Kim Barrett
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Title(s) | Distinguished Professor, Medicine |
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School | Health Sciences |
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Phone | 858-534-2796 |
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vCard | Download vCard |
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Biography University College, London, England | PhD | 1982 | Biological Chemistry | University College, London, England | BSc | 1979 | Medicinal Chemistry |
The Physiological Society | 2016
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| 2021 | Editor-in-Chief, The Journal of Physiology | American Physiological Society | 2013
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| 2014 | President | American Physiological Society | 2017 | | Ray G. Daggs Award for Distinguished Service | American Gastroenterological Association | 2016 | | Intestinal Disorders Section Research Mentor Award | The Physiological Society | 2015 | | Bayliss-Starling Prize Lecturer | American Physiological Society | 2012 | | M. Bodil Schmidt-Nielsen Distinguished Mentor and Scientist Award | Charitable Infirmary Charitable Trust, Royal College of Surgeons in Ireland | 2007 | | Molecular Medicine Medal Lecturer | American Physiological Society | 2006 | | Davenport Lecturer | American Physiological Society | 1996 | | Henry Pickering Bowditch Award | Queens University Belfast | 2004 | | Doctor of Medfical Science, honoris causa |
Research ORNG Applications Bibliographic
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Barrett KE. A new target to treat diarrhea in cholera? J Infect Dis. 2019 Jan 08. PMID: 30624702.
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Doshi A, Khamishon R, Rawson R, Duong L, Dohil L, Myers SJ, Bell B, Dohil R, Newbury RO, Barrett KE, Kurten RC, Aceves SS. IL-9 Alters Epithelial Barrier and E-cadherin in Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2018 Sep 11. PMID: 30211842.
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Barrett KE. New frontiers in gastrointestinal physiology and pathophysiology. J Physiol. 2018 Sep; 596(17):3859-3860. PMID: 29863278.
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Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. PMID: 29912959.
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Barrett KE. Mapping the Duodenal Crypt-Villus Transport Axis. Cell Mol Gastroenterol Hepatol. 2018; 5(4):642-644. PMID: 29713666.
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Das S, Jayaratne R, Barrett KE. The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018; 6(1):33-45. PMID: 29928670.
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Barrett KE. Looking to and nurturing the future of physiology. J Physiol. 2017 12 15; 595(24):7263-7264. PMID: 29164626.
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Barrett KE, Wu GD. Influence of the microbiota on host physiology - moving beyond the gut. J Physiol. 2017 01 15; 595(2):433-435. PMID: 28083941.
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Barrett KE, McCole DF. Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis. Clin Exp Pharmacol Physiol. 2016 Nov; 43(11):1097-1106. PMID: 27543846.
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Manresa MC, Tambuwala MM, Radhakrishnan P, Harnoss JM, Brown E, Cavadas MA, Keogh CE, Cheong A, Barrett KE, Cummins EP, Schneider M, Taylor CT. Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-ß1 signaling. [corrected]. Am J Physiol Gastrointest Liver Physiol. 2016 12 01; 311(6):G1076-G1090. PMID: 27789456.
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Camilleri M, Sellin JH, Barrett KE. Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. Gastroenterology. 2017 02; 152(3):515-532.e2. PMID: 27773805.
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Barrett KE. Rethinking cholera pathogenesis- No longer all in the same "camp". Virulence. 2016 10 02; 7(7):751-3. PMID: 27413815.
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Barrett KE. Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling. J Physiol. 2017 01 15; 595(2):423-432. PMID: 27284010.
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Emge JR, Huynh K, Miller EN, Kaur M, Reardon C, Barrett KE, Gareau MG. Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G989-98. PMID: 27056723.
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Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016 May 27; 291(22):11800-8. PMID: 27044749; PMCID: PMC4882447 [Available on 05/27/17].
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Barrett KE. Changing of the Guard. J Physiol. 2016 Apr 01; 594(7):1795-6. PMID: 27038104; PMCID: PMC4818607 [Available on 04/01/17].
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Molina PE, Horwitz B, Carey HV, Barman SM, Barrett KE, Reckelhoff JF. How Diversity is Becoming a Reality in the American Physiological Society. Physiologist. 2015 Jul; 58(4):159, 161-6. PMID: 26434150.
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Eckmann L, Barrett KE, Carethers JM. Martin F. Kagnoff, MD, January 19, 1941--November 16, 2014. Gastroenterology. 2015 Mar; 148(3):457-8. PMID: 25620667.
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Marchelletta RR, Gareau MG, Okamoto S, Guiney DG, Barrett KE, Fierer J. Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation. J Infect Dis. 2015 Jul 01; 212(1):128-36. PMID: 25538271; PMCID: PMC4542593.
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Kozan PA, McGeough MD, Peña CA, Mueller JL, Barrett KE, Marchelletta RR, Sivagnanam M. Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction. J Mol Med (Berl). 2015 May; 93(5):535-45. PMID: 25482158; PMCID: PMC4408367.
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Barrett KE, Molina PE, Pollock DM. A joy for (the science of) life! Physiology (Bethesda). 2014 Nov; 29(6):382-3. PMID: 25362630.
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Smith CJ, Emge JR, Berzins K, Lung L, Khamishon R, Shah P, Rodrigues DM, Sousa AJ, Reardon C, Sherman PM, Barrett KE, Gareau MG. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G793-802. PMID: 25190473; PMCID: PMC4200314.
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Barman SM, Barrett KE, Pollock D. Reports of physiology's demise have been greatly exaggerated. Physiology (Bethesda). 2013 Nov; 28(6):360-2. PMID: 24186928.
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Gareau MG, Barrett KE. Fluid and electrolyte secretion in the inflamed gut: novel targets for treatment of inflammation-induced diarrhea. Curr Opin Pharmacol. 2013 Dec; 13(6):895-9. PMID: 24054811.
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Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney DG, Fierer J, Barrett KE. Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis. Gastroenterology. 2013 Dec; 145(6):1358-1368.e1-4. PMID: 24001788; PMCID: PMC3899031.
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Barrett KE. 86th President of APS. Physiologist. 2013 Mar; 56(2):37, 39-42. PMID: 23600013.
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Granger JP, Barman SM, Barrett KE. Promoting physiology as an essential element in translational research. Physiology (Bethesda). 2012 Dec; 27(6):326. PMID: 23223625.
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Barrett KE, Montrose MH. Success as a PhD in Gastroenterology. Gastroenterology. 2012 Aug; 143(2):278-81. PMID: 22728000.
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Barrett KE, Paterson DJ. Congratulations, APS! 125 and counting. J Physiol. 2012 Apr 15; 590(8):1771-2. PMID: 22532641; PMCID: PMC3573295.
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Yates B, Barrett KE. Reporting of studies using animal and human subjects in APS journals: how the society protects authors from ethical minefields. Physiologist. 2012 Feb; 55(1):8-10. PMID: 22439361.
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Barrett KE. Epithelial biology in the gastrointestinal system: insights into normal physiology and disease pathogenesis. J Physiol. 2012 Feb 01; 590(3):419-20. PMID: 22298901; PMCID: PMC3379689.
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Paul G, Marchelletta RR, McCole DF, Barrett KE. Interferon-? alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport. J Biol Chem. 2012 Jan 13; 287(3):2144-55. PMID: 22069319; PMCID: PMC3265893.
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Chow JY, Estrema C, Orneles T, Dong X, Barrett KE, Dong H. Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C461-8. PMID: 21562303; PMCID: PMC3154552.
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Barrett KE. Building better bugs to deliver biologics in intestinal inflammation. Gut. 2010 Apr; 59(4):427-8. PMID: 20332513.
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Kimura J, Suzuki Y, Mizumura K, Katagiri C, Azuma K, Hao LY, Gulia KK, Wray S, Iguchi-Ariga SM, Barrett KE. Report on the Women in Physiology Symposium in IUPS 2009. J Physiol Sci. 2010 May; 60(3):227-34. PMID: 20354833.
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Hoda MR, Scharl M, Keely SJ, McCole DF, Barrett KE. Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G714-21. PMID: 20203064.
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Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med. 2010 Mar; 16(3):313-8. PMID: 20154695; PMCID: PMC2834836.
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Scharl M, Paul G, Weber A, Jung BC, Docherty MJ, Hausmann M, Rogler G, Barrett KE, McCole DF. Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2. Gastroenterology. 2009 Dec; 137(6):2030-2040.e5. PMID: 19818778; PMCID: PMC2855721.
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Barrett KE. The world within--impact of the intestinal micobiota on whole body physiology and pathophysiology. J Physiol. 2009 Sep 01; 587(Pt 17):4151. PMID: 19720855; PMCID: PMC2754354.
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Scharl M, Paul G, Barrett KE, McCole DF. AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function. J Biol Chem. 2009 Oct 09; 284(41):27952-63. PMID: 19654324; PMCID: PMC2788847.
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Zhang YQ, Resta S, Jung B, Barrett KE, Sarvetnick N. Upregulation of activin signaling in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G768-80. PMID: 19643954; PMCID: PMC2763799.
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Resta-Lenert SC, Barrett KE. Modulation of intestinal barrier properties by probiotics: role in reversing colitis. Ann N Y Acad Sci. 2009 May; 1165:175-82. PMID: 19538304.
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Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE. Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1839-45. PMID: 18832091; PMCID: PMC2685287.
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Barrett KE. New ways of thinking about (and teaching about) intestinal epithelial function. Adv Physiol Educ. 2008 Mar; 32(1):25-34. PMID: 18334565.
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Chappell AE, Bunz M, Smoll E, Dong H, Lytle C, Barrett KE, McCole DF. Hydrogen peroxide inhibits Ca2+-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins. FASEB J. 2008 Jun; 22(6):2023-36. PMID: 18211955.
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Sellers ZM, Mann E, Smith A, Ko KH, Giannella R, Cohen MB, Barrett KE, Dong H. Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathway. FASEB J. 2008 May; 22(5):1306-16. PMID: 18096816.
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McCole DF, Barrett KE. Varied role of the gut epithelium in mucosal homeostasis. Curr Opin Gastroenterol. 2007 Nov; 23(6):647-54. PMID: 17906442.
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McCole DF, Truong A, Bunz M, Barrett KE. Consequences of direct versus indirect activation of epidermal growth factor receptor in intestinal epithelial cells are dictated by protein-tyrosine phosphatase 1B. J Biol Chem. 2007 May 04; 282(18):13303-15. PMID: 17339316.
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Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H. 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. FASEB J. 2006 Dec; 20(14):2486-95. PMID: 17142798.
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Keely SJ, Scharl MM, Bertelsen LS, Hagey LR, Barrett KE, Hofmann AF. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G290-7. PMID: 16901996.
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Chow JY, Barrett KE. Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C452-9. PMID: 16899552.
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Resta-Lenert S, Barrett KE. Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology. 2006 Mar; 130(3):731-46. PMID: 16530515.
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Barrett KE. A new twist on trefoils. Focus on "TFF3 modulates NF-{kappa}B and a novel regulatory molecule of NF-{kappa}B in intestinal epithelial cells via a mechanism distinct from TNF-{alpha}". Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1069-71. PMID: 16210425.
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McCole DF, Rogler G, Varki N, Barrett KE. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Gastroenterology. 2005 Aug; 129(2):591-608. PMID: 16083715.
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Calandrella SO, Barrett KE, Keely SJ. Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells. J Cell Physiol. 2005 Apr; 203(1):103-10. PMID: 15389641.
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Resta-Lenert S, Smitham J, Barrett KE. Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G153-62. PMID: 15774938.
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Tuo BG, Sellers ZM, Smith AJ, Barrett KE, Isenberg JI, Dong H. A role for CagA/VacA in Helicobacter pylori inhibition of murine duodenal mucosal bicarbonate secretion. Dig Dis Sci. 2004 Nov-Dec; 49(11-12):1845-52. PMID: 15628715.
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Sellers ZM, Childs D, Chow JY, Smith AJ, Hogan DL, Isenberg JI, Dong H, Barrett KE, Pratha VS. Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G654-63. PMID: 15513951.
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Dong H, Sellers ZM, Smith A, Chow JY, Barrett KE. Na(+)/Ca(2+) exchange regulates Ca(2+)-dependent duodenal mucosal ion transport and HCO(3)(-) secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2005 Mar; 288(3):G457-65. PMID: 15499079.
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Zhang S, Yuan JX, Barrett KE, Dong H. Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2005 Feb; 288(2):C245-52. PMID: 15456699.
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Bertelsen LS, Paesold G, Marcus SL, Finlay BB, Eckmann L, Barrett KE. Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C939-48. PMID: 15175224.
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Boland CR, Barrett KE. Posthumous presentation of the Julius M. Friedenwald medal to Jon I. Isenberg, M.D. Gastroenterology. 2004 Jun; 126(7):1884-9. PMID: 15188183.
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Barrett KE. Mechanisms for amplified mediator release from colonic mast cells: implications for intestinal inflammatory diseases. World J Gastroenterol. 2004 Mar 01; 10(5):617-9. PMID: 14991924; PMCID: PMC4716895.
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Tuo BG, Chow JY, Barrett KE, Isenberg JI. Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G814-21. PMID: 14715523.
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Dwinell MB, Ogawa H, Barrett KE, Kagnoff MF. SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G844-50. PMID: 14684377.
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Barrett KE. Loosening the ties that bind--novel strategy to enhance oral bioavailability. Mol Pharmacol. 2003 Dec; 64(6):1279-82. PMID: 14645657.
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Bertelsen LS, Barrett KE, Keely SJ. Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses. J Biol Chem. 2004 Feb 20; 279(8):6271-9. PMID: 14660604.
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McCole DF, Barrett KE. Epithelial transport and gut barrier function in colitis. Curr Opin Gastroenterol. 2003 Nov; 19(6):578-82. PMID: 15703608.
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Barrett KE. How can we battle the scourge of diarrhea? 2003 McKenna Memorial Lecture. Can J Gastroenterol. 2003 Nov; 17(11):667-72. PMID: 14631463.
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Tuo BG, Sellers Z, Paulus P, Barrett KE, Isenberg JI. 5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca2+-dependent signaling pathways and 5-HT4 receptors in mice. Am J Physiol Gastrointest Liver Physiol. 2004 Mar; 286(3):G444-51. PMID: 14576083.
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Chow JY, Carlstrom K, Barrett KE. Growth hormone reduces chloride secretion in human colonic epithelial cells via EGF receptor and extracellular regulated kinase. Gastroenterology. 2003 Oct; 125(4):1114-24. PMID: 14517795.
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Bertelsen LS, Eckmann L, Barrett KE. Prolonged interferon-gamma exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G157-65. PMID: 12958023.
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Bertelsen LS, Paesold G, Eckmann L, Barrett KE. Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2. Infect Immun. 2003 Apr; 71(4):2102-9. PMID: 12654832; PMCID: PMC152023.
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Keely SJ, Barrett KE. p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells. Am J Physiol Cell Physiol. 2003 Feb; 284(2):C339-48. PMID: 12388102.
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Uribe JM, McCole DF, Barrett KE. Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G923-31. PMID: 12223352.
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Barrett KE, Moseley RH. New insights into gastrointestinal and liver diseases based on molecular aspects of transport physiology. J Investig Med. 2002 Sep; 50(5):234S-235S. PMID: 12227651.
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McCole DF, Keely SJ, Coffey RJ, Barrett KE. Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. J Biol Chem. 2002 Nov 08; 277(45):42603-12. PMID: 12202486.
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Barrett KE. Preparing your curriculum vitae. J Pediatr Gastroenterol Nutr. 2002 Apr; 34(4):362-5. PMID: 11930090.
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Resta-Lenert S, Barrett KE. Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology. 2002 Apr; 122(4):1070-87. PMID: 11910358.
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Barrett KE. New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. World J Gastroenterol. 2000 Aug; 6(4):470-474. PMID: 11830825.
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Barrett KE, Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol. 2000; 62:535-72. PMID: 10845102.
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Barrett KE, Smitham J, Traynor-Kaplan A, Uribe JM. Inhibition of Ca(2+)-dependent Cl- secretion in T84 cells: membrane target(s) of inhibition is agonist specific. Am J Physiol. 1998 Apr; 274(4 Pt 1):C958-65. PMID: 9575792.
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Year | Publications |
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1998 | 1 | 2000 | 2 | 2002 | 6 | 2003 | 9 | 2004 | 8 | 2005 | 4 | 2006 | 4 | 2007 | 3 | 2008 | 3 | 2009 | 5 | 2010 | 4 | 2011 | 2 | 2012 | 5 | 2013 | 4 | 2014 | 4 | 2015 | 2 | 2016 | 8 | 2017 | 2 | 2018 | 5 | 2019 | 1 |
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