, Adams JA. Disordered protein interactions for an ordered cellular transition: Cdc2-like kinase 1 is transported to the nucleus via its Ser-Arg protein substrate. J Biol Chem. 2019 Jun 14; 294(24):9631-9641. PMID: 31064840.
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Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2019 03; 21(3):359-371. PMID: 30804505.
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Ondeck MG, Kumar A, Placone JK, Plunkett CM, Matte BF, Wong KC, Fattet L, Yang J, Engler AJ. Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3502-3507. PMID: 30755531.
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Beri P, Matte BF, Fattet L, Kim D, Yang J, Engler AJ. Biomaterials to model and measure epithelial cancers. Nat Rev Mater. 2018 Nov; 3(11):418-430. PMID: 30416759.
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Aubol BE, Serrano P, Fattet L, Wüthrich K, Adams JA. Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1. J Biol Chem. 2018 10 26; 293(43):16751-16760. PMID: 30185622.
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Aubol BE, Keshwani MM, Fattet L, Adams JA. Mobilization of a splicing factor through a nuclear kinase-kinase complex. Biochem J. 2018 02 14; 475(3):677-690. PMID: 29335301.
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Aubol BE, Hailey KL, Fattet L, Jennings PA, Adams JA. Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform. J Mol Biol. 2017 07 07; 429(14):2178-2191. PMID: 28576472.
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Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 07 21; 63(2):218-228. PMID: 27397683.
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Keshwani MM, Hailey KL, Aubol BE, Fattet L, McGlone ML, Jennings PA, Adams JA. Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. Biochem J. 2015 Dec 15; 472(3):329-38. PMID: 26443864.
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Ruff M, Leyme A, Le Cann F, Bonnier D, Le Seyec J, Chesnel F, Fattet L, Rimokh R, Baffet G, Théret N. The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-ß-Induced Epithelial to Mesenchymal Transition. PLoS One. 2015; 10(9):e0139179. PMID: 26407179.
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Wei SC, Fattet L, Yang J. The forces behind EMT and tumor metastasis. Cell Cycle. 2015 Aug 03; 14(15):2387-8. PMID: 26083471.
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Kassem L, Deygas M, Fattet L, Lopez J, Goulvent T, Lavergne E, Chabaud S, Carrabin N, Chopin N, Bachelot T, Gillet G, Treilleux I, Rimokh R. TIF1? interferes with TGFß1/SMAD4 signaling to promote poor outcome in operable breast cancer patients. BMC Cancer. 2015 Jun 04; 15:453. PMID: 26040677.
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Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917.
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Keshwani MM, Aubol BE, Fattet L, Ma CT, Qiu J, Jennings PA, Fu XD, Adams JA. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 01; 466(2):311-22. PMID: 25529026.
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Jung HY, Fattet L, Yang J. Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. Clin Cancer Res. 2015 Mar 01; 21(5):962-968. PMID: 25107915.
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Biarc J, Gonzalo P, Mikaelian I, Fattet L, Deygas M, Gillet G, Lemoine J, Rimokh R. Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature. J Proteomics. 2014 Oct 14; 110:183-94. PMID: 25242195.
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Dardenne E, Polay Espinoza M, Fattet L, Germann S, Lambert MP, Neil H, Zonta E, Mortada H, Gratadou L, Deygas M, Chakrama FZ, Samaan S, Desmet FO, Tranchevent LC, Dutertre M, Rimokh R, Bourgeois CF, Auboeuf D. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep. 2014 Jun 26; 7(6):1900-13. PMID: 24910439.
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Fattet L, Ay AS, Bonneau B, Jallades L, Mikaelian I, Treilleux I, Gillet G, Hesling C, Rimokh R. TIF1? requires sumoylation to exert its repressive activity on TGFß signaling. J Cell Sci. 2013 Aug 15; 126(Pt 16):3713-23. PMID: 23788427.
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Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R. Tif1? is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition. Development. 2013 Jan 01; 140(1):167-75. PMID: 23154409.
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Andrieux G, Fattet L, Le Borgne M, Rimokh R, Théret N. Dynamic regulation of Tgf-B signaling by Tif1?: a computational approach. PLoS One. 2012; 7(3):e33761. PMID: 22461896.
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Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, Vanbelle C, Morel AP, Gillet G, Mikaelian I, Rimokh R. Antagonistic regulation of EMT by TIF1? and Smad4 in mammary epithelial cells. EMBO Rep. 2011 Jul 01; 12(7):665-72. PMID: 21597466.
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