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    Joseph Noel

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
    Phone858-453-4100
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      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel J, Evans RM. Structural basis for specific ligation of the peroxisome proliferator-activated receptor d. Proc Natl Acad Sci U S A. 2017 Mar 28; 114(13):E2563-E2570. PMID: 28320959.
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      2. Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel J. Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246]. Curr Opin Struct Biol. 2016 Nov 21. PMID: 27884574.
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      3. Levsh O, Chiang YC, Tung CF, Noel J, Wang Y, Weng JK. Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry. 2016 Nov 2. PMID: 27805809.
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      4. Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel J. Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. Curr Opin Struct Biol. 2016 Dec; 41:233-246. PMID: 27662376.
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      5. Koo HJ, Vickery CR, Xu Y, Louie GV, O'Maille PE, Bowman M, Nartey CM, Burkart MD, Noel J. Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. J Antibiot (Tokyo). 2016 Jul; 69(7):524-33. PMID: 27328867.
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      6. Zheng Z, Guo Y, Novák O, Chen W, Ljung K, Noel J, Chory J. Local auxin metabolism regulates environment-induced hypocotyl elongation. Nat Plants. 2016; 2:16025. PMID: 27249562.
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      7. El Gamal A, Agarwal V, Diethelm S, Rahman I, Schorn MA, Sneed JM, Louie GV, Whalen KE, Mincer TJ, Noel J, Paul VJ, Moore BS. Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A. 2016 Apr 5; 113(14):3797-802. PMID: 27001835.
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      8. Vickery CR, La Clair JJ, Burkart MD, Noel J. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr Opin Chem Biol. 2016 Apr; 31:66-73. PMID: 26851514.
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      9. Kersten RD, Diedrich JK, Yates JR, Noel J. Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases. ACS Chem Biol. 2015 Nov 20; 10(11):2501-11. PMID: 26378620.
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      10. Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel J, Chappell J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chem Biol. 2015 Jul 17; 10(7):1729-36. PMID: 25897591.
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      11. Pan H, Zhou R, Louie GV, Mühlemann JK, Bomati EK, Bowman ME, Dudareva N, Dixon RA, Noel J, Wang X. Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell. 2014 Sep; 26(9):3709-27. PMID: 25217505.
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      12. Vickery CR, Kosa NM, Casavant EP, Duan S, Noel J, Burkart MD. Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria. ACS Chem Biol. 2014 Sep 19; 9(9):1939-44. PMID: 24963544.
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      13. Bomati EK, Haley JE, Noel J, Deheyn DD. Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus. Sci Rep. 2014; 4:5469. PMID: 24968921.
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      14. Hoppmann C, Lacey VK, Louie GV, Wei J, Noel J, Wang L. Genetically Encoding Photoswitchable Click Amino Acids in Escherichia coli and Mammalian Cells. Angew Chem Int Ed Engl. 2014 Apr 7; 53(15):3932-6. PMID: 24615769.
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      15. Dellas N, Thomas ST, Manning G, Noel J. Discovery of a metabolic alternative to the classical mevalonate pathway. Elife. 2013; 2(0):e00672. PMID: 24327557.
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      16. Beld J, Sonnenschein EC, Vickery CR, Noel J, Burkart MD. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat Prod Rep. 2013 Dec 5; 31(1):61-108. PMID: 24292120.
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      17. Schorn M, Zettler J, Noel J, Dorrestein PC, Moore BS, Kaysser L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem Biol. 2014 Jan 17; 9(1):301-9. PMID: 24168704.
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      18. Lacey VK, Louie GV, Noel J, Wang L. Expanding the Library and Substrate Diversity of the Pyrrolysyl-tRNA Synthetase to Incorporate Unnatural Amino Acids Containing Conjugated Rings. Chembiochem. 2013 Nov 4; 14(16):2100-5. PMID: 24019075.
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      19. Guo Y, Zheng Z, La Clair JJ, Chory J, Noel J. Smoke-derived karrikin perception by the a/ß-hydrolase KAI2 from Arabidopsis. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8284-9. PMID: 23613584.
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      20. Stewart C, Vickery CR, Burkart MD, Noel J. Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. Curr Opin Plant Biol. 2013 Jun; 16(3):365-72. PMID: 23481348.
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      21. Zheng Z, Guo Y, Novák O, Dai X, Zhao Y, Ljung K, Noel J, Chory J. Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. Nat Chem Biol. 2013 Apr; 9(4):244-6. PMID: 23377040.
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      22. Liscombe DK, Louie GV, Noel J. Architectures, mechanisms and molecular evolution of natural product methyltransferases. Nat Prod Rep. 2012 Oct; 29(10):1238-50. PMID: 22850796.
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      23. Zhang M, Wang XJ, Chen X, Bowman ME, Luo Y, Noel J, Ellington AD, Etzkorn FA, Zhang Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. ACS Chem Biol. 2012 Aug 17; 7(8):1462-70. PMID: 22670809.
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      24. Ngaki MN, Louie GV, Philippe RN, Manning G, Pojer F, Bowman ME, Li L, Larsen E, Wurtele ES, Noel J. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature. 2012 May 24; 485(7399):530-3. PMID: 22622584.
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      25. Auldridge ME, Guo Y, Austin MB, Ramsey J, Fridman E, Pichersky E, Noel J. Emergent decarboxylase activity and attenuation of a/ß-hydrolase activity during the evolution of methylketone biosynthesis in tomato. Plant Cell. 2012 Apr; 24(4):1596-607. PMID: 22523203.
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      26. Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel J, Gage FH, Wang L. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40. PMID: 21681861.
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      27. Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel J, Wilson IA, Chory J. Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature. 2011 Jun 23; 474(7352):467-71. PMID: 21666665.
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      28. Takimoto JK, Dellas N, Noel J, Wang L. Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. ACS Chem Biol. 2011 Jul 15; 6(7):733-43. PMID: 21545173.
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      29. Louie GV, Bowman ME, Tu Y, Mouradov A, Spangenberg G, Noel J. Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference. Plant Cell. 2010 Dec; 22(12):4114-27. PMID: 21177481.
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      30. Tu Y, Rochfort S, Liu Z, Ran Y, Griffith M, Badenhorst P, Louie GV, Bowman ME, Smith KF, Noel J, Mouradov A, Spangenberg G. Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). Plant Cell. 2010 Oct; 22(10):3357-73. PMID: 20952635.
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      31. Yu G, Nguyen TT, Guo Y, Schauvinhold I, Auldridge ME, Bhuiyan N, Ben-Israel I, Iijima Y, Fridman E, Noel J, Pichersky E. Enzymatic functions of wild tomato methylketone synthases 1 and 2. Plant Physiol. 2010 Sep; 154(1):67-77. PMID: 20605911.
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      32. Dellas N, Noel J. Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. ACS Chem Biol. 2010 Jun 18; 5(6):589-601. PMID: 20392112.
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      33. Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel J, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 May; 19(5):974-86. PMID: 20222012.
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      34. Noel J, Dellas N, Faraldos JA, Zhao M, Hess BA, Smentek L, Coates RM, O'Maille PE. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. ACS Chem Biol. 2010 Apr 16; 5(4):377-92. PMID: 20175559.
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      35. Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel J, DiPasquale AG, Rheingold AL, La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov; 72(11):1980-7. PMID: 19842686.
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      36. Koeduka T, Orlova I, Baiga TJ, Noel J, Dudareva N, Pichersky E. The lack of floral synthesis and emission of isoeugenol in Petunia axillaris subsp. parodii is due to a mutation in the isoeugenol synthase gene. Plant J. 2009 Jun; 58(6):961-9. PMID: 19222805.
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      37. Savaldi-Goldstein S, Baiga TJ, Pojer F, Dabi T, Butterfield C, Parry G, Santner A, Dharmasiri N, Tao Y, Estelle M, Noel J, Chory J. New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15190-5. PMID: 18818305.
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      38. Eustáquio AS, Härle J, Noel J, Moore BS. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem. 2008 Sep 22; 9(14):2215-9. PMID: 18720493.
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      39. O'Maille PE, Malone A, Dellas N, Andes Hess B, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel J. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol. 2008 Oct; 4(10):617-23. PMID: 18776889.
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      40. Kumano T, Richard SB, Noel J, Nishiyama M, Kuzuyama T. Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. Bioorg Med Chem. 2008 Sep 1; 16(17):8117-26. PMID: 18682327.
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      41. Tello M, Kuzuyama T, Heide L, Noel J, Richard SB. The ABBA family of aromatic prenyltransferases: broadening natural product diversity. Cell Mol Life Sci. 2008 May; 65(10):1459-63. PMID: 18322648.
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      42. Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballaré CL, Sandberg G, Noel J, Chory J. Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants. Cell. 2008 Apr 4; 133(1):164-76. PMID: 18394996.
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      43. Baiga TJ, Guo H, Xing Y, O'Doherty GA, Dillin A, Austin MB, Noel J, La Clair JJ. Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. ACS Chem Biol. 2008 May 16; 3(5):294-304. PMID: 18376812.
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      44. Austin MB, O'Maille PE, Noel J. Evolving biosynthetic tangos negotiate mechanistic landscapes. Nat Chem Biol. 2008 Apr; 4(4):217-22. PMID: 18347585.
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      45. Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel J, Dudareva N, Pichersky E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. Plant J. 2008 May; 54(3):362-74. PMID: 18208524.
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      46. Zhao N, Ferrer JL, Ross J, Guan J, Yang Y, Pichersky E, Noel J, Chen F. Structural, biochemical, and phylogenetic analyses suggest that indole-3-acetic acid methyltransferase is an evolutionarily ancient member of the SABATH family. Plant Physiol. 2008 Feb; 146(2):455-67. PMID: 18162595.
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      47. Eustáquio AS, Pojer F, Noel J, Moore BS. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol. 2008 Jan; 4(1):69-74. PMID: 18059261.
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      48. Noel J. Digging for answers, smelling a hint of success and tasting triumph. Nat Chem Biol. 2007 Nov; 3(11):690-1. PMID: 17948014.
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      49. Faraldos JA, Zhao Y, O'Maille PE, Noel J, Coates RM. Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem. 2007 Oct 15; 8(15):1826-33. PMID: 17886322.
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      50. Louie GV, Baiga TJ, Bowman ME, Koeduka T, Taylor JH, Spassova SM, Pichersky E, Noel J. Structure and reaction mechanism of basil eugenol synthase. PLoS One. 2007; 2(10):e993. PMID: 17912370.
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      51. Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel J, Coates RM, Chappell J. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem. 2007 Oct 26; 282(43):31744-54. PMID: 17715131.
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      52. Wang W, Takimoto JK, Louie GV, Baiga TJ, Noel J, Lee KF, Slesinger PA, Wang L. Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci. 2007 Aug; 10(8):1063-72. PMID: 17603477.
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      53. Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lücke C, Hunter T, Lu KP, Fischer G, Noel J. Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol. 2007 May 22; 2(5):320-8. PMID: 17518432.
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      54. Moffitt MC, Louie GV, Bowman ME, Pence J, Noel J, Moore BS. Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry. 2007 Jan 30; 46(4):1004-12. PMID: 17240984.
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      55. Varbanova M, Yamaguchi S, Yang Y, McKelvey K, Hanada A, Borochov R, Yu F, Jikumaru Y, Ross J, Cortes D, Ma CJ, Noel J, Mander L, Shulaev V, Kamiya Y, Rodermel S, Weiss D, Pichersky E. Methylation of gibberellins by Arabidopsis GAMT1 and GAMT2. Plant Cell. 2007 Jan; 19(1):32-45. PMID: 17220201.
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      56. Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel J. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell. 2006 Dec; 18(12):3656-69. PMID: 17172354.
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      57. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel J. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 8; 24(5):759-70. PMID: 17157258.
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      58. Ferrer JL, Dupuy J, Borel F, Jacquamet L, Noel J, Dulic V. Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1. Cell Cycle. 2006 Dec; 5(23):2760-8. PMID: 17172845.
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      59. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel J. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol. 2006 Dec; 13(12):1327-38. PMID: 17185228.
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      60. Song L, Barona-Gomez F, Corre C, Xiang L, Udwary DW, Austin MB, Noel J, Moore BS, Challis GL. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006 Nov 22; 128(46):14754-5. PMID: 17105255.
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      61. Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore BS, Kay RR, Noel J. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol. 2006 Sep; 2(9):494-502. PMID: 16906151.
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      62. Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel J. Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. Proc Natl Acad Sci U S A. 2006 Aug 1; 103(31):11491-6. PMID: 16864776.
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      63. Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel J, Gruebele M, Kelly JW. Structure-function-folding relationship in a WW domain. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10648-53. PMID: 16807295.
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      64. Coiner H, Schröder G, Wehinger E, Liu CJ, Noel J, Schwab W, Schröder J. Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases. Plant J. 2006 Apr; 46(2):193-205. PMID: 16623883.
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      65. Lherbet C, Pojer F, Richard SB, Noel J, Poulter CD. Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry. 2006 Mar 21; 45(11):3548-53. PMID: 16533036.
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      66. Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel J. [Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding]. Med Sci (Paris). 2005 Nov; 21(11):903-4. PMID: 16274634.
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      67. Testa CA, Lherbet C, Pojer F, Noel J, Poulter CD. Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway. Biochim Biophys Acta. 2006 Jan; 1764(1):85-96. PMID: 16203191.
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      68. Bomati EK, Austin MB, Bowman ME, Dixon RA, Noel J. Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. J Biol Chem. 2005 Aug 26; 280(34):30496-503. PMID: 15970585.
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      69. Kuzuyama T, Noel J, Richard SB. Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature. 2005 Jun 16; 435(7044):983-7. PMID: 15959519.
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      70. Noel J, Austin MB, Bomati EK. Structure-function relationships in plant phenylpropanoid biosynthesis. Curr Opin Plant Biol. 2005 Jun; 8(3):249-53. PMID: 15860421.
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      71. Effmert U, Saschenbrecker S, Ross J, Negre F, Fraser CM, Noel J, Dudareva N, Piechulla B. Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function. Phytochemistry. 2005 Jun; 66(11):1211-30. PMID: 15946712.
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      72. Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel J. Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. PLoS Biol. 2005 May; 3(5):e151. PMID: 15884974.
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      73. Bomati EK, Noel J. Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. Plant Cell. 2005 May; 17(5):1598-611. PMID: 15829607.
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      74. Ferrer JL, Zubieta C, Dixon RA, Noel J. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant Physiol. 2005 Mar; 137(3):1009-17. PMID: 15734921.
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      75. Takahashi S, Zhao Y, O'Maille PE, Greenhagen BT, Noel J, Coates RM, Chappell J. Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. J Biol Chem. 2005 Feb 4; 280(5):3686-96. PMID: 15522862.
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      76. Richard SB, Lillo AM, Tetzlaff CN, Bowman ME, Noel J, Cane DE. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Biochemistry. 2004 Sep 28; 43(38):12189-97. PMID: 15379557.
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      77. Austin MB, Bowman ME, Ferrer JL, Schröder J, Noel J. An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chem Biol. 2004 Sep; 11(9):1179-94. PMID: 15380179.
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      78. Pott MB, Hippauf F, Saschenbrecker S, Chen F, Ross J, Kiefer I, Slusarenko A, Noel J, Pichersky E, Effmert U, Piechulla B. Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. Plant Physiol. 2004 Aug; 135(4):1946-55. PMID: 15310828.
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      79. Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore BS, Noel J. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem. 2004 Oct 22; 279(43):45162-74. PMID: 15265863.
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      80. O'Maille PE, Tsai MD, Greenhagen BT, Chappell J, Noel J. Gene library synthesis by structure-based combinatorial protein engineering. Methods Enzymol. 2004; 388:75-91. PMID: 15289063.
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      81. Chen F, D'Auria JC, Tholl D, Ross JR, Gershenzon J, Noel J, Pichersky E. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. Plant J. 2003 Dec; 36(5):577-88. PMID: 14617060.
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      82. Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel J, Moore BS. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). J Ind Microbiol Biotechnol. 2003 Aug; 30(8):510-5. PMID: 12905073.
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      83. Zubieta C, Ross JR, Koscheski P, Yang Y, Pichersky E, Noel J. Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. Plant Cell. 2003 Aug; 15(8):1704-16. PMID: 12897246.
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      84. Sonnenburg ED, Bilwes A, Hunter T, Noel J. The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry. 2003 Jul 8; 42(26):7904-14. PMID: 12834342.
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      85. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel J, Nicolaou KC, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92. PMID: 12718892.
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      86. Austin MB, Noel J. The chalcone synthase superfamily of type III polyketide synthases. Nat Prod Rep. 2003 Feb; 20(1):79-110. PMID: 12636085.
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      87. Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel J. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell. 2003 Jan; 11(1):249-59. PMID: 12535537.
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      88. Moore BS, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel J. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. J Nat Prod. 2002 Dec; 65(12):1956-62. PMID: 12502351.
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      89. Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel J. Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. Plant Cell. 2002 Jun; 14(6):1265-77. PMID: 12084826.
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      90. Jez JM, Bowman ME, Noel J. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23; 41(16):5168-76. PMID: 11955065.
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      91. Jez JM, Bowman ME, Noel J. Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5319-24. PMID: 11959984.
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      92. Gang DR, Lavid N, Zubieta C, Chen F, Beuerle T, Lewinsohn E, Noel J, Pichersky E. Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. Plant Cell. 2002 Feb; 14(2):505-19. PMID: 11884690.
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      93. Richard SB, Ferrer JL, Bowman ME, Lillo AM, Tetzlaff CN, Cane DE, Noel J. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J Biol Chem. 2002 Mar 8; 277(10):8667-72. PMID: 11786530.
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      94. Jez JM, Bowman ME, Noel J. Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry. 2001 Dec 11; 40(49):14829-38. PMID: 11732902.
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      95. Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel J. Structure and mechanism of chalcone synthase-like polyketide synthases. J Ind Microbiol Biotechnol. 2001 Dec; 27(6):393-8. PMID: 11774005.
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      96. Lu PJ, Zhou XZ, Liou YC, Noel J, Lu KP. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem. 2002 Jan 25; 277(4):2381-4. PMID: 11723108.
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      97. Jez JM, Noel J. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. J Biol Chem. 2002 Jan 11; 277(2):1361-9. PMID: 11698411.
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      98. Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel J. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Nat Struct Biol. 2001 Jul; 8(7):641-8. PMID: 11427897.
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      99. Zubieta C, He XZ, Dixon RA, Noel J. Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Nat Struct Biol. 2001 Mar; 8(3):271-9. PMID: 11224575.
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      100. Jez JM, Noel J. Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. J Biol Chem. 2000 Dec 15; 275(50):39640-6. PMID: 11006298.
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      101. Jez JM, Austin MB, Ferrer J, Bowman ME, Schröder J, Noel J. Structural control of polyketide formation in plant-specific polyketide synthases. Chem Biol. 2000 Dec; 7(12):919-30. PMID: 11137815.
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      102. Jez JM, Bowman ME, Dixon RA, Noel J. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nat Struct Biol. 2000 Sep; 7(9):786-91. PMID: 10966651.
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      103. Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel J. Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol. 2000 Aug; 7(8):639-43. PMID: 10932246.
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      104. Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel J. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol. 2000 Jul; 7(7):602-8. PMID: 10876248.
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      105. Jez JM, Ferrer JL, Bowman ME, Dixon RA, Noel J. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry. 2000 Feb 8; 39(5):890-902. PMID: 10653632.
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      106. Jiang G, den Hertog J, Su J, Noel J, Sap J, Hunter T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. Nature. 1999 Oct 7; 401(6753):606-10. PMID: 10524630.
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      107. Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel J. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nat Struct Biol. 1999 Aug; 6(8):775-84. PMID: 10426957.
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      108. Majeti R, Bilwes AM, Noel J, Hunter T, Weiss A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science. 1998 Jan 2; 279(5347):88-91. PMID: 9417031.
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      109. Starks CM, Back K, Chappell J, Noel J. Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. Science. 1997 Sep 19; 277(5333):1815-20. PMID: 9295271.
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      110. Noel J. Turning off the Ras switch with the flick of a finger. Nat Struct Biol. 1997 Sep; 4(9):677-80. PMID: 9302988.
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      111. Ranganathan R, Lu KP, Hunter T, Noel J. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell. 1997 Jun 13; 89(6):875-86. PMID: 9200606.
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      112. Bilwes AM, den Hertog J, Hunter T, Noel J. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature. 1996 Aug 8; 382(6591):555-9. PMID: 8700232.
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      113. Lambright DG, Noel J, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 1994 Jun 23; 369(6482):621-8. PMID: 8208289.
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      114. Noel J, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 1993 Dec 16; 366(6456):654-63. PMID: 8259210.
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      115. Dupureur CM, Yu BZ, Jain MK, Noel J, Deng T, Li Y, Byeon IJ, Tsai MD. Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73. Biochemistry. 1992 Jul 21; 31(28):6402-13. PMID: 1633153.
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      116. Noel J, Bingman CA, Deng TL, Dupureur CM, Hamilton KJ, Jiang RT, Kwak JG, Sekharudu C, Sundaralingam M, Tsai MD. Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates. Biochemistry. 1991 Dec 24; 30(51):11801-11. PMID: 1751497.
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      117. Noel J, Tsai MD. Phospholipase A2 engineering: design, synthesis, and expression of a gene for bovine (pro)phospholipase A2. J Cell Biochem. 1989 Jul; 40(3):309-20. PMID: 2674160.
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