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Joseph Noel

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0932
La Jolla CA 92093
Phone858-453-4100
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel J, Tawfik DS. Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor. Nat Chem Biol. 2018 May 14. PMID: 29760514.
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    2. Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel J, Tawfik DS. Evolution of chalcone isomerase from a noncatalytic ancestor. Nat Chem Biol. 2018 Apr 23. PMID: 29686356.
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    3. Vickery CR, Cardenas J, Bowman ME, Burkart MD, Da Silva NA, Noel J. A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae. Biotechnol Bioeng. 2018 Jun; 115(6):1394-1402. PMID: 29457628.
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    4. Stewart C, Woods K, Macias G, Allan AC, Hellens RP, Noel J. Molecular architectures of benzoic acid-specific type III polyketide synthases. Acta Crystallogr D Struct Biol. 2017 Dec 01; 73(Pt 12):1007-1019. PMID: 29199980.
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    5. Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel J, Evans RM. Structural basis for specific ligation of the peroxisome proliferator-activated receptor d. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2563-E2570. PMID: 28320959.
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    6. Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel J. Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246]. Curr Opin Struct Biol. 2016 Dec; 41:256-257. PMID: 27884574.
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    7. Levsh O, Chiang YC, Tung CF, Noel J, Wang Y, Weng JK. Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry. 2016 Nov 15; 55(45):6314-6326. PMID: 27805809.
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    8. Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel J. Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. Curr Opin Struct Biol. 2016 12; 41:233-246. PMID: 27662376.
      View in: PubMed
    9. Koo HJ, Vickery CR, Xu Y, Louie GV, O'Maille PE, Bowman M, Nartey CM, Burkart MD, Noel J. Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. J Antibiot (Tokyo). 2016 Jul; 69(7):524-33. PMID: 27328867.
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    10. Zheng Z, Guo Y, Novák O, Chen W, Ljung K, Noel J, Chory J. Local auxin metabolism regulates environment-induced hypocotyl elongation. Nat Plants. 2016 03 21; 2:16025. PMID: 27249562; PMCID: PMC4849989 [Available on 09/21/16].
    11. El Gamal A, Agarwal V, Diethelm S, Rahman I, Schorn MA, Sneed JM, Louie GV, Whalen KE, Mincer TJ, Noel J, Paul VJ, Moore BS. Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3797-802. PMID: 27001835; PMCID: PMC4833250 [Available on 10/05/16].
    12. Vickery CR, La Clair JJ, Burkart MD, Noel J. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr Opin Chem Biol. 2016 Apr; 31:66-73. PMID: 26851514.
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    13. Kersten RD, Diedrich JK, Yates JR, Noel J. Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases. ACS Chem Biol. 2015 Nov 20; 10(11):2501-11. PMID: 26378620; PMCID: PMC4655415.
    14. Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel J, Chappell J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chem Biol. 2015 Jul 17; 10(7):1729-36. PMID: 25897591; PMCID: PMC4570970.
    15. Pan H, Zhou R, Louie GV, Mühlemann JK, Bomati EK, Bowman ME, Dudareva N, Dixon RA, Noel J, Wang X. Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis. Plant Cell. 2014 Sep; 26(9):3709-27. PMID: 25217505; PMCID: PMC4213152.
    16. Vickery CR, Kosa NM, Casavant EP, Duan S, Noel J, Burkart MD. Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria. ACS Chem Biol. 2014 Sep 19; 9(9):1939-44. PMID: 24963544; PMCID: PMC4168790.
    17. Bomati EK, Haley JE, Noel J, Deheyn DD. Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus. Sci Rep. 2014 Jun 27; 4:5469. PMID: 24968921; PMCID: PMC4073121.
    18. Hoppmann C, Lacey VK, Louie GV, Wei J, Noel J, Wang L. Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells. Angew Chem Int Ed Engl. 2014 Apr 07; 53(15):3932-6. PMID: 24615769; PMCID: PMC4051619.
    19. Beld J, Sonnenschein EC, Vickery CR, Noel J, Burkart MD. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat Prod Rep. 2014 Jan; 31(1):61-108. PMID: 24292120; PMCID: PMC3918677.
    20. Dellas N, Thomas ST, Manning G, Noel J. Discovery of a metabolic alternative to the classical mevalonate pathway. Elife. 2013 Dec 10; 2:e00672. PMID: 24327557; PMCID: PMC3857490.
    21. Schorn M, Zettler J, Noel J, Dorrestein PC, Moore BS, Kaysser L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem Biol. 2014 Jan 17; 9(1):301-9. PMID: 24168704; PMCID: PMC4041076.
    22. Teufel R, Miyanaga A, Michaudel Q, Stull F, Louie G, Noel J, Baran PS, Palfey B, Moore BS. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature. 2013 Nov 28; 503(7477):552-556. PMID: 24162851; PMCID: PMC3844076.
    23. Lacey VK, Louie GV, Noel J, Wang L. Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings. Chembiochem. 2013 Nov 04; 14(16):2100-5. PMID: 24019075; PMCID: PMC3947478.
    24. Guo Y, Zheng Z, La Clair JJ, Chory J, Noel J. Smoke-derived karrikin perception by the a/ß-hydrolase KAI2 from Arabidopsis. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8284-9. PMID: 23613584; PMCID: PMC3657771.
    25. Stewart C, Vickery CR, Burkart MD, Noel J. Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. Curr Opin Plant Biol. 2013 Jun; 16(3):365-72. PMID: 23481348.
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    26. Zheng Z, Guo Y, Novák O, Dai X, Zhao Y, Ljung K, Noel J, Chory J. Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. Nat Chem Biol. 2013 Apr; 9(4):244-6. PMID: 23377040; PMCID: PMC3948326.
    27. Liscombe DK, Louie GV, Noel J. Architectures, mechanisms and molecular evolution of natural product methyltransferases. Nat Prod Rep. 2012 Oct; 29(10):1238-50. PMID: 22850796.
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    28. Zhang M, Wang XJ, Chen X, Bowman ME, Luo Y, Noel J, Ellington AD, Etzkorn FA, Zhang Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. ACS Chem Biol. 2012 Aug 17; 7(8):1462-70. PMID: 22670809; PMCID: PMC3423551.
    29. Ngaki MN, Louie GV, Philippe RN, Manning G, Pojer F, Bowman ME, Li L, Larsen E, Wurtele ES, Noel J. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature. 2012 May 13; 485(7399):530-3. PMID: 22622584; PMCID: PMC3880581.
    30. Auldridge ME, Guo Y, Austin MB, Ramsey J, Fridman E, Pichersky E, Noel J. Emergent decarboxylase activity and attenuation of a/ß-hydrolase activity during the evolution of methylketone biosynthesis in tomato. Plant Cell. 2012 Apr; 24(4):1596-607. PMID: 22523203; PMCID: PMC3398566.
    31. Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel J, Gage FH, Wang L. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40. PMID: 21681861; PMCID: PMC3209808.
    32. Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel J, Wilson IA, Chory J. Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature. 2011 Jun 12; 474(7352):467-71. PMID: 21666665; PMCID: PMC3280218.
    33. Takimoto JK, Dellas N, Noel J, Wang L. Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. ACS Chem Biol. 2011 Jul 15; 6(7):733-43. PMID: 21545173; PMCID: PMC3137230.
    34. Louie GV, Bowman ME, Tu Y, Mouradov A, Spangenberg G, Noel J. Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference. Plant Cell. 2010 Dec; 22(12):4114-27. PMID: 21177481; PMCID: PMC3027180.
    35. Noel J. Chemical biology: Synthetic metabolism goes green. Nature. 2010 Nov 18; 468(7322):380-1. PMID: 21085165.
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    36. Tu Y, Rochfort S, Liu Z, Ran Y, Griffith M, Badenhorst P, Louie GV, Bowman ME, Smith KF, Noel J, Mouradov A, Spangenberg G. Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). Plant Cell. 2010 Oct; 22(10):3357-73. PMID: 20952635; PMCID: PMC2990129.
    37. Dellas N, Noel J. Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. ACS Chem Biol. 2010 Jun 18; 5(6):589-601. PMID: 20392112; PMCID: PMC2887675.
    38. Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel J, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 May; 19(5):974-86. PMID: 20222012; PMCID: PMC2868240.
    39. Noel J, Dellas N, Faraldos JA, Zhao M, Hess BA, Smentek L, Coates RM, O'Maille PE. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. ACS Chem Biol. 2010 Apr 16; 5(4):377-92. PMID: 20175559; PMCID: PMC2860371.
    40. Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel J, DiPasquale AG, Rheingold AL, La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov; 72(11):1980-7. PMID: 19842686.
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    41. Savaldi-Goldstein S, Baiga TJ, Pojer F, Dabi T, Butterfield C, Parry G, Santner A, Dharmasiri N, Tao Y, Estelle M, Noel J, Chory J. New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15190-5. PMID: 18818305; PMCID: PMC2567513.
    42. Eustáquio AS, Härle J, Noel J, Moore BS. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem. 2008 Sep 22; 9(14):2215-9. PMID: 18720493; PMCID: PMC2692205.
    43. O'Maille PE, Malone A, Dellas N, Andes Hess B, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel J. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol. 2008 Oct; 4(10):617-23. PMID: 18776889; PMCID: PMC2664519.
    44. Kumano T, Richard SB, Noel J, Nishiyama M, Kuzuyama T. Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. Bioorg Med Chem. 2008 Sep 01; 16(17):8117-26. PMID: 18682327; PMCID: PMC2860626.
    45. Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballaré CL, Sandberg G, Noel J, Chory J. Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants. Cell. 2008 Apr 04; 133(1):164-76. PMID: 18394996; PMCID: PMC2442466.
    46. Austin MB, O'Maille PE, Noel J. Evolving biosynthetic tangos negotiate mechanistic landscapes. Nat Chem Biol. 2008 Apr; 4(4):217-22. PMID: 18347585; PMCID: PMC2703434.
    47. Baiga TJ, Guo H, Xing Y, O'Doherty GA, Dillin A, Austin MB, Noel J, La Clair JJ. Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. ACS Chem Biol. 2008 May 16; 3(5):294-304. PMID: 18376812; PMCID: PMC2692194.
    48. Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel J, Dudareva N, Pichersky E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. Plant J. 2008 May; 54(3):362-74. PMID: 18208524; PMCID: PMC2741023.
    49. Zhao N, Ferrer JL, Ross J, Guan J, Yang Y, Pichersky E, Noel J, Chen F. Structural, biochemical, and phylogenetic analyses suggest that indole-3-acetic acid methyltransferase is an evolutionarily ancient member of the SABATH family. Plant Physiol. 2008 Feb; 146(2):455-67. PMID: 18162595; PMCID: PMC2245846.
    50. Eustáquio AS, Pojer F, Noel J, Moore BS. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol. 2008 Jan; 4(1):69-74. PMID: 18059261; PMCID: PMC2762381.
    51. Noel J. Digging for answers, smelling a hint of success and tasting triumph. Nat Chem Biol. 2007 Nov; 3(11):690-1. PMID: 17948014; PMCID: PMC2859038.
    52. Faraldos JA, Zhao Y, O'Maille PE, Noel J, Coates RM. Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem. 2007 Oct 15; 8(15):1826-33. PMID: 17886322; PMCID: PMC2735885.
    53. Louie GV, Baiga TJ, Bowman ME, Koeduka T, Taylor JH, Spassova SM, Pichersky E, Noel J. Structure and reaction mechanism of basil eugenol synthase. PLoS One. 2007 Oct 03; 2(10):e993. PMID: 17912370; PMCID: PMC1991597.
    54. Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel J, Coates RM, Chappell J. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem. 2007 Oct 26; 282(43):31744-54. PMID: 17715131; PMCID: PMC2695360.
    55. Wang W, Takimoto JK, Louie GV, Baiga TJ, Noel J, Lee KF, Slesinger PA, Wang L. Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci. 2007 Aug; 10(8):1063-72. PMID: 17603477; PMCID: PMC2692200.
    56. Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lücke C, Hunter T, Lu KP, Fischer G, Noel J. Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol. 2007 May 22; 2(5):320-8. PMID: 17518432; PMCID: PMC2692202.
    57. Moffitt MC, Louie GV, Bowman ME, Pence J, Noel J, Moore BS. Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry. 2007 Jan 30; 46(4):1004-12. PMID: 17240984; PMCID: PMC2586389.
    58. Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel J. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell. 2006 Dec; 18(12):3656-69. PMID: 17172354; PMCID: PMC1785397.
    59. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel J. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 08; 24(5):759-770. PMID: 17157258.
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    60. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel J. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol. 2006 Dec; 13(12):1327-38. PMID: 17185228; PMCID: PMC2859959.
    61. Song L, Barona-Gomez F, Corre C, Xiang L, Udwary DW, Austin MB, Noel J, Moore BS, Challis GL. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006 Nov 22; 128(46):14754-5. PMID: 17105255; PMCID: PMC2859292.
    62. Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore BS, Kay RR, Noel J. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol. 2006 Sep; 2(9):494-502. PMID: 16906151; PMCID: PMC2864586.
    63. Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel J. Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11491-6. PMID: 16864776; PMCID: PMC1544197.
    64. Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel J, Gruebele M, Kelly JW. Structure-function-folding relationship in a WW domain. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10648-53. PMID: 16807295; PMCID: PMC1502286.
    65. Coiner H, Schröder G, Wehinger E, Liu CJ, Noel J, Schwab W, Schröder J. Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases. Plant J. 2006 Apr; 46(2):193-205. PMID: 16623883; PMCID: PMC2860623.
    66. Lherbet C, Pojer F, Richard SB, Noel J, Poulter CD. Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry. 2006 Mar 21; 45(11):3548-53. PMID: 16533036; PMCID: PMC2516919.
    67. Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel J. [Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding]. Med Sci (Paris). 2005 Nov; 21(11):903-4. PMID: 16274634.
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    68. Testa CA, Lherbet C, Pojer F, Noel J, Poulter CD. Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway. Biochim Biophys Acta. 2006 Jan; 1764(1):85-96. PMID: 16203191.
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    69. Bomati EK, Austin MB, Bowman ME, Dixon RA, Noel J. Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. J Biol Chem. 2005 Aug 26; 280(34):30496-503. PMID: 15970585; PMCID: PMC2860619.
    70. Kuzuyama T, Noel J, Richard SB. Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature. 2005 Jun 16; 435(7044):983-7. PMID: 15959519; PMCID: PMC2874460.
    71. Noel J, Austin MB, Bomati EK. Structure-function relationships in plant phenylpropanoid biosynthesis. Curr Opin Plant Biol. 2005 Jun; 8(3):249-53. PMID: 15860421; PMCID: PMC2861907.
    72. Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel J. Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. PLoS Biol. 2005 May; 3(5):e151. PMID: 15884974; PMCID: PMC1084334.
    73. Bomati EK, Noel J. Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. Plant Cell. 2005 May; 17(5):1598-611. PMID: 15829607; PMCID: PMC1091777.
    74. Ferrer JL, Zubieta C, Dixon RA, Noel J. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant Physiol. 2005 Mar; 137(3):1009-17. PMID: 15734921; PMCID: PMC1065401.
    75. Richard SB, Lillo AM, Tetzlaff CN, Bowman ME, Noel J, Cane DE. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Biochemistry. 2004 Sep 28; 43(38):12189-97. PMID: 15379557.
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    76. Austin MB, Bowman ME, Ferrer JL, Schröder J, Noel J. An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chem Biol. 2004 Sep; 11(9):1179-94. PMID: 15380179.
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    77. Pott MB, Hippauf F, Saschenbrecker S, Chen F, Ross J, Kiefer I, Slusarenko A, Noel J, Pichersky E, Effmert U, Piechulla B. Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. Plant Physiol. 2004 Aug; 135(4):1946-55. PMID: 15310828; PMCID: PMC520766.
    78. Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore BS, Noel J. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem. 2004 Oct 22; 279(43):45162-74. PMID: 15265863.
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    79. O'Maille PE, Tsai MD, Greenhagen BT, Chappell J, Noel J. Gene library synthesis by structure-based combinatorial protein engineering. Methods Enzymol. 2004; 388:75-91. PMID: 15289063.
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    80. Chen F, D'Auria JC, Tholl D, Ross JR, Gershenzon J, Noel J, Pichersky E. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. Plant J. 2003 Dec; 36(5):577-88. PMID: 14617060.
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    81. Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel J, Moore BS. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). J Ind Microbiol Biotechnol. 2003 Aug; 30(8):510-5. PMID: 12905073.
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    82. Zubieta C, Ross JR, Koscheski P, Yang Y, Pichersky E, Noel J. Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. Plant Cell. 2003 Aug; 15(8):1704-16. PMID: 12897246; PMCID: PMC167163.
    83. Sonnenburg ED, Bilwes A, Hunter T, Noel J. The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry. 2003 Jul 08; 42(26):7904-14. PMID: 12834342.
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    84. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel J, Nicolaou KC, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92. PMID: 12718892.
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    85. Austin MB, Noel J. The chalcone synthase superfamily of type III polyketide synthases. Nat Prod Rep. 2003 Feb; 20(1):79-110. PMID: 12636085.
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    86. Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel J. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell. 2003 Jan; 11(1):249-59. PMID: 12535537.
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    87. Moore BS, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel J. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. J Nat Prod. 2002 Dec; 65(12):1956-62. PMID: 12502351.
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    88. Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel J. Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. Plant Cell. 2002 Jun; 14(6):1265-77. PMID: 12084826; PMCID: PMC150779.
    89. Jez JM, Bowman ME, Noel J. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23; 41(16):5168-76. PMID: 11955065.
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