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Joseph Cantor

Title(s)Assistant Professor, Medicine
SchoolHealth Sciences
Phone858-822-6507
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    Collapse Biography 
    Collapse Education and Training
    UC San DiegoPostdoctoral Fellowship
    University of Colorado Health Sciences CenterPhDImmunology
    Cedarville UniversityBS, BABiology and Chemestry

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting CD98 in Type 1 Diabetes
    NIH/NIDDK K01DK090416Jan 15, 2011 - Dec 31, 2015
    Role: Principal Investigator

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    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 2018 Jun 15; 200(12):4012-4023. PMID: 29703862.
      View in: PubMed
    2. Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arterioscler Thromb Vasc Biol. 2017 07; 37(7):1323-1331. PMID: 28495929.
      View in: PubMed
    3. Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. J Immunol. 2017 05 01; 198(9):3410-3415. PMID: 28348273.
      View in: PubMed
    4. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
      View in: PubMed
    5. Liao Z, Cantor JM. Endothelial Cells Require CD98 for Efficient Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2163-2166. PMID: 27687603.
      View in: PubMed
    6. Abplanalp WT, Conklin DJ, Cantor JM, Ginsberg MH, Wysoczynski M, Bhatnagar A, O'Toole TE. Enhanced Integrin a4ß1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Diabetes. 2016 Nov; 65(11):3505-3515. PMID: 27495221.
      View in: PubMed
    7. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH. Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci. 2015 Dec 01; 128(23):4273-8. PMID: 26493331; PMCID: PMC4712820 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    8. Cantor JM, Rose DM, Slepak M, Ginsberg MH. Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunol Res. 2015 Jun; 3(6):661-7. PMID: 25600437.
      View in: PubMed
    9. Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg MH, H van der Horst E. Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 01; 137(3):710-20. PMID: 25556716.
      View in: PubMed
    10. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. PMID: 25587038; PMCID: PMC4366628.
      View in: PubMed, PubMed Central
    11. Cantor JM. CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis. J Neuroimmunol. 2014 Sep 15; 274(1-2):230-3. PMID: 25002078; PMCID: PMC4152380.
      View in: PubMed, PubMed Central
    12. Cantor JM, Ginsberg MH. CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci. 2012 Mar 15; 125(Pt 6):1373-82. PMID: 22499670; PMCID: PMC3336374.
      View in: PubMed, PubMed Central
    13. Cantor J, Slepak M, Ege N, Chang JT, Ginsberg MH. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. PMID: 21670318; PMCID: PMC3131465.
      View in: PubMed, PubMed Central
    14. Cantor J, Browne CD, Ruppert R, Féral CC, Fässler R, Rickert RC, Ginsberg MH. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol. 2009 Apr; 10(4):412-9. PMID: 19270713; PMCID: PMC2672195.
      View in: PubMed, PubMed Central
    15. Cantor JM, Ginsberg MH, Rose DM. Integrin-associated proteins as potential therapeutic targets. Immunol Rev. 2008 Jun; 223:236-51. PMID: 18613840.
      View in: PubMed
    16. Cantor J, Haskins K. Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha. J Immunol. 2005 Dec 01; 175(11):7738-45. PMID: 16301684.
      View in: PubMed
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