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Kevin Moore

Title(s)Associate Professor In Residence, Radiation Medicine and Applied Science
SchoolHealth Sciences
Phone858-822-6056
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. Louis, St. Louis, MOResidency06/2009Therapeutic Medical Physics
    University of California, Berkeley, Berkeley, CAPhD05/2007Physics
    University of California, Berkeley, Berkeley, CAMA05/2005Physics
    Harvey Mudd College, Claremont, CABS05/1999Physics
    Collapse Awards and Honors
    UC Berkeley2001  - 2007National Science Foundation Graduate Research Fellowship
    Harvey Mudd College1999Thomas B. Brown Thesis Prize
    Harvey Mudd College1995  - 1999National Merit Scholarship
    1995United States Presidential Scholar

    Collapse Overview 
    Collapse Overview
    Dr. Moore is the Deputy Director of the Medical Physics Division and Associate Director of Research. Dr. Moore is a pioneer in the nascent field of knowledge-based planning. Knowledge-based planning involves applying prior knowledge from large datasets of previously treated patients in order to optimize treatment planning of new patients, significantly improving plan quality and efficiency. He is currently engaged in both the development of new knowledge-based dose prediction methods as well as the clinical implementation of knowledge-based radiotherapy treatment planning across the UC San Diego enterprise. Dr. Moore has successfully applied this approach to a wide variety of radiotherapy treatment sites, including head-and-neck, prostate, gynecologic, brain, lung, pancreas, bone, anorectal, and liver cancers. He is lead inventor on two patents regarding knowledge-based dosimetric prediction and is the Principal Investigator on a five-year $1.9M R01 effort to develop a distributed knowledge-based quality control system. His other research interests are focused on the expansion of data-driven methods in radiotherapy, particularly creating efficient decision support systems and the use of application programming interfaces (APIs) to automate error-prone and inefficient clinical processes.

    Collapse Research 
    Collapse Research Activities and Funding
    Distributed knowledge-based platform for radiotherapy plan quality control
    AHRQ R01HS025440Jun 11, 2018 - Mar 31, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Moore KL. Automated Radiotherapy Treatment Planning. Semin Radiat Oncol. 2019 Jul; 29(3):209-218. PMID: 31027638.
      View in: PubMed
    2. Kaderka R, Mundt RC, Li N, Ziemer B, Bry VN, Cornell M, Moore KL. Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites. Pract Radiat Oncol. 2019 Mar 01. PMID: 30826481.
      View in: PubMed
    3. Lim TY, Gillespie E, Murphy J, Moore KL. Clinically Oriented Contour Evaluation Using Dosimetric Indices Generated From Automated Knowledge-Based Planning. Int J Radiat Oncol Biol Phys. 2019 Apr 01; 103(5):1251-1260. PMID: 30508619.
      View in: PubMed
    4. Brown DW, Atwood TF, Moore KL, MacAulay R, Murphy JD, Mundt AJ, Pawlicki T. A program to train medical physicists for direct patient care responsibilities. J Appl Clin Med Phys. 2018 Nov; 19(6):332-335. PMID: 30328675.
      View in: PubMed
    5. Kaderka R, Gillespie EF, Mundt RC, Bryant AK, Sanudo-Thomas CB, Harrison AL, Wouters EL, Moiseenko V, Moore KL, Atwood TF, Murphy JD. Geometric and dosimetric evaluation of atlas based auto-segmentation of cardiac structures in breast cancer patients. Radiother Oncol. 2019 Feb; 131:215-220. PMID: 30107948.
      View in: PubMed
    6. Atwood TF, Brown DW, Murphy JD, Moore KL, Mundt AJ, Pawlicki T. Establishing a New Clinical Role for Medical Physicists: A Prospective Phase II Trial. Int J Radiat Oncol Biol Phys. 2018 Nov 01; 102(3):635-641. PMID: 30244881.
      View in: PubMed
    7. Chen VE, Gillespie EF, Manger RP, Skerritt LA, Tran JH, Proudfoot JA, Sherer MV, Einck JP, Mell LK, Moore KL, Yashar CM. The impact of daily bladder filling on small bowel dose for intensity modulated radiation therapy for cervical cancer. Med Dosim. 2018 Mar 21. PMID: 29573921.
      View in: PubMed
    8. McNutt TR, Benedict SH, Low DA, Moore K, Shpitser I, Jiang W, Lakshminarayanan P, Cheng Z, Han P, Hui X, Nakatsugawa M, Lee J, Moore JA, Robertson SP, Shah V, Taylor R, Quon H, Wong J, DeWeese T. Using Big Data Analytics to Advance Precision Radiation Oncology. Int J Radiat Oncol Biol Phys. 2018 06 01; 101(2):285-291. PMID: 29726357.
      View in: PubMed
    9. Ziemer BP, Sanghvi P, Hattangadi-Gluth J, Moore KL. Heuristic knowledge-based planning for single-isocenter stereotactic radiosurgery to multiple brain metastases. Med Phys. 2017 Oct; 44(10):5001-5009. PMID: 28731267.
      View in: PubMed
    10. Atwood TF, Brown DW, Murphy JD, Moore KL, Mundt AJ, Pawlicki T. Care for Patients, Not for Charts: A Future for Clinical Medical Physics. Int J Radiat Oncol Biol Phys. 2018 01 01; 100(1):21-22. PMID: 29254774.
      View in: PubMed
    11. Li N, Noticewala SS, Williamson CW, Shen H, Sirak I, Tarnawski R, Mahantshetty U, Hoh CK, Moore KL, Mell LK. Feasibility of atlas-based active bone marrow sparing intensity modulated radiation therapy for cervical cancer. Radiother Oncol. 2017 05; 123(2):325-330. PMID: 28528206.
      View in: PubMed
    12. Ziemer BP, Shiraishi S, Hattangadi-Gluth JA, Sanghvi P, Moore KL. Fully automated, comprehensive knowledge-based planning for stereotactic radiosurgery: Preclinical validation through blinded physician review. Pract Radiat Oncol. 2017 Nov - Dec; 7(6):e569-e578. PMID: 28711334.
      View in: PubMed
    13. Connor MJ, Tringale K, Moiseenko V, Marshall DC, Moore K, Cervino L, Atwood T, Brown D, Mundt AJ, Pawlicki T, Recht A, Hattangadi-Gluth JA. Medical Device Recalls in Radiation Oncology: Analysis of US Food and Drug Administration Data, 2002-2015. Int J Radiat Oncol Biol Phys. 2017 06 01; 98(2):438-446. PMID: 28463163.
      View in: PubMed
    14. Connor MJ, Marshall DC, Moiseenko V, Moore K, Cervino L, Atwood T, Sanghvi P, Mundt AJ, Pawlicki T, Recht A, Hattangadi-Gluth JA. Adverse Events Involving Radiation Oncology Medical Devices: Comprehensive Analysis of US Food and Drug Administration Data, 1991 to 2015. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):18-26. PMID: 27979446.
      View in: PubMed
    15. Li N, Carmona R, Sirak I, Kasaova L, Followill D, Michalski J, Bosch W, Straube W, Mell LK, Moore KL. Highly Efficient Training, Refinement, and Validation of a Knowledge-based Planning Quality-Control System for Radiation Therapy Clinical Trials. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):164-172. PMID: 27979445.
      View in: PubMed
    16. Benedict SH, Hoffman K, Martel MK, Abernethy AP, Asher AL, Capala J, Chen RC, Chera B, Couch J, Deye J, Efstathiou JA, Ford E, Fraass BA, Gabriel PE, Huser V, Kavanagh BD, Khuntia D, Marks LB, Mayo C, McNutt T, Miller RS, Moore KL, Prior F, Roelofs E, Rosenstein BS, Sloan J, Theriault A, Vikram B. Overview of the American Society for Radiation Oncology-National Institutes of Health-American Association of Physicists in Medicine Workshop 2015: Exploring Opportunities for Radiation Oncology in the Era of Big Data. Int J Radiat Oncol Biol Phys. 2016 07 01; 95(3):873-879. PMID: 27302503; PMCID: PMC4965164.
      View in: PubMed, PubMed Central
    17. Karunamuni RA, Moore KL, Seibert TM, Li N, White NS, Bartsch H, Carmona R, Marshall D, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell LK, Brewer J, Dale AM, Moiseenko V, Hattangadi-Gluth JA. Radiation sparing of cerebral cortex in brain tumor patients using quantitative neuroimaging. Radiother Oncol. 2016 Jan; 118(1):29-34. PMID: 26806266.
      View in: PubMed
    18. Shiraishi S, Moore KL. Knowledge-based prediction of three-dimensional dose distributions for external beam radiotherapy. Med Phys. 2016 Jan; 43(1):378. PMID: 26745931.
      View in: PubMed
    19. McNutt TR, Moore KL, Quon H. Needs and Challenges for Big Data in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2016 Jul 01; 95(3):909-915. PMID: 27302506.
      View in: PubMed
    20. Moore KL, Schmidt R, Moiseenko V, Olsen LA, Tan J, Xiao Y, Galvin J, Pugh S, Seider MJ, Dicker AP, Bosch W, Michalski J, Mutic S. Quantifying Unnecessary Normal Tissue Complication Risks due to Suboptimal Planning: A Secondary Study of RTOG 0126. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):228-35. PMID: 25847605; PMCID: PMC4431941.
      View in: PubMed, PubMed Central
    21. Shiraishi S, Tan J, Olsen LA, Moore KL. Knowledge-based prediction of plan quality metrics in intracranial stereotactic radiosurgery. Med Phys. 2015 Feb; 42(2):908. PMID: 25652503.
      View in: PubMed
    22. Sharpe MB, Moore KL, Orton CG. Point/Counterpoint: Within the next ten years treatment planning will become fully automated without the need for human intervention. Med Phys. 2014 Dec; 41(12):120601. PMID: 25471945.
      View in: PubMed
    23. Hoisak JD, Pawlicki T, Kim GY, Fletcher R, Moore KL. Improving linear accelerator service response with a real- time electronic event reporting system. J Appl Clin Med Phys. 2014 Sep 08; 15(5):4807. PMID: 25207564.
      View in: PubMed
    24. Moore KL, Kagadis GC, McNutt TR, Moiseenko V, Mutic S. Vision 20/20: Automation and advanced computing in clinical radiation oncology. Med Phys. 2014 Jan; 41(1):010901. PMID: 24387492.
      View in: PubMed
    25. Olsen LA, Robinson CG, He GR, Wooten HO, Yaddanapudi S, Mutic S, Yang D, Moore KL. Automated radiation therapy treatment plan workflow using a commercial application programming interface. Pract Radiat Oncol. 2014 Nov-Dec; 4(6):358-67. PMID: 25407855.
      View in: PubMed
    26. Li N, Zarepisheh M, Uribe-Sanchez A, Moore K, Tian Z, Zhen X, Graves YJ, Gautier Q, Mell L, Zhou L, Jia X, Jiang S. Automatic treatment plan re-optimization for adaptive radiotherapy guided with the initial plan DVHs. Phys Med Biol. 2013 Dec 21; 58(24):8725-38. PMID: 24301071.
      View in: PubMed
    27. Appenzoller LM, Michalski JM, Thorstad WL, Mutic S, Moore KL. Predicting dose-volume histograms for organs-at-risk in IMRT planning. Med Phys. 2012 Dec; 39(12):7446-61. PMID: 23231294.
      View in: PubMed
    28. Yang D, Moore KL. Automated radiotherapy treatment plan integrity verification. Med Phys. 2012 Mar; 39(3):1542-51. PMID: 22380386.
      View in: PubMed
    29. Moore KL, Brame RS, Low DA, Mutic S. Quantitative metrics for assessing plan quality. Semin Radiat Oncol. 2012 Jan; 22(1):62-9. PMID: 22177879.
      View in: PubMed
    30. Zhao T, White B, Moore KL, Lamb J, Yang D, Lu W, Mutic S, Low DA. Biomechanical interpretation of a free-breathing lung motion model. Phys Med Biol. 2011 Dec 07; 56(23):7523-40. PMID: 22079895; PMCID: PMC4295720.
      View in: PubMed, PubMed Central
    31. Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM. Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8628-33. PMID: 21555542; PMCID: PMC3102361.
      View in: PubMed, PubMed Central
    32. Marcello MR, Jia W, Leary JA, Moore KL, Evans JP. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem. 2011 Apr 15; 286(15):13060-70. PMID: 21339297.
      View in: PubMed
    33. Moore KL, Brame RS, Low DA, Mutic S. Experience-based quality control of clinical intensity-modulated radiotherapy planning. Int J Radiat Oncol Biol Phys. 2011 Oct 01; 81(2):545-51. PMID: 21277097.
      View in: PubMed
    34. Moore KL, Palaniswaamy G, White B, Goddu SM, Low DA. Fast, low-dose patient localization on TomoTherapy via topogram registration. Med Phys. 2010 Aug; 37(8):4068-77. PMID: 20879568.
      View in: PubMed
    35. Gupta S, Moore KL, Murch KW, Stamper-Kurn DM. Cavity nonlinear optics at low photon numbers from collective atomic motion. Phys Rev Lett. 2007 Nov 23; 99(21):213601. PMID: 18233217.
      View in: PubMed
    36. Moore KL, Gupta S, Murch KW, Stamper-Kurn DM. Probing the quantum state of a guided atom laser pulse. Phys Rev Lett. 2006 Nov 03; 97(18):180410. PMID: 17155527.
      View in: PubMed
    37. Murch KW, Moore KL, Gupta S, Stamper-Kurn DM. Dispersion management using betatron resonances in an ultracold-atom storage ring. Phys Rev Lett. 2006 Jan 13; 96(1):013202. PMID: 16486451.
      View in: PubMed
    38. Gupta S, Murch KW, Moore KL, Purdy TP, Stamper-Kurn DM. Bose-Einstein condensation in a circular waveguide. Phys Rev Lett. 2005 Sep 30; 95(14):143201. PMID: 16241650.
      View in: PubMed
    39. Higbie JM, Sadler LE, Inouye S, Chikkatur AP, Leslie SR, Moore KL, Savalli V, Stamper-Kurn DM. Direct nondestructive imaging of magnetization in a spin-1 Bose-Einstein gas. Phys Rev Lett. 2005 Jul 29; 95(5):050401. PMID: 16090852.
      View in: PubMed
    40. Moore KL, Donnelly TD. Probing nonequilibrium electron distributions in gold by use of second-harmonic generation. Opt Lett. 1999 Jul 15; 24(14):990-2. PMID: 18073919.
      View in: PubMed
    41. Ouyang YB, Moore KL. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. J Biol Chem. 1998 Sep 18; 273(38):24770-4. PMID: 9733778.
      View in: PubMed
    42. Ouyang Yb, Lane WS, Moore KL. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2896-901. PMID: 9501187.
      View in: PubMed
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