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    Kang Zhang

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentOphthalmology
    Address9500 Gilman Drive #0946
    CA La Jolla 92093
    Phone858-246-0814
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      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Mechanism and Therapy for Ocular Melanoma
      NIH/NCI R01CA217642Mar 14, 2017 - Feb 28, 2022
      Role: Principal Investigator
      Non-coding Variants Predisposing to Age-related Macular Degeneration
      NIH/NHGRI R01HG008135Aug 24, 2015 - Jun 30, 2018
      Role: Principal Investigator
      Limbal Stem Cell Fate and Corneal Specific Enhancers
      NIH/NEI R01EY025090Apr 1, 2015 - Mar 31, 2020
      Role: Principal Investigator
      Biomaterial enhancement of stem cell transplant efficacy for macular degeneration
      NIH/NEI R01EY024134Feb 1, 2014 - Jan 31, 2017
      Role: Principal Investigator
      HTRA1 and Age-Related Macular Degeneration
      VA I01BX001898Oct 1, 2013 - Sep 30, 2017
      Role: Principal Investigator
      Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
      NIH/NEI R01EY021374Sep 30, 2010 - Aug 31, 2015
      Role: Principal Investigator
      Genetic Susceptibility for Development of Proliferative Diabetic Retinopathy
      NIH/NEI R01EY019270Sep 1, 2009 - May 31, 2012
      Role: Principal Investigator
      Genetics and Functional Studies of Age-Related Macular Degeneration
      NIH/NEI R01EY018660Sep 30, 2008 - Jul 31, 2014
      Role: Principal Investigator
      GENETICS OF MACULAR DEGENERATION
      NIH/NEI R01EY014448Sep 1, 2003 - Jun 30, 2009
      Role: Principal Investigator
      ELOVL4 and Retinal Disease
      NIH/NEI R01EY014428May 1, 2002 - Apr 30, 2013
      Role: Principal Investigator
      CLONING OF A GENE FOR DOMINANT STARGARDT'S DISEASE
      NIH/NEI K23EY000401Aug 1, 1999 - Jul 31, 2004
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):7414-7419. PMID: 28652331.
        View in: PubMed
      2. Xiao S, Lu J, Sridhar B, Cao X, Yu P, Zhao T, Chen CC, McDee D, Sloofman L, Wang Y, Rivas-Astroza M, Telugu BP, Levasseur D, Zhang K, Liang H, Zhao JC, Tanaka TS, Stormo G, Zhong S. SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination. Cell Rep. 2017 Mar 28; 18(13):3117-3128. PMID: 28355564.
        View in: PubMed
      3. Guo S, Diep D, Plongthongkum N, Fung HL, Zhang K, Zhang K. Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet. 2017 Apr; 49(4):635-642. PMID: 28263317.
        View in: PubMed
      4. Zhu W, Qu X, Zhu J, Ma X, Patel S, Liu J, Wang P, Lai CS, Gou M, Xu Y, Zhang K, Chen S. Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials. 2017 Apr; 124:106-115. PMID: 28192772.
        View in: PubMed
      5. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1643-1648. PMID: 28130546.
        View in: PubMed
      6. Nguyen TC, Cao X, Yu P, Xiao S, Lu J, Biase FH, Sridhar B, Huang N, Zhang K, Zhong S. Mapping RNA-RNA interactome and RNA structure in vivo by MARIO. Nat Commun. 2016 Jun 24; 7:12023. PMID: 27338251; PMCID: PMC4931010.
      7. Luk BT, Fang RH, Hu CM, Copp JA, Thamphiwatana S, Dehaini D, Gao W, Zhang K, Li S, Zhang L. Safe and Immunocompatible Nanocarriers Cloaked in RBC Membranes for Drug Delivery to Treat Solid Tumors. Theranostics. 2016; 6(7):1004-11. PMID: 27217833; PMCID: PMC4876624.
      8. Zhu W, Ma X, Gou M, Mei D, Zhang K, Chen S. 3D printing of functional biomaterials for tissue engineering. Curr Opin Biotechnol. 2016 Aug; 40:103-112. PMID: 27043763.
        View in: PubMed
      9. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79. PMID: 27018473; PMCID: PMC4833290 [Available on 10/07/16].
      10. Hodgson N, Wu F, Zhu J, Wang W, Ferreyra H, Zhang K, Wang J. Economic and Quality of Life Benefits of Anti-VEGF Therapy. Mol Pharm. 2016 Sep 06; 13(9):2877-80. PMID: 26836112.
        View in: PubMed
      11. Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14670-5. PMID: 26554006; PMCID: PMC4664371.
      12. Wu F, Wang S, Zhu J, Rutgard J, Yan YB, Zhang K, Zhao L. Public impact, prevention, and treatment of cataracts. Sci China Life Sci. 2015 Nov; 58(11):1157-9. PMID: 26423568.
        View in: PubMed
      13. Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21. PMID: 26374997; PMCID: PMC4871317.
      14. Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015 Sep 17; 59(6):931-40. PMID: 26365380; PMCID: PMC4648709.
      15. Liu Y, Wu F, Lu L, Lin D, Zhang K. VIDEOS IN CLINICAL MEDICINE. Examination of the Retina. N Engl J Med. 2015 Aug 20; 373(8):e9. PMID: 26287871.
        View in: PubMed
      16. Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Jefferson J, Perry P, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K. Lanosterol reverses protein aggregation in cataracts. Nature. 2015 Jul 30; 523(7562):607-11. PMID: 26200341.
        View in: PubMed
      17. Huu VA, Luo J, Zhu J, Zhu J, Patel S, Boone A, Mahmoud E, McFearin C, Olejniczak J, de Gracia Lux C, Lux J, Fomina N, Huynh M, Zhang K, Almutairi A. Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye. J Control Release. 2015 Feb 28; 200:71-7. PMID: 25571784; PMCID: PMC4384820.
      18. Lyubasyuk V, Ouyang H, Yu FX, Guan KL, Zhang K. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e970957. PMID: 27308390; PMCID: PMC4905245.
      19. Zhang T, Xie X, Cao G, Jiang H, Wu S, Su Z, Zhang K, Lu F. Malattia leventinese/Doyne honeycomb retinal dystrophy in a chinese family with mutation of the EFEMP1 gene. Retina. 2014 Dec; 34(12):2462-71. PMID: 25111685.
        View in: PubMed
      20. Mistry DS, Chen Y, Wang Y, Zhang K, Sen GL. SNAI2 controls the undifferentiated state of human epidermal progenitor cells. Stem Cells. 2014 Dec; 32(12):3209-18. PMID: 25100569; PMCID: PMC4339269.
      21. Nittala MG, Keane PA, Zhang K, Sadda SR. Risk factors for proliferative diabetic retinopathy in a Latino American population. Retina. 2014 Aug; 34(8):1594-9. PMID: 24662751; PMCID: PMC4110161.
      22. Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Yeh E, Lin J, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature. 2014 Jul 17; 511(7509):358-61. PMID: 25030175; PMCID: PMC4610745.
      23. Yu FX, Zhang K, Guan KL. YAP as oncotarget in uveal melanoma. Oncoscience. 2014; 1(7):480-1. PMID: 25594048; PMCID: PMC4278320.
      24. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. PMID: 24882516; PMCID: PMC4075337.
      25. Gou M, Qu X, Zhu W, Xiang M, Yang J, Zhang K, Wei Y, Chen S. Bio-inspired detoxification using 3D-printed hydrogel nanocomposites. Nat Commun. 2014 May 08; 5:3774. PMID: 24805923; PMCID: PMC4024742.
      26. Zhao JJ, Ouyang H, Luo J, Patel S, Xue Y, Quach J, Sfeir N, Zhang M, Fu X, Ding S, Chen S, Zhang K. Induction of retinal progenitors and neurons from mammalian Müller glia under defined conditions. J Biol Chem. 2014 Apr 25; 289(17):11945-51. PMID: 24523410; PMCID: PMC4002101.
      27. Durack JC, Wang JH, Sebro R, Zhang K, Hoch S, Kerlan RK. Prospective evaluation of absorbable gastropexy anchor indwelling time in 33 patients. J Vasc Interv Radiol. 2013 Sep; 24(9):1377-80. PMID: 23792127.
        View in: PubMed
      28. Nguyen DH, Luo J, Zhang K, Zhang M. Current therapeutic approaches in neovascular age-related macular degeneration. Discov Med. 2013 Jun; 15(85):343-8. PMID: 23819948.
        View in: PubMed
      29. Hu CM, Fang RH, Luk BT, Chen KN, Carpenter C, Gao W, Zhang K, Zhang L. 'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach. Nanoscale. 2013 Apr 07; 5(7):2664-8. PMID: 23462967; PMCID: PMC3667603.
      30. Zhao J, Luo J, Zhang K. Is Era of Ocular Regeneration Near? Asia Pac J Ophthalmol (Phila). 2013 Mar-Apr; 2(2):71-2. PMID: 26108040.
        View in: PubMed
      31. Zhu J, Nguyen D, Ouyang H, Zhang XH, Chen XM, Zhang K. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-ß in ARPE-19. Int J Ophthalmol. 2013; 6(1):8-14. PMID: 23550216; PMCID: PMC3580241.
      32. Fang RH, Chen KN, Aryal S, Hu CM, Zhang K, Zhang L. Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor. Langmuir. 2012 Oct 02; 28(39):13824-9. PMID: 22950917.
        View in: PubMed
      33. Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K. Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. J Biol Chem. 2012 Mar 30; 287(14):11469-80. PMID: 22199362; PMCID: PMC3322886.
      34. Du H, Lim SL, Grob S, Zhang K. Induced pluripotent stem cell therapies for geographic atrophy of age-related macular degeneration. Semin Ophthalmol. 2011 May; 26(3):216-24. PMID: 21609235; PMCID: PMC3805047.
      35. Zhang K, Hopkins JJ, Heier JS, Birch DG, Halperin LS, Albini TA, Brown DM, Jaffe GJ, Tao W, Williams GA. Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6241-5. PMID: 21444807; PMCID: PMC3076847.
      36. Chen Y, Zeng J, Zhao C, Wang K, Trood E, Buehler J, Weed M, Kasuga D, Bernstein PS, Hughes G, Fu V, Chin J, Lee C, Crocker M, Bedell M, Salasar F, Yang Z, Goldbaum M, Ferreyra H, Freeman WR, Kozak I, Zhang K. Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. Arch Ophthalmol. 2011 Mar; 129(3):344-51. PMID: 21402993; PMCID: PMC4134685.
      37. Korn BS, Zhang K. Images in clinical medicine. Carotid-cavernous sinus fistula. N Engl J Med. 2011 Feb 24; 364(8):e15. PMID: 21345097; PMCID: PMC3805040.
      38. Bedell M, Harkewicz R, Wang X, Zhang K. Focus on molecules: ELOVL4. Exp Eye Res. 2010 Apr; 90(4):476-7. PMID: 19853604.
        View in: PubMed
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