Junhui Xu

Title(s)	SRA 1, School of Global Policy & Strategy
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation. Nat Commun. 2024 Jul 17; 15(1):6031. Zhang X, Xu J, Hu J, Zhang S, Hao Y, Zhang D, Qian H, Wang D, Fu XD. PMID: 39019869; PMCID: PMC11255242.

View in: PubMed Mentions: Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2314245121. Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE. PMID: 38194460; PMCID: PMC10801861.

View in: PubMed Mentions: 5 Fields:
Sci Science
Translation:Humans Animals Cells
A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. Nat Commun. 2023 Dec 12; 14(1):8219. Oh J, Shan Z, Hoshika S, Xu J, Chong J, Benner SA, Lyumkis D, Wang D. PMID: 38086811; PMCID: PMC10716388.

View in: PubMed Mentions: Fields:
Bio Biology Sci Science
Translation:Cells
RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. Proc Natl Acad Sci U S A. 2022 01 18; 119(3). Oh J, Jia T, Xu J, Chong J, Dervan PB, Wang D. PMID: 35022237; PMCID: PMC8784135.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Cells
Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs. Nucleic Acids Res. 2021 07 21; 49(13):7618-7627. Xu J, Chong J, Wang D. PMID: 34197619; PMCID: PMC8287942.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Cells
Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. Nat Chem Biol. 2021 08; 17(8):906-914. Oh J, Shin J, Unarta IC, Wang W, Feldman AW, Karadeema RJ, Xu L, Xu J, Chong J, Krishnamurthy R, Huang X, Romesberg FE, Wang D. PMID: 34140682; PMCID: PMC8319059.

View in: PubMed Mentions: 10 Fields:
Bio Biology Che Chemistry
Translation:Animals Cells
Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures. Nucleic Acids Res. 2021 05 21; 49(9):4944-4953. Xu J, Chong J, Wang D. PMID: 33877330; PMCID: PMC8136819.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry
Translation:Cells
Molecular basis of transcriptional pausing, stalling, and transcription-coupled repair initiation. Biochim Biophys Acta Gene Regul Mech. 2021 01; 1864(1):194659. Oh J, Xu J, Chong J, Wang D. PMID: 33271312; PMCID: PMC7836393.

View in: PubMed Mentions: 14 Fields:
Bio Biochemistry Bio Biophysics Gen Genetics Mol Molecular Biology
Translation:Humans Cells
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25486-25493. Xu J, Wang W, Xu L, Chen JY, Chong J, Oh J, Leschziner AE, Fu XD, Wang D. PMID: 32989164; PMCID: PMC7568279.

View in: PubMed Mentions: 20 Fields:
Sci Science
Translation:Animals Cells
RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-π and CH-π interactions. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9338-9348. Oh J, Fleming AM, Xu J, Chong J, Burrows CJ, Wang D. PMID: 32284409; PMCID: PMC7196775.

View in: PubMed Mentions: 20 Fields:
Sci Science
Translation:Animals Cells
Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020 05; 158(6):1728-1744.e14. Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. PMID: 31982409; PMCID: PMC7252905.

View in: PubMed Mentions: 73 Fields:
Gas Gastroenterology
Translation:Humans Animals Cells
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.

View in: PubMed Mentions: 84 Fields:
Gas Gastroenterology
Translation:Humans Animals Cells
3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. J Struct Biol. 2019 09 01; 207(3):270-278. Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. PMID: 31200019; PMCID: PMC6711803.

View in: PubMed Mentions: 13 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Hepatol. 2019 09; 71(3):573-585. Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. PMID: 31071368.

View in: PubMed Mentions: 50 Fields:
Gas Gastroenterology
Translation:Animals Cells
Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6120-6129. Wang W, Xu J, Limbo O, Fei J, Kassavetis GA, Chong J, Kadonaga JT, Russell P, Li B, Wang D. PMID: 30867290; PMCID: PMC6442633.

View in: PubMed Mentions: 9 Fields:
Sci Science
Translation:Animals Cells
Structural and biochemical analysis of DNA lesion-induced RNA polymerase II arrest. Methods. 2019 04 15; 159-160:29-34. Oh J, Xu J, Chong J, Wang D. PMID: 30797902; PMCID: PMC6589100.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Animals Cells
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007; PMCID: PMC6409207.

View in: PubMed Mentions: 50 Fields:
Gas Gastroenterology
Translation:Humans Animals Cells
Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714; PMCID: PMC7871211.

View in: PubMed Mentions: 2 Fields:
Sci Science
Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair. DNA Repair (Amst). 2018 11; 71:43-55. Wang W, Xu J, Chong J, Wang D. PMID: 30174298; PMCID: PMC6340766.

View in: PubMed Mentions: 25 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Humans Animals Cells
Additive Manufacturing as a Method to Design and Optimize Bioinspired Structures. Adv Mater. 2018 Dec; 30(52):e1800940. Velasco-Hogan A, Xu J, Meyers MA. PMID: 30133816.

View in: PubMed Mentions: 31 Fields:
Bio Biophysics Che Chemistry
Translation:Animals
Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 12 12; 8(1):2137. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29233961; PMCID: PMC5727102.

View in: PubMed Mentions: 9 Fields:
Bio Biology Sci Science
Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 11 30; 551(7682):653-657. Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. PMID: 29168508; PMCID: PMC5907806.

View in: PubMed Mentions: 107 Fields:
Sci Science
Translation:Animals Cells
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460; PMCID: PMC5884449.

View in: PubMed Mentions: 268 Fields:
Sci Science
Translation:Humans Animals Cells
The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. PMID: 29404441; PMCID: PMC5721400.

View in: PubMed Mentions: 23 Fields:
Gas Gastroenterology
Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 10 16; 8(1):837. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29038503; PMCID: PMC5643518.

View in: PubMed Mentions: 98 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30; 127(7):2829-2841. Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. PMID: 28530644; PMCID: PMC5490775.

View in: PubMed Mentions: 223 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr). 2016 Aug; 38(4):291-302. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K, You YH, Schilling JM, Jeste D, Sharma K, Brenner DA, Kisseleva T. PMID: 27578257; PMCID: PMC5061686.

View in: PubMed Mentions: 37 Fields:
Ger Geriatrics
Translation:Animals Cells
New Developments on the Treatment of Liver Fibrosis. Dig Dis. 2016; 34(5):589-96. Koyama Y, Xu J, Liu X, Brenner DA. PMID: 27332862; PMCID: PMC4961096.

View in: PubMed Mentions: 42 Fields:
Gas Gastroenterology
Translation:Humans Cells
Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 2016; 7:47. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T. PMID: 26909046; PMCID: PMC4754444.

View in: PubMed Mentions: 32
RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications. Crit Rev Biochem Mol Biol. 2015; 50(6):503-19. Xu L, Wang W, Chong J, Shin JH, Xu J, Wang D. PMID: 26392149; PMCID: PMC4891981.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Humans Animals Cells
Bone marrow-derived fibrocytes contribute to liver fibrosis. Exp Biol Med (Maywood). 2015 Jun; 240(6):691-700. Xu J, Kisseleva T. PMID: 25966982; PMCID: PMC4866973.

View in: PubMed Mentions: 18 Fields:
Bio Biology Med Medicine (General)Phy Physiology
Translation:Humans Animals Cells
Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):34-47. Xu J, Cong M, Park TJ, Scholten D, Brenner DA, Kisseleva T. PMID: 25713803; PMCID: PMC4318956.

View in: PubMed Mentions: 23
Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11223-7. Xu L, Chen YC, Chong J, Fin A, McCoy LS, Xu J, Zhang C, Wang D. PMID: 25159856; PMCID: PMC4227401.

View in: PubMed Mentions: 12 Fields:
Che Chemistry
Translation:Cells
Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3269-76. Xu L, Zhang L, Chong J, Xu J, Huang X, Wang D. PMID: 25074911; PMCID: PMC4136571.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Animals Cells
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies. Front Pharmacol. 2014; 5:167. Xu J, Liu X, Koyama Y, Wang P, Lan T, Kim IG, Kim IH, Ma HY, Kisseleva T. PMID: 25100997; PMCID: PMC4105921.

View in: PubMed Mentions: 54
Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Liu X, Xu J, Brenner DA, Kisseleva T. PMID: 24000319; PMCID: PMC3757252.

View in: PubMed Mentions: 44