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Kevin Bush

TitleProject Scientist
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0693
La Jolla CA 92093
Phone858-822-3478
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bush K, Boichard A, Tsigelny IF. In Vitro Elucidation of Drug Combination Synergy in Treatment of Pancreatic Ductal Adenocarcinoma. Anticancer Res. 2018 04; 38(4):1967-1977. PMID: 29599312.
      View in: PubMed
    2. Bush K, Wu W, Lun C, Nigam SK. The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis. J Biol Chem. 2017 09 22; 292(38):15789-15803. PMID: 28765282.
      View in: PubMed
    3. Wu W, Bush K, Nigam SK. Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Sci Rep. 2017 Jul 10; 7(1):4939. PMID: 28694431.
      View in: PubMed
    4. Liu HC, Goldenberg A, Chen Y, Lun C, Wu W, Bush K, Balac N, Rodriguez P, Abagyan R, Nigam SK. Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach. J Pharmacol Exp Ther. 2016 10; 359(1):215-29. PMID: 27488918.
      View in: PubMed
    5. Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush K, Abagyan R, Palsson BO, Nigam SK. An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network. J Biol Chem. 2016 09 09; 291(37):19474-86. PMID: 27440044; PMCID: PMC5016685 [Available on 09/09/17].
    6. Martovetsky G, Bush K, Nigam SK. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers. Drug Metab Dispos. 2016 07; 44(7):1050-60. PMID: 27044799.
      View in: PubMed
    7. Kumar N, Richter J, Cutts J, Bush K, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 2015 Nov 10; 4. PMID: 26554899; PMCID: PMC4631902.
    8. Zhu C, Nigam KB, Date RC, Bush K, Springer SA, Saier MH, Wu W, Nigam SK. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. PMID: 26536134.
      View in: PubMed
    9. Nigam SK, Wu W, Bush K, Hoenig MP, Blantz RC, Bhatnagar V. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):2039-49. PMID: 26490509; PMCID: PMC4633783.
    10. Wu W, Bush K, Liu HC, Zhu C, Abagyan R, Nigam SK. Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors. Drug Metab Dispos. 2015 Dec; 43(12):1855-63. PMID: 26358290; PMCID: PMC4658493 [Available on 12/01/16].
    11. Nigam SK, Bush K, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev. 2015 Jan; 95(1):83-123. PMID: 25540139; PMCID: PMC4281586.
    12. Bush K, Martovetsky G, Nigam SK. Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease. Curr Opin Organ Transplant. 2014 Apr; 19(2):153-61. PMID: 24503495.
      View in: PubMed
    13. Nigam SK, Bush K. Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis. Pediatr Nephrol. 2014 Apr; 29(4):727-35. PMID: 24488503.
      View in: PubMed
    14. Wu W, Jamshidi N, Eraly SA, Liu HC, Bush K, Palsson BO, Nigam SK. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos. 2013 Oct; 41(10):1825-34. PMID: 23920220; PMCID: PMC3781372.
    15. Tee JB, Choi Y, Dnyanmote A, Decambre M, Ito C, Bush K, Nigam SK. GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biol Open. 2013; 2(9):952-9. PMID: 24143282; PMCID: PMC3773342.
    16. Bush K, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 07; 287(50):42064-70. PMID: 23060443; PMCID: PMC3516752.
    17. Gallegos TF, Martovetsky G, Kouznetsova V, Bush K, Nigam SK. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One. 2012; 7(7):e40796. PMID: 22808265; PMCID: PMC3396597.
    18. Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush K, Willert K, Farquhar MG, Nigam SK. A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol. 2012 Apr 01; 364(1):11-21. PMID: 22290330; PMCID: PMC3310225.
    19. Zhang X, Bush K, Nigam SK. In vitro culture of embryonic kidney rudiments and isolated ureteric buds. Methods Mol Biol. 2012; 886:13-21. PMID: 22639247.
      View in: PubMed
    20. Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush K, Gallegos TF, Sweet DH, Palsson BØ, Nigam SK. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J Biol Chem. 2011 Sep 09; 286(36):31522-31. PMID: 21757732; PMCID: PMC3173137.
    21. Torres AM, Dnyanmote AV, Bush K, Wu W, Nigam SK. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem. 2011 Jul 29; 286(30):26391-5. PMID: 21652719; PMCID: PMC3143602.
    22. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush K, Esko JD, Nigam SK. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 01; 356(1):19-27. PMID: 21600196; PMCID: PMC3130836.
    23. Garner OB, Bush K, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011 Jul 15; 355(2):394-403. PMID: 21586278; PMCID: PMC3118867.
    24. Tee JB, Choi Y, Shah MM, Dnyanmote A, Sweeney DE, Gallegos TF, Johkura K, Ito C, Bush K, Nigam SK. Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2010 Nov 15; 347(2):337-47. PMID: 20816800; PMCID: PMC2981800.
    25. Rosines E, Johkura K, Zhang X, Schmidt HJ, Decambre M, Bush K, Nigam SK. Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A. 2010 Aug; 16(8):2441-55. PMID: 20214453; PMCID: PMC2947461.
    26. Crawford BE, Garner OB, Bishop JR, Zhang DY, Bush K, Nigam SK, Esko JD. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One. 2010 May 18; 5(5):e10691. PMID: 20502530; PMCID: PMC2872662.
    27. Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush K, Esko JD, Nigam SK. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol. 2010 Mar 15; 339(2):354-65. PMID: 20059993; PMCID: PMC2834281.
    28. Choi Y, Tee JB, Gallegos TF, Shah MM, Oishi H, Sakurai H, Kitamura S, Wu W, Bush K, Nigam SK. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development. 2009 Dec; 136(24):4213-24. PMID: 19934016; PMCID: PMC2781055.
    29. Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush K, Sakurai H, Nigam SK. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1330-41. PMID: 19726549; PMCID: PMC2781331.
    30. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush K, Vera DR, Ross RS, Nigam SK. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. PMID: 19439520; PMCID: PMC2711709.
    31. Wu W, Baker ME, Eraly SA, Bush K, Nigam SK. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics. 2009 Jul 09; 38(2):116-24. PMID: 19417012; PMCID: PMC2712220.
    32. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush K, Nigam SK. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008 Dec 09; 1(49):ra16. PMID: 19066399; PMCID: PMC3016920.
    33. Nigam SK, Wu W, Bush K. Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology. Organogenesis. 2008 Jul; 4(3):137-43. PMID: 19279725; PMCID: PMC2634587.
    34. Nigam SK, Bush K, Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007 Aug; 3(8):443-8. PMID: 17653123.
      View in: PubMed
    35. Monte JC, Sakurai H, Bush K, Nigam SK. The developmental nephrome: systems biology in the developing kidney. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):3-9. PMID: 17143064.
      View in: PubMed
    36. Meyer TN, Schwesinger C, Sampogna RV, Vaughn DA, Stuart RO, Steer DL, Bush K, Nigam SK. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation. 2006 Dec; 74(9-10):638-47. PMID: 17177859.
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    37. Bush K, Vaughn DA, Li X, Rosenfeld MG, Rose DW, Mendoza SA, Nigam SK. Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Dev Biol. 2006 Oct 15; 298(2):571-84. PMID: 16934795.
      View in: PubMed
    38. Sakurai H, Bush K, Nigam SK. Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. J Biol Chem. 2005 Dec 23; 280(51):42181-7. PMID: 16183643.
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    39. Meyer TN, Schwesinger C, Bush K, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol. 2004 Nov 01; 275(1):44-67. PMID: 15464572.
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    40. George SK, Meyer TN, Abdeen O, Bush K, Nigam SK. Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):223-31. PMID: 15313195.
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    41. Steer DL, Shah MM, Bush K, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004 Aug 15; 272(2):310-27. PMID: 15282150.
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    42. Shah MM, Sampogna RV, Sakurai H, Bush K, Nigam SK. Branching morphogenesis and kidney disease. Development. 2004 Apr; 131(7):1449-62. PMID: 15023929.
      View in: PubMed
    43. Eraly SA, Bush K, Sampogna RV, Bhatnagar V, Nigam SK. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 2004 Mar; 65(3):479-87. PMID: 14978224.
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    44. Bush K, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol. 2004 Feb 15; 266(2):285-98. PMID: 14738877.
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    45. Stuart RO, Bush K, Nigam SK. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney Int. 2003 Dec; 64(6):1997-2008. PMID: 14633122.
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    46. Li X, Oghi KA, Zhang J, Krones A, Bush K, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20; 426(6964):247-54. PMID: 14628042.
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    47. Steer DL, Bush K, Meyer TN, Schwesinger C, Nigam SK. A strategy for in vitro propagation of rat nephrons. Kidney Int. 2002 Dec; 62(6):1958-65. PMID: 12427120.
      View in: PubMed
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