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    Kelly Doran

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0687
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Development of a Probiotic Therapy for Limiting Group B Streptococcal Vaginal Carriage
      NIH/NIAID R03AI123877Feb 10, 2016 - Jan 31, 2018
      Role: Principal Investigator
      Blood-Brain Barrier failure during bacterial meningitis
      NIH/NINDS R56NS051247Jul 13, 2006 - Jul 31, 2018
      Role: Principal Investigator
      Blood-brain barrier in bacterial meningitis
      NIH/NINDS R01NS051247Apr 1, 2005 - Mar 31, 2016
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran K, Abrink M, Pejler G, Rajagopal L, Piliponsky AM. Mast Cell Chymase Decreases The Severity Of Group B Streptococcus Infections. J Allergy Clin Immunol. 2017 Sep 12. PMID: 28916188.
        View in: PubMed
      2. Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran K, Nizet V, Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem. 2017 Jul 07; 292(27):11243-11249. PMID: 28416607.
        View in: PubMed
      3. Lozano-Pope I, Sharma A, Matthias M, Doran K, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017 Feb 15; 17(1):133. PMID: 28201999.
        View in: PubMed
      4. Hancock BM, Doran K. Importance of strain lineages for Group B streptococcal survival. Virulence. 2016 Dec 29; 1-3. PMID: 28033037.
        View in: PubMed
      5. Patras KA, Doran K. A Murine Model of Group B Streptococcus Vaginal Colonization. J Vis Exp. 2016 Nov 16; (117). PMID: 27911391.
        View in: PubMed
      6. Mu R, Cutting AS, Del Rosario Y, Villarino N, Stewart L, Weston TA, Patras KA, Doran K. Identification of CiaR Regulated Genes That Promote Group B Streptococcal Virulence and Interaction with Brain Endothelial Cells. PLoS One. 2016; 11(4):e0153891. PMID: 27100296; PMCID: PMC4839699.
      7. Patras KA, Wescombe PA, Rösler B, Hale JD, Tagg JR, Doran K. Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization. Infect Immun. 2015 Sep; 83(9):3438-44. PMID: 26077762; PMCID: PMC4534663.
      8. Stoner TD, Weston TA, Trejo J, Doran K. Group B streptococcal infection and activation of human astrocytes. PLoS One. 2015; 10(6):e0128431. PMID: 26030618; PMCID: PMC4452173.
      9. Kim BJ, Hancock BM, Bermudez A, Del Cid N, Reyes E, van Sorge NM, Lauth X, Smurthwaite CA, Hilton BJ, Stotland A, Banerjee A, Buchanan J, Wolkowicz R, Traver D, Doran K. Bacterial induction of Snail1 contributes to blood-brain barrier disruption. J Clin Invest. 2015 Jun; 125(6):2473-83. PMID: 25961453; PMCID: PMC4497739.
      10. Kim BJ, Hancock BM, Del Cid N, Bermudez A, Traver D, Doran K. Streptococcus agalactiae infection in zebrafish larvae. Microb Pathog. 2015 Feb; 79:57-60. PMID: 25617657; PMCID: PMC4340774.
      11. Gendrin C, Lembo A, Whidbey C, Burnside K, Berry J, Ngo L, Banerjee A, Xue L, Arrington J, Doran K, Tao WA, Rajagopal L. The sensor histidine kinase RgfC affects group B streptococcal virulence factor expression independent of its response regulator RgfA. Infect Immun. 2015 Mar; 83(3):1078-88. PMID: 25561709; PMCID: PMC4333453.
      12. Cutting AS, Del Rosario Y, Mu R, Rodriguez A, Till A, Subramani S, Gottlieb RA, Doran K. The role of autophagy during group B Streptococcus infection of blood-brain barrier endothelium. J Biol Chem. 2014 Dec 26; 289(52):35711-23. PMID: 25371213; PMCID: PMC4276841.
      13. Faralla C, Metruccio MM, De Chiara M, Mu R, Patras KA, Muzzi A, Grandi G, Margarit I, Doran K, Janulczyk R. Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness. MBio. 2014 May 20; 5(3):e00870-14. PMID: 24846378; PMCID: PMC4030450.
      14. Mu R, Kim BJ, Paco C, Del Rosario Y, Courtney HS, Doran K. Identification of a group B streptococcal fibronectin binding protein, SfbA, that contributes to invasion of brain endothelium and development of meningitis. Infect Immun. 2014 Jun; 82(6):2276-86. PMID: 24643538; PMCID: PMC4019170.
      15. Wang NY, Patras KA, Seo HS, Cavaco CK, Rösler B, Neely MN, Sullam PM, Doran K. Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization. J Infect Dis. 2014 Sep 15; 210(6):982-91. PMID: 24620021; PMCID: PMC4192050.
      16. Seo HS, Minasov G, Seepersaud R, Doran K, Dubrovska I, Shuvalova L, Anderson WF, Iverson TM, Sullam PM. Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. J Biol Chem. 2013 Dec 13; 288(50):35982-96. PMID: 24165132; PMCID: PMC3861647.
      17. Banerjee A, Thamphiwatana S, Carmona EM, Rickman B, Doran K, Obonyo M. Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Infect Immun. 2014 Jan; 82(1):356-63. PMID: 24166959; PMCID: PMC3911874.
      18. Cavaco CK, Patras KA, Zlamal JE, Thoman ML, Morgan EL, Sanderson SD, Doran K. A novel C5a-derived immunobiotic peptide reduces Streptococcus agalactiae colonization through targeted bacterial killing. Antimicrob Agents Chemother. 2013 Nov; 57(11):5492-9. PMID: 23979760; PMCID: PMC3811312.
      19. Doran K, Banerjee A, Disson O, Lecuit M. Concepts and mechanisms: crossing host barriers. Cold Spring Harb Perspect Med. 2013 Jul 01; 3(7). PMID: 23818514; PMCID: PMC3685877.
      20. Seo HS, Mu R, Kim BJ, Doran K, Sullam PM. Binding of glycoprotein Srr1 of Streptococcus agalactiae to fibrinogen promotes attachment to brain endothelium and the development of meningitis. PLoS Pathog. 2012; 8(10):e1002947. PMID: 23055927; PMCID: PMC3464228.
      21. Alkuwaity K, Taylor A, Heckels JE, Doran K, Christodoulides M. Group B Streptococcus interactions with human meningeal cells and astrocytes in vitro. PLoS One. 2012; 7(8):e42660. PMID: 22900037; PMCID: PMC3416839.
      22. van Sorge NM, Doran K. Defense at the border: the blood-brain barrier versus bacterial foreigners. Future Microbiol. 2012 Mar; 7(3):383-94. PMID: 22393891; PMCID: PMC3589978.
      23. Burnside K, Lembo A, Harrell MI, Gurney M, Xue L, BinhTran NT, Connelly JE, Jewell KA, Schmidt BZ, de los Reyes M, Tao WA, Doran K, Rajagopal L. Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of group B Streptococcus. J Biol Chem. 2011 Dec 23; 286(51):44197-210. PMID: 22081606; PMCID: PMC3243546.
      24. Sheen TR, Jimenez A, Wang NY, Banerjee A, van Sorge NM, Doran K. Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract. J Bacteriol. 2011 Dec; 193(24):6834-42. PMID: 21984789; PMCID: PMC3232834.
      25. Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran K. Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration. Nat Commun. 2011 Sep 06; 2:462. PMID: 21897373; PMCID: PMC3195231.
      26. Ebrahimi CM, Sheen TR, Renken CW, Gottlieb RA, Doran K. Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis. Infect Immun. 2011 Jul; 79(7):2510-8. PMID: 21518787; PMCID: PMC3191953.
      27. van Sorge NM, Zialcita PA, Browne SH, Quach D, Guiney DG, Doran K. Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium. J Infect Dis. 2011 Feb 01; 203(3):401-5. PMID: 21186258; PMCID: PMC3071103.
      28. Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran K, Sussman MA, Whitton JL, Feuer R. A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. J Neurosci. 2010 Jun 23; 30(25):8676-91. PMID: 20573913; PMCID: PMC2902258.
      29. Banerjee A, Van Sorge NM, Sheen TR, Uchiyama S, Mitchell TJ, Doran K. Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization. Cell Microbiol. 2010 Nov; 12(11):1576-88. PMID: 20557315; PMCID: PMC2943548.
      30. Lembo A, Gurney MA, Burnside K, Banerjee A, de los Reyes M, Connelly JE, Lin WJ, Jewell KA, Vo A, Renken CW, Doran K, Rajagopal L. Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration. Mol Microbiol. 2010 Jul; 77(2):431-43. PMID: 20497331; PMCID: PMC2909351.
      31. Sheen TR, Ebrahimi CM, Hiemstra IH, Barlow SB, Peschel A, Doran K. Penetration of the blood-brain barrier by Staphylococcus aureus: contribution of membrane-anchored lipoteichoic acid. J Mol Med (Berl). 2010 Jun; 88(6):633-9. PMID: 20419283; PMCID: PMC2893325.
      32. Ebrahimi CM, Kern JW, Sheen TR, Ebrahimi-Fardooee MA, van Sorge NM, Schneewind O, Doran K. Penetration of the blood-brain barrier by Bacillus anthracis requires the pXO1-encoded BslA protein. J Bacteriol. 2009 Dec; 191(23):7165-73. PMID: 19820089; PMCID: PMC2786561.
      33. Uchiyama S, Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran K, Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J Exp Med. 2009 Aug 31; 206(9):1845-52. PMID: 19687228; PMCID: PMC2737157.
      34. van Sorge NM, Quach D, Gurney MA, Sullam PM, Nizet V, Doran K. The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier. J Infect Dis. 2009 May 15; 199(10):1479-87. PMID: 19392623; PMCID: PMC2674616.
      35. Quach D, van Sorge NM, Kristian SA, Bryan JD, Shelver DW, Doran K. The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses. J Bacteriol. 2009 Apr; 191(7):2023-32. PMID: 19114476; PMCID: PMC2655536.
      36. Maisey HC, Doran K, Nizet V. Recent advances in understanding the molecular basis of group B Streptococcus virulence. Expert Rev Mol Med. 2008 Sep 22; 10:e27. PMID: 18803886; PMCID: PMC2676346.
      37. van Sorge NM, Ebrahimi CM, McGillivray SM, Quach D, Sabet M, Guiney DG, Doran K. Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis. PLoS One. 2008 Aug 13; 3(8):e2964. PMID: 18698416; PMCID: PMC2493037.
      38. Kaplan A, Chung K, Kocak H, Bertolotto C, Uh A, Hobel CJ, Simmons CF, Doran K, Liu GY, Equils O. Group B streptococcus induces trophoblast death. Microb Pathog. 2008 Sep; 45(3):231-5. PMID: 18599257; PMCID: PMC2610016.
      39. Maisey HC, Quach D, Hensler ME, Liu GY, Gallo RL, Nizet V, Doran K. A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J. 2008 Jun; 22(6):1715-24. PMID: 18198218; PMCID: PMC2721339.
      40. Hensler ME, Quach D, Hsieh CJ, Doran K, Nizet V. CAMP factor is not essential for systemic virulence of Group B Streptococcus. Microb Pathog. 2008 Jan; 44(1):84-8. PMID: 17870297; PMCID: PMC2247369.
      41. Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran K, Kotb M, Nizet V. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus. J Bacteriol. 2007 Feb; 189(4):1322-9. PMID: 17114267; PMCID: PMC1797346.
      42. Maisey HC, Hensler M, Nizet V, Doran K. Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells. J Bacteriol. 2007 Feb; 189(4):1464-7. PMID: 17041051; PMCID: PMC1797338.
      43. Doran K, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V. Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J Clin Invest. 2005 Sep; 115(9):2499-507. PMID: 16138192; PMCID: PMC1193870.
      44. Doran K, Nizet V. Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy. Mol Microbiol. 2004 Oct; 54(1):23-31. PMID: 15458402.
        View in: PubMed
      45. Liu GY, Doran K, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V. Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14491-6. PMID: 15381763; PMCID: PMC521972.
      46. Doran K, Liu GY, Nizet V. Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest. 2003 Sep; 112(5):736-44. PMID: 12952922; PMCID: PMC182187.
      47. Doran K, Benoit VM, Gertz RE, Beall B, Nizet V. Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis. J Perinatol. 2002 Jun; 22(4):326-30. PMID: 12032798.
        View in: PubMed
      48. Doran K, Chang JC, Benoit VM, Eckmann L, Nizet V. Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8. J Infect Dis. 2002 Jan 15; 185(2):196-203. PMID: 11807693.
        View in: PubMed
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