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Karen Klein

TitleAssociate Physician Diplomate
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0984
La Jolla CA 92093
Phone858-966-4032
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Klein K, Dragnic S, Soliman AM, Bacher P. Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate. J Pediatr Endocrinol Metab. 2018 May 11. PMID: 29750651.
      View in: PubMed
    2. Williams VSL, Soliman AM, Barrett AM, Klein K. Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty. J Pediatr Endocrinol Metab. 2018 Apr 25; 31(5):485-495. PMID: 29649000.
      View in: PubMed
    3. Klein K, Lee PA. Gonadotropin-Releasing Hormone (GnRHa) Therapy for Central Precocious Puberty (CPP): Review of Nuances in Assessment of Height, Hormonal Suppression, Psychosocial Issues, and Weight Gain, with Patient Examples. Pediatr Endocrinol Rev. 2018 Apr; 15(4):298-312. PMID: 29806750.
      View in: PubMed
    4. Klein K, Rosenfield R, Santen RJ, Gawlik A, Backeljauw P, Gravholt CH, Sas T, Mauras N. Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations. J Clin Endocrinol Metab. 2018 Feb 08. PMID: 29438552.
      View in: PubMed
    5. Gravholt CH, Andersen NH, Conway GS, Dekkers OM, Geffner ME, Klein K, Lin AE, Mauras N, Quigley CA, Rubin K, Sandberg DE, Sas TCJ, Silberbach M, Söderström-Anttila V, Stochholm K, van Alfen-van derVelden JA, Woelfle J, Backeljauw PF. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Eur J Endocrinol. 2017 09; 177(3):G1-G70. PMID: 28705803.
      View in: PubMed
    6. Klein K, Yang J, Aisenberg J, Wright N, Kaplowitz P, Lahlou N, Linares J, Lundström E, Purcea D, Cassorla F. Efficacy and safety of triptorelin 6-month formulation in patients with central precocious puberty. J Pediatr Endocrinol Metab. 2016 Nov 01; 29(11):1241-1248. PMID: 26887034.
      View in: PubMed
    7. Klein K, Newfield RS, Hassink SG. Bone maturation along the spectrum from normal weight to obesity: a complex interplay of sex, growth factors and weight gain. J Pediatr Endocrinol Metab. 2016 Mar; 29(3):311-8. PMID: 26565541.
      View in: PubMed
    8. Pereira A, Corvalán C, Uauy R, Klein K, Mericq V. Ultrasensitive estrogen levels at 7 years of age predict earlier thelarche: evidence from girls of the growth and obesity Chilean cohort. Eur J Endocrinol. 2015 Dec; 173(6):835-42. PMID: 26369578.
      View in: PubMed
    9. Al-Zubeidi H, Klein K. Randomized clinical trial evaluating metformin versus oral contraceptive pills in the treatment of adolescents with polycystic ovarian syndrome. J Pediatr Endocrinol Metab. 2015 Jul; 28(7-8):853-8. PMID: 25781525.
      View in: PubMed
    10. Klein K. Is there a role for estrogen activity assays? Recombinant cell bioassay for estrogen: Development and applications. Steroids. 2015 Jul; 99(Pt A):108-12. PMID: 25159103.
      View in: PubMed
    11. Kletter GB, Klein K, Wong YY. A pediatrician's guide to central precocious puberty. Clin Pediatr (Phila). 2015 May; 54(5):414-24. PMID: 25022947.
      View in: PubMed
    12. Lee PA, Klein K, Mauras N, Lev-Vaisler T, Bacher P. 36-month treatment experience of two doses of leuprolide acetate 3-month depot for children with central precocious puberty. J Clin Endocrinol Metab. 2014 Sep; 99(9):3153-9. PMID: 24926950.
      View in: PubMed
    13. Lee PA, Klein K, Mauras N, Neely EK, Bloch CA, Larsen L, Mattia-Goldberg C, Chwalisz K. Efficacy and safety of leuprolide acetate 3-month depot 11.25 milligrams or 30 milligrams for the treatment of central precocious puberty. J Clin Endocrinol Metab. 2012 May; 97(5):1572-80. PMID: 22344198.
      View in: PubMed
    14. Taboada M, Santen R, Lima J, Hossain J, Singh R, Klein K, Mauras N. Pharmacokinetics and pharmacodynamics of oral and transdermal 17ß estradiol in girls with Turner syndrome. J Clin Endocrinol Metab. 2011 Nov; 96(11):3502-10. PMID: 21880799; PMCID: PMC3205885.
    15. Cohen D, Janfaza M, Klein K. Importance of leuprolide acetate variable dosing for precocious puberty: a range of acceptable suppression. J Pediatr Endocrinol Metab. 2009 Jul; 22(7):629-34. PMID: 19774844.
      View in: PubMed
    16. Mericq V, Lammoglia JJ, Unanue N, Villaroel C, Hernández MI, Avila A, Iñiguez G, Klein K. Comparison of three doses of leuprolide acetate in the treatment of central precocious puberty: preliminary results. Clin Endocrinol (Oxf). 2009 Nov; 71(5):686-90. PMID: 19302581.
      View in: PubMed
    17. Yeboah J, Klein K, Brosnihan B, Reboussin D, Herrington DM. Effects of hormone therapy on soluble cell adhesion molecules in postmenopausal women with coronary artery disease. Menopause. 2008 Nov-Dec; 15(6):1060-4. PMID: 18521047.
      View in: PubMed
    18. Mauras N, Gonzalez de Pijem L, Hsiang HY, Desrosiers P, Rapaport R, Schwartz ID, Klein K, Singh RJ, Miyamoto A, Bishop K. Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebo-controlled, multicenter trial for one to three years. J Clin Endocrinol Metab. 2008 Mar; 93(3):823-31. PMID: 18165285; PMCID: PMC2266949.
    19. Kunz GJ, Sherman TI, Klein K. Luteinizing hormone (LH) and estradiol suppression and growth in girls with central precocious puberty: is more suppression better? Are pre-injection LH levels useful in monitoring treatment? J Pediatr Endocrinol Metab. 2007 Nov; 20(11):1189-98. PMID: 18183790.
      View in: PubMed
    20. Janfaza M, Sherman TI, Larmore KA, Brown-Dawson J, Klein K. Estradiol levels and secretory dynamics in normal girls and boys as determined by an ultrasensitive bioassay: a 10 year experience. J Pediatr Endocrinol Metab. 2006 Jul; 19(7):901-9. PMID: 16995570.
      View in: PubMed
    21. Badaru A, Wilson DM, Bachrach LK, Fechner P, Gandrud LM, Durham E, Wintergerst K, Chi C, Klein K, Neely EK. Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty. J Clin Endocrinol Metab. 2006 May; 91(5):1862-7. PMID: 16449344.
      View in: PubMed
    22. Mauras N, Welch S, Rini A, Klein K. An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys. J Pediatr Endocrinol Metab. 2004 Dec; 17(12):1597-606. PMID: 15645693.
      View in: PubMed
    23. Kunz GJ, Klein K, Clemons RD, Gottschalk ME, Jones KL. Virilization of young children after topical androgen use by their parents. Pediatrics. 2004 Jul; 114(1):282-4. PMID: 15231947.
      View in: PubMed
    24. Wilson CA, Heinrichs C, Larmore KA, Craen M, Brown-Dawson J, Shaywitz S, Ross J, Klein K. Estradiol levels in girls with Turner's syndrome compared to normal prepubertal girls as determined by an ultrasensitive assay. J Pediatr Endocrinol Metab. 2003 Jan; 16(1):91-6. PMID: 12585345.
      View in: PubMed
    25. Santen RJ, Pinkerton JV, Conaway M, Ropka M, Wisniewski L, Demers L, Klein K. Treatment of urogenital atrophy with low-dose estradiol: preliminary results. Menopause. 2002 May-Jun; 9(3):179-87. PMID: 11973441.
      View in: PubMed
    26. Larmore KA, O'Connor D, Sherman TI, Funanage VL, Hassink SG, Klein K. Leptin and estradiol as related to change in pubertal status and body weight. Med Sci Monit. 2002 Mar; 8(3):CR206-10. PMID: 11889458.
      View in: PubMed