Kim Barrett

Title(s)Distinguished Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0063
La Jolla CA 92093
Phone858-534-2796
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    Collapse Biography 
    Collapse Education and Training
    University College, London, EnglandPhD1982Biological Chemistry
    University College, London, EnglandBSc1979Medicinal Chemistry
    Collapse Awards and Honors
    The Physiological Society2016  - 2021Editor-in-Chief, The Journal of Physiology
    American Physiological Society2013  - 2014President
    American Physiological Society 2017Ray G. Daggs Award for Distinguished Service
    American Gastroenterological Association2016Intestinal Disorders Section Research Mentor Award
    The Physiological Society2015Bayliss-Starling Prize Lecturer
    American Physiological Society 2012M. Bodil Schmidt-Nielsen Distinguished Mentor and Scientist Award
    Charitable Infirmary Charitable Trust, Royal College of Surgeons in Ireland2007Molecular Medicine Medal Lecturer
    American Physiological Society2006Davenport Lecturer
    American Physiological Society1996Henry Pickering Bowditch Award
    Queens University Belfast2004Doctor of Medfical Science, honoris causa

    Collapse Research 
    Collapse Research Activities and Funding
    FASEB SRC on Gastrointestinal Tract XVIII: Integrated Biology and Pathobiology of the GI Super-Organ
    NIH R13DK121344Jun 1, 2019 - May 31, 2020
    Role: Principal Investigator
    Neuroimmunophysiology in the Gastrointestinal Tract
    NIH R13DK083822May 1, 2009 - Apr 30, 2010
    Role: Principal Investigator
    PATHOGENS, PROBIOTICS AND THE EPITHELIUM IN COLITIS
    NIH R01AT001180Dec 1, 2003 - Nov 30, 2008
    Role: Principal Investigator
    FASEB CONFERENCE--GI TRACT VIII SIGNALING AND TRANSPORT
    NIH R13DK056017Jul 25, 1999 - Jul 24, 2000
    Role: Principal Investigator
    BYPASSING THE SECRETORY DEFECT IN CYSTIC FIBROSIS
    NIH R01DK053480Apr 10, 1998 - Nov 30, 2001
    Role: Principal Investigator
    EPITHELIAL EICOSANOIDS AND CL- TRANSPORT--ROLE IN IBD
    NIH R01DK047756Sep 15, 1994 - Aug 31, 1997
    Role: Principal Investigator
    NEURO-IMMUNOPHYSIOLOGY OF THE GASTROINTESTINAL MUCOSA
    NIH R13DK044466Sep 25, 1991 - Apr 30, 1992
    Role: Principal Investigator
    MUCOSAL MAST CELLS AND INTESTINAL DISEASES
    NIH R29AI024992Jul 1, 1988 - Jun 30, 1994
    Role: Principal Investigator
    DUODENAL MUCOSAL BICARBONATE SECRETION
    NIH R01DK033491Dec 1, 1984 - Jul 31, 2006
    Role: Principal Investigator
    INTESTINAL SECRETORY MECHANISMS
    NIH R01DK028305Jul 1, 1981 - Nov 30, 2007
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy. Cell Mol Gastroenterol Hepatol. 2021 Jun 29. Das B, Okamoto K, Rabalais J, Young JA, Barrett KE, Sivagnanam M. PMID: 34198013.
      View in: PubMed   Mentions:    Fields:    
    2. Gastrointestinal jabberwocky to bioengineering design: using function diagrams to teach physiology. Adv Physiol Educ. 2021 Jun 01; 45(2):264-268. Wilson TE, Barrett KE. PMID: 33825518.
      View in: PubMed   Mentions:    Fields:    
    3. A Pathobiont Fragments Mitochondrial Networks in Epithelial Cells: Implications for Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2021; 11(2):665-666. Barrett KE. PMID: 33227263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Claudin-2 pore causes leak that breaches the dam in intestinal inflammation. J Clin Invest. 2020 10 01; 130(10):5100-5101. Barrett KE. PMID: 32831294.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea. Physiol Rep. 2020 07; 8(13):e14490. Kim Y, Quach A, Das S, Barrett KE. PMID: 32652816.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. A prebiotic fructo-oligosaccharide promotes tight junction assembly in intestinal epithelial cells via an AMPK-dependent pathway. Biomed Pharmacother. 2020 Sep; 129:110415. Wongkrasant P, Pongkorpsakol P, Ariyadamrongkwan J, Meesomboon R, Satitsri S, Pichyangkura R, Barrett KE, Muanprasat C. PMID: 32603892.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. DRAwing Conclusions About the Basis of Diarrhea in Inflammatory Bowel Disease. Dig Dis Sci. 2020 06; 65(6):1581-1583. Barrett KE. PMID: 31950312.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Presentation of the Julius M. Friedenwald Medal to Gail A. Hecht, MD, MS. Gastroenterology. 2020 06; 158(8):2282-2285. Hecht DW, Barrett KE. PMID: 32407805.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Epithelial transport in digestive diseases: mice, monolayers, and mechanisms. Am J Physiol Cell Physiol. 2020 06 01; 318(6):C1136-C1143. Barrett KE. PMID: 32293934.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease. Cells. 2020 04 11; 9(4). Das B, Okamoto K, Rabalais J, Marchelletta RR, Barrett KE, Das S, Niwa M, Sivagnanam M. PMID: 32290509.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Nod-like receptors are critical for gut-brain axis signalling in mice. J Physiol. 2019 12; 597(24):5777-5797. Pusceddu MM, Barboza M, Keogh CE, Schneider M, Stokes P, Sladek JA, Kim HJD, Torres-Fuentes C, Goldfild LR, Gillis SE, Brust-Mascher I, Rabasa G, Wong KA, Lebrilla C, Byndloss MX, Maisonneuve C, Bäumler AJ, Philpott DJ, Ferrero RL, Barrett KE, Reardon C, Gareau MG. PMID: 31652348.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Reproducibility and data presentation. J Physiol. 2019 11; 597(22):5313. Forsythe ID, Howells S, Barrett KE. PMID: 31657457.
      View in: PubMed   Mentions:    Fields:    
    13. A New Target to Treat Diarrhea in Cholera? J Infect Dis. 2019 10 22; 220(11):1711-1712. Barrett KE. PMID: 30624702.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy. Am J Physiol Gastrointest Liver Physiol. 2019 11 01; 317(5):G580-G591. Das B, Okamoto K, Rabalais J, Kozan PA, Marchelletta RR, McGeough MD, Durali N, Go M, Barrett KE, Das S, Sivagnanam M. PMID: 31433211.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases? Clin Gastroenterol Hepatol. 2019 12; 17(13):2634-2643. Dulai PS, Singh S, Vande Casteele N, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ. PMID: 31009791.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Interleukin 9 Alters Epithelial Barrier and E-cadherin in Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2019 02; 68(2):225-231. Doshi A, Khamishon R, Rawson R, Duong L, Dohil L, Myers SJ, Bell B, Dohil R, Newbury RO, Barrett KE, Kurten RC, Aceves SS. PMID: 30211842.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. New frontiers in gastrointestinal physiology and pathophysiology. J Physiol. 2018 09; 596(17):3859-3860. Barrett KE. PMID: 29863278.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. PMID: 29912959.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    19. Mapping the Duodenal Crypt-Villus Transport Axis. Cell Mol Gastroenterol Hepatol. 2018; 5(4):642-644. Barrett KE. PMID: 29713666.
      View in: PubMed   Mentions:    Fields:    
    20. The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018; 6(1):33-45. Das S, Jayaratne R, Barrett KE. PMID: 29928670.
      View in: PubMed   Mentions: 16     Fields:    
    21. Looking to and nurturing the future of physiology. J Physiol. 2017 12 15; 595(24):7263-7264. Barrett KE. PMID: 29164626.
      View in: PubMed   Mentions:    Fields:    
    22. Influence of the microbiota on host physiology - moving beyond the gut. J Physiol. 2017 01 15; 595(2):433-435. Barrett KE, Wu GD. PMID: 28083941.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    23. Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis. Clin Exp Pharmacol Physiol. 2016 Nov; 43(11):1097-1106. Barrett KE, McCole DF. PMID: 27543846.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    24. Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-ß1 signaling. [corrected]. Am J Physiol Gastrointest Liver Physiol. 2016 12 01; 311(6):G1076-G1090. Manresa MC, Tambuwala MM, Radhakrishnan P, Harnoss JM, Brown E, Cavadas MA, Keogh CE, Cheong A, Barrett KE, Cummins EP, Schneider M, Taylor CT. PMID: 27789456.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    25. Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. Gastroenterology. 2017 02; 152(3):515-532.e2. Camilleri M, Sellin JH, Barrett KE. PMID: 27773805.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    26. Rethinking cholera pathogenesis- No longer all in the same "camp". Virulence. 2016 10 02; 7(7):751-3. Barrett KE. PMID: 27413815.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling. J Physiol. 2017 01 15; 595(2):423-432. Barrett KE. PMID: 27284010.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G989-98. Emge JR, Huynh K, Miller EN, Kaur M, Reardon C, Barrett KE, Gareau MG. PMID: 27056723.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    29. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016 May 27; 291(22):11800-8. Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT. PMID: 27044749.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Changing of the Guard. J Physiol. 2016 Apr 01; 594(7):1795-6. Barrett KE. PMID: 27038104.
      View in: PubMed   Mentions:    Fields:    
    31. How Diversity is Becoming a Reality in the American Physiological Society. Physiologist. 2015 Jul; 58(4):159, 161-6. Molina PE, Horwitz B, Carey HV, Barman SM, Barrett KE, Reckelhoff JF. PMID: 26434150.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Martin F. Kagnoff, MD, January 19, 1941--November 16, 2014. Gastroenterology. 2015 Mar; 148(3):457-8. Eckmann L, Barrett KE, Carethers JM. PMID: 25620667.
      View in: PubMed   Mentions:    Fields:    
    33. Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation. J Infect Dis. 2015 Jul 01; 212(1):128-36. Marchelletta RR, Gareau MG, Okamoto S, Guiney DG, Barrett KE, Fierer J. PMID: 25538271.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction. J Mol Med (Berl). 2015 May; 93(5):535-45. Kozan PA, McGeough MD, Peña CA, Mueller JL, Barrett KE, Marchelletta RR, Sivagnanam M. PMID: 25482158.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    35. A joy for (the science of) life! Physiology (Bethesda). 2014 Nov; 29(6):382-3. Barrett KE, Molina PE, Pollock DM. PMID: 25362630.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G793-802. Smith CJ, Emge JR, Berzins K, Lung L, Khamishon R, Shah P, Rodrigues DM, Sousa AJ, Reardon C, Sherman PM, Barrett KE, Gareau MG. PMID: 25190473.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    37. Reports of physiology's demise have been greatly exaggerated. Physiology (Bethesda). 2013 Nov; 28(6):360-2. Barman SM, Barrett KE, Pollock D. PMID: 24186928.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    38. Fluid and electrolyte secretion in the inflamed gut: novel targets for treatment of inflammation-induced diarrhea. Curr Opin Pharmacol. 2013 Dec; 13(6):895-9. Gareau MG, Barrett KE. PMID: 24054811.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    39. Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis. Gastroenterology. 2013 Dec; 145(6):1358-1368.e1-4. Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney DG, Fierer J, Barrett KE. PMID: 24001788.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. 86th President of APS. Physiologist. 2013 Mar; 56(2):37, 39-42. Barrett KE. PMID: 23600013.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Promoting physiology as an essential element in translational research. Physiology (Bethesda). 2012 Dec; 27(6):326. Granger JP, Barman SM, Barrett KE. PMID: 23223625.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    42. Success as a PhD in Gastroenterology. Gastroenterology. 2012 Aug; 143(2):278-81. Barrett KE, Montrose MH. PMID: 22728000.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Congratulations, APS! 125 and counting. J Physiol. 2012 Apr 15; 590(8):1771-2. Barrett KE, Paterson DJ. PMID: 22532641.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Epithelial biology in the gastrointestinal system: insights into normal physiology and disease pathogenesis. J Physiol. 2012 Feb 01; 590(3):419-20. Barrett KE. PMID: 22298901.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    45. Reporting of studies using animal and human subjects in APS journals: how the society protects authors from ethical minefields. Physiologist. 2012 Feb; 55(1):8-10. Yates B, Barrett KE. PMID: 22439361.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    46. Interferon-? alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport. J Biol Chem. 2012 Jan 13; 287(3):2144-55. Paul G, Marchelletta RR, McCole DF, Barrett KE. PMID: 22069319.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    47. Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells. . 2011 Aug; 301(2):C461-8. Chow JY, Estrema C, Orneles T, Dong X, Barrett KE, Dong H. PMID: 21562303.
      View in: PubMed   Mentions:
    48. Building better bugs to deliver biologics in intestinal inflammation. Gut. 2010 Apr; 59(4):427-8. Barrett KE. PMID: 20332513.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    49. Report on the Women in Physiology Symposium in IUPS 2009. J Physiol Sci. 2010 May; 60(3):227-34. Kimura J, Suzuki Y, Mizumura K, Katagiri C, Azuma K, Hao LY, Gulia KK, Wray S, Iguchi-Ariga SM, Barrett KE. PMID: 20354833.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G714-21. Hoda MR, Scharl M, Keely SJ, McCole DF, Barrett KE. PMID: 20203064.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    51. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med. 2010 Mar; 16(3):313-8. Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK. PMID: 20154695.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    52. Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2. Gastroenterology. 2009 Dec; 137(6):2030-2040.e5. Scharl M, Paul G, Weber A, Jung BC, Docherty MJ, Hausmann M, Rogler G, Barrett KE, McCole DF. PMID: 19818778.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    53. The world within--impact of the intestinal micobiota on whole body physiology and pathophysiology. J Physiol. 2009 Sep 01; 587(Pt 17):4151. Barrett KE. PMID: 19720855.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    54. AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function. J Biol Chem. 2009 Oct 09; 284(41):27952-27963. Scharl M, Paul G, Barrett KE, McCole DF. PMID: 19654324.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    55. Upregulation of activin signaling in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G768-80. Zhang YQ, Resta S, Jung B, Barrett KE, Sarvetnick N. PMID: 19643954.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    56. Modulation of intestinal barrier properties by probiotics: role in reversing colitis. Ann N Y Acad Sci. 2009 May; 1165:175-82. Resta-Lenert SC, Barrett KE. PMID: 19538304.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    57. Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis. . 2008 Dec; 295(6):R1839-45. Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE. PMID: 18832091.
      View in: PubMed   Mentions:
    58. New ways of thinking about (and teaching about) intestinal epithelial function. Adv Physiol Educ. 2008 Mar; 32(1):25-34. Barrett KE. PMID: 18334565.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    59. Hydrogen peroxide inhibits Ca2+-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins. FASEB J. 2008 Jun; 22(6):2023-36. Chappell AE, Bunz M, Smoll E, Dong H, Lytle C, Barrett KE, McCole DF. PMID: 18211955.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    60. Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathway. FASEB J. 2008 May; 22(5):1306-16. Sellers ZM, Mann E, Smith A, Ko KH, Giannella R, Cohen MB, Barrett KE, Dong H. PMID: 18096816.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    61. Varied role of the gut epithelium in mucosal homeostasis. Curr Opin Gastroenterol. 2007 Nov; 23(6):647-54. McCole DF, Barrett KE. PMID: 17906442.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    62. Consequences of direct versus indirect activation of epidermal growth factor receptor in intestinal epithelial cells are dictated by protein-tyrosine phosphatase 1B. J Biol Chem. 2007 May 04; 282(18):13303-15. McCole DF, Truong A, Bunz M, Barrett KE. PMID: 17339316.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    63. 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. FASEB J. 2006 Dec; 20(14):2486-95. Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H. PMID: 17142798.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    64. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G290-7. Keely SJ, Scharl MM, Bertelsen LS, Hagey LR, Barrett KE, Hofmann AF. PMID: 16901996.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    65. Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells. . 2007 Jan; 292(1):C452-9. Chow JY, Barrett KE. PMID: 16899552.
      View in: PubMed   Mentions:
    66. Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology. 2006 Mar; 130(3):731-46. Resta-Lenert S, Barrett KE. PMID: 16530515.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    67. A new twist on trefoils. Focus on "TFF3 modulates NF-{kappa}B and a novel regulatory molecule of NF-{kappa}B in intestinal epithelial cells via a mechanism distinct from TNF-{alpha}". . 2005 Nov; 289(5):C1069-71. Barrett KE. PMID: 16210425.
      View in: PubMed   Mentions:
    68. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Gastroenterology. 2005 Aug; 129(2):591-608. McCole DF, Rogler G, Varki N, Barrett KE. PMID: 16083715.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    69. Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells. J Cell Physiol. 2005 Apr; 203(1):103-10. Calandrella SO, Barrett KE, Keely SJ. PMID: 15389641.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    70. Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G153-62. Resta-Lenert S, Smitham J, Barrett KE. PMID: 15774938.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    71. A role for CagA/VacA in Helicobacter pylori inhibition of murine duodenal mucosal bicarbonate secretion. Dig Dis Sci. 2004 Nov-Dec; 49(11-12):1845-52. Tuo BG, Sellers ZM, Smith AJ, Barrett KE, Isenberg JI, Dong H. PMID: 15628715.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    72. Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G654-63. Sellers ZM, Childs D, Chow JY, Smith AJ, Hogan DL, Isenberg JI, Dong H, Barrett KE, Pratha VS. PMID: 15513951.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    73. Na(+)/Ca(2+) exchange regulates Ca(2+)-dependent duodenal mucosal ion transport and HCO(3)(-) secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2005 Mar; 288(3):G457-65. Dong H, Sellers ZM, Smith A, Chow JY, Barrett KE. PMID: 15499079.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    74. Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. . 2005 Feb; 288(2):C245-52. Zhang S, Yuan JX, Barrett KE, Dong H. PMID: 15456699.
      View in: PubMed   Mentions:
    75. Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD. . 2004 Oct; 287(4):C939-48. Bertelsen LS, Paesold G, Marcus SL, Finlay BB, Eckmann L, Barrett KE. PMID: 15175224.
      View in: PubMed   Mentions:
    76. Posthumous presentation of the Julius M. Friedenwald medal to Jon I. Isenberg, M.D. Gastroenterology. 2004 Jun; 126(7):1884-9. Boland CR, Barrett KE. PMID: 15188183.
      View in: PubMed   Mentions:    Fields:    
    77. Mechanisms for amplified mediator release from colonic mast cells: implications for intestinal inflammatory diseases. World J Gastroenterol. 2004 Mar 01; 10(5):617-9. Barrett KE. PMID: 14991924.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    78. Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G814-21. Tuo BG, Chow JY, Barrett KE, Isenberg JI. PMID: 14715523.
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    79. SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G844-50. Dwinell MB, Ogawa H, Barrett KE, Kagnoff MF. PMID: 14684377.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    80. Loosening the ties that bind--novel strategy to enhance oral bioavailability. Mol Pharmacol. 2003 Dec; 64(6):1279-82. Barrett KE. PMID: 14645657.
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    81. Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses. J Biol Chem. 2004 Feb 20; 279(8):6271-9. Bertelsen LS, Barrett KE, Keely SJ. PMID: 14660604.
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    82. How can we battle the scourge of diarrhea? 2003 McKenna Memorial Lecture. Can J Gastroenterol. 2003 Nov; 17(11):667-72. Barrett KE. PMID: 14631463.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    83. Epithelial transport and gut barrier function in colitis. Curr Opin Gastroenterol. 2003 Nov; 19(6):578-82. McCole DF, Barrett KE. PMID: 15703608.
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    84. 5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca2+-dependent signaling pathways and 5-HT4 receptors in mice. Am J Physiol Gastrointest Liver Physiol. 2004 Mar; 286(3):G444-51. Tuo BG, Sellers Z, Paulus P, Barrett KE, Isenberg JI. PMID: 14576083.
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    85. Growth hormone reduces chloride secretion in human colonic epithelial cells via EGF receptor and extracellular regulated kinase. Gastroenterology. 2003 Oct; 125(4):1114-24. Chow JY, Carlstrom K, Barrett KE. PMID: 14517795.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    86. Prolonged interferon-gamma exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G157-65. Bertelsen LS, Eckmann L, Barrett KE. PMID: 12958023.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    87. Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2. Infect Immun. 2003 Apr; 71(4):2102-9. Bertelsen LS, Paesold G, Eckmann L, Barrett KE. PMID: 12654832.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    88. p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells. . 2003 Feb; 284(2):C339-48. Keely SJ, Barrett KE. PMID: 12388102.
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    89. Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G923-31. Uribe JM, McCole DF, Barrett KE. PMID: 12223352.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    90. New insights into gastrointestinal and liver diseases based on molecular aspects of transport physiology. J Investig Med. 2002 Sep; 50(5):234S-235S. Barrett KE, Moseley RH. PMID: 12227651.
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    91. Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. J Biol Chem. 2002 Nov 08; 277(45):42603-12. McCole DF, Keely SJ, Coffey RJ, Barrett KE. PMID: 12202486.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    92. Preparing your curriculum vitae. J Pediatr Gastroenterol Nutr. 2002 Apr; 34(4):362-5. Barrett KE. PMID: 11930090.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    93. Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology. 2002 Apr; 122(4):1070-87. Resta-Lenert S, Barrett KE. PMID: 11910358.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    94. New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. World J Gastroenterol. 2000 Aug; 6(4):470-474. Barrett KE. PMID: 11830825.
      View in: PubMed   Mentions: 10     Fields:    
    95. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol. 2000; 62:535-72. Barrett KE, Keely SJ. PMID: 10845102.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimals
    96. Inhibition of Ca(2+)-dependent Cl- secretion in T84 cells: membrane target(s) of inhibition is agonist specific. Am J Physiol. 1998 04; 274(4):C958-65. Barrett KE, Smitham J, Traynor-Kaplan A, Uribe JM. PMID: 9575792.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
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