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    Kyle Spinler

    TitlePostdoctoral Scholar
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Alvey CM, Spinler K, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Curr Biol. 2017 Jul 24; 27(14):2065-2077.e6. PMID: 28669759.
        View in: PubMed
      2. Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE. Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Mol Biol Cell. 2017 Jul 07; 28(14):2010-2022. PMID: 28566555.
        View in: PubMed
      3. Nair PR, Karthick SA, Spinler K, Vakili MR, Lavasanifar A, Discher DE. Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers. Nanomedicine (Lond). 2016 Jun; 11(12):1551-69. PMID: 27177319.
        View in: PubMed
      4. Sosale NG, Spinler K, Alvey C, Discher DE. Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. Curr Opin Immunol. 2015 Aug; 35:107-12. PMID: 26172292.
        View in: PubMed
      5. Spinler K, Shin JW, Lambert MP, Discher DE. Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood. 2015 Jan 15; 125(3):525-33. PMID: 25395423.
        View in: PubMed
      6. Buxboim A, Swift J, Irianto J, Spinler K, Dingal PC, Athirasala A, Kao YR, Cho S, Harada T, Shin JW, Discher DE. Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin. Curr Biol. 2014 Aug 18; 24(16):1909-17. PMID: 25127216.
        View in: PubMed
      7. Harada T, Swift J, Irianto J, Shin JW, Spinler K, Athirasala A, Diegmiller R, Dingal PC, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol. 2014 Mar 3; 204(5):669-82. PMID: 24567359.
        View in: PubMed
      8. Shin JW, Buxboim A, Spinler K, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 2014 Jan 2; 14(1):81-93. PMID: 24268694.
        View in: PubMed
      9. Shin JW, Spinler K, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18892-7. PMID: 24191023.
        View in: PubMed
      10. Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler K, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science. 2013 Aug 30; 341(6149):1240104. PMID: 23990565.
        View in: PubMed
      11. Shin JW, Swift J, Ivanovska I, Spinler K, Buxboim A, Discher DE. Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation. 2013 Oct; 86(3):77-86. PMID: 23790394.
        View in: PubMed
      12. Spinler K, Tian A, Christian DA, Pantano DA, Baumgart T, Discher DE. Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH. Langmuir. 2013 Jun 18; 29(24):7499-508. PMID: 23327600.
        View in: PubMed
      13. Shin JW, Swift J, Spinler K, Discher DE. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11458-63. PMID: 21709232.
        View in: PubMed
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