Krishna Sriram

Title(s)Comp Data Sci Res Spec, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells. Front Pharmacol. 2022; 13:833832. Chinn AM, Salmerón C, Lee J, Sriram K, Raz E, Insel PA. PMID: 35387344; PMCID: PMC8977838.
      View in: PubMed   Mentions:
    2. Inhaled β2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome? Pharmacol Rev. 2021 10; 73(4):488-526. Sriram K, Insel MB, Insel PA. PMID: 34795026.
      View in: PubMed   Mentions:
    3. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemp Clin Trials. 2021 04; 103:106330. Ajmera V, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. PMID: 33631357; PMCID: PMC7899027.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    4. Detection of GPCR mRNA Expression in Primary Cells Via qPCR, Microarrays, and RNA-Sequencing. Methods Mol Biol. 2021; 2268:21-42. Sriram K, Salmerón C, Di Nardo A, Insel PA. PMID: 34085259.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29274-29282. Sriram K, Loomba R, Insel PA. PMID: 33203679; PMCID: PMC7703541.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    6. Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets. Physiol Rev. 2021 04 01; 101(2):545-567. Sriram K, Insel PA. PMID: 33124941; PMCID: PMC8238137.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    7. RAAS Inhibitors and Risk of Covid-19. N Engl J Med. 2020 Nov 12; 383(20):1991-1992. Sriram K, Loomba R, Insel PA. PMID: 33108103.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    8. Proteinase-activated receptor 1: A target for repurposing in the treatment of COVID-19? Br J Pharmacol. 2020 11; 177(21):4971-4974. Sriram K, Insel PA. PMID: 32639031; PMCID: PMC7361899.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Assessment of ACE inhibitors/angiotensin receptor blockers in COVID-19 patients. Am J Physiol Lung Cell Mol Physiol. 2020 07 01; 319(1):L37-L38. Sriram K, Insel PA. PMID: 33496632; PMCID: PMC7524453.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance. Br J Pharmacol. 2020 11; 177(21):4825-4844. Sriram K, Insel PA. PMID: 32333398; PMCID: PMC7572451.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension. Br J Pharmacol. 2020 08; 177(15):3505-3518. Gorr MW, Sriram K, Muthusamy A, Insel PA. PMID: 32337710; PMCID: PMC7348089.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence. Clin Pharmacol Ther. 2020 08; 108(2):236-241. Sriram K, Insel PA. PMID: 32320478; PMCID: PMC7264499.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsPHPublic Health
    13. GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets. Br J Pharmacol. 2020 06; 177(11):2434-2455. Sriram K, Salmerón C, Wiley SZ, Insel PA. PMID: 32060895; PMCID: PMC7205828.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets. Future Med Chem. 2020 03; 12(6):523-532. Insel PA, Sriram K, Salmerón C, Wiley SZ. PMID: 32116003; PMCID: PMC7607387.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    15. GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors. PLoS Biol. 2019 11; 17(11):e3000434. Sriram K, Moyung K, Corriden R, Carter H, Insel PA. PMID: 31765370; PMCID: PMC6901242.
      View in: PubMed   Mentions: 14     Fields:    
    16. Detection and Quantification of GPCR mRNA: An Assessment and Implications of Data from High-Content Methods. ACS Omega. 2019 Oct 15; 4(16):17048-17059. Sriram K, Wiley SZ, Moyung K, Gorr MW, Salmerón C, Marucut J, French RP, Lowy AM, Insel PA. PMID: 31646252; PMCID: PMC6796235.
      View in: PubMed   Mentions: 6  
    17. GPCRomics: An Approach to Discover GPCR Drug Targets. Trends Pharmacol Sci. 2019 06; 40(6):378-387. Insel PA, Sriram K, Gorr MW, Wiley SZ, Michkov A, Salmerón C, Chinn AM. PMID: 31078319; PMCID: PMC6604616.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    18. GPR68: An Emerging Drug Target in Cancer. Int J Mol Sci. 2019 Jan 28; 20(3). Wiley SZ, Sriram K, Salmerón C, Insel PA. PMID: 30696114; PMCID: PMC6386835.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    19. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol. 2018; 9:431. Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. PMID: 29872392; PMCID: PMC5972277.
      View in: PubMed   Mentions: 28  
    20. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 03; 32(3):1170-1183. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. PMID: 29092903; PMCID: PMC5892729.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    21. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? Mol Pharmacol. 2018 04; 93(4):251-258. Sriram K, Insel PA. PMID: 29298813; PMCID: PMC5820538.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimals
    22. Shear-Induced Nitric Oxide Production by Endothelial Cells. Biophys J. 2016 Jul 12; 111(1):208-21. Sriram K, Laughlin JG, Rangamani P, Tartakovsky DM. PMID: 27410748; PMCID: PMC4944664.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    23. Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation. FASEB J. 2016 Apr; 30(4):1464-79. Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. PMID: 26675706; PMCID: PMC4799510.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    24. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Mol Pharmacol. 2015 Jul; 88(1):181-7. Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. PMID: 25737495; PMCID: PMC4468643.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    25. Non-Newtonian flow of blood in arterioles: consequences for wall shear stress measurements. Microcirculation. 2014 Oct; 21(7):628-39. Sriram K, Intaglietta M, Tartakovsky DM. PMID: 24703006; PMCID: PMC4185264.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    26. Hematocrit dispersion in asymmetrically bifurcating vascular networks. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1576-86. Sriram K, Intaglietta M, Tartakovsky DM. PMID: 25217657; PMCID: PMC4255010.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1096-106. Sriram K, Salazar Vázquez BY, Tsai AG, Cabrales P, Intaglietta M, Tartakovsky DM. PMID: 22923620; PMCID: PMC3517642.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    28. PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2489-97. Sriram K, Tsai AG, Cabrales P, Meng F, Acharya SA, Tartakovsky DM, Intaglietta M. PMID: 22505638; PMCID: PMC3378262.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    29. Integration of cardiovascular regulation by the blood/endothelium cell-free layer. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug; 3(4):458-70. Hightower CM, Salazar Vázquez BY, Woo Park S, Sriram K, Martini J, Yalcin O, Tsai AG, Cabrales P, Tartakovsky DM, Johnson PC, Intaglietta M. PMID: 21523919.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. The effect of small changes in hematocrit on nitric oxide transport in arterioles. Antioxid Redox Signal. 2011 Jan 15; 14(2):175-85. Sriram K, Vázquez BY, Yalcin O, Johnson PC, Intaglietta M, Tartakovsky DM. PMID: 20560785; PMCID: PMC3014765.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
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