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Krishnan Chakravarthy

Title(s)Assistant Clinical Professor, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Jacobs School of Medicine and Biomedical Sciences , Buffalo, NYM.D., Ph.D.06/2012Medicine
    Griffin Hospital (Yale Affiliated), Derby, CT07/2013Preliminary Medicine
    The Johns Hopkins Hospital, Baltimore, MD07/2016Anesthesiology
    Massachusetts General Hospital/Harvard Medical School , Cambridge, MA07/2017Chronic Pain Medicine
    Collapse Awards and Honors
    American Society of Pain and Neuroscience2019  - 2020American Society of Pain and Neuroscience Young Innovator Award

    Collapse Overview 
    Collapse Overview
    Krishnan Chakravarthy, MD, PhD is an assistant clinical professor who specializes in multi-modal pain management. As a pain management specialist, he evaluates, diagnoses and treats all forms of pain.

    Dr. Chakravarthy completed sub-specialty fellowship training in pain management at Massachusetts General Hospital/Harvard Medical School and residency training in anesthesiology at The Johns Hopkins Hospital in Baltimore, MD. He interned in general medicine at Griffin Hospital (Yale Affiliate) in Derby, Connecticut. He earned his M.D., Ph.D. degrees at Jacobs School of Medicine and Biomedical Sciences in Buffalo, NY.

    Dr. Chakravarthy’s research interests in pain medicine include incorporating new technology into advancing pain care. He is currently focusing on using nanotechnology as an novel system to develop new drug delivery and point of care device platforms to manage chronic pain. Dr. Chakravarthy’s research interests also focus on the effect of anesthetics on host immunity. Prior to joining UCSD he has served as a contractor at the U.S. Centers for Disease Control and Prevention (CDC) where he researched host immunity to influenza virus as a way of developing novel therapeutic and vaccine strategies. His research work has been published in top journals including Anesthesiology, Proceedings of the National Academy of Sciences, and Pain Medicine. His research work has been also featured in Times of India, International Business Times, Futurity, NewsMedical and other national and international venues.

    He is also a founder of several biotechnology startup companies in the nanotechnology space, and new drug development focusing on commercializing paradigm-shifting technology in the field of infectious diseases, and chronic pain. He is an active entrepreneur and believes industry plays a critical role in seeing translational science make it to patients.

    Dr. Chakravarthy currently serves on the editorial board of several national and international peer reviewed journals, and committees on organizations such as the International Neuromodulation Society.

    Notable Honors:
    American Society of Pain and Neuroscience Young Innovator Award Recipient
    American Academy of Pain Medicine (AAPM) Pain Medicine Fellowship Excellence Award Recipient, UC San Diego Faculty
    Nominated for the American Society of Regional Anesthesiology and Pain medicine Resident/Fellow of the year award
    Griffin Hospital (Yale Affiliated) Intern Physician of the Year Award Recipient
    Buffalo Business First “Rising Star”
    University at Buffalo Henry Panasci Technology Entrepreneurship Competition Award Winner
    National Institute of Health Ruth L. Kirschstein National Research Service Award Recipient

    Link to Dr. Chakravarthy’s Laboratory
    https://www.chakravarthylab.com

    Clinical Expertise Areas
    Anesthesiology, Back Pain, Neck Pain, Complex Regional Pain Syndrome, Interventional Pain Management, Intrathecal pumps, Joint Injection, Post-herpetic Neuralgia, Headache, Phantom Limb Pain, Cancer Pain, Neuromodulation, Spinal Cord Stimulation, Ultrasound Techniques

    Collapse Research 
    Collapse Research Activities and Funding
    Prospective multi-arm blinded randomized study to evaluate if ZTLIDO 1.8% is an effective treatment and prevention modality for chronic post-operative pain (CPOP) through down regulation of acute post-operative inflammatory response and pain in post-thoracotomy surgery.
    Scilex Pharmaceuticals Aug 1, 2019
    Role: Principal Investigator
    A Prospective, Open-Label, Long-Term, Multi-Center, Registry to Assess the Safety and Efficacy of the Bioness StimRouter™ Neuromodulation System in Subjects with Chronic Pain of Peripheral Nerve Origin
    Bioness Inc. Jul 15, 2019
    Role: Principal Investigator
    Prospective, multi-center, open-label, post-market PROLONG Study.
    Abbott Laboratories Jul 10, 2019
    Role: Principal Investigator
    Dorsal column stimulation and increased functional outcome feasibility study
    Medtronic Jun 14, 2019
    Role: Principal Investigator
    A novel therapeutic to ameliorate chronic pain and reduce opiate use.
    NIH/NIDA 1UG3DA047680-01Mar 1, 2019 - Mar 1, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A review of the StimRouter® peripheral neuromodulation system for chronic pain management. Pain Manag. 2020 Dec 09. Regnier SM, Chen J, Gabriel RA, Chakravarthy KV. PMID: 33291992.
      View in: PubMed   Mentions:    Fields:    
    2. Sensing Evoked Compound Action Potentials from the Spinal Cord: Novel Preclinical and Clinical Considerations for the Pain Management Researcher and Clinician. J Pain Res. 2020; 13:3269-3279. Chakravarthy K, Bink H, Dinsmoor D. PMID: 33328760.
      View in: PubMed   Mentions:
    3. Psychosocial characteristics of candidates for implantable pain devices: validation of an assessment model. Pain Manag. 2020 Nov 13. Gould HM, D'Eon MS, Grinberg AM, Chakravarthy KV, Castellanos J, Rutledge T. PMID: 33183132.
      View in: PubMed   Mentions:    Fields:    
    4. Strategic testing plan for Ambulatory Surgery Centers (ASCs) after the COVID-19 pandemic. Disaster Med Public Health Prep. 2020 Nov 04; 1-20. Naidu R, Sheth S, Chaturvedi R, Chakravarthy K. PMID: 33143808.
      View in: PubMed   Mentions:    Fields:    
    5. Single arm prospective multicenter case series on the use of burst stimulation to improve pain and motor symptoms in Parkinson's disease. Bioelectron Med. 2020; 6:18. Chakravarthy KV, Chaturvedi R, Agari T, Iwamuro H, Reddy R, Matsui A. PMID: 33005705.
      View in: PubMed   Mentions:
    6. Cybersecurity Risks in a Pandemic. J Med Internet Res. 2020 09 17; 22(9):e23692. Williams CM, Chaturvedi R, Chakravarthy K. PMID: 32897869.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. A Comprehensive Practice Guideline for Magnetic Resonance Imaging Compatibility in Implanted Neuromodulation Devices. Neuromodulation. 2020 Oct; 23(7):893-911. Sayed D, Chakravarthy K, Amirdelfan K, Kalia H, Meacham K, Shirvalkar P, Falowski S, Petersen E, Hagedorn JM, Pope J, Leever J, Deer T. PMID: 32809275.
      View in: PubMed   Mentions: 1     Fields:    
    8. Emergence From the COVID-19 Pandemic and the Care of Chronic Pain: Guidance for the Interventionalist. Anesth Analg. 2020 08; 131(2):387-394. Deer TR, Sayed D, Pope JE, Chakravarthy KV, Petersen E, Moeschler SM, Abd-Elsayed A, Amirdelfan K, Mekhail N. PMID: 32452905.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    9. Composite Score Is a Better Reflection of Patient Response to Chronic Pain Therapy Compared With Pain Intensity Alone. Neuromodulation. 2020 Jun 27. Pilitsis JG, Fahey M, Custozzo A, Chakravarthy K, Capobianco R. PMID: 32592618.
      View in: PubMed   Mentions: 2     Fields:    
    10. Efficacy of Serology Testing in Predicting Reinfection in Patients With SARS-CoV-2. Disaster Med Public Health Prep. 2020 Jun 24; 1-3. Chaturvedi R, Naidu R, Sheth S, Chakravarthy K. PMID: 32576315.
      View in: PubMed   Mentions: 3     Fields:    
    11. Novel Intermittent Dosing Burst Paradigm in Spinal Cord Stimulation. Neuromodulation. 2020 Mar 23. Deer TR, Patterson DG, Baksh J, Pope JE, Mehta P, Raza A, Agnesi F, Chakravarthy KV. PMID: 32202044.
      View in: PubMed   Mentions:    Fields:    
    12. Spinal cord stimulation in Parkinson's disease: a review of the preclinical and clinical data and future prospects. Bioelectron Med. 2020; 6:5. Cai Y, Reddy RD, Varshney V, Chakravarthy KV. PMID: 32232113.
      View in: PubMed   Mentions:
    13. Research Reports in Clinical Cardiology. A Review of Neuromodulation in the Treatment of Cardiovascular Disease. 2020; 11:7-18. Yang A, Chakravarthy KV, Pope JE, Deer TR.
    14. A Review of Clinical Data on Salvage Therapy in Spinal Cord Stimulation. Neuromodulation. 2020 Jul; 23(5):562-571. Reddy RD, Moheimani R, Yu GG, Chakravarthy KV. PMID: 31697457.
      View in: PubMed   Mentions:    Fields:    
    15. Prospective case series on the use of peripheral nerve stimulation for focal mononeuropathy treatment. Pain Manag. 2019 Nov; 9(6):551-558. Oswald J, Shahi V, Chakravarthy KV. PMID: 31686589.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain. Int J Mol Sci. 2019 Sep 24; 20(19). Kinfe TM, Buchfelder M, Chaudhry SR, Chakravarthy KV, Deer TR, Russo M, Georgius P, Hurlemann R, Rasheed M, Muhammad S, Yearwood TL. PMID: 31554241.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. Updated Review and Treatment Recommendations on Paraneoplastic Neurologic Syndromes and Chronic Pain. Pain Physician. 2019 09; 22(5):433-445. Blyakhman I, Chakravarthy K. PMID: 31561645.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling. J Transl Med. 2019 06 19; 17(1):205. Kinfe TM, Asif M, Chakravarthy KV, Deer TR, Kramer JM, Yearwood TL, Hurlemann R, Hussain MS, Motameny S, Wagle P, Nürnberg P, Gravius S, Randau T, Gravius N, Chaudhry SR, Muhammad S. PMID: 31217010.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    19. Mechanism of Action in Burst Spinal Cord Stimulation: Review and Recent Advances. Pain Med. 2019 06 01; 20(Suppl 1):S13-S22. Chakravarthy K, Fishman MA, Zuidema X, Hunter CW, Levy R. PMID: 31152180.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. A Comprehensive Algorithm for Management of Neuropathic Pain. Pain Med. 2019 06 01; 20(Suppl 1):S2-S12. Bates D, Schultheis BC, Hanes MC, Jolly SM, Chakravarthy KV, Deer TR, Levy RM, Hunter CW. PMID: 31152178.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Burst Spinal Cord Stimulation: A Systematic Review and Pooled Analysis of Real-World Evidence and Outcomes Data. Pain Med. 2019 06 01; 20(Suppl 1):S47-S57. Chakravarthy K, Malayil R, Kirketeig T, Deer T. PMID: 31152177.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Human Brain/Cloud Interface. Front Neurosci. 2019; 13:112. Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev MA, Swan M, Garan SA, Rosenfeld JV, Hogg T, Freitas RA. PMID: 30983948.
      View in: PubMed   Mentions:
    23. Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study. J Transl Med. 2019 02 22; 17(1):53. Boström A, Scheele D, Stoffel-Wagner B, Hönig F, Chaudhry SR, Muhammad S, Hurlemann R, Krauss JK, Lendvai IS, Chakravarthy KV, Kinfe TM. PMID: 30795781.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    24. Fluorescence lateral flow immunoassay-based point-of-care nanodiagnostics for orthopedic implant-associated infection. 2019; 280:24-33. Vivek Borse, Scott Nodzo, Donald Hohman, Krishnan Chakravarthy, Rohit Srivastava.
    25. A revised psychosocial assessment model for implantable pain devices to improve their evidence basis and consensus with updated pain management guidelines. Pain Manag. 2019 Mar 01; 9(2):139-149. Grinberg AM, D'Eon MS, Ellison JK, Rutledge T, Castellanos J, Chakravarthy KV. PMID: 30681019.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Neurostimulation for Intractable Chronic Pain. Brain Sci. 2019 Jan 24; 9(2). Deer TR, Jain S, Hunter C, Chakravarthy K. PMID: 30682776.
      View in: PubMed   Mentions:
    27. Progress in noninvasive, abortive neuromodulation therapy for treating acute pain in primary headache disorders. Pain Manag. 2019 01 01; 9(1):9-11. Chakravarthy KV, Kinfe TM, Christo PJ. PMID: 30507293.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Reframing the Role of Neuromodulation Therapy in the Chronic Pain Treatment Paradigm. Pain Physician. 2018 11; 21(6):507-513. Chakravarthy K, Manchikanti L, Kaye AD, Christo PJ. PMID: 30508982.
      View in: PubMed   Mentions: 6     Fields:    
    29. Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns. Neuromodulation. 2019 Jan; 22(1):44-52. Gravius N, Chaudhry SR, Muhammad S, Boström A, Gravius S, Randau T, Scheele D, Westhofen P, Kruppenbacher J, Stoffel-Wagner B, Maier C, Weidlich A, Yearwood TL, Chakravarthy KV, Kramer JM, Hurlemann R, Kinfe TM. PMID: 30358008.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    30. Noninvasive Transdermal Delivery System of Lidocaine Using an Acoustic Droplet-Vaporization Based Wearable Patch. Small. 2018 12; 14(49):e1803266. Soto F, Jeerapan I, Silva-López C, Lopez-Ramirez MA, Chai I, Xiaolong L, Lv J, Kurniawan JF, Martin I, Chakravarthy K, Wang J. PMID: 30369022.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. A Review of Spinal and Peripheral Neuromodulation and Neuroinflammation: Lessons Learned Thus Far and Future Prospects of Biotype Development. Neuromodulation. 2019 Apr; 22(3):235-243. Chakravarthy KV, Xing F, Bruno K, Kent AR, Raza A, Hurlemann R, Kinfe TM. PMID: 30311715.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. 2018 Oct; 159(10):1908-1915. Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. PMID: 29889119.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    33. The Neuromodulation Appropriateness Consensus Committee on Best Practices for Dorsal Root Ganglion Stimulation. Neuromodulation. 2019 Jan; 22(1):1-35. Deer TR, Pope JE, Lamer TJ, Grider JS, Provenzano D, Lubenow TR, FitzGerald JJ, Hunter C, Falowski S, Sayed D, Baranidharan G, Patel NK, Davis T, Green A, Pajuelo A, Epstein LJ, Harned M, Liem L, Christo PJ, Chakravarthy K, Gilmore C, Huygen F, Lee E, Metha P, Nijhuis H, Patterson DG, Petersen E, Pilitsis JG, Rowe JJ, Rupert MP, Skaribas I, Sweet J, Verrills P, Wilson D, Levy RM, Mekhail N. PMID: 30246899.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Burst Spinal Cord Stimulation: Review of Preclinical Studies and Comments on Clinical Outcomes. Neuromodulation. 2018 Jul; 21(5):431-439. Chakravarthy K, Kent AR, Raza A, Xing F, Kinfe TM. PMID: 29431275.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    35. Nanotechnology: A Promising New Paradigm for the Control of Pain. Pain Med. 2018 02 01; 19(2):232-243. Chakravarthy KV, Boehm FJ, Christo PJ. PMID: 29036629.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    36. Anesthetic Management of Pheochromocytoma Resection in Adults with Single Ventricle Physiology. Cureus. 2017 Dec 08; 9(12):e1928. Suffredini G, Diaz-Rodriguez N, Chakravarthy K, Mathur A, Hayanga HK, Frank SM, Ringel RE, Freiberg S, Barodka VM, Steppan J. PMID: 29464136.
      View in: PubMed   Mentions:
    37. Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy. Neuromodulation. 2018 Jan; 21(1):10-18. Chakravarthy K, Richter H, Christo PJ, Williams K, Guan Y. PMID: 29105244.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    38. Stem Cell Therapy for Chronic Pain Management: Review of Uses, Advances, and Adverse Effects. Pain Physician. 2017 05; 20(4):293-305. Chakravarthy K, Chen Y, He C, Christo PJ. PMID: 28535552.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Review of Recent Advances in Peripheral Nerve Stimulation (PNS). Curr Pain Headache Rep. 2016 Nov; 20(11):60. Chakravarthy K, Nava A, Christo PJ, Williams K. PMID: 27671799.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    40. Superseding the Hourglass Effect Toward the Successful Commercialization of Nanotechnology in the Medical Sciences - We Require a Change in Perspective. Cureus. 2016 Jul 05; 8(7):e670. Chakravarthy K, Boehm F, Sanhai-Madar W. PMID: 27551650.
      View in: PubMed   Mentions:
    41. Review of the Uses of Vagal Nerve Stimulation in Chronic Pain Management. Curr Pain Headache Rep. 2015 Dec; 19(12):54. Chakravarthy K, Chaudhry H, Williams K, Christo PJ. PMID: 26493698.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    42. Halothane modulates the type i interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model. Anesthesiology. 2015 Sep; 123(3):590-602. MacDonald BA, Chakravarthy KV, Davidson BA, Mullan BA, Alluri R, Hakansson AP, Knight PR. PMID: 26120770.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. Nanotechnology: why should we care? Am J Orthop (Belle Mead NJ). 2015 Mar; 44(3):E87-8. Nodzo SR, Hohman DW, Chakravarthy K. PMID: 25750958.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    44. Epidural steroid injections: an updated review on recent trends in safety and complications. Pain Manag. 2015; 5(2):129-46. Bicket MC, Chakravarthy K, Chang D, Cohen SP. PMID: 25806907.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    45. Neuroradiology, Anesthesia, Bioengineering, and Hardware Programming in the Clinical Applications of Deep Brain Stimulation. 2014; 6(4):172. Ayden Jacob, Krishnan Chakravarthy . . View Publication.
    46. Engineering Magnetic Nanoparticles for Thermo-Ablation and Drug Delivery in Neurological Cancers. 2014; 6(4):170. Ayden Jacob, Krishnan Chakravarthy. . View Publication.
    47. Doxorubicin-conjugated quantum dots to target alveolar macrophages and inflammation. Nanomedicine. 2011 Feb; 7(1):88-96. Chakravarthy KV, Davidson BA, Helinski JD, Ding H, Law WC, Yong KT, Prasad PN, Knight PR. PMID: 20887813.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    48. Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10172-7. Chakravarthy KV, Bonoiu AC, Davis WG, Ranjan P, Ding H, Hu R, Bowzard JB, Bergey EJ, Katz JM, Knight PR, Sambhara S, Prasad PN. PMID: 20498074.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
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