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    Kumar Sharma

    Address9500 Gilman Drive #0711
    CA La Jolla 92093
    Phone858-822-0870
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Sharma is the Director of Translational Research in Kidney Disease and a Professor of Medicine at the University of California, San Diego. Dr. Sharma is a leading translational researcher whose major area of interest is diabetic complications and kidney disease. His studies have identified several key mediators of early and progressive kidney disease associated with diabetes and obesity. His landmark studies demonstrating the role of the growth factor, TGF-b, have led to the development of clinical applications using approaches to block TGF-b for human diabetic nephropathy. In addition, Dr. Sharma has been involved in his own anti-fibrotic approaches for patients with advanced diabetic nephropathy and recently completed an NIH-funded randomized clinical trial. Most recently, Dr. Sharma’s group has identified a key role for the hormone adiponectin to play a role in early proteinuria associated with obesity. His studies have been published in the JCI, PNAS, JBC, PlOS-Medicine, JCB, AJP-Renal, JASN and Kidney International. Dr. Sharma has recently joined UCSD to lead translational research in kidney disease. He was recently appointed as Chair of the ISN Nexus Symposiums. He has continuous NIH funding since 1996 and presently has several NIH grants, ADA and JDRF support for his research.


      Collapse Research 
      Collapse Research Activities and Funding
      Mitochondrial-Derived Superoxide in Type 2 Diabetic Kidney Disease
      VA I01BX003234Jan 1, 2016 - Dec 31, 2019
      Role: Principal Investigator
      Novel Paradigms in Diabetic Complications
      NIH/NIDDK DP3DK094352Sep 30, 2011 - Jun 30, 2016
      Role: Principal Investigator
      Adiponectin and Podocytes
      VA I01BX000277Oct 1, 2009 - Dec 31, 2013
      Role: Principal Investigator
      Integrated Systems Biology Approach to Diabetic Microvascular Complications
      NIH/NIDDK R24DK082841Sep 30, 2008 - Jul 31, 2019
      Role: Co-Principal Investigator
      Adiponectin and Nox 4 in Diabetic Kidney Disease
      NIH/NIDDK U01DK076133Sep 30, 2006 - Jun 30, 2012
      Role: Principal Investigator
      Pirfenidone: Anti-Scarring Drug for Diabetic Nephropathy
      NIH/NIDDK R01DK063017Sep 30, 2002 - Jun 30, 2008
      Role: Principal Investigator
      TGF-b signaling in diabetic kidney disease
      NIH/NIDDK R01DK053867Jul 1, 1999 - Apr 30, 2011
      Role: Principal Investigator
      REGULATION AND ACTION OF TGFB IN DIABETIC KIDNEY DISEASE
      NIH/NIDDK K08DK002308Jul 1, 1996 - Jun 30, 2002
      Role: Principal Investigator
      THE MEDIATORS OF HIGH GLUCOSE-INDUCED RENAL CELL GROWTH
      NIH/NIDDK F32DK008745Sep 1, 1992
      Role: Principal Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Sharma K. Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease. Am J Nephrol. 2017; 46(1):71-72. PMID: 28715823.
        View in: PubMed
      2. Zhang G, Saito R, Sharma K. A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression. Kidney Int. 2017 Jun; 91(6):1274-1276. PMID: 28501300.
        View in: PubMed
      3. Börgeson E, Wallenius V, Syed GH, Darshi M, Lantero Rodriguez J, Biörserud C, Ragnmark Ek M, Björklund P, Quiding-Järbrink M, Fändriks L, Godson C, Sharma K. AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin. Diabetologia. 2017 Feb 10. PMID: 28188334.
        View in: PubMed
      4. Sharma K. Mitochondrial Dysfunction in the Diabetic Kidney. Adv Exp Med Biol. 2017; 982:553-562. PMID: 28551806.
        View in: PubMed
      5. Saito R, Rocanin-Arjo A, You YH, Darshi M, Van Espen B, Miyamoto S, Pham J, Pu M, Romoli S, Natarajan L, Ju W, Kretzler M, Nelson R, Ono K, Thomasova D, Mulay SR, Ideker T, D'Agati V, Beyret E, Belmonte JC, Anders HJ, Sharma K. Systems biology analysis reveals role of MDM2 in diabetic nephropathy. JCI Insight. 2016 Oct 20; 1(17):e87877. PMID: 27777973.
        View in: PubMed
      6. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K, You YH, Schilling JM, Jeste D, Sharma K, Brenner DA, Kisseleva T. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr). 2016 Aug; 38(4):291-302. PMID: 27578257.
        View in: PubMed
      7. He T, Xiong J, Nie L, Yu Y, Guan X, Xu X, Xiao T, Yang K, Liu L, Zhang D, Huang Y, Zhang J, Wang J, Sharma K, Zhao J. Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway. J Mol Med (Berl). 2016 Dec; 94(12):1359-1371. PMID: 27488452.
        View in: PubMed
      8. Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016 Jul 21; 1(11):e87680. PMID: 27699223.
        View in: PubMed
      9. Darshi M, Van Espen B, Sharma K. Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer. Am J Nephrol. 2016; 44(2):92-103. PMID: 27410520.
        View in: PubMed
      10. Hallan S, Sharma K. The Role of Mitochondria in Diabetic Kidney Disease. Curr Diab Rep. 2016 07; 16(7):61. PMID: 27155611.
        View in: PubMed
      11. Coughlan MT, Sharma K. Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease. Kidney Int. 2016 Aug; 90(2):272-9. PMID: 27217197.
        View in: PubMed
      12. Sharma K. Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance. Antioxid Redox Signal. 2016 Aug 1; 25(4):208-16. PMID: 26983586.
        View in: PubMed
      13. Miyamoto S, Hsu CC, Hamm G, Darshi M, Diamond-Stanic M, Declèves AE, Slater L, Pennathur S, Stauber J, Dorrestein PC, Sharma K. Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator. EBioMedicine. 2016 May; 7:121-34. PMID: 27322466.
        View in: PubMed
      14. Takaori K, Nakamura J, Yamamoto S, Nakata H, Sato Y, Takase M, Nameta M, Yamamoto T, Economides AN, Kohno K, Haga H, Sharma K, Yanagita M. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis. J Am Soc Nephrol. 2016 Aug; 27(8):2393-406. PMID: 26701981.
        View in: PubMed
      15. Mather KJ, Pan Q, Knowler WC, Funahashi T, Bray GA, Arakaki R, Falkner B, Sharma K, Goldstein BJ. Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary Albumin Excretion in the Diabetes Prevention Program Cohort. PLoS One. 2015; 10(8):e0136853. PMID: 26312480.
        View in: PubMed
      16. Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME. Diabetic kidney disease. Nat Rev Dis Primers. 2015; 1:15018. PMID: 27188921.
        View in: PubMed
      17. Groop PH, Cooper ME, Perkovic V, Sharma K, Schernthaner G, Haneda M, Hocher B, Gordat M, Cescutti J, Woerle HJ, von Eynatten M. Dipeptidyl peptidase-4 inhibition with linagliptin and effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: Rationale and design of the MARLINA-T2D™ trial. Diab Vasc Dis Res. 2015 Nov; 12(6):455-62. PMID: 26224765.
        View in: PubMed
      18. You YH, Quach T, Saito R, Pham J, Sharma K. Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease. J Am Soc Nephrol. 2016 Feb; 27(2):466-81. PMID: 26203118.
        View in: PubMed
      19. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1; 309(5):F414-28. PMID: 26136559.
        View in: PubMed
      20. Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson C. Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Cell Metab. 2015 Jul 7; 22(1):125-37. PMID: 26052006.
        View in: PubMed
      21. Sharma K. Mitochondrial hormesis and diabetic complications. Diabetes. 2015 Mar; 64(3):663-72. PMID: 25713188.
        View in: PubMed
      22. Zhu K, Kakehi T, Matsumoto M, Iwata K, Ibi M, Ohshima Y, Zhang J, Liu J, Wen X, Taye A, Fan C, Katsuyama M, Sharma K, Yabe-Nishimura C. NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney. Free Radic Biol Med. 2015 Jun; 83:21-30. PMID: 25701431.
        View in: PubMed
      23. Declèves AE, Sharma K. Obesity and kidney disease: differential effects of obesity on adipose tissue and kidney inflammation and fibrosis. Curr Opin Nephrol Hypertens. 2015 Jan; 24(1):28-36. PMID: 25470014.
        View in: PubMed
      24. Declèves AE, Sharma K, Satriano J. Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers. Nephron Exp Nephrol. 2014 Dec 6. PMID: 25503637.
        View in: PubMed
      25. Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med. 2015 Jan; 21(1):37-46. PMID: 25419705.
        View in: PubMed
      26. Zhao J, Miyamoto S, You YH, Sharma K. AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys. Am J Physiol Renal Physiol. 2015 May 15; 308(10):F1167-77. PMID: 25428125.
        View in: PubMed
      27. Sharma K, Natarajan L. Diabetes: Statins for microvascular complications-all but the kidney. Nat Rev Nephrol. 2014 Dec; 10(12):680-1. PMID: 25366041.
        View in: PubMed
      28. Sharma K. Obesity, oxidative stress, and fibrosis in chronic kidney disease. Kidney Int Suppl (2011). 2014 Nov; 4(1):113-117. PMID: 25401040.
        View in: PubMed
      29. Guan X, Nie L, He T, Yang K, Xiao T, Wang S, Huang Y, Zhang J, Wang J, Sharma K, Liu Y, Zhao J. Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling. J Pathol. 2014 Dec; 234(4):560-72. PMID: 25130652.
        View in: PubMed
      30. Sharma K. Tell-tale signs of perturbed podocytes. J Am Soc Nephrol. 2014 Jul; 25(7):1367-9. PMID: 24676633.
        View in: PubMed
      31. Borsting E, Patel SV, Declèves AE, Lee SJ, Rahman QM, Akira S, Satriano J, Sharma K, Vallon V, Cunard R. Tribbles homolog 3 attenuates Mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney. J Am Soc Nephrol. 2014 Sep; 25(9):2067-78. PMID: 24676635.
        View in: PubMed
      32. Declèves AE, Sharma K. Novel targets of antifibrotic and anti-inflammatory treatment in CKD. Nat Rev Nephrol. 2014 May; 10(5):257-67. PMID: 24662433.
        View in: PubMed
      33. Bánsághi S, Golenár T, Madesh M, Csordás G, Ramachandrarao S, Sharma K, Yule DI, Joseph SK, Hajnóczky G. Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species. J Biol Chem. 2014 Mar 21; 289(12):8170-81. PMID: 24469450.
        View in: PubMed
      34. Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K. Regulation of lipid accumulation by AMK-activated kinase in high fat diet-induced kidney injury. Kidney Int. 2014 Mar; 85(3):611-23. PMID: 24304883.
        View in: PubMed
      35. Miyamoto S, Sharma K. Adipokines protecting CKD. Nephrol Dial Transplant. 2013 Nov; 28 Suppl 4:iv15-iv22. PMID: 24179009.
        View in: PubMed
      36. Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, Decleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest. 2013 Nov 1; 123(11):4888-99. PMID: 24135141.
        View in: PubMed
      37. Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013 Nov; 24(11):1901-12. PMID: 23949796.
        View in: PubMed
      38. Declèves AE, Rychak JJ, Smith DJ, Sharma K. Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging. Am J Physiol Renal Physiol. 2013 Nov; 305(9):F1343-51. PMID: 24049144.
        View in: PubMed
      39. Sweiss N, Sharma K. Adiponectin effects on the kidney. Best Pract Res Clin Endocrinol Metab. 2014 Jan; 28(1):71-9. PMID: 24417947.
        View in: PubMed
      40. Satriano J, Sharma K. Autophagy and metabolic changes in obesity-related chronic kidney disease. Nephrol Dial Transplant. 2013 Nov; 28 Suppl 4:iv29-iv36. PMID: 23901047.
        View in: PubMed
      41. Hu X, Caskey CF, Mahakian LM, Kruse DE, Beegle JR, Declèves AE, Rychak JJ, Sutcliffe PL, Sharma K, Ferrara KW. In vivo validation and 3D visualization of broadband ultrasound molecular imaging. Am J Nucl Med Mol Imaging. 2013; 3(4):336-49. PMID: 23901359.
        View in: PubMed
      42. Satriano J, Sharma K, Blantz RC, Deng A. Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease. Am J Physiol Renal Physiol. 2013 Sep 1; 305(5):F727-33. PMID: 23825068.
        View in: PubMed
      43. Börgeson E, Sharma K. Obesity, immunomodulation and chronic kidney disease. Curr Opin Pharmacol. 2013 Aug; 13(4):618-24. PMID: 23751262.
        View in: PubMed
      44. You YH, Okada S, Ly S, Jandeleit-Dahm K, Barit D, Namikoshi T, Sharma K. Role of Nox2 in diabetic kidney disease. Am J Physiol Renal Physiol. 2013 Apr 1; 304(7):F840-8. PMID: 23389458.
        View in: PubMed
      45. Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013 Jan 15; 304(2):F156-67. PMID: 23152292.
        View in: PubMed
      46. Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K, Yu W, Chen S. Visualizing the mouse podocyte with multiphoton microscopy. Biochem Biophys Res Commun. 2012 Oct 26; 427(3):525-30. PMID: 23022193.
        View in: PubMed
      47. Østergaard JA, Bjerre M, RamachandraRao SP, Sharma K, Nyengaard JR, Hansen TK, Thiel S, Flyvbjerg A. Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model. Exp Diabetes Res. 2012; 2012:678381. PMID: 22645604.
        View in: PubMed
      48. Diamond-Stanic MK, You YH, Sharma K. Sugar, sex, and TGF-ß in diabetic nephropathy. Semin Nephrol. 2012 May; 32(3):261-8. PMID: 22835457.
        View in: PubMed
      49. Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1293-9. PMID: 22338083.
        View in: PubMed
      50. Declèves AE, Mathew AV, Cunard R, Sharma K. AMPK mediates the initiation of kidney disease induced by a high-fat diet. J Am Soc Nephrol. 2011 Oct; 22(10):1846-55. PMID: 21921143.
        View in: PubMed
      51. Maher P, Dargusch R, Ehren JL, Okada S, Sharma K, Schubert D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One. 2011; 6(6):e21226. PMID: 21738623.
        View in: PubMed
      52. Mathew A, Cunard R, Sharma K. Antifibrotic treatment and other new strategies for improving renal outcomes. Contrib Nephrol. 2011; 170:217-27. PMID: 21659774.
        View in: PubMed
      53. Sanchez AP, Zhao J, You Y, Declèves AE, Diamond-Stanic M, Sharma K. Role of the USF1 transcription factor in diabetic kidney disease. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F271-9. PMID: 21543418.
        View in: PubMed
      54. Sharma K, Ix JH, Mathew AV, Cho M, Pflueger A, Dunn SR, Francos B, Sharma S, Falkner B, McGowan TA, Donohue M, Ramachandrarao S, Xu R, Fervenza FC, Kopp JB. Pirfenidone for diabetic nephropathy. J Am Soc Nephrol. 2011 Jun; 22(6):1144-51. PMID: 21511828.
        View in: PubMed
      55. Anderson CR, Hu X, Zhang H, Tlaxca J, Declèves AE, Houghtaling R, Sharma K, Lawrence M, Ferrara KW, Rychak JJ. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011 Apr; 46(4):215-24. PMID: 21343825.
        View in: PubMed
      56. Cunard R, Sharma K. The endoplasmic reticulum stress response and diabetic kidney disease. Am J Physiol Renal Physiol. 2011 May; 300(5):F1054-61. PMID: 21345978.
        View in: PubMed
      57. Mathew AV, Okada S, Sharma K. Obesity related kidney disease. Curr Diabetes Rev. 2011 Jan; 7(1):41-9. PMID: 21067508.
        View in: PubMed
      58. Deelman LE, Declèves AE, Rychak JJ, Sharma K. Targeted renal therapies through microbubbles and ultrasound. Adv Drug Deliv Rev. 2010 Nov 30; 62(14):1369-77. PMID: 20946925.
        View in: PubMed
      59. Vallon V, Sharma K. Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Curr Opin Nephrol Hypertens. 2010 Sep; 19(5):425-31. PMID: 20539226.
        View in: PubMed
      60. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Circ Cardiovasc Genet. 2010 Oct; 3(5):414-25. PMID: 20729505.
        View in: PubMed
      61. Morse E, Schroth J, You YH, Pizzo DP, Okada S, Ramachandrarao S, Vallon V, Sharma K, Cunard R. TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1. Am J Physiol Renal Physiol. 2010 Nov; 299(5):F965-72. PMID: 20660016.
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      62. Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC, Thomson SC. Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C374-80. PMID: 20505038.
        View in: PubMed
      63. Declèves AE, Sharma K. New pharmacological treatments for improving renal outcomes in diabetes. Nat Rev Nephrol. 2010 Jun; 6(6):371-80. PMID: 20440278.
        View in: PubMed
      64. Huan Y, DeLoach S, Daskalakis C, Dunn SR, Sharma K, Falkner B. Regulation of transforming growth factor-beta1 by insulin in prediabetic African Americans. Kidney Int. 2010 Aug; 78(3):318-24. PMID: 20393450.
        View in: PubMed
      65. Ix JH, Sharma K. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol. 2010 Mar; 21(3):406-12. PMID: 20150538.
        View in: PubMed
      66. Rossini M, Naito T, Yang H, Freeman M, Donnert E, Ma LJ, Dunn SR, Sharma K, Fogo AB. Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Nephrol Dial Transplant. 2010 Jun; 25(6):1803-10. PMID: 20061322.
        View in: PubMed
      67. Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2009 Dec; 20(12):2503-12. PMID: 19729434.
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      68. RamachandraRao SP, Zhu Y, Ravasi T, McGowan TA, Toh I, Dunn SR, Okada S, Shaw MA, Sharma K. Pirfenidone is renoprotective in diabetic kidney disease. J Am Soc Nephrol. 2009 Aug; 20(8):1765-75. PMID: 19578007.
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      69. Sharma K. The link between obesity and albuminuria: adiponectin and podocyte dysfunction. Kidney Int. 2009 Jul; 76(2):145-8. PMID: 19404275.
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      70. Sanchez AP, Sharma K. Transcription factors in the pathogenesis of diabetic nephropathy. Expert Rev Mol Med. 2009; 11:e13. PMID: 19397838.
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      71. Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009 Jun; 75(12):1272-7. PMID: 19357717.
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      72. Deelman L, Sharma K. Mechanisms of kidney fibrosis and the role of antifibrotic therapies. Curr Opin Nephrol Hypertens. 2009 Jan; 18(1):85-90. PMID: 19077695.
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      73. Kalantar-Zadeh K, Derose SF, Nicholas S, Benner D, Sharma K, Kovesdy CP. Burnt-out diabetes: impact of chronic kidney disease progression on the natural course of diabetes mellitus. J Ren Nutr. 2009 Jan; 19(1):33-7. PMID: 19121768.
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      74. Pacher P, Sharma K, Csordás G, Zhu Y, Hajnóczky G. Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1303-12. PMID: 18653477.
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      75. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008 Aug; 8(2):157-68. PMID: 18599363.
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      76. Kovesdy CP, Sharma K, Kalantar-Zadeh K. Glycemic control in diabetic CKD patients: where do we stand? Am J Kidney Dis. 2008 Oct; 52(4):766-77. PMID: 18572289.
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      77. Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008 May; 118(5):1645-56. PMID: 18431508.
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      78. Williams KJ, Qiu G, Usui HK, Dunn SR, McCue P, Bottinger E, Iozzo RV, Sharma K. Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol. 2007 Nov; 171(5):1441-50. PMID: 17884968.
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      79. Kalantar-Zadeh K, Kopple JD, Regidor DL, Jing J, Shinaberger CS, Aronovitz J, McAllister CJ, Whellan D, Sharma K. A1C and survival in maintenance hemodialysis patients. Diabetes Care. 2007 May; 30(5):1049-55. PMID: 17337501.
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      80. Zhu Y, Usui HK, Sharma K. Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment. Semin Nephrol. 2007 Mar; 27(2):153-60. PMID: 17418684.
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      81. Ramachandra Rao SP, Wassell R, Shaw MA, Sharma K. Profiling of human mesangial cell subproteomes reveals a role for calmodulin in glucose uptake. Am J Physiol Renal Physiol. 2007 Apr; 292(4):F1182-9. PMID: 17200159.
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      82. Tchekneva EE, Rinchik EM, Polosukhina D, Davis LS, Kadkina V, Mohamed Y, Dunn SR, Sharma K, Qi Z, Fogo AB, Breyer MD. A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. J Am Soc Nephrol. 2007 Jan; 18(1):103-12. PMID: 17151334.
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      83. Tao L, Jiao X, Gao E, Lau WB, Yuan Y, Lopez B, Christopher T, RamachandraRao SP, Williams W, Southan G, Sharma K, Koch W, Ma XL. Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis. Circulation. 2006 Sep 26; 114(13):1395-402. PMID: 16966583.
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      84. Cai Q, Keck M, McReynolds MR, Klein JD, Greer K, Sharma K, Hoying JB, Sands JM, Brooks HL. Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein. Am J Physiol Renal Physiol. 2006 Jul; 291(1):F218-24. PMID: 16478974.
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      85. Kataoka H, Sharma K. Renal handling of adipokines. Contrib Nephrol. 2006; 151:91-105. PMID: 16929135.
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      86. McGowan TA, Dunn SR, Falkner B, Sharma K. Stimulation of urinary TGF-beta and isoprostanes in response to hyperglycemia in humans. Clin J Am Soc Nephrol. 2006 Mar; 1(2):263-8. PMID: 17699215.
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      87. Ewens KG, George RA, Sharma K, Ziyadeh FN, Spielman RS. Assessment of 115 candidate genes for diabetic nephropathy by transmission/disequilibrium test. Diabetes. 2005 Nov; 54(11):3305-18. PMID: 16249459.
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      88. Hu T, Ramachandrarao SP, Siva S, Valancius C, Zhu Y, Mahadev K, Toh I, Goldstein BJ, Woolkalis M, Sharma K. Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F816-25. PMID: 16159901.
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      89. Madesh M, Hawkins BJ, Milovanova T, Bhanumathy CD, Joseph SK, Ramachandrarao SP, Sharma K, Kurosaki T, Fisher AB. Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis. J Cell Biol. 2005 Sep 26; 170(7):1079-90. PMID: 16186254.
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      90. Heeg MH, Koziolek MJ, Vasko R, Schaefer L, Sharma K, Müller GA, Strutz F. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int. 2005 Jul; 68(1):96-109. PMID: 15954899.
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      91. Sharma K, Lee S, Han S, Lee S, Francos B, McCue P, Wassell R, Shaw MA, RamachandraRao SP. Two-dimensional fluorescence difference gel electrophoresis analysis of the urine proteome in human diabetic nephropathy. Proteomics. 2005 Jul; 5(10):2648-55. PMID: 15984045.
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      92. Zhu Y, Casado M, Vaulont S, Sharma K. Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1. Diabetes. 2005 Jul; 54(7):1976-84. PMID: 15983197.
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      93. Williams KJ, Liu ML, Zhu Y, Xu X, Davidson WR, McCue P, Sharma K. Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II. Diabetes. 2005 Apr; 54(4):1116-22. PMID: 15793251.
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      94. Susztak K, Ciccone E, McCue P, Sharma K, Böttinger EP. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2005 Feb; 2(2):e45. PMID: 15737001.
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      95. Sharma K, Cook A, Smith M, Valancius C, Inscho EW. TGF-beta impairs renal autoregulation via generation of ROS. Am J Physiol Renal Physiol. 2005 May; 288(5):F1069-77. PMID: 15644487.
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      96. Kim YS, Xu ZG, Reddy MA, Li SL, Lanting L, Sharma K, Adler SG, Natarajan R. Novel interactions between TGF-{beta}1 actions and the 12/15-lipoxygenase pathway in mesangial cells. J Am Soc Nephrol. 2005 Feb; 16(2):352-62. PMID: 15615821.
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      97. McGowan TA, Zhu Y, Sharma K. Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy. Curr Diab Rep. 2004 Dec; 4(6):447-54. PMID: 15539010.
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      98. Breyer MD, Böttinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, Sharma K. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2005 Jan; 16(1):27-45. PMID: 15563560.
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      99. Dunn SR, Qi Z, Bottinger EP, Breyer MD, Sharma K. Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney Int. 2004 May; 65(5):1959-67. PMID: 15086941.
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      100. Susztak K, Böttinger E, Novetsky A, Liang D, Zhu Y, Ciccone E, Wu D, Dunn S, McCue P, Sharma K. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes. 2004 Mar; 53(3):784-94. PMID: 14988265.
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      101. Yuen PS, Dunn SR, Miyaji T, Yasuda H, Sharma K, Star RA. A simplified method for HPLC determination of creatinine in mouse serum. Am J Physiol Renal Physiol. 2004 Jun; 286(6):F1116-9. PMID: 14970000.
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      102. Susztak K, Sharma K, Schiffer M, McCue P, Ciccone E, Böttinger EP. Genomic strategies for diabetic nephropathy. J Am Soc Nephrol. 2003 Aug; 14(8 Suppl 3):S271-8. PMID: 12874445.
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      103. Sharma K, Deelman L, Madesh M, Kurz B, Ciccone E, Siva S, Hu T, Zhu Y, Wang L, Henning R, Ma X, Hajnoczky G. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1258-70. PMID: 12876066.
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      104. Sharma K, McCue P, Dunn SR. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol. 2003 Jun; 284(6):F1138-44. PMID: 12736165.
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      105. Tsuchida K, Zhu Y, Siva S, Dunn SR, Sharma K. Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells. Kidney Int. 2003 Jun; 63(6):2000-9. PMID: 12753287.
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      106. McGowan TA, Madesh M, Zhu Y, Wang L, Russo M, Deelman L, Henning R, Joseph S, Hajnoczky G, Sharma K. TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton. Am J Physiol Renal Physiol. 2002 May; 282(5):F910-20. PMID: 11934702.
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      107. Agarwal R, Siva S, Dunn SR, Sharma K. Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels. Am J Kidney Dis. 2002 Mar; 39(3):486-92. PMID: 11877567.
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