Loading...

Juan Carlos Izpisua Belmonte

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0932
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Generation of functional human organs and tissues using interspecific blastocyst complementation
    NIH DP1DK113616Sep 30, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Improving cell fate conversion by tracking cells and RNA over time and space
    NIH/NHLBI R01HL123755May 5, 2015 - Apr 30, 2019
    Role: Principal Investigator
    REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
    NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Reconstruction and Modeling of Networks Involved in Cardiomyocyte Differentiation
    NIH R33HL088293Aug 1, 2007 - Jan 31, 2011
    Role: Principal Investigator
    Interaction of BMP, WNT and SHH in the Vertebrate Limb
    NIH R01HD042167Apr 11, 2002 - Mar 31, 2007
    Role: Principal Investigator
    Notch Signaling and Left-Right Asymmetry Determination
    NIH R01HD034538Dec 8, 1997 - May 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Li M, Izpisua Belmonte J. Deconstructing the pluripotency gene regulatory network. Nat Cell Biol. 2018 Apr; 20(4):382-392. PMID: 29593328.
      View in: PubMed
    2. Bogliotti YS, Wu J, Vilarino M, Okamura D, Soto DA, Zhong C, Sakurai M, Sampaio RV, Suzuki K, Izpisua Belmonte J, Ross PJ. Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. Proc Natl Acad Sci U S A. 2018 Feb 27; 115(9):2090-2095. PMID: 29440377.
      View in: PubMed
    3. Beyret E, Martinez Redondo P, Platero Luengo A, Izpisua Belmonte J. Elixir of Life: Thwarting Aging With Regenerative Reprogramming. Circ Res. 2018 Jan 05; 122(1):128-141. PMID: 29301845.
      View in: PubMed
    4. Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Núñez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte J. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. 2017 Dec 14; 171(7):1495-1507.e15. PMID: 29224783.
      View in: PubMed
    5. Suzuki K, Izpisua Belmonte J. In vivo genome editing via the HITI method as a tool for gene therapy. J Hum Genet. 2018 Feb; 63(2):157-164. PMID: 29215090.
      View in: PubMed
    6. Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte J, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D. Human Embryo Editing: Opportunities and Importance of Transnational Cooperation. Cell Stem Cell. 2017 Oct 05; 21(4):423-426. PMID: 28985523.
      View in: PubMed
    7. Wu MZ, Cheng WC, Chen SF, Nieh S, O'Connor C, Liu CL, Tsai WW, Wu CJ, Martin L, Lin YS, Wu KJ, Lu LF, Izpisua Belmonte J. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol. 2017 Oct; 19(10):1286-1296. PMID: 28920955.
      View in: PubMed
    8. Ren R, Ocampo A, Liu GH, Izpisua Belmonte J. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017 Sep 05; 26(3):460-474. PMID: 28826795.
      View in: PubMed
    9. Hatanaka F, Ocampo A, Izpisua Belmonte J. Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging. Cell. 2017 08 10; 170(4):599-600. PMID: 28802034.
      View in: PubMed
    10. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte J, Qu J, Tang F, Liu GH. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017 Sep; 27(9):1178-1181. PMID: 28685772.
      View in: PubMed
    11. Li M, Borrelli E, Magistretti PJ, Izpisua Belmonte J, Sassone-Corsi P, Orlando V. Gathering by the Red Sea highlights links between environment and epigenetics. Nat Struct Mol Biol. 2017 06 06; 24(6):491-493. PMID: 28586330.
      View in: PubMed
    12. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte J, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 04 11; 8(4):1086-1100. PMID: 28410642.
      View in: PubMed
    13. Panopoulos AD, Smith EN, Arias AD, Shepard PJ, Hishida Y, Modesto V, Diffenderfer KE, Conner C, Biggs W, Sandoval E, D'Antonio-Chronowska A, Berggren WT, Izpisua Belmonte J, Frazer KA. Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics. Cell Stem Cell. 2017 04 06; 20(4):505-517.e6. PMID: 28388429.
      View in: PubMed
    14. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte J. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Cell. 2017 Jan 26; 168(3):473-486.e15. PMID: 28129541.
      View in: PubMed
    15. Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Rodriguez Esteban C, Nuñez G, Nuñez Delicado E, Campistol JM, Guillen I, Guillen P, Izpisua Belmonte J. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 2016 Dec 15; 167(7):1719-1733.e12. PMID: 27984723.
      View in: PubMed
    16. Garreta E, Marco A, Izpisua Belmonte J, Montserrat N. Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease. Stem Cell Investig. 2016; 3:76. PMID: 28066778.
      View in: PubMed
    17. Wu J, Platero Luengo A, Gil MA, Suzuki K, Cuello C, Morales Valencia M, Parrilla I, Martinez CA, Nohalez A, Roca J, Martinez EA, Izpisua Belmonte J. Generation of human organs in pigs via interspecies blastocyst complementation. Reprod Domest Anim. 2016 Oct; 51 Suppl 2:18-24. PMID: 27762052.
      View in: PubMed
    18. Li Z, Araoka T, Wu J, Liao HK, Li M, Lazo M, Zhou B, Sui Y, Wu MZ, Tamura I, Xia Y, Beyret E, Matsusaka T, Pastan I, Rodriguez Esteban C, Guillen I, Guillen P, Campistol JM, Izpisua Belmonte J. 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors. Cell Stem Cell. 2016 10 06; 19(4):516-529. PMID: 27570066.
      View in: PubMed
    19. Li M, Izpisua Belmonte J. Looking to the future following 10 years of induced pluripotent stem cell technologies. Nat Protoc. 2016 Sep; 11(9):1579-85. PMID: 27490631.
      View in: PubMed
    20. Eguizabal C, Herrera L, De Oñate L, Montserrat N, Hajkova P, Izpisua Belmonte J. Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming. Stem Cells. 2016 09; 34(9):2418-28. PMID: 27300161; PMCID: PMC5018215 [Available on 09/01/17].
      View in: PubMed, PubMed Central
    21. Sancho-Martinez I, Izpisua Belmonte J. Reprogramming strategies for the establishment of novel human cancer models. Cell Cycle. 2016 Sep 16; 15(18):2393-7. PMID: 27314153.
      View in: PubMed
    22. Wu J, Izpisua Belmonte J. Stem Cells: A Renaissance in Human Biology Research. Cell. 2016 Jun 16; 165(7):1572-1585. PMID: 27315475.
      View in: PubMed
    23. Wu J, Yamauchi T, Izpisua Belmonte J. An overview of mammalian pluripotency. Development. 2016 05 15; 143(10):1644-8. PMID: 27190034.
      View in: PubMed
    24. Garreta E, de Oñate L, Fernández-Santos ME, Oria R, Tarantino C, Climent AM, Marco A, Samitier M, Martínez E, Valls-Margarit M, Matesanz R, Taylor DA, Fernández-Avilés F, Izpisua Belmonte J, Montserrat N. Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts. Biomaterials. 2016 08; 98:64-78. PMID: 27179434.
      View in: PubMed
    25. Suzuki A, Hirasaki M, Hishida T, Wu J, Okamura D, Ueda A, Nishimoto M, Nakachi Y, Mizuno Y, Okazaki Y, Matsui Y, Izpisua Belmonte J, Okuda A. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. Nat Commun. 2016 Mar 30; 7:11056. PMID: 27025988; PMCID: PMC4820925.
      View in: PubMed, PubMed Central
    26. Montserrat N, Garreta E, Izpisua Belmonte J. Regenerative strategies for kidney engineering. FEBS J. 2016 09; 283(18):3303-24. PMID: 26938311.
      View in: PubMed
    27. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte J. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. PMID: 26899176; PMCID: PMC4764898.
      View in: PubMed, PubMed Central
    28. Fu L, Xu X, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Izpisua Belmonte J, Qu J, Liu GH. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell. 2016 Mar; 7(3):210-21. PMID: 26874523; PMCID: PMC4791426.
      View in: PubMed, PubMed Central
    29. Wu J, Izpisua Belmonte J. Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts. Transgenic Res. 2016 06; 25(3):375-84. PMID: 26820411.
      View in: PubMed
    30. Beyret E, Izpisua Belmonte J. The XEN of reprogramming. Cell Res. 2016 Feb; 26(2):147-8. PMID: 26794872; PMCID: PMC4746615 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    31. Li M, Izpisua Belmonte J. Mending a Faltering Heart. Circ Res. 2016 Jan 22; 118(2):344-51. PMID: 26838318.
      View in: PubMed
    32. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte J, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015 Dec 03; 6:10068. PMID: 26632666; PMCID: PMC4686761.
      View in: PubMed, PubMed Central
    33. Krause MN, Sancho-Martinez I, Izpisua Belmonte J. Understanding the molecular mechanisms of reprogramming. Biochem Biophys Res Commun. 2016 05 06; 473(3):693-7. PMID: 26655812.
      View in: PubMed
    34. Wu J, Izpisua Belmonte J. Metabolic exit from naive pluripotency. Nat Cell Biol. 2015 Dec; 17(12):1519-21. PMID: 26612574.
      View in: PubMed
    35. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte J, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945. PMID: 26610635.
      View in: PubMed
    36. Jiménez G, López-Ruiz E, Kwiatkowski W, Montañez E, Arrebola F, Carrillo E, Gray PC, Izpisua Belmonte J, Choe S, Perán M, Marchal JA. Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes. Sci Rep. 2015 Nov 13; 5:16400. PMID: 26563344; PMCID: PMC4643338.
      View in: PubMed, PubMed Central
    37. Wu J, Izpisua Belmonte J. Dynamic Pluripotent Stem Cell States and Their Applications. Cell Stem Cell. 2015 Nov 05; 17(5):509-25. PMID: 26544113.
      View in: PubMed
    38. Wu MZ, Chen SF, Nieh S, Benner C, Ger LP, Jan CI, Ma L, Chen CH, Hishida T, Chang HT, Lin YS, Montserrat N, Gascon P, Sancho-Martinez I, Izpisua Belmonte J. Hypoxia Drives Breast Tumor Malignancy through a TET-TNFa-p38-MAPK Signaling Axis. Cancer Res. 2015 Sep 15; 75(18):3912-24. PMID: 26294212.
      View in: PubMed
    39. Féron F, Gepner B, Lacassagne E, Stephan D, Mesnage B, Blanchard MP, Boulanger N, Tardif C, Devèze A, Rousseau S, Suzuki K, Izpisua Belmonte J, Khrestchatisky M, Nivet E, Erard-Garcia M. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Mol Psychiatry. 2016 09; 21(9):1215-24. PMID: 26239292; PMCID: PMC4995547.
      View in: PubMed, PubMed Central
    40. Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte J, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13; 524(7564):234-8. PMID: 26176921.
      View in: PubMed
    41. Liao HK, Li M, Martinez Martinez L, Izpisua Belmonte J. Stem cell, CRISPR and HIV. Cell Cycle. 2015; 14(13):1991-2. PMID: 26039637; PMCID: PMC4615082.
      View in: PubMed, PubMed Central
    42. Hashem SI, Perry CN, Bauer M, Han S, Clegg SD, Ouyang K, Deacon DC, Spinharney M, Panopoulos AD, Izpisua Belmonte J, Frazer KA, Chen J, Gong Q, Zhou Z, Chi NC, Adler ED. Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure. Stem Cells. 2015 Jul; 33(7):2343-50. PMID: 25826782; PMCID: PMC4651661.
      View in: PubMed, PubMed Central
    43. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte J. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. PMID: 25945737.
      View in: PubMed
    44. Izpisua Belmonte J, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F. Brains, genes, and primates. Neuron. 2015 May 06; 86(3):617-31. PMID: 25950631.
      View in: PubMed
    45. Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban CR, Yu X, Yang Z, Li J, Wang X, Izpisua Belmonte J, Liu GH, Yi F, Qu J. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein Cell. 2015 May; 6(5):386-9. PMID: 25412771; PMCID: PMC4417681.
      View in: PubMed, PubMed Central
    46. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte J. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell. 2015 Apr 23; 161(3):459-469. PMID: 25910206; PMCID: PMC4505837.
      View in: PubMed, PubMed Central
    47. Ocampo A, Izpisua Belmonte J. Stem cells. Holding your breath for longevity. Science. 2015 Mar 20; 347(6228):1319-20. PMID: 25792319; PMCID: PMC4494667.
      View in: PubMed, PubMed Central
    48. Liao HK, Gu Y, Diaz A, Marlett J, Takahashi Y, Li M, Suzuki K, Xu R, Hishida T, Chang CJ, Esteban CR, Young J, Izpisua Belmonte J. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells. Nat Commun. 2015 Mar 10; 6:6413. PMID: 25752527.
      View in: PubMed
    49. Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte J, Okuda A. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells. Stem Cells. 2015 Mar; 33(3):713-25. PMID: 25385436.
      View in: PubMed
    50. Wang L, Wu J, Fang W, Liu GH, Izpisua Belmonte J. Regenerative medicine: targeted genome editing in vivo. Cell Res. 2015 Mar; 25(3):271-2. PMID: 25633595; PMCID: PMC4349243.
      View in: PubMed, PubMed Central
    51. Hansson ML, Albert S, González Somermeyer L, Peco R, Mejía-Ramírez E, Montserrat N, Izpisua Belmonte J. Efficient delivery and functional expression of transfected modified mRNA in human embryonic stem cell-derived retinal pigmented epithelial cells. J Biol Chem. 2015 Feb 27; 290(9):5661-72. PMID: 25555917; PMCID: PMC4342478.
      View in: PubMed, PubMed Central
    52. Li M, Izpisua Belmonte J. Roles for noncoding RNAs in cell-fate determination and regeneration. Nat Struct Mol Biol. 2015 Jan; 22(1):2-4. PMID: 25565025.
      View in: PubMed
    53. Wu J, Izpisua Belmonte J. Stem cells: A designer's guide to pluripotency. Nature. 2014 Dec 11; 516(7530):172-3. PMID: 25503227.
      View in: PubMed
    54. Krause MN, Sancho-Martinez I, Izpisua Belmonte J. RE: stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy. J Natl Cancer Inst. 2015 Jan; 107(1):368. PMID: 25473104; PMCID: PMC4296197.
      View in: PubMed, PubMed Central
    55. Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, Kurian L, Ocampo A, Vazquez-Ferrer E, Rodriguez-Esteban C, Kumar S, Moresco JJ, Yates JR, Campistol JM, Sancho-Martinez I, Giacca M, Izpisua Belmonte J. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell. 2014 Nov 06; 15(5):589-604. PMID: 25517466; PMCID: PMC4270016.
      View in: PubMed, PubMed Central
    56. Xia Y, Sancho-Martinez I, Nivet E, Rodriguez Esteban C, Campistol JM, Izpisua Belmonte J. The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat Protoc. 2014 Nov; 9(11):2693-704. PMID: 25340442.
      View in: PubMed
    57. Sancho-Martinez I, Ocampo A, Izpisua Belmonte J. Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. Curr Opin Genet Dev. 2014 Oct; 28:57-63. PMID: 25461451; PMCID: PMC4262641.
      View in: PubMed, PubMed Central
    58. Beyret E, Izpisua Belmonte J. Worming toward transdifferentiation, one (Epigenetic) step at a time. Dev Cell. 2014 Sep 29; 30(6):641-2. PMID: 25268170.
      View in: PubMed
    59. Zhu X, Fu L, Yi F, Liu GH, Ocampo A, Qu J, Izpisua Belmonte J. Regeneration: making muscle from hPSCs. Cell Res. 2014 Oct; 24(10):1159-61. PMID: 25001388; PMCID: PMC4185353.
      View in: PubMed, PubMed Central
    60. Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla RD, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH, Li Y, Izpisua Belmonte J. Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones. Cell Stem Cell. 2014 Jul 03; 15(1):31-6. PMID: 24996168; PMCID: PMC4144407.
      View in: PubMed, PubMed Central
    61. Masuda S, Izpisua Belmonte J. A recipe for targeted therapy in prostate cancer. Nat Rev Urol. 2014 Jul; 11(7):419. PMID: 24980194.
      View in: PubMed
    62. Wu K, Ren R, Su W, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte J, Liu GH, Chen C. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014 Jul 18; 289(29):20193-9. PMID: 24895131; PMCID: PMC4106335.
      View in: PubMed, PubMed Central
    63. Wu MZ, Li M, Liu GH, Izpisua Belmonte J. A chemical approach to "rewire" neural progenitor cells. Cell Res. 2014 Jun; 24(6):641-2. PMID: 24743789; PMCID: PMC4042174.
      View in: PubMed, PubMed Central
    64. Morris R, Sancho-Martinez I, Sharpee TO, Izpisua Belmonte J. Mathematical approaches to modeling development and reprogramming. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5076-82. PMID: 24706886; PMCID: PMC3986203.
      View in: PubMed, PubMed Central
    65. Masuda S, Izpisua Belmonte J. Re: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst. 2014 Mar; 106(3):djt457. PMID: 24586105.
      View in: PubMed
    66. Li M, Izpisua Belmonte J. Ageing: Genetic rejuvenation of old muscle. Nature. 2014 Feb 20; 506(7488):304-5. PMID: 24522526.
      View in: PubMed
    67. Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte J, Pinna LA, Sarno S. The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2. Biochim Biophys Acta. 2014 Apr; 1844(4):722-9. PMID: 24486797.
      View in: PubMed
    68. Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Izpisua Belmonte J. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. Protein Cell. 2014 Jan; 5(1):59-68. PMID: 24474197; PMCID: PMC3938846.
      View in: PubMed, PubMed Central
    69. Zhang K, Liu GH, Yi F, Montserrat N, Hishida T, Esteban CR, Izpisua Belmonte J. Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. Protein Cell. 2014 Jan; 5(1):48-58. PMID: 24474194; PMCID: PMC3938849.
      View in: PubMed, PubMed Central
    70. Xu XL, Yang JP, Fu LN, Ren RT, Yi F, Suzuki K, Liu K, Ding ZC, Qu J, Zhang WQ, Li Y, Yuan TT, Yuan GH, Sui LN, Guan D, Duan SL, Pan HZ, Wang P, Zhu XP, Montserrat N, Li M, Bai RJ, Liu L, Izpisua Belmonte J, Liu GH. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein Cell. 2014 Jan; 5(1):4-7. PMID: 24492924; PMCID: PMC3938843.
      View in: PubMed, PubMed Central
    71. Li M, Suzuki K, Kim NY, Liu GH, Izpisua Belmonte J. A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. J Biol Chem. 2014 Feb 21; 289(8):4594-9. PMID: 24362028; PMCID: PMC3931021.
      View in: PubMed, PubMed Central
    72. Fu L, Zhu X, Yi F, Liu GH, Izpisua Belmonte J. Regenerative medicine: transdifferentiation in vivo. Cell Res. 2014 Feb; 24(2):141-2. PMID: 24343579; PMCID: PMC3915906.
      View in: PubMed, PubMed Central
    73. Esquivies L, Blackler A, Peran M, Rodriguez-Esteban C, Izpisua Belmonte J, Booker E, Gray PC, Ahn C, Kwiatkowski W, Choe S. Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structure. J Biol Chem. 2014 Jan 17; 289(3):1788-97. PMID: 24311780; PMCID: PMC3894355.
      View in: PubMed, PubMed Central
    74. Vitaloni M, Pulecio J, Bilic J, Kuebler B, Laricchia-Robbio L, Izpisua Belmonte J. MicroRNAs contribute to induced pluripotent stem cell somatic donor memory. J Biol Chem. 2014 Jan 24; 289(4):2084-98. PMID: 24311783; PMCID: PMC3900956.
      View in: PubMed, PubMed Central
    75. Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM, Izpisua Belmonte J. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat Cell Biol. 2013 Dec; 15(12):1507-15. PMID: 24240476.
      View in: PubMed
    76. Yang J, Cai N, Yi F, Liu GH, Qu J, Izpisua Belmonte J. Gating pluripotency via nuclear pores. Trends Mol Med. 2014 Jan; 20(1):1-7. PMID: 24211182.
      View in: PubMed
    77. Aguirre A, Sancho-Martinez I, Izpisua Belmonte J. Heart regeneration: a tale of cell reprogramming. Circ Res. 2013 Oct 25; 113(10):1109-11. PMID: 24158574.
      View in: PubMed
    78. Gallegos TF, Sancho-Martinez I, Izpisua Belmonte J. Advances in cellular reprogramming: moving toward a reprieve from immunogenicity. Immunol Lett. 2013 Sep-Oct; 155(1-2):14-7. PMID: 24076314.
      View in: PubMed
    79. Masuda S, Suzuki K, Izpisua Belmonte J. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013 Sep 19; 369(12):1171. PMID: 24047071.
      View in: PubMed
    80. Marti M, Montserrat N, Pardo C, Mulero L, Miquel-Serra L, Rodrigues AM, Andrés Vaquero J, Kuebler B, Morera C, Barrero MJ, Izpisua Belmonte J. M-cadherin-mediated intercellular interactions activate satellite cell division. J Cell Sci. 2013 Nov 15; 126(Pt 22):5116-31. PMID: 24046443.
      View in: PubMed
    81. Masuda S, Wu J, Hishida T, Pandian GN, Sugiyama H, Izpisua Belmonte J. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. J Mol Cell Biol. 2013 Oct; 5(5):354-5. PMID: 24014886.
      View in: PubMed
    82. Sancho-Martinez I, Izpisua Belmonte J. Will SCNT-ESCs be better than iPSCs for personalized regenerative medicine? Cell Stem Cell. 2013 Aug 01; 13(2):141-2. PMID: 23910080.
      View in: PubMed
    83. Zhang W, Qu J, Suzuki K, Liu GH, Izpisua Belmonte J. Concealing cellular defects in pluripotent stem cells. Trends Cell Biol. 2013 Dec; 23(12):587-92. PMID: 23916626.
      View in: PubMed
    84. Montserrat N, Nivet E, Sancho-Martinez I, Hishida T, Kumar S, Miquel L, Cortina C, Hishida Y, Xia Y, Esteban CR, Izpisua Belmonte J. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell. 2013 Sep 05; 13(3):341-50. PMID: 23871606.
      View in: PubMed
    85. Xu X, Duan S, Yi F, Ocampo A, Liu GH, Izpisua Belmonte J. Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013 Sep 03; 18(3):325-32. PMID: 23850316.
      View in: PubMed
    86. Wang P, Qu J, Wu MZ, Zhang W, Liu GH, Izpisua Belmonte J. "TET-on" pluripotency. Cell Res. 2013 Jul; 23(7):863-5. PMID: 23732523; PMCID: PMC3698639.
      View in: PubMed, PubMed Central
    87. Masuda S, Izpisua Belmonte J. Cotransplantation of MSCs and HSCs. Transplantation. 2013 May 27; 95(10):e62-3. PMID: 23689086.
      View in: PubMed
    88. Nivet E, Liu GH, Montserrat N, Izpisua Belmonte J. [Resetting Parkinson's disease patient-derived cells to unveil new pathological marks]. Med Sci (Paris). 2013 Apr; 29(4):353-5. PMID: 23621928.
      View in: PubMed
    89. Barrero MJ, Sese B, Martí M, Izpisua Belmonte J. Macro histone variants are critical for the differentiation of human pluripotent cells. J Biol Chem. 2013 May 31; 288(22):16110-6. PMID: 23595991; PMCID: PMC3668766.
      View in: PubMed, PubMed Central
    90. Masuda S, Izpisua Belmonte J. At the crossroads of targeted treatment and resistance in melanoma. Lancet Oncol. 2013 Apr; 14(4):e136-7. PMID: 23561743.
      View in: PubMed
    91. Barrero MJ, Izpisua Belmonte J. Polycomb complex recruitment in pluripotent stem cells. Nat Cell Biol. 2013 Apr; 15(4):348-50. PMID: 23548929.
      View in: PubMed
    92. Sander V, Suñe G, Jopling C, Morera C, Izpisua Belmonte J. Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. Nat Protoc. 2013 Apr; 8(4):800-9. PMID: 23538883.
      View in: PubMed
    93. Barrero MJ, Sese B, Kuebler B, Bilic J, Boue S, Martí M, Izpisua Belmonte J. Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency. Cell Rep. 2013 Apr 25; 3(4):1005-11. PMID: 23545500.
      View in: PubMed
    94. Aguirre A, Sancho-Martinez I, Izpisua Belmonte J. Reprogramming toward heart regeneration: stem cells and beyond. Cell Stem Cell. 2013 Mar 07; 12(3):275-84. PMID: 23472869.
      View in: PubMed
    95. Pan H, Cai N, Li M, Liu GH, Izpisua Belmonte J. Autophagic control of cell 'stemness'. EMBO Mol Med. 2013 Mar; 5(3):327-31. PMID: 23495139; PMCID: PMC3598074.
      View in: PubMed, PubMed Central
    96. Peran M, Ruiz S, Kwiatkowski W, Marchal JA, Yang SL, Aranega A, Choe S, Izpisua Belmonte J. Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation. Stem Cell Res. 2013 May; 10(3):464-76. PMID: 23500646.
      View in: PubMed
    97. Sui L, Liu GH, Izpisua Belmonte J. hESC-derived pancreatic progenitors. Cell Res. 2013 May; 23(5):592-4. PMID: 23381137; PMCID: PMC3641592.
      View in: PubMed, PubMed Central
    98. Masuda S, Li M, Izpisua Belmonte J. Niche-less maintenance of HSCs by 2i. Cell Res. 2013 Apr; 23(4):458-9. PMID: 23357848; PMCID: PMC3616430.
      View in: PubMed, PubMed Central
    99. Eguizabal C, Montserrat N, Veiga A, Izpisua Belmonte J. Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine. Semin Reprod Med. 2013 Jan; 31(1):82-94. PMID: 23329641.
      View in: PubMed
    100. Sancho-Martinez I, Izpisua Belmonte J. Stem cells: Surf the waves of reprogramming. Nature. 2013 Jan 17; 493(7432):310-1. PMID: 23325209.
      View in: PubMed
    101. Nivet E, Sancho-Martinez I, Izpisua Belmonte J. Conversion of pericytes to neurons: a new guest at the reprogramming convention. Stem Cell Res Ther. 2013 Jan 11; 4(1):2. PMID: 23312036; PMCID: PMC3706921.
      View in: PubMed, PubMed Central
    102. Martí M, Mulero L, Pardo C, Morera C, Carrió M, Laricchia-Robbio L, Esteban CR, Izpisua Belmonte J. Characterization of pluripotent stem cells. Nat Protoc. 2013 Feb; 8(2):223-53. PMID: 23306458.
      View in: PubMed
    103. Sesé B, Barrero MJ, Fabregat MC, Sander V, Izpisua Belmonte J. SMYD2 is induced during cell differentiation and participates in early development. Int J Dev Biol. 2013; 57(5):357-64. PMID: 23873367.
      View in: PubMed
    104. Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K, Izpisua Belmonte J. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun. 2013; 4:1382. PMID: 23340422; PMCID: PMC3856317.
      View in: PubMed, PubMed Central
    105. Masuda S, Izpisua Belmonte J. The microenvironment and resistance to personalized cancer therapy. Nat Rev Clin Oncol. 2013 Feb; 10(2). PMID: 23247379.
      View in: PubMed
    106. Izpisua Belmonte J. Reprogramming development and aging: cell differentiation as a malleable process. Curr Opin Cell Biol. 2012 Dec; 24(6):713-5. PMID: 23246129.
      View in: PubMed
    107. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Izpisua Belmonte J. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. PMID: 23202434; PMCID: PMC3531579.
      View in: PubMed, PubMed Central
    108. Gu Y, Yi F, Liu GH, Izpisua Belmonte J. Beating in a dish: new hopes for cardiomyocyte regeneration. Cell Res. 2013 Mar; 23(3):314-6. PMID: 23184058; PMCID: PMC3587704.
      View in: PubMed, PubMed Central
    109. Yang SL, Harnish E, Leeuw T, Dietz U, Batchelder E, Wright PS, Peppard J, August P, Volle-Challier C, Bono F, Herbert JM, Izpisua Belmonte J. Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis. Protein Cell. 2012 Dec; 3(12):934-42. PMID: 23161332; PMCID: PMC4875386.
      View in: PubMed, PubMed Central
    110. Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte J, Matsui Y. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15; 26(22):2477-82. PMID: 23154982; PMCID: PMC3505818.
      View in: PubMed, PubMed Central
    111. Jopling C, Suñé G, Faucherre A, Fabregat C, Izpisua Belmonte J. Hypoxia induces myocardial regeneration in zebrafish. Circulation. 2012 Dec 18; 126(25):3017-27. PMID: 23151342.
      View in: PubMed
    112. Tiscornia G, Vivas EL, Matalonga L, Berniakovich I, Barragán Monasterio M, Eguizábal C, Gort L, González F, Ortiz Mellet C, García Fernández JM, Ribes A, Veiga A, Izpisua Belmonte J. Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds. Hum Mol Genet. 2013 Feb 15; 22(4):633-45. PMID: 23118351.
      View in: PubMed
    113. Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J, Esteban CR, Sancho-Martinez I, Izpisua Belmonte J. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012 Nov 22; 491(7425):603-7. PMID: 23075850; PMCID: PMC3504651.
      View in: PubMed, PubMed Central
    114. Masuda S, Li M, Izpisua Belmonte J. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). Cell Res. 2013 Feb; 23(2):176-8. PMID: 23044804; PMCID: PMC3567822.
      View in: PubMed, PubMed Central
    115. Masuda S, Izpisua Belmonte J. Trametinib for patients with advanced melanoma. Lancet Oncol. 2012 Oct; 13(10):e409; author reply e409-10. PMID: 23026823.
      View in: PubMed
    116. Ruiz S, Panopoulos AD, Montserrat N, Multon MC, Daury A, Rocher C, Spanakis E, Batchelder EM, Orsini C, Deleuze JF, Izpisua Belmonte J. Generation of a drug-inducible reporter system to study cell reprogramming in human cells. J Biol Chem. 2012 Nov 23; 287(48):40767-78. PMID: 23019325; PMCID: PMC3504789.
      View in: PubMed, PubMed Central
    117. Liu GH, Ding Z, Izpisua Belmonte J. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol. 2012 Dec; 24(6):765-74. PMID: 22999273.
      View in: PubMed
    118. Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K, Izpisua Belmonte J. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16196-201. PMID: 22991473; PMCID: PMC3479609.
      View in: PubMed, PubMed Central
    119. Yi F, Qu J, Liu GH, Izpisua Belmonte J. The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells. Cell Res. 2013 Jan; 23(1):3-5. PMID: 22964710; PMCID: PMC3541658.
      View in: PubMed, PubMed Central
    120. Sancho-Martinez I, Baek SH, Izpisua Belmonte J. Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol. 2012 Sep; 14(9):892-9. PMID: 22945254.
      View in: PubMed
    121. Zhang K, Yi F, Liu GH, Izpisua Belmonte J. Huntington's disease: dancing in a dish. Cell Res. 2012 Dec; 22(12):1627-30. PMID: 22868272; PMCID: PMC3515752.
      View in: PubMed, PubMed Central
    122. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte J, Cashman J, Mercola M. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52. PMID: 22862949; PMCID: PMC3419596.
      View in: PubMed, PubMed Central
    123. Barrero MJ, Berdasco M, Paramonov I, Bilic J, Vitaloni M, Esteller M, Izpisua Belmonte J. DNA hypermethylation in somatic cells correlates with higher reprogramming efficiency. Stem Cells. 2012 Aug; 30(8):1696-702. PMID: 22653871.
      View in: PubMed
    124. Li M, Liu GH, Izpisua Belmonte J. Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol. 2012 Jul 23; 13(8):524-35. PMID: 22820889.
      View in: PubMed
    125. Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte J. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12556-61. PMID: 22814375; PMCID: PMC3412010.
      View in: PubMed, PubMed Central
    126. Masuda S, Montserrat N, Monserrat N, Okamura D, Suzuki K, Izpisua Belmonte J. Cardiosphere-derived cells for heart regeneration. Lancet. 2012 Jun 30; 379(9835):2425-6; author reply 2426-7. PMID: 22748584.
      View in: PubMed
    127. Cai N, Li M, Qu J, Liu GH, Izpisua Belmonte J. Post-translational modulation of pluripotency. J Mol Cell Biol. 2012 Aug; 4(4):262-5. PMID: 22679102.
      View in: PubMed
    128. Christen B, Rodrigues AM, Monasterio MB, Roig CF, Izpisua Belmonte J. Transient downregulation of Bmp signalling induces extra limbs in vertebrates. Development. 2012 Jul; 139(14):2557-65. PMID: 22675213.
      View in: PubMed
    129. Gu Y, Liu GH, Izpisua Belmonte J. Gametogenesis in a dish. Cell Res. 2012 Oct; 22(10):1422-5. PMID: 22641372; PMCID: PMC3463271.
      View in: PubMed, PubMed Central
    130. Montserrat N, Ramírez-Bajo MJ, Xia Y, Sancho-Martinez I, Moya-Rull D, Miquel-Serra L, Yang S, Nivet E, Cortina C, González F, Izpisua Belmonte J, Campistol JM. Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2. J Biol Chem. 2012 Jul 13; 287(29):24131-8. PMID: 22613719; PMCID: PMC3397840.
      View in: PubMed, PubMed Central
    131. Letamendia A, Quevedo C, Ibarbia I, Virto JM, Holgado O, Diez M, Izpisua Belmonte J, Callol-Massot C. Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One. 2012; 7(5):e36690. PMID: 22615792; PMCID: PMC3352927.
      View in: PubMed, PubMed Central
    132. Liu GH, Yi F, Suzuki K, Qu J, Izpisua Belmonte J. Induced neural stem cells: a new tool for studying neural development and neurological disorders. Cell Res. 2012 Jul; 22(7):1087-91. PMID: 22547025; PMCID: PMC3391017.
      View in: PubMed, PubMed Central
    133. Vassena R, Montserrat N, Carrasco Canal B, Aran B, de Oñate L, Veiga A, Izpisua Belmonte J. Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells. Hum Mol Genet. 2012 Aug 01; 21(15):3366-73. PMID: 22547223; PMCID: PMC3491960.
      View in: PubMed, PubMed Central
    134. Xu X, Qu J, Suzuki K, Li M, Zhang W, Liu GH, Izpisua Belmonte J. Reprogramming based gene therapy for inherited red blood cell disorders. Cell Res. 2012 Jun; 22(6):941-4. PMID: 22473006; PMCID: PMC3367524.
      View in: PubMed, PubMed Central
    135. Yi F, Liu GH, Izpisua Belmonte J. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy. Protein Cell. 2012 Apr; 3(4):246-50. PMID: 22441839; PMCID: PMC4875479.
      View in: PubMed, PubMed Central
    136. Jopling C, Suñe G, Morera C, Izpisua Belmonte J. p38a MAPK regulates myocardial regeneration in zebrafish. Cell Cycle. 2012 Mar 15; 11(6):1195-201. PMID: 22391208; PMCID: PMC3679222.
      View in: PubMed, PubMed Central
    137. Liu GH, Li M, Qu J, Izpisua Belmonte J. Gating neural development and aging via nuclear pores. Cell Res. 2012 Aug; 22(8):1212-4. PMID: 22410792; PMCID: PMC3411164.
      View in: PubMed, PubMed Central
    138. Yi F, Liu GH, Izpisua Belmonte J. Rejuvenating liver and pancreas through cell transdifferentiation. Cell Res. 2012 Apr; 22(4):616-9. PMID: 22373548; PMCID: PMC3317567.
      View in: PubMed, PubMed Central
    139. Berniakovich I, Laricchia-Robbio L, Izpisua Belmonte J. N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome. Int J Dev Biol. 2012; 56(9):729-35. PMID: 23319348.
      View in: PubMed
    140. Bilic J, Izpisua Belmonte J. Concise review: Induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? Stem Cells. 2012 Jan; 30(1):33-41. PMID: 22213481.
      View in: PubMed
    141. Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L, Izpisua Belmonte J. Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. Oncogene. 2012 Sep 27; 31(39):4333-42. PMID: 22179836.
      View in: PubMed
    142. Liu GH, Sancho-Martinez I, Izpisua Belmonte J. Cut and paste: restoring cellular function by gene correction. Cell Res. 2012 Feb; 22(2):283-4. PMID: 22143565; PMCID: PMC3271590.
      View in: PubMed, PubMed Central
    143. Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J, Sancho-Martinez I, Liu GH, Izpisua Belmonte J. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs. Cell Res. 2011 Dec; 21(12):1740-4. PMID: 22105484; PMCID: PMC3357996.
      View in: PubMed, PubMed Central
    144. Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua Belmonte J. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Hum Gene Ther. 2012 Jan; 23(1):56-69. PMID: 21877920; PMCID: PMC3472681.
      View in: PubMed, PubMed Central
    145. Sancho-Martinez I, Nivet E, Izpisua Belmonte J. The labyrinth of nuclear reprogramming. J Mol Cell Biol. 2011 Dec; 3(6):327-9. PMID: 22090451; PMCID: PMC3491615.
      View in: PubMed, PubMed Central
    146. Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisua Belmonte J. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res. 2012 Jan; 22(1):168-77. PMID: 22064701; PMCID: PMC3252494.
      View in: PubMed, PubMed Central
    147. Sancho-Martinez I, Nivet E, Izpisua Belmonte J. Purging and isolating pluripotent cells, "sweet" dreams become true? Cell Res. 2011 Nov; 21(11):1526-7. PMID: 22025252; PMCID: PMC3364727.
      View in: PubMed, PubMed Central
    148. Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM, Izpisua Belmonte J. Islet1-mediated activation of the ß-catenin pathway is necessary for hindlimb initiation in mice. Development. 2011 Oct; 138(20):4465-73. PMID: 21937598; PMCID: PMC3177316.
      View in: PubMed, PubMed Central
    149. Adamo A, Barrero MJ, Izpisua Belmonte J. LSD1 and pluripotency: a new player in the network. Cell Cycle. 2011 Oct 01; 10(19):3215-6. PMID: 21926475.
      View in: PubMed
    150. Montserrat N, de Oñate L, Garreta E, González F, Adamo A, Eguizábal C, Häfner S, Vassena R, Izpisua Belmonte J. Generation of feeder-free pig induced pluripotent stem cells without Pou5f1. Cell Transplant. 2012; 21(5):815-25. PMID: 21944493.
      View in: PubMed
    151. Li M, Izpisua Belmonte J. No factor left behind: generation of transgene-free induced pluripotent stem cells. Am J Stem Cells. 2012; 1(1):75-80. PMID: 23671799; PMCID: PMC3643386.
      View in: PubMed, PubMed Central
    152. Panopoulos AD, Izpisua Belmonte J. Anaerobicizing into pluripotency. Cell Metab. 2011 Aug 03; 14(2):143-4. PMID: 21803281.
      View in: PubMed
    153. Eguizabal C, Montserrat N, Vassena R, Barragan M, Garreta E, Garcia-Quevedo L, Vidal F, Giorgetti A, Veiga A, Izpisua Belmonte J. Complete meiosis from human induced pluripotent stem cells. Stem Cells. 2011 Aug; 29(8):1186-95. PMID: 21681858.
      View in: PubMed
    154. Vassena R, Boué S, González-Roca E, Aran B, Auer H, Veiga A, Izpisua Belmonte J. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development. 2011 Sep; 138(17):3699-709. PMID: 21775417; PMCID: PMC4074286.
      View in: PubMed, PubMed Central
    155. Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ, Izpisua Belmonte J. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol. 2011 Jun; 13(6):652-9. PMID: 21602794.
      View in: PubMed
    156. Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisua Belmonte J. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011 Jun 03; 8(6):688-94. PMID: 21596650; PMCID: PMC3480729.
      View in: PubMed, PubMed Central
    157. Panopoulos AD, Ruiz S, Yi F, Herrerías A, Batchelder EM, Izpisua Belmonte J. Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells. PLoS One. 2011; 6(5):e19743. PMID: 21603572; PMCID: PMC3095638.
      View in: PubMed, PubMed Central
    158. Robles V, Martí M, Izpisua Belmonte J. Study of pluripotency markers in zebrafish embryos and transient embryonic stem cell cultures. Zebrafish. 2011 Jun; 8(2):57-63. PMID: 21563922; PMCID: PMC3472678.
      View in: PubMed, PubMed Central
    159. Menchón C, Edel MJ, Izpisua Belmonte J. The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle. 2011 May 01; 10(9):1435-47. PMID: 21478681; PMCID: PMC3685623.
      View in: PubMed, PubMed Central
    160. Barrero MJ, Izpisua Belmonte J. iPS cells forgive but do not forget. Nat Cell Biol. 2011 May; 13(5):523-5. PMID: 21540851.
      View in: PubMed
    161. Edel MJ, Menchon C, Vaquero JM, Izpisua Belmonte J. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells. Cell Commun Signal. 2011 Apr 11; 9(1):8. PMID: 21481269; PMCID: PMC3101157.
      View in: PubMed, PubMed Central
    162. Panopoulos AD, Ruiz S, Izpisua Belmonte J. iPSCs: induced back to controversy. Cell Stem Cell. 2011 Apr 08; 8(4):347-8. PMID: 21474093.
      View in: PubMed
    163. Kim S, Izpisua Belmonte J. Pluripotency of male germline stem cells. Mol Cells. 2011 Aug; 32(2):113-21. PMID: 21448589; PMCID: PMC3887674.
      View in: PubMed, PubMed Central
    164. Tiscornia G, Monserrat N, Izpisua Belmonte J. Modelling long QT syndrome with iPS cells: be still, my beating heart ... Circ Res. 2011 Mar 18; 108(6):648-9. PMID: 21415406.
      View in: PubMed
    165. Sancho-Martinez I, Li M, Izpisua Belmonte J. Disease correction the iPSC way: advances in iPSC-based therapy. Clin Pharmacol Ther. 2011 May; 89(5):746-9. PMID: 21389982.
      View in: PubMed
    166. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte J, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. PMID: 21368825; PMCID: PMC3074107.
      View in: PubMed, PubMed Central
    167. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J, Izpisua Belmonte J. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011 Apr 14; 472(7342):221-5. PMID: 21346760; PMCID: PMC3088088.
      View in: PubMed, PubMed Central
    168. Barrero MJ, Izpisua Belmonte J. Regenerating the epigenome. EMBO Rep. 2011 Mar; 12(3):208-15. PMID: 21311559; PMCID: PMC3059915.
      View in: PubMed, PubMed Central
    169. Li M, Sancho-Martinez I, Izpisua Belmonte J. Cell fate conversion by mRNA. Stem Cell Res Ther. 2011 Feb 09; 2(1):5. PMID: 21345255; PMCID: PMC3092145.
      View in: PubMed, PubMed Central
    170. Jopling C, Boue S, Izpisua Belmonte J. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol. 2011 Feb; 12(2):79-89. PMID: 21252997.
      View in: PubMed
    171. Montserrat N, Garreta E, González F, Gutiérrez J, Eguizábal C, Ramos V, Borrós S, Izpisua Belmonte J. Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system. J Biol Chem. 2011 Apr 08; 286(14):12417-28. PMID: 21285354; PMCID: PMC3069445.
      View in: PubMed, PubMed Central
    172. Oishi I, Kim S, Yoshii K, Esteban CR, Izpisua Belmonte J. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. BMC Biotechnol. 2011 Jan 14; 11:5. PMID: 21235743; PMCID: PMC3033811.
      View in: PubMed, PubMed Central
    173. Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisua Belmonte J, Murry C, Keirstead HS, Park HS, Schmidt U, Laslett AL, Muller FJ, Nievergelt CM, Shamir R, Loring JF. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011 Jan 07; 8(1):106-18. PMID: 21211785; PMCID: PMC3043464.
      View in: PubMed, PubMed Central
    174. Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte J. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol. 2011 Jan 11; 21(1):45-52. PMID: 21167714; PMCID: PMC3034649.
      View in: PubMed, PubMed Central
    175. Menendez S, Camus S, Izpisua Belmonte J. p53: guardian of reprogramming. Cell Cycle. 2010 Oct 01; 9(19):3887-91. PMID: 20948296.
      View in: PubMed
    176. Edel MJ, Boué S, Menchon C, Sánchez-Danés A, Izpisua Belmonte J. Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. Cell Cycle. 2010 Sep 01; 9(17):3414-22. PMID: 20729629.
      View in: PubMed
    177. Santamaria P, Rodriguez-Piza I, Clemente-Casares X, Yamanouchi J, Mulero-Perez L, Aasen T, Raya A, Izpisua Belmonte J. Turning human epidermis into pancreatic endoderm. Rev Diabet Stud. 2010; 7(2):158-67. PMID: 21060974; PMCID: PMC2989788.
      View in: PubMed, PubMed Central
    178. Edel MJ, Izpisua Belmonte J. The cell cycle and pluripotency: Is there a direct link? Cell Cycle. 2010 Jul 15; 9(14):2694-5. PMID: 20581443.
      View in: PubMed
    179. Isaacs MJ, Kawakami Y, Allendorph GP, Yoon BH, Izpisua Belmonte J, Choe S. Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Mol Endocrinol. 2010 Jul; 24(7):1469-77. PMID: 20484413; PMCID: PMC2903903.
      View in: PubMed, PubMed Central
    180. Sleep E, Boué S, Jopling C, Raya M, Raya A, Izpisua Belmonte J. Transcriptomics approach to investigate zebrafish heart regeneration. J Cardiovasc Med (Hagerstown). 2010 May; 11(5):369-80. PMID: 20179605.
      View in: PubMed
    181. Edel MJ, Menchon C, Menendez S, Consiglio A, Raya A, Izpisua Belmonte J. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev. 2010 Mar 15; 24(6):561-73. PMID: 20231315; PMCID: PMC2841334.
      View in: PubMed, PubMed Central
    182. Stewart S, Tsun ZY, Izpisua Belmonte J. A histone demethylase is necessary for regeneration in zebrafish. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19889-94. PMID: 19897725; PMCID: PMC2785262.
      View in: PubMed, PubMed Central
    183. Giorgetti A, Montserrat N, Aasen T, Gonzalez F, Rodríguez-Pizà I, Vassena R, Raya A, Boué S, Barrero MJ, Corbella BA, Torrabadella M, Veiga A, Izpisua Belmonte J. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell. 2009 Oct 02; 5(4):353-7. PMID: 19796614; PMCID: PMC2779776.
      View in: PubMed, PubMed Central
    184. Kan NG, Junghans D, Izpisua Belmonte J. Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. FASEB J. 2009 Oct; 23(10):3516-25. PMID: 19546304; PMCID: PMC2747679.
      View in: PubMed, PubMed Central
    185. Gonzalez F, Barragan Monasterio M, Tiscornia G, Montserrat Pulido N, Vassena R, Batlle Morera L, Rodriguez Piza I, Izpisua Belmonte J. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8918-22. PMID: 19458047; PMCID: PMC2690033.
      View in: PubMed, PubMed Central
    186. Jopling C, Izpisua Belmonte J. Cilia--where two Wnts collide. Zebrafish. 2009 Mar; 6(1):15-9. PMID: 19250031.
      View in: PubMed
    187. Kawakami Y, Uchiyama Y, Rodriguez Esteban C, Inenaga T, Koyano-Nakagawa N, Kawakami H, Marti M, Kmita M, Monaghan-Nichols P, Nishinakamura R, Izpisua Belmonte J. Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development. 2009 Feb; 136(4):585-94. PMID: 19168674; PMCID: PMC3266482.
      View in: PubMed, PubMed Central
    188. Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte J, Giles W, Bodmer R, Ocorr K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques. 2009 Feb; 46(2):101-13. PMID: 19317655; PMCID: PMC2855226.
      View in: PubMed, PubMed Central
    189. Pekarik V, Izpisua Belmonte J. NFIX--one gene, two knockouts, multiple effects. J Biol. 2008 Oct 23; 7(8):29. PMID: 18983696.
      View in: PubMed
    190. Tugores A, Izpisua Belmonte J. Differential display of eukaryotic mRNA. Methods Mol Biol. 2008; 461:589-604. PMID: 19030825.
      View in: PubMed
    191. Allendorph GP, Isaacs MJ, Kawakami Y, Izpisua Belmonte J, Choe S. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry. 2007 Oct 30; 46(43):12238-47. PMID: 17924656.
      View in: PubMed
    192. Sahara S, Kawakami Y, Izpisua Belmonte J, O'Leary DD. Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Dev. 2007 May 17; 2:10. PMID: 17509151; PMCID: PMC1890288.
      View in: PubMed, PubMed Central
    193. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte J, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730; PMCID: PMC1317903.
      View in: PubMed, PubMed Central
    194. Raya A, Izpisua Belmonte J. Unveiling the establishment of left-right asymmetry in the chick embryo. Mech Dev. 2004 Sep; 121(9):1043-54. PMID: 15296970.
      View in: PubMed
    195. Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL, Izpisua Belmonte J. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev. 2003 May 15; 17(10):1213-8. PMID: 12730123; PMCID: PMC196060.
      View in: PubMed, PubMed Central
    196. Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Baban K, Affolter M, Vale WW, Izpisua Belmonte J, Choe S. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. J Bone Joint Surg Am. 2003; 85-A Suppl 3:52-8. PMID: 12925610.
      View in: PubMed
    197. Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW, Izpisua Belmonte J, Choe S. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 2002 Dec 12; 420(6916):636-42. PMID: 12478285.
      View in: PubMed
    198. Rodriguez-Esteban C, Tsukui T, Yonei S, Magallon J, Tamura K, Izpisua Belmonte J. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Nature. 1999 Apr 29; 398(6730):814-8. PMID: 10235264.
      View in: PubMed
    Juan Carlos's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (678) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (30) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    ↑