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    Juan Carlos Izpisua Belmonte

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Generation of functional human organs and tissues using interspecific blastocyst complementation
      NIH DP1DK113616Sep 30, 2016 - Jul 31, 2021
      Role: Principal Investigator
      Improving cell fate conversion by tracking cells and RNA over time and space
      NIH R01HL123755May 5, 2015 - Apr 30, 2019
      Role: Principal Investigator
      REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
      NIH U01HL107442Jul 15, 2011 - Jun 30, 2017
      Role: Principal Investigator
      Reconstruction and Modeling of Networks Involved in Cardiomyocyte Differentiation
      NIH R33HL088293Aug 1, 2007 - Jan 31, 2011
      Role: Principal Investigator
      Interaction of BMP, WNT and SHH in the Vertebrate Limb
      NIH R01HD042167Apr 11, 2002 - Mar 31, 2007
      Role: Principal Investigator
      Notch Signaling and Left-Right Asymmetry Determination
      NIH R01HD034538Dec 8, 1997 - May 31, 2009
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte J. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Cell. 2017 Jan 26; 168(3):473-486.e15. PMID: 28129541.
        View in: PubMed
      2. Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Rodriguez Esteban C, Nuñez G, Nuñez Delicado E, Campistol JM, Guillen I, Guillen P, Izpisua Belmonte J. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 2016 Dec 15; 167(7):1719-1733.e12. PMID: 27984723.
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      3. Garreta E, Marco A, Izpisua Belmonte J, Montserrat N. Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease. Stem Cell Investig. 2016; 3:76. PMID: 28066778.
        View in: PubMed
      4. Wu J, Platero Luengo A, Gil MA, Suzuki K, Cuello C, Morales Valencia M, Parrilla I, Martinez CA, Nohalez A, Roca J, Martinez EA, Izpisua Belmonte J. Generation of human organs in pigs via interspecies blastocyst complementation. Reprod Domest Anim. 2016 Oct; 51 Suppl 2:18-24. PMID: 27762052.
        View in: PubMed
      5. Wu J, Ocampo A, Izpisua Belmonte J. Cellular Metabolism and Induced Pluripotency. Cell. 2016 Sep 8; 166(6):1371-85. PMID: 27610564.
        View in: PubMed
      6. Li Z, Araoka T, Wu J, Liao HK, Li M, Lazo M, Zhou B, Sui Y, Wu MZ, Tamura I, Xia Y, Beyret E, Matsusaka T, Pastan I, Rodriguez Esteban C, Guillen I, Guillen P, Campistol JM, Izpisua Belmonte J. 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors. Cell Stem Cell. 2016 Oct 6; 19(4):516-529. PMID: 27570066.
        View in: PubMed
      7. Li M, Izpisua Belmonte J. Looking to the future following 10 years of induced pluripotent stem cell technologies. Nat Protoc. 2016 Sep; 11(9):1579-85. PMID: 27490631.
        View in: PubMed
      8. Ocampo A, Reddy P, Izpisua Belmonte J. Anti-Aging Strategies Based on Cellular Reprogramming. Trends Mol Med. 2016 Aug; 22(8):725-38. PMID: 27426043.
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      9. Eguizabal C, Herrera L, De Oñate L, Montserrat N, Hajkova P, Izpisua Belmonte J. Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming. Stem Cells. 2016 Sep; 34(9):2418-28. PMID: 27300161.
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      10. Sancho-Martinez I, Izpisua Belmonte J. Reprogramming strategies for the establishment of novel human cancer models. Cell Cycle. 2016 Sep 16; 15(18):2393-7. PMID: 27314153.
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      11. Wu J, Izpisua Belmonte J. Stem Cells: A Renaissance in Human Biology Research. Cell. 2016 Jun 16; 165(7):1572-85. PMID: 27315475.
        View in: PubMed
      12. Wu J, Yamauchi T, Izpisua Belmonte J. An overview of mammalian pluripotency. Development. 2016 May 15; 143(10):1644-8. PMID: 27190034.
        View in: PubMed
      13. Garreta E, de Oñate L, Fernández-Santos ME, Oria R, Tarantino C, Climent AM, Marco A, Samitier M, Martínez E, Valls-Margarit M, Matesanz R, Taylor DA, Fernández-Avilés F, Izpisua Belmonte J, Montserrat N. Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts. Biomaterials. 2016 Aug; 98:64-78. PMID: 27179434.
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      14. Suzuki A, Hirasaki M, Hishida T, Wu J, Okamura D, Ueda A, Nishimoto M, Nakachi Y, Mizuno Y, Okazaki Y, Matsui Y, Izpisua Belmonte J, Okuda A. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. Nat Commun. 2016; 7:11056. PMID: 27025988.
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      15. Wu J, Izpisua Belmonte J. The Molecular Harbingers of Early Mammalian Embryo Patterning. Cell. 2016 Mar 24; 165(1):13-5. PMID: 27015301.
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      16. Montserrat N, Garreta E, Izpisua Belmonte J. Regenerative strategies for kidney engineering. FEBS J. 2016 Sep; 283(18):3303-24. PMID: 26938311.
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      17. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte J. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016; 7:10743. PMID: 26899176.
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      18. Fu L, Xu X, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Izpisua Belmonte J, Qu J, Liu GH. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell. 2016 Mar; 7(3):210-21. PMID: 26874523.
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      19. Wu J, Izpisua Belmonte J. Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts. Transgenic Res. 2016 Jun; 25(3):375-84. PMID: 26820411.
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      20. Beyret E, Izpisua Belmonte J. The XEN of reprogramming. Cell Res. 2016 Feb; 26(2):147-8. PMID: 26794872.
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      21. Li M, Izpisua Belmonte J. Mending a Faltering Heart. Circ Res. 2016 Jan 22; 118(2):344-51. PMID: 26838318.
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      22. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte J, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015; 6:10068. PMID: 26632666.
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      23. Krause MN, Sancho-Martinez I, Izpisua Belmonte J. Understanding the molecular mechanisms of reprogramming. Biochem Biophys Res Commun. 2016 May 6; 473(3):693-7. PMID: 26655812.
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      24. Wu J, Izpisua Belmonte J. Metabolic exit from naive pluripotency. Nat Cell Biol. 2015 Nov 27; 17(12):1519-21. PMID: 26612574.
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      25. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte J, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 8; 5(6):933-45. PMID: 26610635.
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      26. Jiménez G, López-Ruiz E, Kwiatkowski W, Montañez E, Arrebola F, Carrillo E, Gray PC, Izpisua Belmonte J, Choe S, Perán M, Marchal JA. Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes. Sci Rep. 2015; 5:16400. PMID: 26563344; PMCID: PMC4643338.
        View in: PubMed, PubMed Central
      27. Wu J, Izpisua Belmonte J. Dynamic Pluripotent Stem Cell States and Their Applications. Cell Stem Cell. 2015 Nov 5; 17(5):509-25. PMID: 26544113.
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      28. Wu MZ, Chen SF, Nieh S, Benner C, Ger LP, Jan CI, Ma L, Chen CH, Hishida T, Chang HT, Lin YS, Montserrat N, Gascon P, Sancho-Martinez I, Izpisua Belmonte J. Hypoxia Drives Breast Tumor Malignancy through a TET-TNFa-p38-MAPK Signaling Axis. Cancer Res. 2015 Sep 15; 75(18):3912-24. PMID: 26294212.
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      29. Féron F, Gepner B, Lacassagne E, Stephan D, Mesnage B, Blanchard MP, Boulanger N, Tardif C, Devèze A, Rousseau S, Suzuki K, Izpisua Belmonte J, Khrestchatisky M, Nivet E, Erard-Garcia M. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Mol Psychiatry. 2016 Sep; 21(9):1215-24. PMID: 26239292.
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      30. Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte J, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13; 524(7564):234-8. PMID: 26176921.
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      31. Liao HK, Li M, Martinez Martinez L, Izpisua Belmonte J. Stem cell, CRISPR and HIV. Cell Cycle. 2015 Jul 3; 14(13):1991-2. PMID: 26039637.
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      32. Hashem SI, Perry CN, Bauer M, Han S, Clegg SD, Ouyang K, Deacon DC, Spinharney M, Panopoulos AD, Izpisua Belmonte J, Frazer KA, Chen J, Gong Q, Zhou Z, Chi NC, Adler ED. Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure. Stem Cells. 2015 Jul; 33(7):2343-50. PMID: 25826782.
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      33. Izpisua Belmonte J, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F. Brains, genes, and primates. Neuron. 2015 May 6; 86(3):617-31. PMID: 25950631.
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      34. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte J. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. PMID: 25945737.
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      35. Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban CR, Yu X, Yang Z, Li J, Wang X, Izpisua Belmonte J, Liu GH, Yi F, Qu J. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein Cell. 2015 May; 6(5):386-9. PMID: 25412771.
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      36. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte J. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell. 2015 Apr 23; 161(3):459-69. PMID: 25910206.
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      37. Ocampo A, Izpisua Belmonte J. Stem cells. Holding your breath for longevity. Science. 2015 Mar 20; 347(6228):1319-20. PMID: 25792319.
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      38. Liao HK, Gu Y, Diaz A, Marlett J, Takahashi Y, Li M, Suzuki K, Xu R, Hishida T, Chang CJ, Esteban CR, Young J, Izpisua Belmonte J. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells. Nat Commun. 2015; 6:6413. PMID: 25752527.
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      39. Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte J, Okuda A. Functional Compensation Between Myc and PI3K Signaling Supports Self-Renewal of Embryonic Stem Cells. Stem Cells. 2015 Mar; 33(3):713-25. PMID: 25385436.
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      40. Wang L, Wu J, Fang W, Liu GH, Izpisua Belmonte J. Regenerative medicine: targeted genome editing in vivo. Cell Res. 2015 Mar; 25(3):271-2. PMID: 25633595.
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      41. Li M, Izpisua Belmonte J. Roles for noncoding RNAs in cell-fate determination and regeneration. Nat Struct Mol Biol. 2015 Jan 7; 22(1):2-4. PMID: 25565025.
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      42. Hansson ML, Albert S, González Somermeyer L, Peco R, Mejía-Ramírez E, Montserrat N, Izpisua Belmonte J. Efficient Delivery and Functional Expression of Transfected Modified mRNA in Human Embryonic Stem Cell-derived Retinal Pigmented Epithelial Cells. J Biol Chem. 2015 Feb 27; 290(9):5661-72. PMID: 25555917.
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      43. Wu J, Izpisua Belmonte J. Stem cells: A designer's guide to pluripotency. Nature. 2014 Dec 10; 516(7530):172-3. PMID: 25503227.
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      44. Krause MN, Sancho-Martinez I, Izpisua Belmonte J. RE: Stem Cells Loaded with Multimechanistic Oncolytic Herpes Simplex Virus Variants for Brain Tumor Therapy. J Natl Cancer Inst. 2015 Jan; 107(1). PMID: 25473104.
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      45. Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, Kurian L, Ocampo A, Vazquez-Ferrer E, Rodriguez-Esteban C, Kumar S, Moresco JJ, Yates JR, Campistol JM, Sancho-Martinez I, Giacca M, Izpisua Belmonte J. In Vivo Activation of a Conserved MicroRNA Program Induces Mammalian Heart Regeneration. Cell Stem Cell. 2014 Nov 6; 15(5):589-604. PMID: 25517466.
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      46. Xia Y, Sancho-Martinez I, Nivet E, Rodriguez Esteban C, Campistol JM, Izpisua Belmonte J. The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat Protoc. 2014 Nov; 9(11):2693-704. PMID: 25340442.
        View in: PubMed
      47. Sancho-Martinez I, Ocampo A, Izpisua Belmonte J. Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. Curr Opin Genet Dev. 2014 Oct; 28:57-63. PMID: 25461451.
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      48. Beyret E, Izpisua Belmonte J. Worming toward Transdifferentiation, One (Epigenetic) Step at a Time. Dev Cell. 2014 Sep 29; 30(6):641-2. PMID: 25268170.
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      49. Zhu X, Fu L, Yi F, Liu GH, Ocampo A, Qu J, Izpisua Belmonte J. Regeneration: making muscle from hPSCs. Cell Res. 2014 Oct; 24(10):1159-61. PMID: 25001388.
        View in: PubMed
      50. Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla RD, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH, Li Y, Izpisua Belmonte J. Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones. Cell Stem Cell. 2014 Jul 3; 15(1):31-6. PMID: 24996168.
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      51. Masuda S, Izpisua Belmonte J. A recipe for targeted therapy in prostate cancer. Nat Rev Urol. 2014 Jul; 11(7):419. PMID: 24980194.
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      52. Wu K, Ren R, Su W, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte J, Liu GH, Chen C. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014 Jul 18; 289(29):20193-9. PMID: 24895131.
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      53. Wu MZ, Li M, Liu GH, Izpisua Belmonte J. A chemical approach to "rewire" neural progenitor cells. Cell Res. 2014 Jun; 24(6):641-2. PMID: 24743789.
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      54. Morris R, Sancho-Martinez I, Sharpee TO, Izpisua Belmonte J. Mathematical approaches to modeling development and reprogramming. Proc Natl Acad Sci U S A. 2014 Apr 8; 111(14):5076-82. PMID: 24706886.
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      55. Masuda S, Izpisua Belmonte J. Re: Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer. J Natl Cancer Inst. 2014 Mar 1; 106(3):djt457. PMID: 24586105.
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      56. Li M, Izpisua Belmonte J. Ageing: Genetic rejuvenation of old muscle. Nature. 2014 Feb 20; 506(7488):304-5. PMID: 24522526.
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      57. Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte J, Pinna LA, Sarno S. The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2. Biochim Biophys Acta. 2014 Apr; 1844(4):722-9. PMID: 24486797.
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      58. Zhang K, Liu GH, Yi F, Montserrat N, Hishida T, Esteban CR, Izpisua Belmonte J. Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. Protein Cell. 2014 Jan; 5(1):48-58. PMID: 24474194.
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      59. Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Izpisua Belmonte J. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. Protein Cell. 2014 Jan; 5(1):59-68. PMID: 24474197.
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      60. Xu XL, Yang JP, Fu LN, Ren RT, Yi F, Suzuki K, Liu K, Ding ZC, Qu J, Zhang WQ, Li Y, Yuan TT, Yuan GH, Sui LN, Guan D, Duan SL, Pan HZ, Wang P, Zhu XP, Montserrat N, Li M, Bai RJ, Liu L, Izpisua Belmonte J, Liu GH. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein Cell. 2014 Jan; 5(1):4-7. PMID: 24492924.
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      61. Li M, Suzuki K, Kim NY, Liu GH, Izpisua Belmonte J. A Cut above the Rest: Targeted Genome Editing Technologies in Human Pluripotent Stem Cells. J Biol Chem. 2014 Feb 21; 289(8):4594-9. PMID: 24362028.
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      62. Fu L, Zhu X, Yi F, Liu GH, Izpisua Belmonte J. Regenerative medicine: Transdifferentiation in vivo. Cell Res. 2014 Feb; 24(2):141-2. PMID: 24343579.
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      63. Esquivies L, Blackler A, Peran M, Rodriguez-Esteban C, Izpisua Belmonte J, Booker E, Gray PC, Ahn C, Kwiatkowski W, Choe S. Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure. J Biol Chem. 2014 Jan 17; 289(3):1788-97. PMID: 24311780.
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      64. Vitaloni M, Pulecio J, Bilic J, Kuebler B, Laricchia-Robbio L, Izpisua Belmonte J. MicroRNAs Contribute to Induced Pluripotent Stem Cell Somatic Donor Memory. J Biol Chem. 2014 Jan 24; 289(4):2084-98. PMID: 24311783.
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      65. Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM, Izpisua Belmonte J. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat Cell Biol. 2013 Dec; 15(12):1507-15. PMID: 24240476.
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      66. Yang J, Cai N, Yi F, Liu GH, Qu J, Izpisua Belmonte J. Gating pluripotency via nuclear pores. Trends Mol Med. 2014 Jan; 20(1):1-7. PMID: 24211182.
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      67. Aguirre A, Sancho-Martinez I, Izpisua Belmonte J. Heart regeneration: a tale of cell reprogramming. Circ Res. 2013 Oct 25; 113(10):1109-11. PMID: 24158574.
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      68. Gallegos TF, Sancho-Martinez I, Izpisua Belmonte J. Advances in cellular reprogramming: Moving toward a reprieve from immunogenicity. Immunol Lett. 2013 Sep-Oct; 155(1-2):14-7. PMID: 24076314.
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      69. Masuda S, Suzuki K, Izpisua Belmonte J. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013 Sep 19; 369(12):1171. PMID: 24047071.
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      70. Marti M, Montserrat N, Pardo C, Mulero L, Miquel-Serra L, Cavaco Rodrigues AM, Andrés Vaquero J, Kuebler B, Morera C, Barrero MJ, Izpisua Belmonte J. M-cadherin-mediated intercellular interactions activate satellite cell division. J Cell Sci. 2013 Nov 15; 126(Pt 22):5116-31. PMID: 24046443.
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      71. Masuda S, Wu J, Hishida T, Pandian GN, Sugiyama H, Izpisua Belmonte J. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. J Mol Cell Biol. 2013 Oct; 5(5):354-5. PMID: 24014886.
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      72. Zhang W, Qu J, Suzuki K, Liu GH, Izpisua Belmonte J. Concealing cellular defects in pluripotent stem cells. Trends Cell Biol. 2013 Dec; 23(12):587-92. PMID: 23916626.
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      73. Sancho-Martinez I, Izpisua Belmonte J. Will SCNT-ESCs be better than iPSCs for personalized regenerative medicine? Cell Stem Cell. 2013 Aug 1; 13(2):141-2. PMID: 23910080.
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      74. Montserrat N, Nivet E, Sancho-Martinez I, Hishida T, Kumar S, Miquel L, Cortina C, Hishida Y, Xia Y, Esteban CR, Izpisua Belmonte J. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell. 2013 Sep 5; 13(3):341-50. PMID: 23871606.
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      75. Xu X, Duan S, Yi F, Ocampo A, Liu GH, Izpisua Belmonte J. Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013 Sep 3; 18(3):325-32. PMID: 23850316.
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      76. Wang P, Qu J, Wu MZ, Zhang W, Liu GH, Izpisua Belmonte J. "TET-on" pluripotency. Cell Res. 2013 Jul; 23(7):863-5. PMID: 23732523.
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      77. Masuda S, Izpisua Belmonte J. Cotransplantation of MSCs and HSCs. Transplantation. 2013 May 27; 95(10):e62-3. PMID: 23689086.
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      78. Nivet E, Liu GH, Montserrat N, Izpisua Belmonte J. [Resetting Parkinson's disease patient-derived cells to unveil new pathological marks]. Med Sci (Paris). 2013 Apr; 29(4):353-5. PMID: 23621928.
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      79. Barrero MJ, Sese B, Martí M, Izpisua Belmonte J. Macro histone variants are critical for the differentiation of human pluripotent cells. J Biol Chem. 2013 May 31; 288(22):16110-6. PMID: 23595991.
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      80. Barrero MJ, Izpisua Belmonte J. Polycomb complex recruitment in pluripotent stem cells. Nat Cell Biol. 2013 Apr; 15(4):348-50. PMID: 23548929.
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      81. Masuda S, Izpisua Belmonte J. At the crossroads of targeted treatment and resistance in melanoma. Lancet Oncol. 2013 Apr; 14(4):e136-7. PMID: 23561743.
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      82. Barrero MJ, Sese B, Kuebler B, Bilic J, Boue S, Martí M, Izpisua Belmonte J. Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency. Cell Rep. 2013 Apr 25; 3(4):1005-11. PMID: 23545500.
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      83. Sander V, Suñe G, Jopling C, Morera C, Izpisua Belmonte J. Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. Nat Protoc. 2013 Apr; 8(4):800-9. PMID: 23538883.
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      84. Aguirre A, Sancho-Martinez I, Izpisua Belmonte J. Reprogramming toward heart regeneration: stem cells and beyond. Cell Stem Cell. 2013 Mar 7; 12(3):275-84. PMID: 23472869.
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      85. Pan H, Cai N, Li M, Liu GH, Izpisua Belmonte J. Autophagic control of cell 'stemness'. EMBO Mol Med. 2013 Mar; 5(3):327-31. PMID: 23495139.
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      86. Peran M, Ruiz S, Kwiatkowski W, Marchal JA, Yang SL, Aranega A, Choe S, Izpisua Belmonte J. Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation. Stem Cell Res. 2013 May; 10(3):464-76. PMID: 23500646.
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      87. Sui L, Liu GH, Izpisua Belmonte J. hESC-derived pancreatic progenitors. Cell Res. 2013 May; 23(5):592-4. PMID: 23381137.
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      88. Masuda S, Li M, Izpisua Belmonte J. Niche-less maintenance of HSCs by 2i. Cell Res. 2013 Apr; 23(4):458-9. PMID: 23357848.
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      89. Eguizabal C, Montserrat N, Veiga A, Izpisua Belmonte J. Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine. Semin Reprod Med. 2013 Jan; 31(1):82-94. PMID: 23329641.
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      91. Nivet E, Sancho-Martinez I, Izpisua Belmonte J. Conversion of pericytes to neurons: a new guest at the reprogramming convention. Stem Cell Res Ther. 2013; 4(1):2. PMID: 23312036.
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      92. Martí M, Mulero L, Pardo C, Morera C, Carrió M, Laricchia-Robbio L, Esteban CR, Izpisua Belmonte J. Characterization of pluripotent stem cells. Nat Protoc. 2013 Feb; 8(2):223-53. PMID: 23306458.
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      93. Sesé B, Barrero MJ, Fabregat MC, Sander V, Izpisua Belmonte J. SMYD2 is induced during cell differentiation and participates in early development. Int J Dev Biol. 2013; 57(5):357-64. PMID: 23873367.
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      94. Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K, Izpisua Belmonte J. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun. 2013; 4:1382. PMID: 23340422.
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      95. Masuda S, Izpisua Belmonte J. The microenvironment and resistance to personalized cancer therapy. Nat Rev Clin Oncol. 2013 Feb; 10(2). PMID: 23247379.
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      97. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Izpisua Belmonte J. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. PMID: 23202434.
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      98. Gu Y, Yi F, Liu GH, Izpisua Belmonte J. Beating in a dish: new hopes for cardiomyocyte regeneration. Cell Res. 2013 Mar; 23(3):314-6. PMID: 23184058.
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      99. Yang SL, Harnish E, Leeuw T, Dietz U, Batchelder E, Wright PS, Peppard J, August P, Volle-Challier C, Bono F, Herbert JM, Izpisua Belmonte J. Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis. Protein Cell. 2012 Dec; 3(12):934-42. PMID: 23161332.
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      100. Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte J, Matsui Y. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15; 26(22):2477-82. PMID: 23154982.
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      101. Jopling C, Suñé G, Faucherre A, Fabregat C, Izpisua Belmonte J. Hypoxia induces myocardial regeneration in zebrafish. Circulation. 2012 Dec 18; 126(25):3017-27. PMID: 23151342.
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      102. Tiscornia G, Vivas EL, Matalonga L, Berniakovich I, Barragán Monasterio M, Eguizábal C, Gort L, González F, Ortiz Mellet C, García Fernández JM, Ribes A, Veiga A, Izpisua Belmonte J. Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds. Hum Mol Genet. 2013 Feb 15; 22(4):633-45. PMID: 23118351.
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      103. Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J, Esteban CR, Sancho-Martinez I, Izpisua Belmonte J. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012 Nov 22; 491(7425):603-7. PMID: 23075850.
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      104. Masuda S, Li M, Izpisua Belmonte J. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). Cell Res. 2013 Feb; 23(2):176-8. PMID: 23044804.
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      105. Masuda S, Izpisua Belmonte J. Trametinib for patients with advanced melanoma. Lancet Oncol. 2012 Oct; 13(10):e409; author reply e409-10. PMID: 23026823.
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      106. Ruiz S, Panopoulos AD, Montserrat N, Multon MC, Daury A, Rocher C, Spanakis E, Batchelder EM, Orsini C, Deleuze JF, Izpisua Belmonte J. Generation of a drug-inducible reporter system to study cell reprogramming in human cells. J Biol Chem. 2012 Nov 23; 287(48):40767-78. PMID: 23019325.
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      107. Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K, Izpisua Belmonte J. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16196-201. PMID: 22991473.
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      108. Liu GH, Ding Z, Izpisua Belmonte J. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol. 2012 Dec; 24(6):765-74. PMID: 22999273.
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      109. Yi F, Qu J, Liu GH, Izpisua Belmonte J. The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells. Cell Res. 2013 Jan; 23(1):3-5. PMID: 22964710.
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      110. Sancho-Martinez I, Baek SH, Izpisua Belmonte J. Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol. 2012 Sep; 14(9):892-9. PMID: 22945254.
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      111. Zhang K, Yi F, Liu GH, Izpisua Belmonte J. Huntington's disease: dancing in a dish. Cell Res. 2012 Dec; 22(12):1627-30. PMID: 22868272.
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      112. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte J, Cashman J, Mercola M. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3; 11(2):242-52. PMID: 22862949.
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      114. Li M, Liu GH, Izpisua Belmonte J. Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol. 2012 Aug; 13(8):524-35. PMID: 22820889.
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      115. Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte J. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12556-61. PMID: 22814375.
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      116. Masuda S, Montserrat N, Monserrat N, Okamura D, Suzuki K, Izpisua Belmonte J. Cardiosphere-derived cells for heart regeneration. Lancet. 2012 Jun 30; 379(9835):2425-6; author reply 2426-7. PMID: 22748584.
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      118. Christen B, Rodrigues AM, Monasterio MB, Roig CF, Izpisua Belmonte J. Transient downregulation of Bmp signalling induces extra limbs in vertebrates. Development. 2012 Jul; 139(14):2557-65. PMID: 22675213.
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      119. Gu Y, Liu GH, Izpisua Belmonte J. Gametogenesis in a dish. Cell Res. 2012 Oct; 22(10):1422-5. PMID: 22641372.
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      120. Montserrat N, Ramírez-Bajo MJ, Xia Y, Sancho-Martinez I, Moya-Rull D, Miquel-Serra L, Yang S, Nivet E, Cortina C, González F, Izpisua Belmonte J, Campistol JM. Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2. J Biol Chem. 2012 Jul 13; 287(29):24131-8. PMID: 22613719.
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      121. Letamendia A, Quevedo C, Ibarbia I, Virto JM, Holgado O, Diez M, Izpisua Belmonte J, Callol-Massot C. Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One. 2012; 7(5):e36690. PMID: 22615792.
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      122. Liu GH, Yi F, Suzuki K, Qu J, Izpisua Belmonte J. Induced neural stem cells: a new tool for studying neural development and neurological disorders. Cell Res. 2012 Jul; 22(7):1087-91. PMID: 22547025.
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      123. Vassena R, Montserrat N, Carrasco Canal B, Aran B, de Oñate L, Veiga A, Izpisua Belmonte J. Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells. Hum Mol Genet. 2012 Aug 1; 21(15):3366-73. PMID: 22547223.
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      124. Xu X, Qu J, Suzuki K, Li M, Zhang W, Liu GH, Izpisua Belmonte J. Reprogramming based gene therapy for inherited red blood cell disorders. Cell Res. 2012 Jun; 22(6):941-4. PMID: 22473006.
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      125. Yi F, Liu GH, Izpisua Belmonte J. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy. Protein Cell. 2012 Apr; 3(4):246-50. PMID: 22441839.
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      126. Jopling C, Suñe G, Morera C, Izpisua Belmonte J. p38a MAPK regulates myocardial regeneration in zebrafish. Cell Cycle. 2012 Mar 15; 11(6):1195-201. PMID: 22391208.
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      127. Liu GH, Li M, Qu J, Izpisua Belmonte J. Gating neural development and aging via nuclear pores. Cell Res. 2012 Aug; 22(8):1212-4. PMID: 22410792.
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      128. Yi F, Liu GH, Izpisua Belmonte J. Rejuvenating liver and pancreas through cell transdifferentiation. Cell Res. 2012 Apr; 22(4):616-9. PMID: 22373548.
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      131. Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L, Izpisua Belmonte J. Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. Oncogene. 2012 Sep 27; 31(39):4333-42. PMID: 22179836.
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      132. Liu GH, Sancho-Martinez I, Izpisua Belmonte J. Cut and paste: restoring cellular function by gene correction. Cell Res. 2012 Feb; 22(2):283-4. PMID: 22143565.
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      133. Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J, Sancho-Martinez I, Liu GH, Izpisua Belmonte J. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs. Cell Res. 2011 Dec; 21(12):1740-4. PMID: 22105484.
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      134. Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua Belmonte J. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Hum Gene Ther. 2012 Jan; 23(1):56-69. PMID: 21877920.
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      136. Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisua Belmonte J. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res. 2012 Jan; 22(1):168-77. PMID: 22064701.
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      146. Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisua Belmonte J. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011 Jun 3; 8(6):688-94. PMID: 21596650.
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      150. Menchón C, Edel MJ, Izpisua Belmonte J. The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle. 2011 May 1; 10(9):1435-47. PMID: 21478681.
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      153. Kim S, Izpisua Belmonte J. Pluripotency of male germline stem cells. Mol Cells. 2011 Aug; 32(2):113-21. PMID: 21448589.
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      154. Tiscornia G, Monserrat N, Izpisua Belmonte J. Modelling long QT syndrome with iPS cells: be still, my beating heart ... Circ Res. 2011 Mar 18; 108(6):648-9. PMID: 21415406.
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      156. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte J, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 3; 471(7336):63-7. PMID: 21368825.
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      157. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J, Izpisua Belmonte J. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011 Apr 14; 472(7342):221-5. PMID: 21346760.
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      159. Li M, Sancho-Martinez I, Izpisua Belmonte J. Cell fate conversion by mRNA. Stem Cell Res Ther. 2011; 2(1):5. PMID: 21345255.
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      162. Oishi I, Kim S, Yoshii K, Esteban CR, Izpisua Belmonte J. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. BMC Biotechnol. 2011; 11:5. PMID: 21235743.
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      163. Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisua Belmonte J, Murry C, Keirstead HS, Park HS, Schmidt U, Laslett AL, Muller FJ, Nievergelt CM, Shamir R, Loring JF. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011 Jan 7; 8(1):106-18. PMID: 21211785.
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      167. Santamaria P, Rodriguez-Piza I, Clemente-Casares X, Yamanouchi J, Mulero-Perez L, Aasen T, Raya A, Izpisua Belmonte J. Turning human epidermis into pancreatic endoderm. Rev Diabet Stud. 2010; 7(2):158-67. PMID: 21060974.
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      169. Isaacs MJ, Kawakami Y, Allendorph GP, Yoon BH, Izpisua Belmonte J, Choe S. Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Mol Endocrinol. 2010 Jul; 24(7):1469-77. PMID: 20484413.
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      173. Giorgetti A, Montserrat N, Aasen T, Gonzalez F, Rodríguez-Pizà I, Vassena R, Raya A, Boué S, Barrero MJ, Corbella BA, Torrabadella M, Veiga A, Izpisua Belmonte J. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell. 2009 Oct 2; 5(4):353-7. PMID: 19796614.
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      174. Kan NG, Junghans D, Izpisua Belmonte J. Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. FASEB J. 2009 Oct; 23(10):3516-25. PMID: 19546304.
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      175. Gonzalez F, Barragan Monasterio M, Tiscornia G, Montserrat Pulido N, Vassena R, Batlle Morera L, Rodriguez Piza I, Izpisua Belmonte J. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22):8918-22. PMID: 19458047.
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      176. Jopling C, Izpisua Belmonte J. Cilia--where two Wnts collide. Zebrafish. 2009 Mar; 6(1):15-9. PMID: 19250031.
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      177. Kawakami Y, Uchiyama Y, Rodriguez Esteban C, Inenaga T, Koyano-Nakagawa N, Kawakami H, Marti M, Kmita M, Monaghan-Nichols P, Nishinakamura R, Izpisua Belmonte J. Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development. 2009 Feb; 136(4):585-94. PMID: 19168674.
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      178. Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte J, Giles W, Bodmer R, Ocorr K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques. 2009 Feb; 46(2):101-13. PMID: 19317655.
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      179. Pekarik V, Izpisua Belmonte J. NFIX--one gene, two knockouts, multiple effects. J Biol. 2008; 7(8):29. PMID: 18983696.
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      180. Tugores A, Izpisua Belmonte J. Differential display of eukaryotic mRNA. Methods Mol Biol. 2008; 461:589-604. PMID: 19030825.
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      181. Allendorph GP, Isaacs MJ, Kawakami Y, Izpisua Belmonte J, Choe S. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry. 2007 Oct 30; 46(43):12238-47. PMID: 17924656.
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      182. Sahara S, Kawakami Y, Izpisua Belmonte J, O'Leary DD. Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Dev. 2007; 2:10. PMID: 17509151.
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      183. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte J, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730.
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      184. Raya A, Izpisua Belmonte J. Unveiling the establishment of left-right asymmetry in the chick embryo. Mech Dev. 2004 Sep; 121(9):1043-54. PMID: 15296970.
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      185. Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL, Izpisua Belmonte J. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev. 2003 May 15; 17(10):1213-8. PMID: 12730123.
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      186. Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Baban K, Affolter M, Vale WW, Izpisua Belmonte J, Choe S. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. J Bone Joint Surg Am. 2003; 85-A Suppl 3:52-8. PMID: 12925610.
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      187. Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW, Izpisua Belmonte J, Choe S. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 2002 Dec 12; 420(6916):636-42. PMID: 12478285.
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      188. Rodriguez-Esteban C, Tsukui T, Yonei S, Magallon J, Tamura K, Izpisua Belmonte J. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Nature. 1999 Apr 29; 398(6730):814-8. PMID: 10235264.
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