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Juan Carlos Izpisua Belmonte
Title
Adjunct Professor
School
University of California, San Diego
Department
Cell and Developmental Biology
Address
9500 Gilman Drive #0932
CA La Jolla 92093
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Research
Research Activities and Funding
Generation of functional human organs and tissues using interspecific blastocyst complementation
NIH
DP1DK113616
Sep 30, 2016 - Jul 31, 2021
Role: Principal Investigator
Improving cell fate conversion by tracking cells and RNA over time and space
NIH/NHLBI
R01HL123755
May 5, 2015 - Apr 30, 2019
Role: Principal Investigator
REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
NIH/NHLBI
U01HL107442
Jul 15, 2011 - Jun 30, 2017
Role: Principal Investigator
Reconstruction and Modeling of Networks Involved in Cardiomyocyte Differentiation
NIH
R33HL088293
Aug 1, 2007 - Jan 31, 2011
Role: Principal Investigator
Interaction of BMP, WNT and SHH in the Vertebrate Limb
NIH
R01HD042167
Apr 11, 2002 - Mar 31, 2007
Role: Principal Investigator
Notch Signaling and Left-Right Asymmetry Determination
NIH
R01HD034538
Dec 8, 1997 - May 31, 2009
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Wu MZ, Cheng WC, Chen SF, Nieh S, O'Connor C, Liu CL, Tsai WW, Wu CJ, Martin L, Lin YS, Wu KJ, Lu LF,
Izpisua Belmonte J
. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol. 2017 Oct; 19(10):1286-1296. PMID: 28920955.
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PubMed
Ren R, Ocampo A, Liu GH,
Izpisua Belmonte J
. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017 Sep 05; 26(3):460-474. PMID: 28826795.
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PubMed
Hatanaka F, Ocampo A,
Izpisua Belmonte J
. Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging. Cell. 2017 08 10; 170(4):599-600. PMID: 28802034.
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PubMed
Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P,
Izpisua Belmonte J
, Qu J, Tang F, Liu GH. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017 Sep; 27(9):1178-1181. PMID: 28685772.
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PubMed
Li M, Borrelli E, Magistretti PJ,
Izpisua Belmonte J
, Sassone-Corsi P, Orlando V. Gathering by the Red Sea highlights links between environment and epigenetics. Nat Struct Mol Biol. 2017 06 06; 24(6):491-493. PMID: 28586330.
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PubMed
Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB,
Izpisua Belmonte J
, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 Apr 11; 8(4):1086-1100. PMID: 28410642.
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Panopoulos AD, Smith EN, Arias AD, Shepard PJ, Hishida Y, Modesto V, Diffenderfer KE, Conner C, Biggs W, Sandoval E, D'Antonio-Chronowska A, Berggren WT,
Izpisua Belmonte J
, Frazer KA. Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics. Cell Stem Cell. 2017 Apr 06; 20(4):505-517.e6. PMID: 28388429.
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Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MK, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LS,
Izpisua Belmonte J
, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 Apr 03. PMID: 28392216.
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PubMed
Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Rodriguez Esteban C, Nuñez G, Nuñez Delicado E, Campistol JM, Guillen I, Guillen P,
Izpisua Belmonte J
. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 2016 Dec 15; 167(7):1719-1733.e12. PMID: 27984723.
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PubMed
Garreta E, Marco A,
Izpisua Belmonte J
, Montserrat N. Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease. Stem Cell Investig. 2016; 3:76. PMID: 28066778.
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PubMed
Wu J, Platero Luengo A, Gil MA, Suzuki K, Cuello C, Morales Valencia M, Parrilla I, Martinez CA, Nohalez A, Roca J, Martinez EA,
Izpisua Belmonte J
. Generation of human organs in pigs via interspecies blastocyst complementation. Reprod Domest Anim. 2016 Oct; 51 Suppl 2:18-24. PMID: 27762052.
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PubMed
Li Z, Araoka T, Wu J, Liao HK, Li M, Lazo M, Zhou B, Sui Y, Wu MZ, Tamura I, Xia Y, Beyret E, Matsusaka T, Pastan I, Rodriguez Esteban C, Guillen I, Guillen P, Campistol JM,
Izpisua Belmonte J
. 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors. Cell Stem Cell. 2016 Oct 06; 19(4):516-529. PMID: 27570066.
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PubMed
Li M,
Izpisua Belmonte J
. Looking to the future following 10 years of induced pluripotent stem cell technologies. Nat Protoc. 2016 Sep; 11(9):1579-85. PMID: 27490631.
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PubMed
Eguizabal C, Herrera L, De Oñate L, Montserrat N, Hajkova P,
Izpisua Belmonte J
. Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming. Stem Cells. 2016 Sep; 34(9):2418-28. PMID: 27300161; PMCID: PMC5018215 [Available on 09/01/17].
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PubMed Central
Sancho-Martinez I,
Izpisua Belmonte J
. Reprogramming strategies for the establishment of novel human cancer models. Cell Cycle. 2016 Sep 16; 15(18):2393-7. PMID: 27314153.
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PubMed
Wu J,
Izpisua Belmonte J
. Stem Cells: A Renaissance in Human Biology Research. Cell. 2016 Jun 16; 165(7):1572-1585. PMID: 27315475.
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PubMed
Wu J, Yamauchi T,
Izpisua Belmonte J
. An overview of mammalian pluripotency. Development. 2016 May 15; 143(10):1644-8. PMID: 27190034.
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PubMed
Garreta E, de Oñate L, Fernández-Santos ME, Oria R, Tarantino C, Climent AM, Marco A, Samitier M, Martínez E, Valls-Margarit M, Matesanz R, Taylor DA, Fernández-Avilés F,
Izpisua Belmonte J
, Montserrat N. Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts. Biomaterials. 2016 Aug; 98:64-78. PMID: 27179434.
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Suzuki A, Hirasaki M, Hishida T, Wu J, Okamura D, Ueda A, Nishimoto M, Nakachi Y, Mizuno Y, Okazaki Y, Matsui Y,
Izpisua Belmonte J
, Okuda A. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. Nat Commun. 2016 Mar 30; 7:11056. PMID: 27025988; PMCID: PMC4820925.
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Montserrat N, Garreta E,
Izpisua Belmonte J
. Regenerative strategies for kidney engineering. FEBS J. 2016 Sep; 283(18):3303-24. PMID: 26938311.
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PubMed
Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC,
Izpisua Belmonte J
. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. PMID: 26899176; PMCID: PMC4764898.
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PubMed Central
Fu L, Xu X, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J,
Izpisua Belmonte J
, Qu J, Liu GH. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell. 2016 Mar; 7(3):210-21. PMID: 26874523; PMCID: PMC4791426.
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Wu J,
Izpisua Belmonte J
. Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts. Transgenic Res. 2016 Jun; 25(3):375-84. PMID: 26820411.
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PubMed
Beyret E,
Izpisua Belmonte J
. The XEN of reprogramming. Cell Res. 2016 Feb; 26(2):147-8. PMID: 26794872; PMCID: PMC4746615 [Available on 02/01/17].
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Li M,
Izpisua Belmonte J
. Mending a Faltering Heart. Circ Res. 2016 Jan 22; 118(2):344-51. PMID: 26838318.
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PubMed
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C,
Izpisua Belmonte J
, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015 Dec 03; 6:10068. PMID: 26632666; PMCID: PMC4686761.
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Krause MN, Sancho-Martinez I,
Izpisua Belmonte J
. Understanding the molecular mechanisms of reprogramming. Biochem Biophys Res Commun. 2016 May 06; 473(3):693-7. PMID: 26655812.
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PubMed
Wu J,
Izpisua Belmonte J
. Metabolic exit from naive pluripotency. Nat Cell Biol. 2015 Dec; 17(12):1519-21. PMID: 26612574.
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PubMed
Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A,
Izpisua Belmonte J
, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-45. PMID: 26610635; PMCID: PMC4881284.
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PubMed Central
Jiménez G, López-Ruiz E, Kwiatkowski W, Montañez E, Arrebola F, Carrillo E, Gray PC,
Izpisua Belmonte J
, Choe S, Perán M, Marchal JA. Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes. Sci Rep. 2015 Nov 13; 5:16400. PMID: 26563344; PMCID: PMC4643338.
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Wu J,
Izpisua Belmonte J
. Dynamic Pluripotent Stem Cell States and Their Applications. Cell Stem Cell. 2015 Nov 05; 17(5):509-25. PMID: 26544113.
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PubMed
Wu MZ, Chen SF, Nieh S, Benner C, Ger LP, Jan CI, Ma L, Chen CH, Hishida T, Chang HT, Lin YS, Montserrat N, Gascon P, Sancho-Martinez I,
Izpisua Belmonte J
. Hypoxia Drives Breast Tumor Malignancy through a TET-TNFa-p38-MAPK Signaling Axis. Cancer Res. 2015 Sep 15; 75(18):3912-24. PMID: 26294212.
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PubMed
Féron F, Gepner B, Lacassagne E, Stephan D, Mesnage B, Blanchard MP, Boulanger N, Tardif C, Devèze A, Rousseau S, Suzuki K,
Izpisua Belmonte J
, Khrestchatisky M, Nivet E, Erard-Garcia M. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Mol Psychiatry. 2016 Sep; 21(9):1215-24. PMID: 26239292; PMCID: PMC4995547.
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PubMed Central
Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC,
Izpisua Belmonte J
, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13; 524(7564):234-8. PMID: 26176921.
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PubMed
Liao HK, Li M, Martinez Martinez L,
Izpisua Belmonte J
. Stem cell, CRISPR and HIV. Cell Cycle. 2015; 14(13):1991-2. PMID: 26039637; PMCID: PMC4615082.
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PubMed Central
Hashem SI, Perry CN, Bauer M, Han S, Clegg SD, Ouyang K, Deacon DC, Spinharney M, Panopoulos AD,
Izpisua Belmonte J
, Frazer KA, Chen J, Gong Q, Zhou Z, Chi NC, Adler ED. Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure. Stem Cells. 2015 Jul; 33(7):2343-50. PMID: 25826782; PMCID: PMC4651661.
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PubMed Central
Izpisua Belmonte J
, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F. Brains, genes, and primates. Neuron. 2015 May 06; 86(3):617-31. PMID: 25950631; PMCID: PMC4425847.
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Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR,
Izpisua Belmonte J
. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. PMID: 25945737.
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PubMed
Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban CR, Yu X, Yang Z, Li J, Wang X,
Izpisua Belmonte J
, Liu GH, Yi F, Qu J. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein Cell. 2015 May; 6(5):386-9. PMID: 25412771; PMCID: PMC4417681.
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Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT,
Izpisua Belmonte J
. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell. 2015 Apr 23; 161(3):459-469. PMID: 25910206; PMCID: PMC4505837.
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Ocampo A,
Izpisua Belmonte J
. Stem cells. Holding your breath for longevity. Science. 2015 Mar 20; 347(6228):1319-20. PMID: 25792319; PMCID: PMC4494667.
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Liao HK, Gu Y, Diaz A, Marlett J, Takahashi Y, Li M, Suzuki K, Xu R, Hishida T, Chang CJ, Esteban CR, Young J,
Izpisua Belmonte J
. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells. Nat Commun. 2015 Mar 10; 6:6413. PMID: 25752527.
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PubMed
Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I,
Izpisua Belmonte J
, Okuda A. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells. Stem Cells. 2015 Mar; 33(3):713-25. PMID: 25385436.
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PubMed
Wang L, Wu J, Fang W, Liu GH,
Izpisua Belmonte J
. Regenerative medicine: targeted genome editing in vivo. Cell Res. 2015 Mar; 25(3):271-2. PMID: 25633595; PMCID: PMC4349243.
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Hansson ML, Albert S, González Somermeyer L, Peco R, Mejía-Ramírez E, Montserrat N,
Izpisua Belmonte J
. Efficient delivery and functional expression of transfected modified mRNA in human embryonic stem cell-derived retinal pigmented epithelial cells. J Biol Chem. 2015 Feb 27; 290(9):5661-72. PMID: 25555917; PMCID: PMC4342478.
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Li M,
Izpisua Belmonte J
. Roles for noncoding RNAs in cell-fate determination and regeneration. Nat Struct Mol Biol. 2015 Jan; 22(1):2-4. PMID: 25565025.
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Wu J,
Izpisua Belmonte J
. Stem cells: A designer's guide to pluripotency. Nature. 2014 Dec 11; 516(7530):172-3. PMID: 25503227.
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PubMed
Krause MN, Sancho-Martinez I,
Izpisua Belmonte J
. RE: stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy. J Natl Cancer Inst. 2015 Jan; 107(1):368. PMID: 25473104; PMCID: PMC4296197.
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Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, Kurian L, Ocampo A, Vazquez-Ferrer E, Rodriguez-Esteban C, Kumar S, Moresco JJ, Yates JR, Campistol JM, Sancho-Martinez I, Giacca M,
Izpisua Belmonte J
. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell. 2014 Nov 06; 15(5):589-604. PMID: 25517466; PMCID: PMC4270016.
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Xia Y, Sancho-Martinez I, Nivet E, Rodriguez Esteban C, Campistol JM,
Izpisua Belmonte J
. The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat Protoc. 2014 Nov; 9(11):2693-704. PMID: 25340442.
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Sancho-Martinez I, Ocampo A,
Izpisua Belmonte J
. Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. Curr Opin Genet Dev. 2014 Oct; 28:57-63. PMID: 25461451; PMCID: PMC4262641.
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Beyret E,
Izpisua Belmonte J
. Worming toward transdifferentiation, one (Epigenetic) step at a time. Dev Cell. 2014 Sep 29; 30(6):641-2. PMID: 25268170.
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Zhu X, Fu L, Yi F, Liu GH, Ocampo A, Qu J,
Izpisua Belmonte J
. Regeneration: making muscle from hPSCs. Cell Res. 2014 Oct; 24(10):1159-61. PMID: 25001388; PMCID: PMC4185353.
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Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla RD, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH, Li Y,
Izpisua Belmonte J
. Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones. Cell Stem Cell. 2014 Jul 03; 15(1):31-6. PMID: 24996168; PMCID: PMC4144407.
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Masuda S,
Izpisua Belmonte J
. A recipe for targeted therapy in prostate cancer. Nat Rev Urol. 2014 Jul; 11(7):419. PMID: 24980194.
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Wu K, Ren R, Su W, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L,
Izpisua Belmonte J
, Liu GH, Chen C. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014 Jul 18; 289(29):20193-9. PMID: 24895131; PMCID: PMC4106335.
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Wu MZ, Li M, Liu GH,
Izpisua Belmonte J
. A chemical approach to "rewire" neural progenitor cells. Cell Res. 2014 Jun; 24(6):641-2. PMID: 24743789; PMCID: PMC4042174.
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Morris R, Sancho-Martinez I, Sharpee TO,
Izpisua Belmonte J
. Mathematical approaches to modeling development and reprogramming. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5076-82. PMID: 24706886; PMCID: PMC3986203.
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Masuda S,
Izpisua Belmonte J
. Re: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst. 2014 Mar; 106(3):djt457. PMID: 24586105.
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Li M,
Izpisua Belmonte J
. Ageing: Genetic rejuvenation of old muscle. Nature. 2014 Feb 20; 506(7488):304-5. PMID: 24522526.
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PubMed
Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R,
Izpisua Belmonte J
, Pinna LA, Sarno S. The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2. Biochim Biophys Acta. 2014 Apr; 1844(4):722-9. PMID: 24486797.
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Zhang K, Liu GH, Yi F, Montserrat N, Hishida T, Esteban CR,
Izpisua Belmonte J
. Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. Protein Cell. 2014 Jan; 5(1):48-58. PMID: 24474194; PMCID: PMC3938849.
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Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K,
Izpisua Belmonte J
. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. Protein Cell. 2014 Jan; 5(1):59-68. PMID: 24474197; PMCID: PMC3938846.
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Xu XL, Yang JP, Fu LN, Ren RT, Yi F, Suzuki K, Liu K, Ding ZC, Qu J, Zhang WQ, Li Y, Yuan TT, Yuan GH, Sui LN, Guan D, Duan SL, Pan HZ, Wang P, Zhu XP, Montserrat N, Li M, Bai RJ, Liu L,
Izpisua Belmonte J
, Liu GH. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein Cell. 2014 Jan; 5(1):4-7. PMID: 24492924; PMCID: PMC3938843.
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Li M, Suzuki K, Kim NY, Liu GH,
Izpisua Belmonte J
. A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. J Biol Chem. 2014 Feb 21; 289(8):4594-9. PMID: 24362028; PMCID: PMC3931021.
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Fu L, Zhu X, Yi F, Liu GH,
Izpisua Belmonte J
. Regenerative medicine: transdifferentiation in vivo. Cell Res. 2014 Feb; 24(2):141-2. PMID: 24343579; PMCID: PMC3915906.
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PubMed Central
Esquivies L, Blackler A, Peran M, Rodriguez-Esteban C,
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Vitaloni M, Pulecio J, Bilic J, Kuebler B, Laricchia-Robbio L,
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Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM,
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. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat Cell Biol. 2013 Dec; 15(12):1507-15. PMID: 24240476.
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Yang J, Cai N, Yi F, Liu GH, Qu J,
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Aguirre A, Sancho-Martinez I,
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. Heart regeneration: a tale of cell reprogramming. Circ Res. 2013 Oct 25; 113(10):1109-11. PMID: 24158574.
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Gallegos TF, Sancho-Martinez I,
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. Advances in cellular reprogramming: moving toward a reprieve from immunogenicity. Immunol Lett. 2013 Sep-Oct; 155(1-2):14-7. PMID: 24076314.
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Masuda S, Suzuki K,
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. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013 Sep 19; 369(12):1171. PMID: 24047071.
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Marti M, Montserrat N, Pardo C, Mulero L, Miquel-Serra L, Rodrigues AM, Andrés Vaquero J, Kuebler B, Morera C, Barrero MJ,
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. M-cadherin-mediated intercellular interactions activate satellite cell division. J Cell Sci. 2013 Nov 15; 126(Pt 22):5116-31. PMID: 24046443.
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Masuda S, Wu J, Hishida T, Pandian GN, Sugiyama H,
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. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. J Mol Cell Biol. 2013 Oct; 5(5):354-5. PMID: 24014886.
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Zhang W, Qu J, Suzuki K, Liu GH,
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. Concealing cellular defects in pluripotent stem cells. Trends Cell Biol. 2013 Dec; 23(12):587-92. PMID: 23916626.
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Sancho-Martinez I,
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. Will SCNT-ESCs be better than iPSCs for personalized regenerative medicine? Cell Stem Cell. 2013 Aug 01; 13(2):141-2. PMID: 23910080.
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Montserrat N, Nivet E, Sancho-Martinez I, Hishida T, Kumar S, Miquel L, Cortina C, Hishida Y, Xia Y, Esteban CR,
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. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell. 2013 Sep 05; 13(3):341-50. PMID: 23871606.
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Xu X, Duan S, Yi F, Ocampo A, Liu GH,
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. Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013 Sep 03; 18(3):325-32. PMID: 23850316.
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Wang P, Qu J, Wu MZ, Zhang W, Liu GH,
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. "TET-on" pluripotency. Cell Res. 2013 Jul; 23(7):863-5. PMID: 23732523; PMCID: PMC3698639.
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Masuda S,
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. Cotransplantation of MSCs and HSCs. Transplantation. 2013 May 27; 95(10):e62-3. PMID: 23689086.
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Nivet E, Liu GH, Montserrat N,
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. [Resetting Parkinson's disease patient-derived cells to unveil new pathological marks]. Med Sci (Paris). 2013 Apr; 29(4):353-5. PMID: 23621928.
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Barrero MJ, Sese B, Martí M,
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. Macro histone variants are critical for the differentiation of human pluripotent cells. J Biol Chem. 2013 May 31; 288(22):16110-6. PMID: 23595991; PMCID: PMC3668766.
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Barrero MJ,
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. Polycomb complex recruitment in pluripotent stem cells. Nat Cell Biol. 2013 Apr; 15(4):348-50. PMID: 23548929.
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Masuda S,
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. At the crossroads of targeted treatment and resistance in melanoma. Lancet Oncol. 2013 Apr; 14(4):e136-7. PMID: 23561743.
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Barrero MJ, Sese B, Kuebler B, Bilic J, Boue S, Martí M,
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. Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency. Cell Rep. 2013 Apr 25; 3(4):1005-11. PMID: 23545500.
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Sander V, Suñe G, Jopling C, Morera C,
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. Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. Nat Protoc. 2013 Apr; 8(4):800-9. PMID: 23538883.
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Aguirre A, Sancho-Martinez I,
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. Reprogramming toward heart regeneration: stem cells and beyond. Cell Stem Cell. 2013 Mar 07; 12(3):275-84. PMID: 23472869.
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Pan H, Cai N, Li M, Liu GH,
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. Autophagic control of cell 'stemness'. EMBO Mol Med. 2013 Mar; 5(3):327-31. PMID: 23495139; PMCID: PMC3598074.
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Peran M, Ruiz S, Kwiatkowski W, Marchal JA, Yang SL, Aranega A, Choe S,
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. Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation. Stem Cell Res. 2013 May; 10(3):464-76. PMID: 23500646.
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Sui L, Liu GH,
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. hESC-derived pancreatic progenitors. Cell Res. 2013 May; 23(5):592-4. PMID: 23381137; PMCID: PMC3641592.
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Masuda S, Li M,
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. Niche-less maintenance of HSCs by 2i. Cell Res. 2013 Apr; 23(4):458-9. PMID: 23357848; PMCID: PMC3616430.
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Eguizabal C, Montserrat N, Veiga A,
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. Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine. Semin Reprod Med. 2013 Jan; 31(1):82-94. PMID: 23329641.
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Sancho-Martinez I,
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. Stem cells: Surf the waves of reprogramming. Nature. 2013 Jan 17; 493(7432):310-1. PMID: 23325209.
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Nivet E, Sancho-Martinez I,
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. Conversion of pericytes to neurons: a new guest at the reprogramming convention. Stem Cell Res Ther. 2013 Jan 11; 4(1):2. PMID: 23312036; PMCID: PMC3706921.
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Martí M, Mulero L, Pardo C, Morera C, Carrió M, Laricchia-Robbio L, Esteban CR,
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. Characterization of pluripotent stem cells. Nat Protoc. 2013 Feb; 8(2):223-53. PMID: 23306458.
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Sesé B, Barrero MJ, Fabregat MC, Sander V,
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. SMYD2 is induced during cell differentiation and participates in early development. Int J Dev Biol. 2013; 57(5):357-64. PMID: 23873367.
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Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K,
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. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun. 2013; 4:1382. PMID: 23340422; PMCID: PMC3856317.
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Masuda S,
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. The microenvironment and resistance to personalized cancer therapy. Nat Rev Clin Oncol. 2013 Feb; 10(2). PMID: 23247379.
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. Reprogramming development and aging: cell differentiation as a malleable process. Curr Opin Cell Biol. 2012 Dec; 24(6):713-5. PMID: 23246129.
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Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC,
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. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. PMID: 23202434; PMCID: PMC3531579.
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Gu Y, Yi F, Liu GH,
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. Beating in a dish: new hopes for cardiomyocyte regeneration. Cell Res. 2013 Mar; 23(3):314-6. PMID: 23184058; PMCID: PMC3587704.
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Yang SL, Harnish E, Leeuw T, Dietz U, Batchelder E, Wright PS, Peppard J, August P, Volle-Challier C, Bono F, Herbert JM,
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. Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis. Protein Cell. 2012 Dec; 3(12):934-42. PMID: 23161332; PMCID: PMC4875386.
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Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T,
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, Matsui Y. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15; 26(22):2477-82. PMID: 23154982; PMCID: PMC3505818.
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Jopling C, Suñé G, Faucherre A, Fabregat C,
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. Hypoxia induces myocardial regeneration in zebrafish. Circulation. 2012 Dec 18; 126(25):3017-27. PMID: 23151342.
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Tiscornia G, Vivas EL, Matalonga L, Berniakovich I, Barragán Monasterio M, Eguizábal C, Gort L, González F, Ortiz Mellet C, García Fernández JM, Ribes A, Veiga A,
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. Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds. Hum Mol Genet. 2013 Feb 15; 22(4):633-45. PMID: 23118351.
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Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J, Esteban CR, Sancho-Martinez I,
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. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012 Nov 22; 491(7425):603-7. PMID: 23075850; PMCID: PMC3504651.
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Masuda S, Li M,
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. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). Cell Res. 2013 Feb; 23(2):176-8. PMID: 23044804; PMCID: PMC3567822.
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Masuda S,
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. Trametinib for patients with advanced melanoma. Lancet Oncol. 2012 Oct; 13(10):e409; author reply e409-10. PMID: 23026823.
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Ruiz S, Panopoulos AD, Montserrat N, Multon MC, Daury A, Rocher C, Spanakis E, Batchelder EM, Orsini C, Deleuze JF,
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. Generation of a drug-inducible reporter system to study cell reprogramming in human cells. J Biol Chem. 2012 Nov 23; 287(48):40767-78. PMID: 23019325; PMCID: PMC3504789.
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Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K,
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. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16196-201. PMID: 22991473; PMCID: PMC3479609.
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Liu GH, Ding Z,
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. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol. 2012 Dec; 24(6):765-74. PMID: 22999273.
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Yi F, Qu J, Liu GH,
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. The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells. Cell Res. 2013 Jan; 23(1):3-5. PMID: 22964710; PMCID: PMC3541658.
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Sancho-Martinez I, Baek SH,
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. Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol. 2012 Sep; 14(9):892-9. PMID: 22945254.
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Zhang K, Yi F, Liu GH,
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. Huntington's disease: dancing in a dish. Cell Res. 2012 Dec; 22(12):1627-30. PMID: 22868272; PMCID: PMC3515752.
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Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T,
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, Cashman J, Mercola M. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52. PMID: 22862949; PMCID: PMC3419596.
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Barrero MJ, Berdasco M, Paramonov I, Bilic J, Vitaloni M, Esteller M,
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. DNA hypermethylation in somatic cells correlates with higher reprogramming efficiency. Stem Cells. 2012 Aug; 30(8):1696-702. PMID: 22653871.
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Li M, Liu GH,
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. Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol. 2012 Jul 23; 13(8):524-35. PMID: 22820889.
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Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH,
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. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12556-61. PMID: 22814375; PMCID: PMC3412010.
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Masuda S, Montserrat N, Monserrat N, Okamura D, Suzuki K,
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. Cardiosphere-derived cells for heart regeneration. Lancet. 2012 Jun 30; 379(9835):2425-6; author reply 2426-7. PMID: 22748584.
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Cai N, Li M, Qu J, Liu GH,
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. Post-translational modulation of pluripotency. J Mol Cell Biol. 2012 Aug; 4(4):262-5. PMID: 22679102.
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Christen B, Rodrigues AM, Monasterio MB, Roig CF,
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. Transient downregulation of Bmp signalling induces extra limbs in vertebrates. Development. 2012 Jul; 139(14):2557-65. PMID: 22675213.
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Gu Y, Liu GH,
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. Gametogenesis in a dish. Cell Res. 2012 Oct; 22(10):1422-5. PMID: 22641372; PMCID: PMC3463271.
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Montserrat N, Ramírez-Bajo MJ, Xia Y, Sancho-Martinez I, Moya-Rull D, Miquel-Serra L, Yang S, Nivet E, Cortina C, González F,
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, Campistol JM. Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2. J Biol Chem. 2012 Jul 13; 287(29):24131-8. PMID: 22613719; PMCID: PMC3397840.
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Letamendia A, Quevedo C, Ibarbia I, Virto JM, Holgado O, Diez M,
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, Callol-Massot C. Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One. 2012; 7(5):e36690. PMID: 22615792; PMCID: PMC3352927.
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Liu GH, Yi F, Suzuki K, Qu J,
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Vassena R, Montserrat N, Carrasco Canal B, Aran B, de Oñate L, Veiga A,
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. Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells. Hum Mol Genet. 2012 Aug 01; 21(15):3366-73. PMID: 22547223; PMCID: PMC3491960.
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Xu X, Qu J, Suzuki K, Li M, Zhang W, Liu GH,
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. Reprogramming based gene therapy for inherited red blood cell disorders. Cell Res. 2012 Jun; 22(6):941-4. PMID: 22473006; PMCID: PMC3367524.
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Yi F, Liu GH,
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. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy. Protein Cell. 2012 Apr; 3(4):246-50. PMID: 22441839; PMCID: PMC4875479.
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Jopling C, Suñe G, Morera C,
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Liu GH, Li M, Qu J,
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. Gating neural development and aging via nuclear pores. Cell Res. 2012 Aug; 22(8):1212-4. PMID: 22410792; PMCID: PMC3411164.
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Yi F, Liu GH,
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. Rejuvenating liver and pancreas through cell transdifferentiation. Cell Res. 2012 Apr; 22(4):616-9. PMID: 22373548; PMCID: PMC3317567.
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Bilic J,
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. Concise review: Induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? Stem Cells. 2012 Jan; 30(1):33-41. PMID: 22213481.
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Berniakovich I, Laricchia-Robbio L,
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. N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome. Int J Dev Biol. 2012; 56(9):729-35. PMID: 23319348.
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Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L,
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. Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. Oncogene. 2012 Sep 27; 31(39):4333-42. PMID: 22179836.
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Liu GH, Sancho-Martinez I,
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. Cut and paste: restoring cellular function by gene correction. Cell Res. 2012 Feb; 22(2):283-4. PMID: 22143565; PMCID: PMC3271590.
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Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J, Sancho-Martinez I, Liu GH,
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. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs. Cell Res. 2011 Dec; 21(12):1740-4. PMID: 22105484; PMCID: PMC3357996.
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Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A,
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. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Hum Gene Ther. 2012 Jan; 23(1):56-69. PMID: 21877920; PMCID: PMC3472681.
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Sancho-Martinez I, Nivet E,
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Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G,
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Sancho-Martinez I, Nivet E,
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Adamo A, Barrero MJ,
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Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM,
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Montserrat N, de Oñate L, Garreta E, González F, Adamo A, Eguizábal C, Häfner S, Vassena R,
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Li M,
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Panopoulos AD,
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Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC,
Izpisua Belmonte J
. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011 Jun 03; 8(6):688-94. PMID: 21596650; PMCID: PMC3480729.
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Panopoulos AD, Ruiz S, Yi F, Herrerías A, Batchelder EM,
Izpisua Belmonte J
. Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells. PLoS One. 2011; 6(5):e19743. PMID: 21603572; PMCID: PMC3095638.
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Robles V, Martí M,
Izpisua Belmonte J
. Study of pluripotency markers in zebrafish embryos and transient embryonic stem cell cultures. Zebrafish. 2011 Jun; 8(2):57-63. PMID: 21563922; PMCID: PMC3472678.
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Barrero MJ,
Izpisua Belmonte J
. iPS cells forgive but do not forget. Nat Cell Biol. 2011 May; 13(5):523-5. PMID: 21540851.
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Menchón C, Edel MJ,
Izpisua Belmonte J
. The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle. 2011 May 01; 10(9):1435-47. PMID: 21478681; PMCID: PMC3685623.
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Edel MJ, Menchon C, Vaquero JM,
Izpisua Belmonte J
. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells. Cell Commun Signal. 2011 Apr 11; 9(1):8. PMID: 21481269; PMCID: PMC3101157.
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Panopoulos AD, Ruiz S,
Izpisua Belmonte J
. iPSCs: induced back to controversy. Cell Stem Cell. 2011 Apr 08; 8(4):347-8. PMID: 21474093.
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Kim S,
Izpisua Belmonte J
. Pluripotency of male germline stem cells. Mol Cells. 2011 Aug; 32(2):113-21. PMID: 21448589; PMCID: PMC3887674.
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Tiscornia G, Monserrat N,
Izpisua Belmonte J
. Modelling long QT syndrome with iPS cells: be still, my beating heart ... Circ Res. 2011 Mar 18; 108(6):648-9. PMID: 21415406.
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Sancho-Martinez I, Li M,
Izpisua Belmonte J
. Disease correction the iPSC way: advances in iPSC-based therapy. Clin Pharmacol Ther. 2011 May; 89(5):746-9. PMID: 21389982.
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Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF,
Izpisua Belmonte J
, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. PMID: 21368825; PMCID: PMC3074107.
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Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J,
Izpisua Belmonte J
. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011 Apr 14; 472(7342):221-5. PMID: 21346760; PMCID: PMC3088088.
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Barrero MJ,
Izpisua Belmonte J
. Regenerating the epigenome. EMBO Rep. 2011 Mar; 12(3):208-15. PMID: 21311559; PMCID: PMC3059915.
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Li M, Sancho-Martinez I,
Izpisua Belmonte J
. Cell fate conversion by mRNA. Stem Cell Res Ther. 2011 Feb 09; 2(1):5. PMID: 21345255; PMCID: PMC3092145.
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Jopling C, Boue S,
Izpisua Belmonte J
. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol. 2011 Feb; 12(2):79-89. PMID: 21252997.
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Montserrat N, Garreta E, González F, Gutiérrez J, Eguizábal C, Ramos V, Borrós S,
Izpisua Belmonte J
. Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system. J Biol Chem. 2011 Apr 08; 286(14):12417-28. PMID: 21285354; PMCID: PMC3069445.
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Oishi I, Kim S, Yoshii K, Esteban CR,
Izpisua Belmonte J
. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. BMC Biotechnol. 2011 Jan 14; 11:5. PMID: 21235743; PMCID: PMC3033811.
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Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J,
Izpisua Belmonte J
, Murry C, Keirstead HS, Park HS, Schmidt U, Laslett AL, Muller FJ, Nievergelt CM, Shamir R, Loring JF. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011 Jan 07; 8(1):106-18. PMID: 21211785; PMCID: PMC3043464.
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Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM,
Izpisua Belmonte J
. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol. 2011 Jan 11; 21(1):45-52. PMID: 21167714; PMCID: PMC3034649.
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Menendez S, Camus S,
Izpisua Belmonte J
. p53: guardian of reprogramming. Cell Cycle. 2010 Oct 01; 9(19):3887-91. PMID: 20948296.
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Edel MJ, Boué S, Menchon C, Sánchez-Danés A,
Izpisua Belmonte J
. Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. Cell Cycle. 2010 Sep 01; 9(17):3414-22. PMID: 20729629.
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Santamaria P, Rodriguez-Piza I, Clemente-Casares X, Yamanouchi J, Mulero-Perez L, Aasen T, Raya A,
Izpisua Belmonte J
. Turning human epidermis into pancreatic endoderm. Rev Diabet Stud. 2010; 7(2):158-67. PMID: 21060974; PMCID: PMC2989788.
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Edel MJ,
Izpisua Belmonte J
. The cell cycle and pluripotency: Is there a direct link? Cell Cycle. 2010 Jul 15; 9(14):2694-5. PMID: 20581443.
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Isaacs MJ, Kawakami Y, Allendorph GP, Yoon BH,
Izpisua Belmonte J
, Choe S. Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Mol Endocrinol. 2010 Jul; 24(7):1469-77. PMID: 20484413; PMCID: PMC2903903.
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Sleep E, Boué S, Jopling C, Raya M, Raya A,
Izpisua Belmonte J
. Transcriptomics approach to investigate zebrafish heart regeneration. J Cardiovasc Med (Hagerstown). 2010 May; 11(5):369-80. PMID: 20179605.
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Edel MJ, Menchon C, Menendez S, Consiglio A, Raya A,
Izpisua Belmonte J
. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev. 2010 Mar 15; 24(6):561-73. PMID: 20231315; PMCID: PMC2841334.
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Stewart S, Tsun ZY,
Izpisua Belmonte J
. A histone demethylase is necessary for regeneration in zebrafish. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19889-94. PMID: 19897725; PMCID: PMC2785262.
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Giorgetti A, Montserrat N, Aasen T, Gonzalez F, Rodríguez-Pizà I, Vassena R, Raya A, Boué S, Barrero MJ, Corbella BA, Torrabadella M, Veiga A,
Izpisua Belmonte J
. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell. 2009 Oct 02; 5(4):353-7. PMID: 19796614; PMCID: PMC2779776.
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Kan NG, Junghans D,
Izpisua Belmonte J
. Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. FASEB J. 2009 Oct; 23(10):3516-25. PMID: 19546304; PMCID: PMC2747679.
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Gonzalez F, Barragan Monasterio M, Tiscornia G, Montserrat Pulido N, Vassena R, Batlle Morera L, Rodriguez Piza I,
Izpisua Belmonte J
. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8918-22. PMID: 19458047; PMCID: PMC2690033.
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Jopling C,
Izpisua Belmonte J
. Cilia--where two Wnts collide. Zebrafish. 2009 Mar; 6(1):15-9. PMID: 19250031.
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Kawakami Y, Uchiyama Y, Rodriguez Esteban C, Inenaga T, Koyano-Nakagawa N, Kawakami H, Marti M, Kmita M, Monaghan-Nichols P, Nishinakamura R,
Izpisua Belmonte J
. Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development. 2009 Feb; 136(4):585-94. PMID: 19168674; PMCID: PMC3266482.
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Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P,
Izpisua Belmonte J
, Giles W, Bodmer R, Ocorr K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques. 2009 Feb; 46(2):101-13. PMID: 19317655; PMCID: PMC2855226.
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Pekarik V,
Izpisua Belmonte J
. NFIX--one gene, two knockouts, multiple effects. J Biol. 2008 Oct 23; 7(8):29. PMID: 18983696.
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Tugores A,
Izpisua Belmonte J
. Differential display of eukaryotic mRNA. Methods Mol Biol. 2008; 461:589-604. PMID: 19030825.
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Allendorph GP, Isaacs MJ, Kawakami Y,
Izpisua Belmonte J
, Choe S. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry. 2007 Oct 30; 46(43):12238-47. PMID: 17924656.
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Sahara S, Kawakami Y,
Izpisua Belmonte J
, O'Leary DD. Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Dev. 2007 May 17; 2:10. PMID: 17509151; PMCID: PMC1890288.
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Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P,
Izpisua Belmonte J
, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730; PMCID: PMC1317903.
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Raya A,
Izpisua Belmonte J
. Unveiling the establishment of left-right asymmetry in the chick embryo. Mech Dev. 2004 Sep; 121(9):1043-54. PMID: 15296970.
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Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL,
Izpisua Belmonte J
. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev. 2003 May 15; 17(10):1213-8. PMID: 12730123; PMCID: PMC196060.
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Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Baban K, Affolter M, Vale WW,
Izpisua Belmonte J
, Choe S. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. J Bone Joint Surg Am. 2003; 85-A Suppl 3:52-8. PMID: 12925610.
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Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW,
Izpisua Belmonte J
, Choe S. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 2002 Dec 12; 420(6916):636-42. PMID: 12478285.
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Rodriguez-Esteban C, Tsukui T, Yonei S, Magallon J, Tamura K,
Izpisua Belmonte J
. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Nature. 1999 Apr 29; 398(6730):814-8. PMID: 10235264.
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33
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36
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34
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18
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21
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Juan Carlos's Networks
Concepts
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Induced Pluripotent Stem Cells
Embryonic Stem Cells
Regeneration
Cell Differentiation
Pluripotent Stem Cells
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Benner, Christopher
Frazer, Kelly
Laurent, Louise
Plongthongkum, Nongluk
Verma, Inder
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