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Kevin Moore

Title(s)Associate Professor In Residence, Radiation Medicine and Applied Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. Louis, St. Louis, MOResidency06/2009Therapeutic Medical Physics
    University of California, Berkeley, Berkeley, CAPhD05/2007Physics
    University of California, Berkeley, Berkeley, CAMA05/2005Physics
    Harvey Mudd College, Claremont, CABS05/1999Physics
    Collapse Awards and Honors
    UC Berkeley2001  - 2007National Science Foundation Graduate Research Fellowship
    Harvey Mudd College1999Thomas B. Brown Thesis Prize
    Harvey Mudd College1995  - 1999National Merit Scholarship
    1995United States Presidential Scholar

    Collapse Overview 
    Collapse Overview
    Dr. Moore is the Deputy Director of the Medical Physics Division and Associate Director of Research. Dr. Moore is a pioneer in the nascent field of knowledge-based planning. Knowledge-based planning involves applying prior knowledge from large datasets of previously treated patients in order to optimize treatment planning of new patients, significantly improving plan quality and efficiency. He is currently engaged in both the development of new knowledge-based dose prediction methods as well as the clinical implementation of knowledge-based radiotherapy treatment planning across the UC San Diego enterprise. Dr. Moore has successfully applied this approach to a wide variety of radiotherapy treatment sites, including head-and-neck, prostate, gynecologic, brain, lung, pancreas, bone, anorectal, and liver cancers. He is lead inventor on two patents regarding knowledge-based dosimetric prediction and is the Principal Investigator on a five-year $1.9M R01 effort to develop a distributed knowledge-based quality control system. His other research interests are focused on the expansion of data-driven methods in radiotherapy, particularly creating efficient decision support systems and the use of application programming interfaces (APIs) to automate error-prone and inefficient clinical processes.

    Collapse Research 
    Collapse Research Activities and Funding
    Distributed knowledge-based platform for radiotherapy plan quality control
    NIH R01HS025440Jun 11, 2018 - Mar 31, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A practical method to quantify knowledge-based DVH prediction accuracy and uncertainty with reference cohorts. J Appl Clin Med Phys. 2021 Feb 26. Covele BM, Carroll CJ, Moore KL. PMID: 33634947.
      View in: PubMed   Mentions:    Fields:    
    2. ORBIT-RT: A Real-Time, Open Platform for Knowledge-Based Quality Control of Radiotherapy Treatment Planning. JCO Clin Cancer Inform. 2021 Jan; 5:134-142. Covele BM, Puri KS, Kallis K, Murphy JD, Moore KL. PMID: 33513032.
      View in: PubMed   Mentions: 1     Fields:    
    3. Automated contouring and planning pipeline for hippocampal-avoidant whole-brain radiotherapy. Radiat Oncol. 2020 Oct 30; 15(1):251. Feng CH, Cornell M, Moore KL, Karunamuni R, Seibert TM. PMID: 33126894.
      View in: PubMed   Mentions:    Fields:    
    4. Using in vivo EPID images to detect and quantify patient anatomy changes with gradient dose segmented analysis. Med Phys. 2020 Nov; 47(11):5419-5427. Steers JM, Zavala Bojorquez J, Moore K, Bojechko C. PMID: 32964446.
      View in: PubMed   Mentions:    Fields:    
    5. Knowledge-Based Planning for Intact Cervical Cancer. Semin Radiat Oncol. 2020 Oct; 30(4):328-339. Yusufaly TI, Meyers SM, Mell LK, Moore KL. PMID: 32828388.
      View in: PubMed   Mentions:    Fields:    
    6. Evaluation of a Patient Communication Skills Training Program for Medical Physicists. Int J Radiat Oncol Biol Phys. 2020 Dec 01; 108(5):1284-1291. Brown DW, Atwood TF, Juang T, Moore KL, MacAulay R, Bazzo D, Murphy JD, Mundt AJ, Pawlicki T. PMID: 32711038.
      View in: PubMed   Mentions:    Fields:    
    7. A Multi-atlas Approach for Active Bone Marrow Sparing Radiation Therapy: Implementation in the NRG-GY006 Trial. Int J Radiat Oncol Biol Phys. 2020 Dec 01; 108(5):1240-1247. Yusufaly T, Miller A, Medina-Palomo A, Williamson CW, Nguyen H, Lowenstein J, Leath CA, Xiao Y, Moore KL, Moxley KM, Chevere-Mourino CM, Eng TY, Zaid T, Mell LK. PMID: 32629079.
      View in: PubMed   Mentions:    Fields:    
    8. A review of patient questions from physicist-patient consults. J Appl Clin Med Phys. 2020 Aug; 21(8):305-308. Atwood TF, Brown DW, Juang T, Moore KL, McConnell KA, Steers JM, Murphy JD, Mundt AJ, Pawlicki T. PMID: 32519450.
      View in: PubMed   Mentions:    Fields:    
    9. A knowledge-based organ dose prediction tool for brachytherapy treatment planning of patients with cervical cancer. Brachytherapy. 2020 Sep - Oct; 19(5):624-634. Yusufaly TI, Kallis K, Simon A, Mayadev J, Yashar CM, Einck JP, Mell LK, Brown D, Scanderbeg D, Hild SJ, Covele B, Moore KL, Meyers SM. PMID: 32513446.
      View in: PubMed   Mentions:    Fields:    
    10. Framework for Evaluation of Automated Knowledge-Based Planning Systems Using Multiple Publicly Available Prostate Routines. Pract Radiat Oncol. 2020 Mar - Apr; 10(2):112-124. Ray X, Kaderka R, Hild S, Cornell M, Moore KL. PMID: 31812828.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Noninferiority Study of Automated Knowledge-Based Planning Versus Human-Driven Optimization Across Multiple Disease Sites. Int J Radiat Oncol Biol Phys. 2020 02 01; 106(2):430-439. Cornell M, Kaderka R, Hild SJ, Ray XJ, Murphy JD, Atwood TF, Moore KL. PMID: 31678227.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Evaluating the sensitivity of Halcyon's automatic transit image acquisition for treatment error detection: A phantom study using static IMRT. J Appl Clin Med Phys. 2019 Nov; 20(11):131-143. Ray X, Bojechko C, Moore KL. PMID: 31587477.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Use of Big Data for Quality Assurance in Radiation Therapy. Semin Radiat Oncol. 2019 10; 29(4):326-332. McNutt TR, Moore KL, Wu B, Wright JL. PMID: 31472734.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Automated Radiotherapy Treatment Planning. Semin Radiat Oncol. 2019 Jul; 29(3):209-218. Moore KL. PMID: 31027638.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites. Pract Radiat Oncol. 2019 Jul - Aug; 9(4):257-265. Kaderka R, Mundt RC, Li N, Ziemer B, Bry VN, Cornell M, Moore KL. PMID: 30826481.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Clinically Oriented Contour Evaluation Using Dosimetric Indices Generated From Automated Knowledge-Based Planning. Int J Radiat Oncol Biol Phys. 2019 04 01; 103(5):1251-1260. Lim TY, Gillespie E, Murphy J, Moore KL. PMID: 30508619.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. A program to train medical physicists for direct patient care responsibilities. J Appl Clin Med Phys. 2018 Nov; 19(6):332-335. Brown DW, Atwood TF, Moore KL, MacAulay R, Murphy JD, Mundt AJ, Pawlicki T. PMID: 30328675.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Geometric and dosimetric evaluation of atlas based auto-segmentation of cardiac structures in breast cancer patients. Radiother Oncol. 2019 02; 131:215-220. Kaderka R, Gillespie EF, Mundt RC, Bryant AK, Sanudo-Thomas CB, Harrison AL, Wouters EL, Moiseenko V, Moore KL, Atwood TF, Murphy JD. PMID: 30107948.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Establishing a New Clinical Role for Medical Physicists: A Prospective Phase II Trial. Int J Radiat Oncol Biol Phys. 2018 11 01; 102(3):635-641. Atwood TF, Brown DW, Murphy JD, Moore KL, Mundt AJ, Pawlicki T. PMID: 30244881.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    20. The impact of daily bladder filling on small bowel dose for intensity modulated radiation therapy for cervical cancer. Med Dosim. 2019 Summer; 44(2):102-106. Chen VE, Gillespie EF, Manger RP, Skerritt LA, Tran JH, Proudfoot JA, Sherer MV, Einck JP, Mell LK, Moore KL, Yashar CM. PMID: 29573921.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Using Big Data Analytics to Advance Precision Radiation Oncology. Int J Radiat Oncol Biol Phys. 2018 06 01; 101(2):285-291. McNutt TR, Benedict SH, Low DA, Moore K, Shpitser I, Jiang W, Lakshminarayanan P, Cheng Z, Han P, Hui X, Nakatsugawa M, Lee J, Moore JA, Robertson SP, Shah V, Taylor R, Quon H, Wong J, DeWeese T. PMID: 29726357.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Heuristic knowledge-based planning for single-isocenter stereotactic radiosurgery to multiple brain metastases. Med Phys. 2017 Oct; 44(10):5001-5009. Ziemer BP, Sanghvi P, Hattangadi-Gluth J, Moore KL. PMID: 28731267.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Care for Patients, Not for Charts: A Future for Clinical Medical Physics. Int J Radiat Oncol Biol Phys. 2018 01 01; 100(1):21-22. Atwood TF, Brown DW, Murphy JD, Moore KL, Mundt AJ, Pawlicki T. PMID: 29254774.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Feasibility of atlas-based active bone marrow sparing intensity modulated radiation therapy for cervical cancer. Radiother Oncol. 2017 05; 123(2):325-330. Li N, Noticewala SS, Williamson CW, Shen H, Sirak I, Tarnawski R, Mahantshetty U, Hoh CK, Moore KL, Mell LK. PMID: 28528206.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Fully automated, comprehensive knowledge-based planning for stereotactic radiosurgery: Preclinical validation through blinded physician review. Pract Radiat Oncol. 2017 Nov - Dec; 7(6):e569-e578. Ziemer BP, Shiraishi S, Hattangadi-Gluth JA, Sanghvi P, Moore KL. PMID: 28711334.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Medical Device Recalls in Radiation Oncology: Analysis of US Food and Drug Administration Data, 2002-2015. Int J Radiat Oncol Biol Phys. 2017 06 01; 98(2):438-446. Connor MJ, Tringale K, Moiseenko V, Marshall DC, Moore K, Cervino L, Atwood T, Brown D, Mundt AJ, Pawlicki T, Recht A, Hattangadi-Gluth JA. PMID: 28463163.
      View in: PubMed   Mentions: 3     Fields:    Translation:PHPublic Health
    27. Adverse Events Involving Radiation Oncology Medical Devices: Comprehensive Analysis of US Food and Drug Administration Data, 1991 to 2015. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):18-26. Connor MJ, Marshall DC, Moiseenko V, Moore K, Cervino L, Atwood T, Sanghvi P, Mundt AJ, Pawlicki T, Recht A, Hattangadi-Gluth JA. PMID: 27979446.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    28. Highly Efficient Training, Refinement, and Validation of a Knowledge-based Planning Quality-Control System for Radiation Therapy Clinical Trials. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):164-172. Li N, Carmona R, Sirak I, Kasaova L, Followill D, Michalski J, Bosch W, Straube W, Mell LK, Moore KL. PMID: 27979445.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    29. Overview of the American Society for Radiation Oncology-National Institutes of Health-American Association of Physicists in Medicine Workshop 2015: Exploring Opportunities for Radiation Oncology in the Era of Big Data. Int J Radiat Oncol Biol Phys. 2016 07 01; 95(3):873-879. Benedict SH, Hoffman K, Martel MK, Abernethy AP, Asher AL, Capala J, Chen RC, Chera B, Couch J, Deye J, Efstathiou JA, Ford E, Fraass BA, Gabriel PE, Huser V, Kavanagh BD, Khuntia D, Marks LB, Mayo C, McNutt T, Miller RS, Moore KL, Prior F, Roelofs E, Rosenstein BS, Sloan J, Theriault A, Vikram B. PMID: 27302503.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    30. Radiation sparing of cerebral cortex in brain tumor patients using quantitative neuroimaging. Radiother Oncol. 2016 Jan; 118(1):29-34. Karunamuni RA, Moore KL, Seibert TM, Li N, White NS, Bartsch H, Carmona R, Marshall D, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell LK, Brewer J, Dale AM, Moiseenko V, Hattangadi-Gluth JA. PMID: 26806266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    31. Knowledge-based prediction of three-dimensional dose distributions for external beam radiotherapy. Med Phys. 2016 Jan; 43(1):378. Shiraishi S, Moore KL. PMID: 26745931.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    32. Needs and Challenges for Big Data in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2016 Jul 01; 95(3):909-915. McNutt TR, Moore KL, Quon H. PMID: 27302506.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Quantifying Unnecessary Normal Tissue Complication Risks due to Suboptimal Planning: A Secondary Study of RTOG 0126. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):228-35. Moore KL, Schmidt R, Moiseenko V, Olsen LA, Tan J, Xiao Y, Galvin J, Pugh S, Seider MJ, Dicker AP, Bosch W, Michalski J, Mutic S. PMID: 25847605.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    34. Knowledge-based prediction of plan quality metrics in intracranial stereotactic radiosurgery. Med Phys. 2015 Feb; 42(2):908. Shiraishi S, Tan J, Olsen LA, Moore KL. PMID: 25652503.
      View in: PubMed   Mentions: 16     Fields:    
    35. Point/Counterpoint: Within the next ten years treatment planning will become fully automated without the need for human intervention. Med Phys. 2014 Dec; 41(12):120601. Sharpe MB, Moore KL, Orton CG. PMID: 25471945.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. Improving linear accelerator service response with a real- time electronic event reporting system. J Appl Clin Med Phys. 2014 Sep 08; 15(5):4807. Hoisak JD, Pawlicki T, Kim GY, Fletcher R, Moore KL. PMID: 25207564.
      View in: PubMed   Mentions:    Fields:    
    37. Vision 20/20: Automation and advanced computing in clinical radiation oncology. Med Phys. 2014 Jan; 41(1):010901. Moore KL, Kagadis GC, McNutt TR, Moiseenko V, Mutic S. PMID: 24387492.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Automated radiation therapy treatment plan workflow using a commercial application programming interface. Pract Radiat Oncol. 2014 Nov-Dec; 4(6):358-67. Olsen LA, Robinson CG, He GR, Wooten HO, Yaddanapudi S, Mutic S, Yang D, Moore KL. PMID: 25407855.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Automatic treatment plan re-optimization for adaptive radiotherapy guided with the initial plan DVHs. Phys Med Biol. 2013 Dec 21; 58(24):8725-38. Li N, Zarepisheh M, Uribe-Sanchez A, Moore K, Tian Z, Zhen X, Graves YJ, Gautier Q, Mell L, Zhou L, Jia X, Jiang S. PMID: 24301071.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Predicting dose-volume histograms for organs-at-risk in IMRT planning. Med Phys. 2012 Dec; 39(12):7446-61. Appenzoller LM, Michalski JM, Thorstad WL, Mutic S, Moore KL. PMID: 23231294.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansPHPublic Health
    41. Automated radiotherapy treatment plan integrity verification. Med Phys. 2012 Mar; 39(3):1542-51. Yang D, Moore KL. PMID: 22380386.
      View in: PubMed   Mentions: 5     Fields:    
    42. Quantitative metrics for assessing plan quality. Semin Radiat Oncol. 2012 Jan; 22(1):62-9. Moore KL, Brame RS, Low DA, Mutic S. PMID: 22177879.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Biomechanical interpretation of a free-breathing lung motion model. Phys Med Biol. 2011 Dec 07; 56(23):7523-40. Zhao T, White B, Moore KL, Lamb J, Yang D, Lu W, Mutic S, Low DA. PMID: 22079895.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    44. Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8628-33. Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM. PMID: 21555542.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem. 2011 Apr 15; 286(15):13060-70. Marcello MR, Jia W, Leary JA, Moore KL, Evans JP. PMID: 21339297.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    46. Experience-based quality control of clinical intensity-modulated radiotherapy planning. Int J Radiat Oncol Biol Phys. 2011 Oct 01; 81(2):545-51. Moore KL, Brame RS, Low DA, Mutic S. PMID: 21277097.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansPHPublic Health
    47. Fast, low-dose patient localization on TomoTherapy via topogram registration. Med Phys. 2010 Aug; 37(8):4068-77. Moore KL, Palaniswaamy G, White B, Goddu SM, Low DA. PMID: 20879568.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Cavity nonlinear optics at low photon numbers from collective atomic motion. Phys Rev Lett. 2007 Nov 23; 99(21):213601. Gupta S, Moore KL, Murch KW, Stamper-Kurn DM. PMID: 18233217.
      View in: PubMed   Mentions: 6     Fields:    
    49. Probing the quantum state of a guided atom laser pulse. Phys Rev Lett. 2006 Nov 03; 97(18):180410. Moore KL, Gupta S, Murch KW, Stamper-Kurn DM. PMID: 17155527.
      View in: PubMed   Mentions:    Fields:    
    50. Dispersion management using betatron resonances in an ultracold-atom storage ring. Phys Rev Lett. 2006 Jan 13; 96(1):013202. Murch KW, Moore KL, Gupta S, Stamper-Kurn DM. PMID: 16486451.
      View in: PubMed   Mentions:    Fields:    
    51. Bose-Einstein condensation in a circular waveguide. Phys Rev Lett. 2005 Sep 30; 95(14):143201. Gupta S, Murch KW, Moore KL, Purdy TP, Stamper-Kurn DM. PMID: 16241650.
      View in: PubMed   Mentions: 4     Fields:    
    52. Direct nondestructive imaging of magnetization in a spin-1 Bose-Einstein gas. Phys Rev Lett. 2005 Jul 29; 95(5):050401. Higbie JM, Sadler LE, Inouye S, Chikkatur AP, Leslie SR, Moore KL, Savalli V, Stamper-Kurn DM. PMID: 16090852.
      View in: PubMed   Mentions: 2     Fields:    
    53. Probing nonequilibrium electron distributions in gold by use of second-harmonic generation. Opt Lett. 1999 Jul 15; 24(14):990-2. Moore KL, Donnelly TD. PMID: 18073919.
      View in: PubMed   Mentions:    Fields:    
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